• 한국IT서비스학회지
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• 제14권4호
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• pp.185-197
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• 2015

As the uncertainty of demand in B2B electronics market has increased, firms need a strong method to estimate the market demand. An accurate prediction on the market demand is crucial for a firm not to overproduce or underproduce its goods, which would influence the performance of the firm. However, it is complicated to estimate the demand in a B2B market, particularly for the private sector, because firms are very diverse in terms of size, industry, and types of business. This study proposes both qualitative and quantitative demand forecasting approaches for B2B PC products. Four different measures for predicting PC products in B2B market with consideration of the different PC uses-personal work, common work, promotion, and welfare-are developed as the qualitative model's input variables. These measures are verified by survey data collected from experts in 139 firms, and can be applied when individual firms estimate the demand of PC goods in a B2B market. As the quantitative approach, the multiple regression model is proposed and it includes variables of region, type of industry, and size of the firm. The regression model can be applied when the aggregated demand for overall domestic PC market needs to be estimated.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.308-314
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• 2013

Although global construction spending has experienced slow growth due to consecutive economic crises, global contractors have consistently attempted to expand their overseas market share, leading to more intense competition among contractors in the international construction market. In this market environment, owners, clients and financial institutions require reasonable and systematic criteria to effectively assess the business capabilities of international construction firms. However, the existing evaluation methods for construction firms rarely consider overseas-focused business capabilities. To address this problem, this study proposes a quantitative approach to assessing the overseas business capabilities of international construction firms. The limitations of existing approaches are reviewed, and the capabilities required to perform overseas businesses are analyzed through expert interviews. Finally, 18 evaluation indices are suggested in four categories: technology resources, project management, experience and performance, and sustainability. The relative weight of each index is determined according to the Analytical Hierarchy Process (AHP) method, and a preliminary investigation of 11 Korean construction firms is conducted. The proposed method is expected that it will provide the rational criteria for international owners, clients, and financial institutions for decision-making and for evaluating international contractors.

• 한국지하수토양환경학회지:지하수토양환경
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• 제17권6호
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• pp.69-81
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• 2012

Diverse geostatistical tools such as kriging have been used to estimate the volume and spatial coverage of contaminated soil needed for remediation. However, many approaches frequently yield estimation errors, due to inherent geostatistical uncertainties. Such errors may yield over- or under-estimation of the amounts of polluted soils, which cause an over-estimation of remediation cost as well as an incomplete clean-up of a contaminated land. Therefore, it is very important to use a better estimation tool considering uncertainties arising from incomplete field investigation (i.e., contamination survey) and mathematical spatial estimation. In the current work, as better estimation tools we propose stochastic simulation approaches which allow the remediation volume to be assessed more accurately along with uncertainty estimation. To test the efficiency of proposed methods, heavy metals (esp., Pb) contaminated soil of a shooting range area was selected. In addition, we suggest a quantitative method to delineate the confident interval of estimated volume (and spatial extent) of polluted soil based on the spatial aspect of uncertainty. The methods proposed in this work can improve a better decision making on soil remediation.

• 보건의료기술평가
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• 제1권1호
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• pp.22-26
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• 2013

Objectives: Balancing benefits and risks through the drug life cycle has been discussed for many decades. The objective of this study was to review the processes and tools currently proposed for benefit-risk assessment of medicinal drugs. It aimed to establish scientific and efficient drug safety management system based on the synthetic analysis of benefit-risk evidence. Methods: We conducted a review of exiting literatures published by regulatory agencies or initiatives. Not only quantitative methodologies but also qualitative method were compared to understand their key characteristics for the benefit and risk assessment of drugs. Results: Recently, benefit-risk assessments have more structured approaches to decision making as part of regulatory science. Regulatory agencies such as European Medicines Agency, FDA have prepared plans to apply benefit-risk assessment to regulatory decision making. Also many initiatives such as IMI (Innovative Medicine Initiative) have conducted research and published reports about benefit-risk assessment. For benefit-risk assessment, four kinds of methods are necessary. Frameworks such as BRAT (Benefit Risk Action Team) framework, PrOACT-URL provide guidance for the whole process of decision-making. Metrics are measurements of risk benefit. The estimation techniques are methods to synthesis and combine evidences from various sources. The utility survey techniques are necessary to explicit preferences of various outcome from stakeholders. Conclusion: There is the lack of widely accepted, validated model for benefit-risk assessment. Nor there is an agreement among academia, industry, and government on methods for the quantitative valuation. It is also limited by available evidence and underlying assumptions. Nevertheless, benefit-risk assessment is fundamental to improve transparency, consistency and predictability for decision making through the structured systematic approaches.

