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http://dx.doi.org/10.7314/APJCP.2013.14.2.1057

Identification of Serum MicroRNA-21 as a Biomarker for Early Detection and Prognosis in Human Epithelial Ovarian Cancer  

Xu, Yun-Zhao (Department of Obstetrics and Gynecology, Affiliated Hospital of Nan Tong University)
Xi, Qing-Hua (Department of Obstetrics and Gynecology, Affiliated Hospital of Nan Tong University)
Ge, Wen-Liang (Department of Pediatric Surgery, Affiliated Hospital of Nan Tong University)
Zhang, Xiao-Qian (Department of Obstetrics and Gynecology, Affiliated Hospital of Nan Tong University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.2, 2013 , pp. 1057-1060 More about this Journal
Abstract
Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ovarian cancer (EOC) patients, and explored its association with clinicopathological factors and prognosis. The results showed significantly higher serum miR-21 levels in EOC patients than in healthy controls. In addition, increased serum miR-21 expression was correlated with advanced FIGO stage, high tumor grade, and shortened overall survival. These findings indicate that serum miR-21 may serve as a novel diagnostic and prognostic marker, and be used as a therapeutic target for the treatment of EOC.
Keywords
miR-21; real-time reverse transcriptase-PCR; epithelial ovarian cancer; tumor stage; prognosis;
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