• Title/Summary/Keyword: Quality Management Practices

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The Korean Pharmacogenomic Database at NIFDS: 2008 Update

  • Kang, T.S.;Woo, S.W.;Park, H.J.;Han, S.Y.;Park, M.H.;Chung, M.W.
    • Genomics & Informatics
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    • v.7 no.3
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    • pp.163-167
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    • 2009
  • Since its first release in 2007, the National Institute of Food and Drug Safety Evaluation (NIFDS) has provided pharmacogenomic and comparative information specific to Koreans to allow regulatory reviewers and researchers to adapt their working practices to pharmacogenomics. The highlights of this year's additions include "Drug Information", "Gene Information" and "Pharmacogenomic information in the drug labels" sections. These new additions provide information on 737 genes, 719 drugs and pharmacogenomic data of the labels or relabels of 253 approved drugs as of November 2008. The latest version of the Korean Pharmacogenomic Database (KPD, release 2.0) has expanded significantly since its previous release. More SNP and haplotype information has been added to the database with the latest version of the KPD containing approximately four times as many SNPs and haplotypes than the previous version (719 vs. 152, and 30 vs. 7 respectively). Through the "SNP" and "Haplotype" sections, the KPD provides unique Korean SNP and haplotype information as well as comparative information of other populations (Japanese, Chinese, European, African) to offer a range of pharmacogenomic data that can help reviewers and the public understand pharmacogenomic information. The quality and quantity of information in the KPD has also been improved considerably. This data can be found at: http://www.nitr.go.kr/nitr/contents/m134700/view.do/.

Chemical and Biological Properties of Soils Converted from Paddies and Uplands to Organic Ginseng Farming System in Sangju Region

  • Lim, Jin-Soo;Park, Kee-Choon;Eo, Jinu
    • Korean Journal of Soil Science and Fertilizer
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    • v.47 no.6
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    • pp.500-505
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    • 2014
  • In recent years, organic ginseng cultivation has increased because customers prefer organic ginseng products due to the morphological quality as well as the safety such as the residuals of chemically-synthesized pesticides. Therefore, some of paddy and upland fields were converted into organic ginseng fields. Soil chemical properties, soil microflora, and soil-inhabiting animals were investigated in paddy-converted and upland organic ginseng fields in Sangju city, Korea. There was few difference in the soil chemical properties, and the soil nutrient concentrations, such as nitrate-N, Av. $P_2O_5$ between the two field types, and exchangeable cations such as K and Ca were within the ranges which are recommended by the standard ginseng-farming manual. Changes in microflora were also assessed by analyzing phospholipid fatty acid composition. Overall, indicators of microbial groups were greater in the upland field than in the paddy-converted soil, but they were not significantly different. In addition, there was no significant change in the abundance of nematodes, collembolans, and mites between the two field types probably because of the high variation within the field types. In this study, it was suggested that soil chemical and biological properties for organic ginseng cultivation were greatly influenced by the variation of topography and soil management practices rather than field types. Further study may be needed to investigate the influence of these factors on soil chemical and biological properties in organic ginseng soils.

Application of Free Water Surface Constructed Wetland for NPS Control in Livestock Watershed Area (축산단지 비점오염물질 저감을 위한 자유수면형 인공습지 적용)

  • Lee, Jeong-Yong;Kang, Chang-Guk;Lee, So-Young;Kim, Lee-Hyung
    • Journal of Wetlands Research
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    • v.13 no.3
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    • pp.481-488
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    • 2011
  • Various development activities have lead to the destruction of the ecosystem such as natural wetlands. In order to protect these natural wetlands, the Ministry of Environment (MOE) in Korea enacted the Wetland Conservation Act in 1999 and designated protected areas for wetland conservation. The MOE adapted the use of Best Management Practices (BMP) such as retention ponds and constructed wetlands to treat the polluted water before entering the water system. One of these projects was a free-water surface flow (FWS) constructed wetland built as a secondary treatment unit for piggery wastewater effluent coming from a livestock wastewater treatment facility. Water quality monitoring for the constructed wetland was conducted during rainfall events. The results showed that the average removal efficiencies of TSS, BOD, TN, TP were 86, 60, 45, 70%, respectively. It was observed that the removal efficiency of particulate matter and phosphorus was high compared to nitrogen. Therefore, a longer hydraulic retention time was needed in order to improve the treatment efficiency of nitrogen. The results of this study can contribute to the wetland design, operation and maintenance of constructed wetlands.