• 한국수학교육학회지시리즈C:초등수학교육
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• 제20권2호
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• pp.177-192
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• 2017

본 연구는 수학교육연구에서 적용되고 있는 혼합연구법이 질적연구와 양적연구를 어떻게 결합하여 활용하고 있는가를 탐색해 보고자 한다. 구체적으로 수학교육분야에서 질적연구와 양적연구의 혼합이 방법론적으로 어떠한 시사점과 과제를 줄 수 있는가를 탐구하고자 한다. 이와 같은 연구 목적을 달성하기 위하여, 본 연구에서는 한국초등수학교육학회에서 발간하는 '초등수학교육학회지'에 2015년 게재된 전체 32편의 논문 중, 혼합연구법을 적용한 4편의 논문을 분석 대상으로 선정하였다. 기존의 선행연구들에서는 혼합연구에 대한 분석 결과를, 일반적인 양적연구의 결과와 유사하게 비교 항목별로 수치화시키며 양적인 정보를 중심으로 간략하게 설명하는 경향이 있어 왔다. 이와는 대조적으로, 본 연구에서는 질적 연구자의 관점에서 질적연구와 양적연구의 장점을 최적화할 수 있는 방안을 상세하게 논의하는 형식으로 분석 결과와 시사점을 제시하고 있다.

• Molecules and Cells
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• 제44권7호
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• pp.500-516
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• 2021

Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation. Recent developments in mass spectrometry-based phosphoproteomics have led to the identification of thousands of differentially phosphorylated proteins and their phosphorylation sites. However, functional studies of these differentially phosphorylated proteins have not been conducted in a large-scale or high-throughput manner due to a lack of methods capable of revealing the functional relevance of each phosphorylation site. In this study, an integrated approach combining quantitative phosphoproteomics and cell-based functional screening using phosphorylation competition peptides was developed. A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. A cell-based functional assay system measuring hypertrophic cell growth of neonatal rat ventricle cardiomyocytes (NRVMs) following phenylephrine treatment was applied, and changes in phosphorylation of individual differentially phosphorylated sites were induced by incorporation of phosphorylation competition peptides conjugated with cell-penetrating peptides. Cell-based functional screening against 18 selected phosphorylation sites identified three phosphorylation sites (Ser-98, Ser-179 of Ldb3, and Ser-1146 of palladin) displaying near-complete inhibition of cardiac hypertrophic growth of NRVMs. Changes in phosphorylation levels of Ser-98 and Ser-179 in Ldb3 were further confirmed in NRVMs and other pathological/physiological hypertrophy models, including transverse aortic constriction and swimming models, using site-specific phospho-antibodies. Our integrated approach can be used to identify functionally important phosphorylation sites among differentially phosphorylated sites, and unlike conventional approaches, it is easily applicable for large-scale and/or high-throughput analyses.

• 과학기술학연구
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• 제2권2호
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• pp.25-54
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• 2002

