• 한국문헌정보학회지
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• 제43권2호
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• pp.277-298
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• 2009

한국학술진흥재단 기초학문자료센터(Korean Research Memory: KRM)의 기 구축된 인문사회 학술용어는 각 용어 및 연구 성과물간에 성립하는 의미관계의 분석을 통해 수요에 적합한 정보를 보다 효율적으로 탐색 활용할 수 있도록 연구성과물 메타데이터의 유기적 연동이 요구되었다. 본 연구에서는 첫째, 연구성과물의 핵심적 개념을 표현하는 주제 색인어로 구성된 인문사회 학술용어 온톨로지를 기반으로 각 해당 연구성과물 지식구조를 표현하는 개념모델를 정의하고, 둘째, 연구성과물 간에 성립하는 의미관계 정의를 통해, 연구성과물에 대응하는 연구자 정보수요를 분석하여 이에 맞춘 정보 탐색서비스 모델을 설계하였다. 셋째, 학술용어 온톨로지 및 연구성과물 DB의 유기적 연계통합 운영을 위한 기술적이고 관리적 체계 수립방안을 제시하였다.

• 기술혁신학회지
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• 제19권3호
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• pp.511-544
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• 2016

표준은 호환성 증진, 품질확보 및 안정성 증진, 정보제공 등의 긍정적인 기능과 함께 기술혁신을 유발하는 것으로 알려져 있다. 표준의 순기능이 어떤 특정 기업 집단의 기술혁신 활동이나 사업화에 영향을 주는지 밝히는 것은 표준관련 정책을 수요 집단에 맞춰 적절하게 기획하고 집행하는 것을 가능하게 한다. 따라서 본 연구는 표준 정책 수립과 집행에서 증거기반 정책이라는 측면에서 기여하고자 중소기업 중에서 연구개발 동기가 표준 대응인 기업과 기술사업화를 위해서 표준제도 도입이 필요한 기업을 프로파일링하여, 이런 특정 기업을 판별할 수 있는 예측모형을 개발하고자 한다. 이를 위해, 본 연구는 의사결정나무 분석을 통해 표준 대응을 위해 연구개발을 하는 중소기업과 기술사업화를 위해 표준 규격이나 기술인증 정책을 필요로 하는 중소기업의 특징을 데이터마이닝을 통해 프로파일링 했다. 또한 판별분석을 활용하여 프로파일링된 두 가지 조건의 기업군을 몇 가지 변수로 판별할 수 있는 예측모형을 제시하였으며 판별식의 활용 가능성도 통계적으로 확인했다. 연구결과에 따르면 표준 및 규제 대응을 위해 연구개발을 수행하는 기업은 R&D기획 소요기간, 표준산업분류, 종업원 수, 기술의 신규성 등의 변수에서 차이가 있는 것으로 나타났다. 기술사업화를 위한 표준정책지원 수요기업의 프로파일링 결과에 따르면 표준산업분류, 주거래처, 연구개발 소요기간, 시험검사 능력 등의 변수에서 차이가 있었다. 본 연구에서 프로파일링 결과와 판별분석을 통해 제시한 모형은 향후 표준관련 정책을 기획하거나 집행할 때 표준지원을 필요로 하는 기업에 대한 객관적인 정보를 제공하여 표준관련 사업 성공률을 제고하는데 기여할 것으로 기대된다.

• 한국지역사회생활과학회지
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• 제25권1호
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• pp.39-49
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• 2014

This study identifies the necessity and importance of innovation in rural communities and highlights the role of rural revitalization support centers in facilitating the diffusion of community innovation. The study provides a literature review and employs the survey method to verify the arguments. There is an urgent need for rural communities to be distinct, attractive, and competitive in the wake of globalization. It is clear that they must recognize the need to facilitate innovation under growing trends toward trade liberalization, environment-oriented life styles, diversified consumer needs, and a knowledge-based society. The results provide support for the legitimacy of establishing rural revitalization support centers to help community leaders and local stakeholders develop their communities. More specifically, rural communities should employ R&D outcomes from diverse fields and capacity building by community members, leaders, and local governments to foster sustainable growth by overcoming limitations in spatial access and resources. The results suggest that rural revitalization support centers can be established as intermediary organizations that can be operated to facilitate community innovation in rural development. In addition, these centers should play key roles such as empowering communities, facilitating region-specific rural development policies, motivating R&D applications for rural development, encouraging rural development networks. Further, close attention should be paid to facilitate mutual learning by expanding networks and interactions between these centers.

