• Educational Technology International
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• 제23권2호
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• pp.157-181
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• 2022

Scale scores for cognitive domains have been used as an important indicator for both academic achievement and clinical diagnosis. For example, in education, Cognitive Abilities Test (CogAT) has been used to measure student's capability in academic learning. In a clinical setting, Cognitive Impairment Screening Test utilizes items measuring cognitive ability as a dementia screening test. We demonstrated a procedure of generating cognitive ability test items similar as in CogAT but the theory associated with the generation is totally different. When creating cognitive test items, we applied automatic item generation (AIG) that reduces errors in predictions of cognitive ability but attains higher reliability. We selected two cognitive ability test items, categorized as a time estimation item for measuring quantitative reasoning and a paper-folding item for measuring visualization. As CogAT has widely used as a cognitive measurement test, developing an AIG-based cognitive test items will greatly contribute to education field. Since CLASS is the only LMS including AIG technology, we used it for the AIG software to construct item models. The purpose of this study is to demonstrate the item generation process using AIG implemented within CLASS, along with proving quantitative and qualitative strengths of AIG. In result, we confirmed that more than 10,000 items could be made by a single item model in the quantitative aspect and the validity of items could be assured by the procedure based on ECD and AE in the qualitative aspect. This reliable item generation process based on item models would be the key of developing accurate cognitive measurement tests.

• Bulletin of the Korean Chemical Society
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• 제30권5호
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• pp.1177-1180
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• 2009

• 한국재난정보학회 논문집
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• 제18권2호
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• pp.252-260
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• 2022

연구목적: 기후변화 등으로 인해 자연재해의 빈도 및 강도가 증가하고 있어, 원자력발전소에 영향을 주는 외부사건이 발생할 수 있다. 원자력발전소는 자연재해, 인공재해 등 외부사건으로부터 안전해야 한다. 따라서 원자력발전소에 발생할 수 있는 외부사건을 식별하여야 하며, 원자력발전소에 큰 영향을 줄 수 있는 외부사건을 선별하여야 한다. 본 연구에서는 외부사건을 식별 및 선별하는 방법의 연구동향을 소개한다. 연구방법: 원자력발전소의 확률론적 안전성 평가를 위한 외부사건의 식별 및 선별에 관한 문헌조사를 실시하였다. 또한 국내외 외부사건의 식별 및 선별에 관한 규정을 조사하였다. 연구결과: 원자력발전소의 외부사건 영향분석의 비용을 최소화하고자 외부사건을 식별 및 선별하는 연구가 이루어지고 있다. 각 연구는 관점에 따라 차이를 보이지만 공통적으로 식별과정에서는 원자력발전소 부지에서 발생할 수 있는 모든 사건을 식별하고자 하며, 선별과정에서는 정성적 기준과 정량적 기준을 바탕으로 외부사건을 선별한다. 결론:기후변화 등으로 인하여 자연재해의 강도가 변화하고 있어, 원자력발전소에 영향을 주는 외부사건을 식별 및 선별하는 과정이 중요해지고 있다. 따라서 본 논문에서는 외부사건을 식별과 선별하는 방법에 대해 조사하여 정리하였다. 국내의 경우 원자력발전소의 확률론적 안전성 평가를 위한 외부사건의 식별과 선별에 관한 연구가 미미한 실정이다. 또한 외부사건 정량적 선별과정에서 수행하는 '경계분석'과 '명백히 보수적인 분석' 방법에 관한 연구가 필요할 것으로 보인다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5759-5765
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• 2014

Electrical impedance tomography (EIT) is a potential supplement for mammogram screening. This study aimed to evaluate and feasibility of EIT as opposed to mammography and to determine pain perception with both imaging methods. Women undergoing screening mammography at the Radiology Department of National University of Malaysia Medical Centre were randomly selected for EIT imaging. All women were requested to give a pain score after each imaging session. Two independent raters were chosen to define the image findings of EIT. A total of 164 women in the age range from 40 to 65-year-old participated and were divided into two groups; normal and abnormal. EIT sensitivity and specificity for rater 1 were 69.4% and 63.3, whereas for rater 2 they were 55.3% and 57.0% respectively. The reliability for each rater ranged between good to very good (p<0.05). Quantitative values of EIT showed there were significant differences in all values between groups (ANCOVA, p<0.05). Interestingly, EIT scored a median pain score of $1.51{\pm}0.75$ whereas mammography scored $4.15{\pm}0.87$ (Mann Whitney U test, p<0.05). From these quantitative values, EIT has the potential as a health discriminating index. Its ability to replace image findings from mammography needs further investigation.

• Journal of Preventive Medicine and Public Health
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• 제34권4호
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• pp.408-416
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• 2001

Objectives : To evaluate the diagnostic value of quantitative ultrasound (QUS) in the prediction of osteoporosis as defined by dual energy x-ray absorptiometry (DEXA) in postmenopausal women. Methods : Questionnaires and height and weight measurements were used in the investigation of 176 postmenopausal women. QUS measurements were taken on the right calcaneus while bone mineral density (BMD) measurements of the lumbar spine and femoral neck were made with DEXA. The areas under the curves (AUC) of the speed of sound (SOS) for osteoporosis in the lumbar spine and femoral neck were obtained through receiver operating characteristic (ROC) analysis and evaluated. A comparison was made, for osteoporosis in the lumbar spine and femoral neck, between the AUCs of the logistic model with clinical risk factors and SOS. Results : Pearson's correlation coefficients of SOS and lumbar spine BMD, and of SOS and femoral neck BMD were 0.26 and 0.37. The AUC for the logistic model in its discrimination for lumbar spine osteoporosis was 0.764, and for SOS 0.605. The AUCs for the logistic model in its discrimination for femoral neck osteoporosis and for SOS were 0.890 and 0.892, respectively. Conclusions : These results suggest that the diagnostic value of QUS as a screening tool for osteoporosis is moderate for the femoral neck, but merely low for the lumbar spine and that the predictability provided by SOS is no better than that by the sole use of clinical risk factors in postmenopausal women.

