• 한국임상약학회지
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• 제16권1호
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• pp.63-68
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• 2006

Gabapentin, 1-(aminomethyl-1-cyclohexyl)acetic acid, is anew antiepileptic drug related to ${\gamma}-aminobutyric$ acid(GABA) currently being introduced in therapy worldwide. The bioavailability and pharmacokinetics of gabapentin capsules were examined in 22 volunteers who received a single oral dose in the fasting state by randomized balanced $2{\times}2$ crossover design. After dosing, blood samples were collected for a period of 24 hours and analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). Time course of plasma gabapentin concentration was analyzed with non-compartmental and compartmental approaches. $WinNonlin^{(R)}$, the kinetic computer program, was used for compartmental analysis. One compartment model with first-order input, first-order output with no lag time and weighting by $1/(predieted\;y)^2$ was chosen as the most appropriate pharmacokinetic model for the volunteers. The major pharmacokinetic parameters $(AUC_{0-24hr},\;AUC_{inf},\;C_{max}\;and\;T_{max})$ and other parameters $(K_a,\;K_{el},\;V_d/F\;and\;Cl/F)$ of $Gapentin^{TM}$ (test drug) and $Neurontin^{TM}$ (reference drug) were estimated by non-compartmental analysis and compartmental analysis. The 90% confidence intervals of mean difference of logarithmic transformed $AUC_{0-24hr}\;and\;C_{max}$ were $log(0.9106){\sim}log(1.l254)\;and\;log(0.8521){\sim}log(1.0505)$, respectively. It shows that the bioavailability of the test drug is equivalent with that of the reference drug. There was no statistically significant difference between the two drugs in all pharmacokinetic parameters.

• Asian-Australasian Journal of Animal Sciences
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• 제7권3호
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• pp.325-333
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• 1994

This study was undertaken at Gowa, South Sulawesi, Indonesia as part of a larger forage genetic resource evaluation project. The experimental program consisted of a field experiment where grasses and legume species were grown in monocultures and the yield, N content and rumen bag digestibility using goats were measured. The field experiment was conducted from December 1985 to October 1986. Eight species of legumes (Desmodium heterophyllum cv. John-stone, Desmodium triflorum from Gowa, South Sulawesi, Arachis sp. from Maiwa, South Sulawesi, Clitoria ternalea CPI 50973, Macroptilium atropurpureum ev. Siratro, Neonotonia wightii cv. Tinaroo, Centrosema pubescens CPI 58575, Centrosema plumeri CPI 58568) were grown as monocultures. After establishment all plants were cut to a uniform height of 5 cm, and subsequent cuts were made on regrowth after 14, 28, 42, and 56 days (cycle 1). Cycle 2 commenced towards the end of the wet season and continued for 157 days into the dry season. The highest yielding legumes were C. ternatea in the wet season and Arachis sp. in the dry season. The mean rumen bag dry matter digestibility (RBDMD) of legumes of 67.6% for leaf material (averaged over all cycles and ages) was 7.6% higher than for stem material. The RBDMD of Arachis was significantly higher than all other species. The RBDMD of all legumes declined with age. Calculation of yield of digestible DM (yield $\times$ RBDMD) showed that Arachis sp. was the best legume. The combination of plant "quality" with yield measures is a valuable adjunct to routine agronomic survey procedures in plant evaluation programs. Arachis sp. appears to offer considerable promise and should be more widely evaluated.

• 성인간호학회지
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• 제28권2호
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• pp.180-190
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• 2016

Purpose: This study examined the influence of occupational type and lifestyle habits on the prevalence of metabolic syndrome (MetS) among Korean male workers. Methods: Through secondary analysis of their four-year health examination data, 3,892 subjects were divided into four subgroups according to the presence of MetS now and four years ago. Results: Nineteen percent (n=739) suffered from MetS and these 739 subjects were classified into following occupations: 7.1% were office workers, 17.6% were non-office workers, and 42.2% were drivers. Multiple logistic regression analyses showed that when the data adjusted for age, the predicting factors on the prevalence of MetS were heavy drinking (OR 1.34, 95% CI 1.09~1.64) and the occupation of non-office workers (OR 2.99, 95% CI 2.13~4.18) and drivers (OR 7.97, 95% CI 4.89~10.83) among workers without MetS four years ago. Among workers already with a history of MetS, the predicting factors were less exercise (OR 1.55, 95% CI 1.02~2.35) and drivers (OR 2.21, 95% CI 1.03~2.94). Conclusion: Heavy drinking and less exercise and drivers were reported as influencing factors on the prevalence of MetS by this sample. The findings suggest that employers need to provide their employees with screening and management program for those at risk of MetS.

