• Nuclear Medicine and Molecular Imaging
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• 제40권2호
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• pp.82-89
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• 2006

Bone metastasis is a common sequelae of solid malignant tumors such as prostate, breast, lung, and renal cancers, which can lead to various complications, including fractures, hypercalcemia, and bone pain, as well as reduced performance status and quality of life it occurs as a result of a complex pathophysiologic process between host and tumor cells leading to cellular invasion, migration adhesion, and stimulation of osteoclastic and osteoblastic activity. Several sequelae occur as a result of osseous metastases and resulting bone pain can lead to significant debilitation. A multidisciplinary approach is usually required not only to address the etiology of the pain and its complicating factors but also to treat the patient appropriately. Pharmaceutical therapy of bone pain, includes non-steroidal analgesics, opiates, steroids, hormones, bisphosphonates, and chemotherapy. While external beam radiation therapy remains the mainstay of pain palliation of a solitary lesions, bone seeking radiopharmaceuticals have entered the therapeutic armamentarium for the treatment of multiple painful osseous lesions. $^{32}P,\;^{89}SrCl,\;^{153}Sm-EDTMP,\;^{188}Re/^{186}Re-HEDP,\;and\;^{177}Lu-EDTMP$ can be used to treat painful osseous metastases. These various radiopharmaceuticals have shown good efficacy in relieving bone pain secondary to bone metastasis. This systemic form of metabolic radiotherapy is simple to administer and complements other treatment options. This has been associated with improved mobility in many patients, reduced dependence on narcotic and non-narcotic analgesics, improved performance status and quality of life, and, in some studios, improved survival. All of these agents, although comprising different physical and chemical characteristics, offer certain advantages in that they are simple to administer, are well tolerated by the patient if used appropriately, and can be used alone or in combination with the other forms of treatment. This article illustrates the salient features of these radiopharmaceuticals, including the usual therapuetic dose, method of administration, and indications for use and also describe about the pre-management checklists, and jndication/contraindication and follow-up protocol.

• 정보관리연구
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• 제34권3호
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• pp.41-67
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• 2003

이 연구는 도서관목록의 역할과 기능이 커다란 변화에 직면하면서 그 본래의 가치보다 훨씬 평가절하되고 있다는 인식에서 출발한다. 이러한 전제 하에, 현재의 상황을 초래한 구조적인 원인을 밝혀내는 것에서부터 시작하여, 현단계 도서관목록이 안고 있는 각종 '부실'을 제거하고 '유용성'을 최대화하기 위해서는 무엇을 어떻게 해야 하는지를 중점적으로 논의해 보고자 하였다. 그리하여 도서관 이용자가 자신의 문제 해결에 도움이 되는 작은 실마리를 찾아낼 수 있는 논리적 경로로써 그동안 도서관목록은 본연의 역할에 얼마나 충실했는지를 검증해 보고자 하였다. 이러한 목적에서, 이 연구는 우리 도서관목록의 유용성이 저하된 근본 원인이 무엇인지를 우선적으로 분석하고, 다음 유용성을 향상시키기 위해서는 향후 무엇을 어떻게 해야 할 것인지를 편목 정책과 실무 방안으로 구분하여 제시하였다.

• 산업경영시스템학회지
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• 제26권3호
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• pp.24-30
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• 2003

As domestic buildings have been large-scaled, diversified and high-rise, there have been a consistent demand for design, development of construction technology and accident prevention activity as well as quality enhancement. In spite of governmental and related institutions' efforts for reducing national losses which come from numerous accidents, there have been endless small and large accidents on the construction site and thus, it is urgent to conduct empirical researches in this area. Currently safety supervision system in construction industry has enforced harm and danger prevention planning system, however it merely stick to other existing materials. In addition, it is difficult to put it into practice in that it requires bearing too much burden to draw out the planning itself in a case of large construction work. Consequently in this paper we select evaluation criteria by construction progress, classify into several categories, and regard potential danger which often occurs, as a evaluation criterion. Further step is to allow workers or collaborated companies to express their expert opinions or experiences and to encourage quality and process control and autonomous safety control by applying PSM(Process Safety Management) method using AHP(Analytic Hierarchy Process) and to development of PSM evaluation method in the construction. The reason why PSM method should be quantitative and substantial progress is because it contributes Korean constructing companies to enhancing their safety control ability and to taking an equal stance just like developed countries, thereby strengthening their competitive edges. Boost of safety control system by PSM method could make an enormous contribution to preventing construction accidents on the site by establishing and securing an autonomous safety control system.

