• Journal of Korean Institute of Industrial Engineers
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• v.43 no.2
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• pp.83-89
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• 2017

This study aims to investigate the compatibility between 'quality' and 'R&D' and to ascertain what methodology can be applied. To consider the compatibility, this study discussed whether quality management can expand into R&D area in future and whether the quality management principles in ISO9000 can work well in R&D environment. Our conclusion is that the application of the quality management in R&D is valid and can serve as a new paradigm for improving R&D performance. In addition, this study divided the quality concept in R&D into several types from the viewpoints of quality definition and suggested quality methodologies for each type.

• Molecules and Cells
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• v.40 no.3
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• pp.195-201
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• 2017

In this study, qRT-PCR was employed to identify that miR-186 expression level in NSCLC tissues are highly associated with lymph node metastasis. In addition, through the application of western blotting, luciferase assay and qRT-PCR, it was found that miR-186 targeted 3'UTR of cdc42 mRNA and down-regulated cdc42 protein level in a post-transcriptional manner. Transwell assay indicated that cdc42 partially reversed the effect of miR-186 mimics. Besides, miR-186 was proved to regulate EMT by influencing biomarkers of this process and cell adhesion ability. Thus, miR-186 is a potential target for NSCLC therapy. miR-186 is proposed to be one of tumor-suppressors and may serve as a therapeutic target in NSCLC treatment.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.20 no.44
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• pp.257-261
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• 1997

Patents often serve as leading indicators of technological change. This patenting activity reflected R&D (Research & Development) of new technology. The purpose of this study is to set up a forecasting model that anticipate the number of domestic patent applications and the number of patents granted relating to R&D inputs (R&D expenditure, R&D manpower) at the level of three industrial sectors in Korea : electrical-electronic, machinery, chemical etc. In this study, forecasting models were used trend extrapolation and a set of regressions. Both Theil's inequality coefficient and MAE(Mean Absolute Error) were utilized to test the precision of predicted value. The patent data and the R&D data were based on Indicators of Industrial Technology data throught 1980 to 1996. The major results obtained in this study are as follows (1) The regression model is more useful for forecasting the trends of the number of patent applications and patents granted than the trend extrapolation method. (2) The variance of Theil's inequality is smaller in patent applications than in patent granted.

• Proceedings of the KIEE Conference
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• 1988.07a
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• pp.514-518
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• 1988

The switching system and transport will be developed and serve as hybrid switching system and link respectively according to the needs of mixed voice and data service in ISDN era. This paper describes a theory of optimal band width allocation in multiplexing voice and nonvoice traffic, and analyzes traffic performances on a model network.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.1057-1060
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• 2013

Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ovarian cancer (EOC) patients, and explored its association with clinicopathological factors and prognosis. The results showed significantly higher serum miR-21 levels in EOC patients than in healthy controls. In addition, increased serum miR-21 expression was correlated with advanced FIGO stage, high tumor grade, and shortened overall survival. These findings indicate that serum miR-21 may serve as a novel diagnostic and prognostic marker, and be used as a therapeutic target for the treatment of EOC.

• Nuclear Engineering and Technology
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• v.39 no.3
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• pp.187-192
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• 2007

The basic research on fast reactor technology was started in the mid-1960's in China. The emphasis was put on fast reactor neutronics, thermohydraulics, sodium technology, materials, fuels, safety, sodium devices and instrumentation. In 1987, the research turned to applied basic research with the conceptual design of a 60 MW experimental fast reactor as a target. The Project of the China Experimental Fast Reactor(CEFR) with a thermal power 65 MW was launched in 1993. The R&D of fast reactor technology then carried out to serve a design demonstration connected with the different phases of the conceptual, preliminary and detailed design of the CEFR. Recently, three directions of fast rector technology R&D activities have been considered, and some research programs have been developed. They are: (1) R&D related to the CEFR, i.e. experiments to be conducted on the CEFR for its safe operation, (2) R&D related to the projects of a prototype and the demonstration of fast reactors, and(3) advanced SFR technology within the framework of the international cooperation of INPRO and GIF.

• Structural Engineering and Mechanics
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• v.17 no.3_4
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• pp.393-408
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• 2004

There exists a clear need to monitor the performance of civil structures over their operational lives. Current commercial monitoring systems suffer from various technological and economic limitations that prevent their widespread adoption. The wires used to route measurements from system sensors to the centralized data server represent one of the greatest limitations since they are physically vulnerable and expensive from an installation and maintenance standpoint. In lieu of cables, the introduction of low-cost wireless communications is proposed. The result is the design of a prototype wireless sensing unit that can serve as the fundamental building block of wireless modular monitoring systems (WiMMS). An additional feature of the wireless sensing unit is the incorporation of computational power in the form of state-of-art microcontrollers. The prototype unit is validated with a series of laboratory and field tests. The Alamosa Canyon Bridge is employed to serve as a full-scale benchmark structure to validate the performance of the wireless sensing unit in the field. A traditional cable-based monitoring system is installed in parallel with the wireless sensing units for performance comparison.

• Molecules and Cells
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• v.40 no.5
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• pp.322-330
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• 2017

This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anti-cancer drug-resistant $Malme3M^R$ cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and $Malme3M^R$ cells. Furthermore, the self-renewal activity and the tumorigenic potential of $Malme3M^R$-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas.

• Journal of Platform Technology
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• v.6 no.1
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• pp.9-16
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• 2018

In recent years, many analysts have been using Python and R to analyze data using efficient analysis and statistics. However, it is difficult to solve the requirement to express various analyzes in real time through the web system using only two languages. In addition, it is possible to confirm that the extracted P-Value is different from the value in R because there is no corresponding algorithm in Java or the corresponding source is not verified. Therefore, in this paper, we propose a method to apply analyst 's analysis algorithm contents directly to his system using R in other languages.

• BMB Reports
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• v.52 no.5
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• pp.312-317
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• 2019

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide. MiR-371 has recently emerged as an important regulator in tumorigenesis, and may serve as a biomarker for malignant tumors. We transfected miR-371 or its inhibitor in two human HCC cell lines, then used 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, soft agar colony formation, and transwell migration assays to evaluate the effects on cell proliferation, migration, and invasion. We found that miR-371 was positively correlated with HCC metastasis and poor prognosis in the inflicted patients, and the high expression of miR-371 was promoted, whereas a low level of miR-371 depressed cell proliferation and invasion. We found PTEN to be a direct target of miR-371. The overexpression or knockdown of PTEN exhibited the opposite effects from those of miR-371 on cell proliferation and migration. Our study demonstrates that miR-371 promotes proliferation and metastasis in HCC by targeting PTEN.