• International Journal of Stem Cells
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• v.16 no.2
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• pp.145-155
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• 2023

Background and Objectives: Embryologically, mesodermal development is closely related to the development of various organs such as muscles, blood vessels, and hearts, which are the main organs that make up the body. However, treatment for mesoderm developmental disorders caused by congenital or acquired factors has so far relied on surgery and drug treatment for symptom relief, and more fundamentally, treatment for mesoderm developmental disorders is needed. Methods and Results: In our study, microRNA (miRNA), which plays an important role in the mesoderm development process, was identified and the developmental function was evaluated. miRNAs consist of small nucleotides, which act as transcription factors that bind to the 3' untranslated region and suppressed target gene expression. We constructed the human embryonic stem cell (hESC) knockout cell line and analyzed the function and characteristics of miR-5739, which plays an important role in mesoderm lineage. miR-5739 acts as a transcription factor targeting SMA, Brachyury T, Hand1, which controls muscle proliferation and differentiation, and KDR gene, which regulates vessel formation in vitro. In vivo results suggest a role in regulating muscle proliferation and differentiation. Gene ontology analysis confirmed that the miR-5739 is closely related to genes that regulate muscle and vessel proliferation and differentiation. Importantly, abnormal expression of miR-5739 was detected in somatic cells derived from patients with congenital muscle disease. Conclusions: Our study demonstrate that miR-5739 gene function significantly affects transcriptional circuits that regulate muscle and vascular differentiation during embryonic development.

• Publications of The Korean Astronomical Society
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• v.7 no.1
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• pp.25-30
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• 1992

Recent redshift surveys suggest that most galaxies may be distributed on the surfaces of bubbles surrounding large voids. To investigate the quantitative consistency of this qualitative picture of large-scale structure, we study analytically the clustering properties of galaxies in a universe filled with spherical shells. In this paper, we report the results of the calculations for the spatial and angular two-point correlation functions of galaxies. With ${\sim}20%$ of galaxies in clusters and a power law distribution of shell sizes, $n_{sh}(R){\sim}R^{-{\alpha}}$, ${\alpha}\;{\simeq}\;4$, the observed slope and amplitude of the spatial two-point correlation function ${\xi}_{gg}(r)$ can be reproduced. (It has been shown that the same model parameters reproduce the enhanced cluster two-point correlation function, ${\xi}_{cc}(r)$). The corresponding angular two-point correlation function $w({\theta})$ is calculated using the relativistic form of Limber's equation and the Schecter-type luminosity function. The calculated w(${\theta}$) agrees with the observed one quite well on small separations (${\theta}{\lesssim}2deg$).

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.14 no.3
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• pp.216-221
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• 2014

In this paper, we introduce the concept of generalized double fuzzy semi-basically disconnected space and related notions such as (r, s)-generalized fuzzy semiopen-$F_{\sigma}$ sets, (r, s)-generalized fuzzy semiclosed-$G_{\delta}$ sets, generalized double fuzzy $semi^*$-open function, generalized double fuzzy $semi^*$-continuous function and generalized double fuzzy $semi^*$-irresolute function. Some interesting properties and characterizations of the concepts introduced are studied.

• The Journal of Korea Robotics Society
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• v.8 no.4
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• pp.273-282
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• 2013

The purpose of this study was to investigate effect of robot-assisted hand rehabilitation(Amadeo(R)) on hand motor function in chronic stroke patients. This study used a single-subject experimental design with multiple baselines across individuals. Three chronic stroke survivors with mild to sever motor impairment took part in study. Each participants had 2 weeks interval of starting intervention. Participants received robot-assisted therapy(45min/session. 3session/wk for 6wks). Finger active range of motion(AROM) was assessed by Range of Assessment program in Amadeo(R), and test-retest reliability was verified using Pearson correlation analysis. To investigate effect of Amadeo(R), finger AROM was measured immediately after each sessions and Fugl-Meyer Assessment of Upper extremity, Motor Activity Log, Nine hole peg board test and Jebsen-Taylor hand motor function test were assessed at pre-post intervention. Results were analyzed by visual analysis and comparison of pre-post tests. The test-retest reliability of Range of Assessment was good(r=.99). After robot-assisted therapy, finger AROM of participant 1, 2, and 3 was respectively improved by 18%, 3.6%, and 6% each. Hand motor function of participant 1, 3 was improved on all four tests, but not effect in participant 2. Robot-assisted hand rehabilitation could improve finger AROM and effect on hand motor function in chronic stroke patients.