• 한국안광학회지
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• 제8권1호
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• pp.11-15
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• 2003

이 연구의 목적은 근시와 정시에서 근거리 작업의 결과로서 각막 지도의 변화를 조사한 것이다. 18세에서 24세 사이의 30명의 대학생을 무작위로 선택하였다. 그들은 각각 15명씩의 두 굴절 그룹으로 분류하였다. 즉 근시와 정시로 하였다. 각 피검자의 각박 지도는 Eye-Sys Videokeratography system으로 측정하였다. 측정은 근거리 작업의 30분 전후에 수행하였다(복사한 N10 교체를 20cm 근거리에서 수행함). 자극 받은 케라토 미터와 반경선 케라토미터 지도 프로그램은 자료의 분석에 사용하였다. 우리의 결과들은 단지 정시를 위한 근거리 작업 후 각막 지도의 중심 부위(3 mm)의 가장 연명한 경선에서 유의성 변화(P<0.005)의 발견을 제외하고는 근시와 정시 모두에 근거리 작업의 결과로서 자극된 케라토 미터와 반경선 나타남은 유의성을 가지는 변화는 없는 것으로 나타났다. 우리는 각막 지도는 근시와 정시 모두에서 근거리 작업의 결과로서 의미 있는 변화가 없다는 것을 결론지었다.

• 한국통신학회논문지
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• 제41권12호
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• pp.1861-1867
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• 2016

지난 2014년 한국형 SBAS (satellite based augmentation system)인 KASS (korea augmentation satellite system) 개발 구축 사업을 본격적으로 착수하였다. SBAS는 항공용으로 제정된 규격이지만, 비항공 분야에서도 활용이 가능하다. SBAS 규격으로 정해져 있는 메시지에 전송되는 정보의 종류 및 내용이 한정되어 있다. 전송되는 정보를 통해 센티미터 수준의 고정밀 위치 정보가 요구되는 분야에서 활용하기에는 정확도 수준이 낮기 때문에 추가적인 정보 제공이 필요하다. 비항공 분야에서 활용되는 정보를 항공기 항법에 영향을 주지 않으면서 안전하게 전송하기 위해서는 이에 대한 방법이 필요하다. 따라서, 이 논문에서는 항공용 SBAS 수신기에 대한 안전을 확보하면서 비항공 분야에서 활용할 수 있는 비규격 SBAS 데이터를 전송하는 방법에 대해 고찰하였다.

• Journal of Animal Science and Technology
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• 제47권2호
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• pp.147-158
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• 2005

The purpose of this study was to find out the effects that daughters' incomplete lactation records affect sire's breeding values through genetic evaluation using RRTDM(random regression test-day model). First, we estimated genetic parameters and breeding values on sires having complete lactation records of daughter by RRTDM, second, we changed complete lactation records of specific sires into incomplete records by various methods. Third, the breeding values were compared between complete and incomplete records. Finally, this study aimed to find out the methods to minimize the estimation errors of young bulls' breeding values. Data used in this study were collected from the dairy herd improvement program, and a total of 97,562 records were composed of 10,929 first parity with both parents known, since 1999. Breeding values on the daughters from randomly chosen sires were calculated and compared with among 90 day, 150day, and 200 day's incomplete records. For milk yields, sire's ranks of breeding values used by complete lactation records were very different from sire's ranks of breeding values obtained by incomplete lactation records(Rank_90 cut, 150cut, 200 cut).The differences were also obtained between complete lactation records(per305_full) and incomplete lactation record (per_90 cut, 150cut, 200 cut) in breeding values regarding persistency. Especially, the differences between per_90 cut and per305_full were very large(from 1.8 kg to 145kg).