그 동안 공중의 과학이해(PUS) 연구는 대규모 서베이조사 중심의 계량적 PUS연구와 사례분석을 중심으로 하는 구성주의 PUS연구로 양분되어 발전해왔다. 이 두 연구방식의 보완적인 성격에도 불구하고 지금까지 방법론적 선호도 뿐 아니라 각 유형의 연구들이 암묵적으로 전제하고 지지하고 있다고 여겨지는 가치지향에 대한 반감이 조사연구 중심의 계량적 PUS연구와 구성주의 PUS연구가 상보적으로 발전하는데 큰장애물로 작용해왔다. 이러한 현실을 극복하기 위해 이 논문은 특히 계량적 PUS연구에 있어서 이 연구들을 인도하는 가치관심이 구성주의 PUS연구자들이 생각하는 것보다 훨씬 다양하고 또 많은 조사연구들이 구성주의 PUS연구의 성과들을 보완하는 결과를 이끌어 내고 있음을 보여준다. 마지막으로 이 논문은 조사연구와 구성주의 PUS가 보완적으로 발전하기 위해 이론 틀의 부족으로 학문적인 발전이 정체되어온 조사연구는 구성주의 PUS가 주장하는 명제들을 검증하는 작업을 통해 PUS의 이론화와 연구결과의 정책화를 제고하는 반면 구성주의 PUS 연구는 일반시민들을 이질적인 존재로 이해하고, 과학에 대한 신뢰도의 변화추이를 중시하며, 추상적인 과학일반에 대한 태도와 특정한 맥락에서의 구체적인 과학에 대한 태도가 어떻게 서로 영향을 미치는지를 고려하는 보다 복합적인 사례연구를 발전시키는데 계량적 PUS연구성과들을 이용할 것을 제안한다.

• 한국사회복지학회:학술대회논문집
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• 한국사회복지학회 2004년도 춘계학술대회 자료집
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• pp.757-779
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• 2004

The purpose of study is to provide efficient initial approaches for counseling in social work practice settings. First, it attempts to identify the correlation between the Myers-Brigg's Type Indicator(MBTI), a personality index based on the theory of psychological typology, and Personality Adaptation Types(PAT) models. Second, it attempts to develop a counseling method which can be applied to the initial interview, using the paradigm of door to therapy such as "Open Door", "Target Door", and "Trap Door" based on the PAT theory. The result of the quantitative study showed the correlation between MBTI and PAT as follows: MBTI Extrovert and Feeling(E, F) type was statistically correlated to hysterical PAT. MBTI Extrovert, Intuition and Perceiving(E, N, P) type was statistically correlated to Obsessive-Compulsive PAT. In conclusion, this study finds that when a clinical social worker approaches a client with the client's MBTI personality type and an interventional personality adaptation theory approach such as "Open Door", "Target Door", or "Trap Door", the efficiency of communication is increased significantly.

• 한국대기환경학회지
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• 제29권4호
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• pp.447-458
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• 2013

The present operating system for the atmospheric monitoring network in the city of Seoul, Korea, has been established since the late 90s by the Korean Ministry of Environment (KMOE). In this research, it was evaluated by the multi-statistical approaches through combinations of time series analysis, correlation matrix, and multiple cluster analysis. Finally, road traffic including resuspended materials can be one of the main sources of particulate matter in the atmosphere. Based on its importance, it will be significant challenges in quantitative evaluation of its contribution to airborne concentrations. The future directions for their amendments such as a new management plan for the source of road dust (including car emissions) were devised and proposed based on the statistical judgements derived in this research.

• Molecules and Cells
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• 제43권8호
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• pp.728-738
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• 2020

Time and cost-effective production of next-generation sequencing data has enabled the performance of population-scale comparative and evolutionary studies for various species, which are essential for obtaining the comprehensive insight into molecular mechanisms underlying species- or breed-specific traits. In this study, the evolutionary and functional analysis of Korean native pig (KNP) was performed using single nucleotide polymorphism (SNP) data by comparative and population genomic approaches with six different mammalian species and five pig breeds. We examined the evolutionary history of KNP SNPs, and the specific genes of KNP based on the uniqueness of non-synonymous SNPs among the used species and pig breeds. We discovered the evolutionary trajectory of KNP SNPs within the used mammalian species as well as pig breeds. We also found olfaction-associated functions that have been characterized and diversified during evolution, and quantitative trait loci associated with the unique traits of KNP. Our study provides new insight into the evolution of KNP and serves as a good example for a better understanding of domestic animals in terms of evolution and domestication using the combined approaches of comparative and population genomics.