• Journal of the Korean Mathematical Society
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• v.55 no.6
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• pp.1469-1483
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• 2018

We study a subclass of p-ary functions in n variables, denoted by ${\mathcal{A}}_n$, which is a collection of p-ary functions in n variables satisfying a certain condition on the exponents of its monomial terms. Firstly, we completely classify all p-ary (n - 1)-plateaued functions in n variables by proving that every (n - 1)-plateaued function should be contained in ${\mathcal{A}}_n$. Secondly, we prove that if f is a p-ary r-plateaued function contained in ${\mathcal{A}}_n$ with deg f > $1+{\frac{n-r}{4}}(p-1)$, then the highest degree term of f is only a single term. Furthermore, we prove that there is no p-ary r-plateaued function in ${\mathcal{A}}_n$ with maximum degree $(p-1){\frac{n-4}{2}}+1$. As application, we partially classify all (n - 2)-plateaued functions in ${\mathcal{A}}_n$ when p = 3, 5, and 7, and p-ary bent functions in ${\mathcal{A}}_2$ are completely classified for the cases p = 3 and 5.

• The Korean Journal of Health Service Management
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• v.6 no.2
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• pp.57-69
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• 2012

The purpose of this study was to investigate correlation with self-care behaviors and physiological index according to cognitive function of hemodialysis patients. The data were collected from 108 patients on hemodialysis in university hospital. The period of data collection was from January 4 to January 31, 2010. The instruments of research were MMSE, Self-care behavior scale for hemodialysis patients. The 17.6% of patients showed the cognitive disorder. Self-care behaviors of patients showed that normal cognitive function group was significantly higher than dysfunction group. Creatinine and parathyroid hormone of patients showed that normal cognitive function group was significantly lower than dysfunction group. The cognitive function of patients showed positive correlations with self-care behavior(r=.283, p=.003) and Kt/V(r=.214. p=.026), showed significant negative correlations with phosphorus(r=-.223, p=.020) and creatinine(r=-.318, p=.001). The results of this study can be used to develop nursing education program to improve self-care behaviors according to cognitive function of hemodialysis patients.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.5
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• pp.325-333
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• 2022

Heart failure (HF) has become one of the severe public health problems. The detailed role of mitochondrial function in HF was still unclear. Benzoylaconine (BAC) is a traditional Chinese medicine, but its role in HF still needs to be explored. In this study, oxygen-glucose deprivation and reperfusion (OGD/R) was executed to mimic the injury of H9C2 cells in HF. The viability of H9C2 cells was assessed via MTT assay. OGD/R treatment markedly decreased the viability of H9C2 cells, but BAC treatment evidently increased the viability of OGD/R-treated H9C2 cells. The apoptosis of H9C2 was enhanced by OGD/R treatment but suppressed by BAC treatment. The mitochondrial membrane potential was evaluated via JC-1 assay. BAC improved the mitochondrial function and suppressed oxidative stress in OGD/R-treated H9C2 cells. Moreover, Western blot analysis revealed that the protein expression of p-AMPK and PGC-1α were reduced in OGD/R-treated H9C2 cells, which was reversed by BAC. Rescue assays indicated that AMPK attenuation reversed the BAC-mediated protective effect on OGD/R-treated cardiomyocytes. Moreover, BAC alleviated myocardial injury in vivo. In a word, BAC modulated the mitochondrial function in OGD/R-induced cardiomyocyte injury by activation of the AMPK/PGC-1 axis. The findings might provide support for the application of BAC in the treatment of HF.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.31B no.10
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• pp.21-31
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• 1994