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2002년도 춘계학술대회논문집
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• pp.441-447
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• 2002

KSR-III(Korea Sounding Rocket - III), which is being developed by Space Technology R&D Division of KARI(Korea Aerospace Research Institute) will be launched in late 2002. It is a three-stage, liquid propellant rocket which can reach 250 km altitude and will carry out observation of ozone layer and scientific experiments, such as microgravity experiment, and atmospheric measurement. KSR-III is believed to be an intermediate to the launch vehicle capable of carrying a satellite to its orbit. Space Test Department of KARI performed GVT(Ground Vibration Test) fer KSR-III EM at Rocket Test Building of KARI. GVT is very important for predicting the behavior of rocket in its operation, developing flight control program and performing aerodynamic analysis. This paper gives an introduction of rocket GVT configuration and information on test procedures, techniques and results of It. In this test. to simulate free-free condition, test object hung in the air laterally by 4 bungee cords specially devised. For the excitation of test object, pure random signal by two electromagnetic shakers was used and total 22 frequency response functions were achieved. Polyreference parameter estimation was performed to identify the modal parameters with MIMO(Multi-Input-Multi-Output) method. As the result of the test, low frequency mode shapes and modal parameters below 60Hz were identified

• 토지주택연구
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• 제2권2호
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• pp.145-155
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• 2011

It is very important for successful construction to estimate the soil volume conversion factor of domestic weathered ground accurately and reasonably. However, it is very difficult to quantify the weathering degree of weathered ground at the field, so that the soil volume conversion factor used in Korea is often dependent upon the standard of foreign countries. Besides, the soil volume conversion factor of domestic weathered ground has been rarely studied and the use and accuracy of the soil volume conversion factor have been questioned persistingly. This study suggests a simple but robust method for estimating the soil volume conversion factor and measuring the weathering degree reasonably, and attempts to establish the utilization of a soil volume conversion factor measurement system based on experimental and analytical results. We made relationship between electrical resistivity and weathering degree presented from weathering index obtained through laboratory tests using field samples, and an estimation method of in-situ weathering degree for granites and a calculation method of soil volume conversion factor using electrical resistivity. And also, we suggested the photogrametry measurement-equipment system for measuring the volume of cargo box and the application plan of stand equipment and RFID for calculating the earth volume and distinguishing buggies in order to design the measurement system for soil volume conversion factor applicable to the field. Ultimately, the Weathered Earth-work Management Program (WEMP) was developed, so field managers may easily obtain the information about earth volume and soil volume conversion factor at the weathered ground.

• Nuclear Engineering and Technology
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• 제27권1호
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• pp.53-66
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• 1995

현재 사용중인 Non-LOCA 해석용 인허가 코드들은 특정한 형태의 가압경수로에 맞게 짜여진 것들이어서 모든 형태의 가압 경수로에 적용할 수 있는 범용 코드의 개발이 필요한 실정이다. 이를 위하여 한국원자력연구소에서는 웨스팅하우스 및 CE형 발전소에 공히 적용할 수 있는 과도현상 해석 코드인 TASS 로드를 개발하고있다. 이 TASS 코드는 실시 간 보다 빠르게 핵증기계통에 대한 모의 계산을 수행하며 대화식의 입출력을 통하여 사용자가 원하는 과도현상을 정확히 모사할 수 있다. 본 논문에서는 웨스팅하우스형 발전소에 대하여 TASS 코드를 적용하여 Non-LOCA 인허가 해석을 하기 위한 검증을 위해, 교류 전원 상실사고와 부하상실사고에 대하여 발전소 실측자료와의 비교계산을 수행하였고 주급수관 파단사고, 펌프축 고착사고, 증기발생기 세관 파열사고 및 주증기관 파단사고들에 대하여 대형코드인 RELAP5 /MOD3 코드와의 비교계산을 수행하였다.

• 융합정보논문지
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• 제10권2호
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• pp.82-88
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• 2020

본 연구는 화공용 열교환기에서 법랑코팅 적용을 위한 고온의 소성 공정조건 최적화에 대한 기초자료를 얻고자 하는데 그 목적이 있다. Shell & Tube 형태인 열교환기에 법랑코팅 적용을 위해 소성온도를 순차적으로 높이는 방안에 대해 검토하였다. 소성로 내부에서 열교환기의 온도분포에 대해 CFD 상용 프로그램으로 수치계산하여 구한 온도를 하중조건으로 열응력 해석을 수행하는 연성 해석(FSI) 방식을 이용하여 열교환기의 구조 안전성에 미치는 영향을 확인하였다. 수치해석 및 실험결과 상온의 열교환기를 바로 860℃도의 소성로에 넣으면 열교환기의 국부적 온도차로 인한 구조 안전성에 문제가 발생하므로 온도차를 줄이기 위한 예열 과정이 필요하다. 소성공정 단계가 적은 Case2와 같이 1단계 예열온도 445℃, 2단계 소성온도 860℃가 가장 적합한 것으로 판단된다.