• Journal of Microbiology
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• 제41권4호
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• pp.320-326
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• 2003

In order to identify Vibrio vulnificus in the Yellow Sea near Gunsan, Korea during the early and late summers, the efficiency of the real-time quantitative TaqMan PCR was compared to the efficiency of the conventional PCR and Biolog identification system^TM. Primers and a probe were designed from the hemolysin/cytolysin gene sequence of V. vulnificus strains. The number of positive detections by real-time quantitative TaqMan PCR, conventional PCR, and the Biolog identification system from seawater were 53 (36.8%), 36 (25%), and 10 strains (6.9%), respectively, among 144 samples collected from Yellow Sea near Gunsan, Korea. Thus, the detection method of the real-time quantitative TaqMan PCR assay was more effective in terms of accuracy than that of the conventional PCR and Biolog system. Therefore, our results showed that the real-time TaqMan probe and the primer set developed in this study can be applied successfully as a rapid screening tool for the detection of V. vulnificus.

• 대한토목학회논문집
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• 제43권6호
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• pp.699-708
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• 2023

원자력 발전소는 안전하게 운영될 수 있도록 설계단계에서 자연재해를 포함한 예상 가능한 모든 외부사건들이 고려되고 있다. 그러나 최근에 기후변화로 인해 설계를 초과하는 자연재해의 발생 가능성이 증가하면서 설계 당시에 예측하지 못했던 극한자연재해와 외부사건에 대해 세심한 검토가 요구되고 있다. 본 연구에서는 국내 원전 부지별 잠재적 극한자연재해를 선별하고자 하였다. 이를 위해서 원전 부지특성과 원전 부지별 외부재해로 인해 발생한 사건을 조사하고 분석하였다. 그리고 기존 문헌과 연구 자료를 조사하여 국내 원전 실정에 맞는 선별절차와 기준을 수립하였다. 본 연구에서 수립된 선별기준에 근거하여 원전 부지별로 정성적 선별을 수행하였고, 선별된 자연재해를 대상으로 정량적 선별과 현장실사를 통해 국내 원전 부지별 잠재적 극한자연재해를 선별하였다. 선별 결과, 폭우에 의한 내부침수 이외에도 강풍에 의한 풍압과 극한 공기압이 모든 부지에서 공통적인 잠재적 극한자연재해로 선별되었다. 그리고 고리부지의 경우 폭풍해일이 1순위의 잠재적 극한자연재해로 선정되었다.

• Journal of Genetic Medicine
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• 제12권2호
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• pp.72-78
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• 2015

Recently, noninvasive prenatal test (NIPT) has been adopted as a primary screening tool for fetal chromosomal aneuploidy. The principle of NIPT lies in isolating the fetal fraction of cell-free DNA in maternal plasma and analyzing it with bioinformatic tools to measure the amount of gene from the target chromosome, such as chromosomes 21, 18, and 13. NIPT will contribute to decreasing the need for unnecessary invasive procedures, including amniocentesis and chorionic villi sampling, for confirming fetal aneuploidy because of its higher positive predictive value than that of the conventional prenatal screening method. However, its greater cost than that of the current antenatal screening protocol may be an obstacle to the adoption of this innovative technique in clinical practice. Digital polymerase chain reaction (dPCR) is a novel approach for detecting and quantifying nucleic acid. dPCR provides real-time diagnostic advantages with higher sensitivity, accuracy, and absolute quantification than conventional quantitative PCR. Since the groundbreaking discovery that fetal cell-free nucleic acid exists in maternal plasma was reported, dPCR has been used for the quantification of fetal DNA and for screening for fetal aneuploidy. It has been suggested that dPCR will decrease the cost by targeting specific sequences in the target chromosome, and dPCR-based noninvasive testing will facilitate progress toward the implementation of a noninvasive approach for screening for trisomy 21, 18, and 13. In this review, we highlight the principle of dPCR and discuss its future implications in clinical practice.

• 환경분석과 독성보건
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• 제21권4호
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• pp.304-315
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• 2018

Located in Gimhae, Hwapo is the biggest riverine wetland in the province of Gyeongsangsam-do, Korea, and is a major habitat for various species. However, it is suspected that various pollutants enter the wetlands from agricultural and industrial areas. This study identifies major organic pollutants in this wetland and their sources using high performance liquid chromatography-high resolution mass spectrometry during one summer season. Forty-five substances were selected for quantitative analysis using target screening, and other non-selected compounds were screened using suspect and non-target screening methods. The results were that 21 and 17 targeted substances were detected in July and August, respectively. Major pollutants in July and August were oxadiazon (July: 17-220 ng/L, August: 66-460 ng/L), carbendazim (July: 10-110 ng/L, August: 64-520 ng/L), caffeine (July: 33-1,100 ng/L, August: 56-580 ng/L), and niflumic acid (July: 23-75 ng/L, August: 42-290 ng/L). Sampling sites S4 in July and S2 in August were the major inflow points. Ten substances (tricyclazole, hexaconazole, diuron, fexofenadine, irbesartan, simetryn, cimetidine, valsartan, tebuconazole, and benzotriazole) and four metabolites (valsartan acid, azoxystrobin acid, TEB_M324c, and 2-aminobenzimidazole) were tentatively identified through suspect and non-target screening, respectively.

• Genomics & Informatics
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• 제11권4호
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• pp.200-210
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• 2013

Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.