• Journal of Ginseng Research
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• 제42권3호
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• pp.356-360
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• 2018

The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speeding up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, and echocardiographic studies. The results exhibited that body weights were significantly reduced and the gain of different organ weights were partly eased by GBCK25 treatment. Echocardiography results proposed the amelioration of heart function through normalized levels of left ventricle systolic pressure, ejection fraction, and fractional shortening. These outcomes deliver straight confirmation that GBCK25 could be a potential nutraceutical source for the relief of HFD-induced obesity mediated cardiac dysfunctions.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(역학)
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• pp.270-284
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• 1994

Interim analyses of randomized trials enable investigators to make more efficient use of limited research resources and to satisfy ethical requirements that a regimen be discontinued as soon as it has been established to have an inferior efficacy/toxicity profile. Unfortunately. the integrity and credibility of these trials can be compromised if inappropriate procedures are used in monitoring interim data. 'In this paper we discuss how group sequential designs provide useful guidelines that enable one to satisfy the valid objectives of interim monitoring while avoiding undesirable consequences, and we consider how flexible one can be in the way such designs are implemented. We also provide motivation for the role of data-monitoring committees in preserving study integrity and credibility in either government- or industry-sponsored trials. In our view. these committees should have multidisciplinary representation and membership limited to individuals free of apparent significant conflict of interest, and ideally should be the only individuals to whom the data analysis center provides interim results on relative efficacy of treatment regimens. Finally. we discuss some important practical issues such as estimation following group sequential testing, anal ysis of secondary outcomes after using a group sequential design applied to a primary outcome, early stopping of negative trials. and the role of administrative analyses.

• Journal of Information Science Theory and Practice
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• 제10권spc호
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• pp.1-11
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• 2022

As data-based research activities and outcomes increase and ontact or non-face-to-face activities become common, the demand for easy utilization of resources, tools, functions, and easily accessible information required for research in the R&D sector has increased accordingly. With the rapid increase in the demand for collaborative research based on online platforms, research support institutions strive to provide venues for research activities that merge various information and functions. ScienceON, an integrated science & technology (S&T) knowledge infrastructure service developed and operated by the Korea Institute of S&T Information (KISTI), supports open collaboration by connecting and merging all the information, functions, and infrastructure required for research activities. This paper describes the online research activity support tool provided by ScienceON and the remarkable results achieved through this activity. Specifically, the excellent creation of the following flow of meta-material research activities in the ontact space is elucidated. First, the papers required for a meta-material analysis are retrieved, virtual simulation is conducted with the experimental data extracted from the papers, and research data are accumulated. ScienceON's tools for supporting ontact research activity will play a role as an important service in the era of digital transformation and open science.

• 기술혁신학회지
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• 제20권2호
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• pp.334-367
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• 2017

국내 ICT 산업은 글로벌 경쟁력을 갖추고 경제발전에 크게 이바지 해왔으며, 침체된 우리나라의 경제상황을 활성화할 수 있는 성장 동력으로 주목받고 있다. 이러한 ICT 산업을 국내외에서 다양한 모습으로 바라보고 있는데, 이 중에는 객관적인 근거가 부족한 고정 관념도 많다. 이런 특정 집단에 대해 많은 사람이 가지는 공통되고 고정된 견해가 스테레오타입인데, 스테레오타입은 항상 부정적인 것은 아니지만 우리의 의사결정에 큰 영향을 주기 때문에 간과할 수 없다. 따라서 본 연구는 ICT 산업에 대한 스테레오타입을 살펴보고 보다 객관적이고 상대적인 스테레오타입을 제공하고자 한다. 이를 위해, 본 연구는 3,300개 중소기업 설문을 토대로 의사결정나무 분석을 통해 국내 ICT 기업이 다른 기술 기업과 비교해서 가지는 특징을 도출했다. 기업일반, 기술개발 활동, 기술개발 조직과 인력 등 10가지 R&D 정책 주제에 대해서 291개 변수를 대상으로 분석했는데, 기계학습을 활용한 데이터마이닝의 한 가지 방법인 의사결정나무 분석을 활용해서 ICT 기업과 다른 기술 기업이 구분되는 변수를 찾고 그 특징을 통해 객관적인 ICT 기업의 스테레오타입을 제시했다. 이 연구의 결과로 제시된 ICT 기업의 스테레오타입에 따르면, 국내 ICT 기업을 위해서는 첫째 R&D 기획이나 판로개척을 지원할 수 있는 기술정책이 필요하며, 둘째 신제품이나 신규 분야 진출을 위한 R&D 지원정책이 강화되어야 하고, 셋째 기술개발 결과에 대한 보안과 지재권 관리를 위한 지원정책이 요구되며, 넷째 ICT 기업과 관련된 정부 R&D 지원 제도관련 행정 간소화가 요구되는 것으로 나타났다. 이 연구의 결과는 ICT 중소기업을 위한 기술정책 수립 집행 평가에 다양한 시사점을 제공할 수 있으며, 특히 ICT 중소기업을 위한 R&D 정책을 수립하는 정책당국자나 유관기관의 연구자에게 여러 가지 정책적 가이드를 제공해 줄 것으로 기대한다.