This paper describes the multichannel combined R2MFC/DTMF/CCT reciver which provides a signaling service functions for call processing control in digital switching system. Using the TMS320C25 DSP chip, we have implemented multi-function receriver shich processes 8 channels of R2MFC, DTMF, and CCT signals simultaneously. In order to increase the channel multiplicity of the combined receiver. R2MFC and CCT receiver were employed by discrete Fourier transform(DFT) method using Goertzel algorithm, and DTMFreceiver was employ by infinite impulse reponse(IIR) filtering method using 4KHz subsampling technique. The combined receiver has 4 function modes for each channel such as R2MFC, DTMF, CCT, and Idle modes. The function mode of each channel may be selected at any time by single-chip micro-controller(.mu.C). Hence, the number of channels assigned for each function mode can be adjusted dynamically according to the signaling traffic variations. From the experimental test results using the test-bed, it has been proved that the combined receiver statisfies all receiver satisfies all receiver specifications, and provides good channel multiplicity and performance, Therefore, it may give a great improvement than existing receiver in cost, reliability, availability, and serviceability.

• Journal of Magnetics
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• v.19 no.2
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• pp.192-196
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• 2014

The aim of the present study was to examine the effects of high and low frequency repetitive transcranial magnetic stimulation on motor cortical excitability and the balance function in subacute stroke patients. Twenty-four subjects were randomly assigned to either the high frequency (HF) rTMS group, or the low frequency (LF) rTMS group, with 12 subjects each. All subjects received routine physical therapy. In addition, both groups performed a total of 20 sessions of rTMS for 20 minutes, once a day, 5 times per week, for a 4-week period. In the HF rTMS group, 10 Hz rTMS was applied daily to the hotspot of the lesional hemisphere; and in the LF rTMS group, 1 Hz rTMS was applied daily to the hotspot of the nonlesional hemisphere. Motor cortex excitability was determined by motor evoked potentials, and the balance function was evaluated by use of the Balance Index (BI) and the Berg Balance Scale (BBS), before and after the intervention. The change rate in the value of each variable differed significantly between the two groups (p<0.05). Furthermore, significant differences were observed between all post-test variables of the two groups (p<0.05). In the HF rTMS, significant differences were found in all the pre- and post-test variables (p<0.05). On the other hand, in the LF rTMS, significant difference was observed only between the pre- and post-test results of BI and BBS (p<0.05). The findings demonstrate that HF rTMS can be more helpful in improving the motor cortical excitability and balance function of patients with subacute stroke treatment than LF rTMS, and that it may be used as a practical adjunct to routine rehabilitation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.10
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• pp.7078-7088
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• 2015

This study examined effects of health behaviors and sleep related factor on cognitive function in the elderly hypertensive patients. Data were collected through a face to face interview survey with structured questionnaire form 140 elderly with hypertension ($age{\geq}65years$) from February 5 to May 1, 2013. Research instruments included Pittsburgh Sleep Quality Index(PSQI), Epworth Sleepiness Scale(ESS) and Korean version the Mini-Mental State Examination(MMSE-K). Cognitive function was negatively related to degradation in quality of sleep(r=-.29, p<.001). Sleep duration were negatively related to body mass index(r=-.18, p=.032) and degradation in quality of sleep(r=-.59, p<.001). Sleep duration was positively related to daytime sleepiness(r=.22, p=.008). Hierarchical multiple regression showed that age, education levels and living arrangement were associated with cognitive function(F=8.56, p<.001, Adjusted $R^2=.14$). After controlling for demographic characteristics and health behaviors, degradation in quality of sleep(${\beta}=-.27$, p=.008) was identified as significant predictors of cognitive function. This final model explained 17.0% of the cognitive function in the elderly hypertensive patients(F=4.09, p<.001). Therefore, as a strategy improving cognitive function of the elderly with hypertension, therapeutic intervention should be developed to improve quality of sleep considering age, education levels and living arrangement.