• 대한지역사회영양학회지
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• 제26권5호
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• pp.363-381
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• 2021

Objectives: This study examined the Korean elderly's dietary intake status, subjective health-related perception and chronic disease prevalence among age groups. Associations of dietary quality with subjective health-related perception and chronic diseases were also examined. Methods: Based on data from the 7th National Health and Nutrition Examination Survey, a total of 3,231 elderly were selected and categorized into 4 age groups of '65 ~ 69', '70 ~ 74', '75 ~ 79' and 'over 80'. Nutrient intakes, proportions of those with insufficient nutrient intakes, Korean Healthy Eating Index (KHEI), some subjective health-related perceptions and prevalence of major chronic diseases were compared according to the age groups. Differences in the subjective health-related perceptions and odds ratios of the chronic diseases according to the quartile levels of KHEI within the same age group were analyzed. Results: With the increase of age, several nutrient intakes (P < 0.001) and KHEI scores significantly decreased (P < 0.01). In women, activity restriction increased (P < 0.05), and EQ-5D score decreased with age (P < 0.001). Prevalence of hypertension (P < 0.0001), hypercholesterolemia (P < 0.05) and anemia (P < 0.01) significantly increased, while hypertriglyceridemia (P < 0.01) significantly decreased only in men. Obesity prevalence decreased, while underweight prevalence increased (P < 0.05). Subjective health status, EQ-5D score and PHQ-9 score significantly improved as KHEI score increased in certain age groups of women (P < 0.05). Odds ratio of hypercholesterolemia significantly increased with the increase of KHEI score in 65 ~ 69-year-old women. However, hypertension and anemia significantly decreased with the increase of KHEI score in 75 ~ 79-year-old women (P < 0.05). Conclusions: The study findings suggest that nutrition management and policy for the Korean elderly need to apply a segmented age standard that can better reflect their dynamic characteristics.

• 생약학회지
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• 제52권1호
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• pp.1-12
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• 2021

Platycodon (Platycodon grandiflorum) is used as a food and medicinal ingredient worldwide, particularly in Northeast Asia. Although a large number of studies have been conducted to determine its medicinal efficacy, there is still a paucity of literature summarizing the clinical activity of Platycodon. In this systematic review, we aimed to summarize the clinical efficacy of Platycodon. All literature describing the clinical efficacy of Platycodon was collected from international databases, and relevant papers were carefully evaluated for eligibility. Data were extracted from the selected papers and quality evaluation was conducted in accordance with the standards provided by the National Institutes of Health (NIH), with all procedures being conducted in accordance with PRISMA 2009 checklist guidelines. After the removal of 342 papers, 644 studies were fully screened for their titles and abstracts, among which, 19 studies were finally selected for full summarization. Extraction of data indicated evidence of the effectiveness of Platycodon in the treatment of respiratory system-related diseases and cancer, and in the provision of immunity. However, we found that the quality and objectivity of evaluation, management of variable factors, sample size, and reproducibility were generally poor. Although Platycodon has shown potential antiviral, antibacterial, anticancer, and antidepressant effects, and promotion of immunity in clinical settings, it was not possible to integrate objective indicators to conduct a meta-analysis due to the lack of literature and insufficient studies. More investigations in the clinical setting should be conducted to confirm the functional effects of Platycodon.