• 산업경영시스템학회지
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• 제39권2호
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• pp.64-71
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• 2016

Recently, nanotechnology has grown as one of the leading science technology along with other converging technologies such as biology, information, medicine etc., bringing the continuous investment of the government in nano-related field. However, it is difficult to measure and evaluate the performance of the national research and development programs because of the multidimensional character of the expected outcomes. This study aims to measuring efficiency of the national nanotechnology research and development programs using DEA model. The decision making units are nine nano-related ministries including the Ministry of Science, ICT and Future Planning. The input variables are total expenditure, number of the programs and average expenditure per program. The output variables are science, technology and economic indicator, and the combination of these outputs are respectively measured as seven different DEA cases. The Ministry of Science, ICT and Future was the first efficient ministry in total technical efficiency. Ministry of Agriculture, Food and Rural Affairs and the Ministry of Food and Drug Safety were efficient in pure technical efficiency, when the Ministry of Commerce Industry and Energy took the first in the scale efficiency. The program efficiency was affected by organizational characteristics such as the institution's scale, the concentration of the research paper or the patent, technology transfer or the commercialization. The result of this study could be utilized in development of the policy in the nanotechnology and the related field. Furthermore, it could be applied for the modification of expenditure management or the adjustment of the research and development programs' input and output scale for each ministry.

• Journal of Korean Neurosurgical Society
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• 제65권6호
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• pp.861-867
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• 2022

Objective : High-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer cell activity (NKA) after Gamma Knife Radiosurgery (GKS) in patients with brain cancer. Methods : We performed an open-label, prospective, cross-sectional study of 38 patients who were treated with GKS for brain tumors, including metastatic and benign brain tumors. All of the patients underwent GKS, and blood samples were collected before and after GKS. NKA was measured using an enzyme-linked immunosorbent assay kit, to measure interferon-gamma (IFNγ) secreted by ex vivo-stimulated NK cells from whole blood. We explored the correlations between NK cell-produced IFNγ (NKA-IFNγ) levels and clinical parameters of patients who were treated with GKS for brain tumors. Results : NKA-IFNγ levels were decreased in metastatic brain tumor patients compared to those with benign brain tumors (p<0.0001). All the patients who used steroid treatment to reduce brain swelling after GKS had an NKA-IFNγ level of zero except one patient. High NKA-IFNγ levels were not associated with a rapid decrease in brain metastasis and did not increase after GKS. Conclusion : The activity of NK cells in metastatic brain tumors decreased more than that in benign brain tumors after GKS.

• 한국수산과학회지
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• 제56권6호
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• pp.930-935
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• 2023

This study aimed to analyze the structure of the value chain of the olive flounder aquaculture industry to increase the value of this industry. Based on the value chain theory, olive flounder aquaculture industry activities were classified as primary and support activities. The primary activities included seed production, fish production, producer distribution, consumer distribution, and consumption. The support activities were production infrastructure, organization and specialization, R&D, and government policy. A survey was conducted on the costs of seed and fish production in the primary activities to investigate the business structure, and the distribution structure was analyzed to examine distribution costs and margins. In the support activities, the recent trends in R&D and government policy were mainly examined, based on which, a measure to reduce costs and maximize profits was suggested. It is necessary to reduce costs across the production processes by improving seed quality and reducing labor, feed, and management costs, which are strongly associated with support activities. Therefore, lowering costs will be possible in the olive flounder aquaculture industry when R&D outcomes, such as species development, feed quality improvement, and aquaculture system development, are stably diffused and applied in tandem with government policy regarding the industry.