System and Utilization for E-Catalog Classifier (전자 카탈로그 자동분류기 시스템과 그 활용)

  • Lee, Ig-Hoon;Chun, Jong-Hoon
    • Journal of KIISE:Computing Practices and Letters
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    • v.14 no.9
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    • pp.876-883
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    • 2008
  • A clearly defined e-catalog (or product) information is a key foundation for an e-commerce system. A classification (or categorization) is a core information to build clear e-catalogs, can play an important role in quality of e-commerce systems using e-catalogs. However, as the wide use of online business transactions, the volume of e-catalog information that needs to be managed in a system has become drastically large, and the classification task of such data has become highly complex. In this paper, we present an e-catalog classifier system, and report on our effort to improve an e-catalog management process and to standardize e-catalogs for enterprises by use of automated approach for e-catalog classifier systems. Also we introduce some of the issues that we have experienced in the projects, so that our work may help those who do a similar project in the future.

A Study on the Introduction of a Rigging and Slinging Certificate System to Reduce a Struck by Object Accidents (건설현장 물체에 맞음 사고 저감을 위한 줄걸이 작업 전문 자격제도 도입에 관한 연구)

  • Yeom, Chun Ho;Lee, Jinho;Park, Hyeon
    • Journal of the Korean Society of Safety
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    • v.33 no.5
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    • pp.92-100
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    • 2018
  • According to 'The Analysis of Industrial Accidents in 2016' by Ministry of Employment and Labor, the number of deaths caused by accidents in the construction field is 391, accounting for 47% of 826 industrial fatalities in all industries. The breakdown of the 391 fatalities of the construction industry shows that 'struck by an object' accident had 30 fatalities, the 3rd in frequency following falling (235) and crashing (32) accidents. This study aims to explore ways to reduce the 'struck by an object' accident with emphasis on safety education and certificate system for rigging and slinging works. This study reviews literature on rigging and slinging works and analyzes 'struck by an object' accidents. The rules and regulation on the rigging and slinging works are also reviewed both for Korea and other countries with best practices in construction safety such as Singapore, Japan, U.K., and U.S. The rigging and slinging certificate systems of those countries are also reviewed to find any advantage in the construction safety management. In addition, a pilot rigging and slinging certificate system was executed in one of domestic construction site followed by two surveys: one on the riggers who participated in the pilot operation and the other on general managers in domestic construction sites. Based on the analysis of the 'struck by an object' accidents and pilot operation, this study proposes a rigging and slinging certificate system to reduce accidents, enhancing safety condition of construction sites. The certificate system was proposed in a way to accommodate working practice of construction sites. Depending on rigging careers and a crane load capacity, riggers are eligible to apply either basic or master certificate which makes difference in the level of rigging works. The safety condition of rigging and slinging work could be substantially enhanced if workers, managers, supervisors, administrators, and policy makers work together consistently.

Response of Soil Microbial Communities to Applications of Green Manures in Paddy at an Early Rice-Growing Stage (녹비 시용이 초기 논 토양 미생물군집에 미치는 영향)

  • Kim, Eun-Seok;Lee, Young-Han
    • Korean Journal of Soil Science and Fertilizer
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    • v.44 no.2
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    • pp.221-227
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    • 2011
  • Applications of green manures generally improve the soil quality in rice paddy in part through restructuring of soil microbial communities. To determine how different green manures affect soil microbial communities during the early stages of rice growth, fatty acid methyl ester (FAME) profiles were used to the effects of different management practices: 1) conventional farming (CF), 2) no-treatment (NT), 3) Chinese milk vetch (CMV), 4) green barley (GB), and 5) triticale in paddy field. With applications of green manures, soil organic matter was significantly higher than CF, while soil Na concentration was significantly lower compared with CF (p<0.05). Total soil microbial biomass of CMV was higher (p<0.05) than NF by approximately 31%. The highest ratio of monounsaturated fatty acid to saturated fatty acid was found in the GB plot, followed by CMV and triticale compared with CF (p<0.05), possibly indicating that microbial stress was less in GB and CMV plots. Populations of Gram-negative bacteria and arbuscular mycorrhizal fungi also were significantly higher green manures than CF (p<0.05). Our findings suggest that GB should be considered as optimum green manure for enhancing soil microbial community at an early growing stage in paddy field.