• International Journal of Computer Science & Network Security
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• 제22권12호
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• pp.91-97
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• 2022

Analyzing the psychological and pedagogical literature, we showed the interest of researchers in the problem posed. The concept of competence is considered, which is interpreted as giving the key to solving a wide range of educational and life tasks. Research competence implies the ability to cooperate, enter into contacts, readiness for changes, for self-determination and is an integral quality of the individual, expressed in the readiness and ability to independently search for solutions to new problems and creative transformation of reality based on a set of personal and meaningful knowledge, skills, methods of activity and value attitudes.The article offers conditions that certify the improvement of forms and methods of training students in the formation of research competence of future specialists. The use of innovative technologies contributes to improving the level of training of future specialists: students are better prepared for classes, take an active part in the assimilation of program material in laboratory classes. It is noted that this creates a subject-subject relationship between the student and the teacher, and changes the attitude of students to classes. In the process of such organization of educational activities, students are convinced of the need for knowledge and its effectiveness, learn to compare, generalize, classify, establish cause-and-effect relationships, express opinions, defend their point of view, they ensure success in their studies, and develop research competence. It is proved that in order to apply the latest technologies, the teacher himself must know them well, that is, constantly improve himself, master new methods, techniques, ideas, which will help him create new pedagogical technologies and implement them in the educational process.

• Child Health Nursing Research
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• 제29권2호
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• pp.111-127
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• 2023

Purpose: This study investigated the effects of healthy lifestyle interventions (HLSIs) on health-related quality of life (HR-QoL) in childhood and adolescent cancer survivors (CACS). Methods: Major databases were searched for English-language original articles published between January 1, 2000 and May 2, 2021. Randomized controlled trials (RCTs) and non-RCTs were included. Quality was assessed using the revised Cochrane risk-of-bias tool, and a meta-analysis was conducted using RevMan 5.3 software. Results: Nineteen studies were included. Significant effects on HR-QoL were found for interventions using a multi-modal approach (exercise and education) (d=-0.46; 95% confidence interval [CI]=-0.84 to -0.07, p=.02), lasting not less than 6 months (d=-0.72; 95% CI=-1.15 to -0.29, p=.0010), and using a group approach (d=-0.46; 95% CI=-0.85 to -0.06, p=.02). Self-efficacy showed significant effects when HLSIs provided health education only (d=-0.55; 95% CI=-0.92 to -0.18; p=.003), lasted for less than 6 months (d=-0.40; 95% CI=-0.69 to -0.11, p=.006), and were conducted individually (d=-0.55; 95% CI=-0.92 to -0.18, p=.003). The physical outcomes (physical activity, fatigue, exercise capacity-VO₂, exercise capacity-upper body, body mass index) revealed no statistical significance. Conclusion: Areas of HLSIs for CACS requiring further study were identified, and needs and directions of research for holistic health management were suggested.

• The Korean Journal of Pain
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• 제36권4호
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• pp.408-424
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• 2023

Central post-stroke pain (CPSP) is an incapacitating disorder that impacts a substantial proportion of stroke survivors and can diminish their quality of life. Conventional therapies for CPSP, including tricyclic antidepressants, anticonvulsants, and opioids, are frequently ineffective, necessitating the investigation of alternative therapeutic strategies. Repetitive transcranial magnetic stimulation (rTMS) is now recognized as a promising noninvasive pain management method for CPSP. rTMS modulates neural activity through the administration of magnetic pulses to specific cortical regions. Trials analyzing the effects of rTMS on CPSP have generated various outcomes, but the evidence suggests possible analgesic benefits. In CPSP and other neuropathic pain conditions, high-frequency rTMS targeting the primary motor cortex (M1) with figure-eight coils has demonstrated significant pain alleviation. Due to its associaton with analgesic benefits, M1 is the most frequently targeted area. The duration and frequency of rTMS sessions, as well as the stimulation intensity, have been studied in an effort to optimize treatment outcomes. The short-term pain relief effects of rTMS have been observed, but the long-term effects (> 3 months) require further investigation. Aspects such as stimulation frequency, location, and treatment period can influence the efficacy of rTMS and ought to be considered while planning the procedure. Standardized guidelines for using rTMS in CPSP would optimize therapy protocols and improve patient outcomes. This review article provides an up-to-date overview of the incidence, clinical characteristics, outcome of rTMS in CPSP patients, and future perspective in the field.

• 한국콘텐츠학회논문지
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• 제22권8호
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• pp.503-517
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• 2022

본 연구는 초등아동 대상의 공적 돌봄 서비스 제공이 사교육 참여 및 사교육비에 미치는 영향을 검증하고자 여성가족패널조사 자료를 패널 프로빗 분석과 최소자승더미변수 모형을 활용해 분석하였다. 연구결과는 두 가지로 요약할 수 있다. 첫째, 초등아동 대상의 공적 돌봄 서비스 제공은 자녀의 사교육 참여 경감에 통계적으로 유의한 영향을 미치는 것으로 확인되었다. 둘째, 어머니의 경제활동상태와는 무관하게 공적 돌봄 서비스의 제공은 자녀의 사교육비 경감에 통계적으로 유의한 영향을 미치는 것으로 나타났다. 이를 바탕으로 본 연구는 다음과 같은 정책적 및 실천적 제안을 도출하였다. 첫째, 초등 자녀를 양육하는 '일하는 어머니'의 양육 부담 경감을 위해 공적 돌봄 서비스의 제공 확대가 필요하다. 둘째, 초등아동을 대상으로 하는 공적 돌봄 서비스의 질 제고가 필요하며, 이를 위해 정책적으로는 서비스의 통합적 관리와 서비스 제공자에 대한 처우개선이 수반되어야 한다. 실천적으로는 초등아동을 대상으로 공적 돌봄 서비스를 제공하는 기관에서 서비스 제공자를 대상으로 교육과 슈퍼비전을 제공함으로써 서비스 제공자의 돌봄 서비스 질을 제고해야 한다.

• 지능정보연구
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• 제25권3호
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• pp.117-140
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• 2019

고령화 현상이 가속화되고, 취약계층 노인과 관련된 다양한 사회문제가 제기됨에 따라 노인세대의 건강과 안전을 보호하기 위한 효과적인 노인 돌봄 솔루션의 필요성이 커지고 있다. 최근에는 노인 돌봄의 수단으로 첨단화된 ICT 기술을 탑재한 스마트 토이를 활용하고자 하는 사례가 늘고 있다. 특히 스마트 토이를 통해 기록되는 노인 행태에 대한 로그 데이터는 노인 돌봄 관련 정책 수립, 노인 돌봄 서비스 컨셉 기획 및 개발과 같은 분야에 정량적이고 객관적인 설명지표로써 활용 가치가 높을 것으로 전망된다. 그러나 현재까지 노인 돌봄 스마트 토이와 관련된 연구 중 스마트 토이를 통해 기록된 사용자 행동 로그에 주목하여 이를 의사결정에 활용하고자 하는 연구는 부족한 실정이다. 본 연구는 기존에 충분히 논의되지 않았던 스마트 토이 사용자 행동 로그 데이터에 대한 분석을 중심으로, 노인 돌봄 솔루션의 사용자 경험 증진을 위한 효과적인 인사이트를 도출하는 것을 목적으로 한다. 구체적으로 사용자 프로파일링 기반 행태 분석과 사용 행태에 따른 삶의 질 변화 메커니즘 도출을 단계적으로 수행하였다. 분석 결과, 5개의 노인 생활관리 요인으로부터 노인집단 유형을 분류할 수 있는 2개의 중요한 차원을 도출하였으며, 도출한 차원에 근거하여 전체 노인 사용자를 3개의 유형으로 분류하고 유형별 스마트 토이 사용 행태 차이를 프로파일링 분석을 통해 확인할 수 있었다. 이후 스마트 토이 사용 행태에 따른 삶의 질 변화 메커니즘을 도출하기 위한 단계적 회귀분석을 수행하였으며, 스마트 토이와의 상호작용, 스마트 토이의 콘텐츠 사용, 스마트 토이가 관찰한 노인의 가정 내 활동 정도가 노인의 우울감 개선과 생활패턴 개선에 미치는 영향 및 이를 중재하는 경로로써 스마트 토이에 대한 사용자의 성능평가와 만족감의 역할을 밝혀내었다.