Establishment of Pre-Harvest Residue Limits (PHRLs) of Insecticide Clothianidin and Fungicide Fluquinconazole on Peaches during Cultivation Period (복숭아의 재배기간 중 살충제 Clothianidin 및 살균제 Fluquinconazole의 생산단계 농약잔류허용기준의 설정)

  • Park, Jae-Hun;Lim, Jong-Sung;Yoon, Ji-Yeong;Moon, Hye-Ree;Han, Ye-Hoon;Lee, Yong-Jae;Lee, Kyu-Seung
    • Korean Journal of Environmental Agriculture
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    • v.31 no.3
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    • pp.271-276
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    • 2012
  • BACKGROUND: It is hard to control the agricultural products exceeding MRL (maximum residue limit) before forwarding. Therefore, NAQS (National Agricultural Products Quality Management Service, South Korea) established PHRL (pre-harvest residue limit) on agricultural products during their cultivation periods. This study was performed to set the PHRLs of peach during cultivation period, and also to estimate biological half-lives for residues of clothianidin and fluquinconazole. METHODS AND RESULTS: Two groups of peach were treated under Korean GAP (Good Agricultural Practices) with application time, single and triple treatments. Sample was collected over 14days (each after 0, 2, 4, 6, 8, 10, 12, 14 days. 8times), and clothianidin and fluquinconazole were analyzed by HPLC/DAD and GC/ECD, respectively. CONCLUSION: The biological half-life of clothianidin in single treatment and triple treatment was 5.2days and 7.0days. That of fluquinconazole was also 3.9days and 4.1days, respectively. The PHRL of peach on 10days before harvest was 1.4 mg/kg in clothianidin and 1.8 mg/kg in fluquinconazole.

Lipid Metabolism and Fatty Liver in Poultry (닭의 지방대사와 지방간)

  • Moon, Yang Soo
    • Korean Journal of Poultry Science
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    • v.45 no.2
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    • pp.109-118
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    • 2018
  • A great progress in genetic selection, nutrition and management practices has contributed to the improved growth rate of broilers and egg production in laying hens. For the increased productivity of modern poultry, a healthy chicken liver needs to cope with the increased metabolic demands. The liver is the major site of de novo fatty acid synthesis; therefore, hepatic lipogenesis is crucial for producing better quality meat and eggs. When de novo lipogenesis exceeds the capacity of lipid metabolism and secretion, large amounts of lipids accumulate in the liver of broilers, leading to a fatty liver. Upon onset of egg-laying in hens, lipids including free fatty acids, triglycerides, and phospholipids are dramatically increased in blood plasma for the synthesis of yolk precursors in oocytes. Productive hens with fatty liver often have hemorrhagic syndrome and sudden death due to the heavy demands of yolk synthesis, which burdens the liver. Understanding the lipid metabolism and hepatic lipid disorders is a key point in the improvement of the growth and production of chickens. This review focuses on the recent studies on lipid metabolism, the hepatic lipid disorders, and the prevention or reduction of fatty liver in poultry.

Defect Severity-based Ensemble Model using FCM (FCM을 적용한 결함심각도 기반 앙상블 모델)

  • Lee, Na-Young;Kwon, Ki-Tae
    • KIISE Transactions on Computing Practices
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    • v.22 no.12
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    • pp.681-686
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    • 2016
  • Software defect prediction is an important factor in efficient project management and success. The severity of the defect usually determines the degree to which the project is affected. However, existing studies focus only on the presence or absence of a defect and not the severity of defect. In this study, we proposed an ensemble model using FCM based on defect severity. The severity of the defect of NASA data set's PC4 was reclassified. To select the input column that affected the severity of the defect, we extracted the important defect factor of the data set using Random Forest (RF). We evaluated the performance of the model by changing the parameters in the 10-fold cross-validation. The evaluation results were as follows. First, defect severities were reclassified from 58, 40, 80 to 30, 20, 128. Second, BRANCH_COUNT was an important input column for the degree of severity in terms of accuracy and node impurities. Third, smaller tree number led to more variables for good performance.

A Study on the Evaluation of Improvement Factors of Tug Services in Korea (우리나라 예선 서비스 개선요인 평가에 관한 연구)

  • Yeou, Young-Hun;Ryoo, Dong-Keun
    • Journal of Navigation and Port Research
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    • v.37 no.5
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    • pp.559-565
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    • 2013
  • The purpose of this study is to prioritize improvement factors of the tug services in terms of the structural problem, operating system and the present condition of the tug at each port in Korea. It was identified that the tug operating system needs to be mostly improved among the improvement factors of the tug services in Korea. In addition, free contract and rotating system were found to be important factors which need to be improved comparing to other factors such as service quality, tug rules, operating practices of council for tug operation and customer factor. The service attitude of the tug companies was regarded as an important element. And the tug entry system appeared to be an important item. Finally, laws relating to tug business needs to be revised which allow new tug companies enter into the market. As the result of AHP analysis for tug systems and service improvement factors, some fundamental changes of tug operation systems are urgently needed.