• Journal of Astronomy and Space Sciences
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• 제19권2호
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• pp.163-172
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• 2002

위성에 탑재된 GPS 수신기의 관측 자료를 활용하여 저궤도위성의 정밀궤도 결정을 위해서 반드시 필요한 관측 자료 전처리에 관련된 연구를 수행하였다. 전처리 과정에서는 반송파 위상 자료와 코드 자료에 있는 사이클 슬립, 시계 오차, 불량 관측값, 이온층 지연 효과 등을 제거하거나 보정하여 일정한 간격으로 재정렬된 이중차분 자료를 생성한다. DGPS 방식을 이용하여 저궤도 위성의 정밀궤도결정을 수행하면 그 정밀도가 수 미터에서 수 센티미터 수준에 달하기 때문에 전처리 과정에서도 그 정밀도에 영향을 미치지 않을 정도로 관측 자료의 편집이 정밀하게 수행되어야 한다. 그러나 GPS수신기가 자료를 수집하는 시간간격에 따라 관측 자료를 분해할 수 있는 한계가 달라지기 때문에 자료의 수신시간간격은 전처리의 성능과 직결된다. 또한 수신기의 성능과 수신기를 탑재한 위성의 고도에 따라서 자료의 질이 달라지기도 하므로, 이 논문에서는 DGPS 방식에 의한 위성의 정밀궤도결정을 수행하기 위한 전처리 과정에서 수신시간간격, 수신기의 성능과 위성의 고도에 따른 전처리의 성능을 분석하여 시간간격과 수신기의 종류에 따라 사용할 수 있는 전처리 방법을 제안하였다.

• 산경연구논집
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• 제8권5호
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• pp.65-75
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• 2017

Purpose - The purpose of this study is to verify a role of organizational culture as antecedents to influence psychological empowerment of organizational members, focusing on service workers of casino companies. Therefore, this study sought to examine the question of each clan, adhocracy, market, and hierarchy culture that the workers perceive to influence their psychological empowerment. Thus, the current study examined the relationship between organizational culture and the psychological empowerment by empirical analysis. Research design, data, and methodology - This study chose four domestic casino companies that are run only for foreigners. Using an offline survey, it analyzed the questionnaire data of the 249 surveys collected from employees working in the sales and service sectors. Independent variables were four types of organizational culture: clan, adhocracy, market, and hierarchy. Dependent variables were four subcategories of psychological empowerment: meaning, competence, self-determination, and impact. As research methods, the study applied descriptive statistics, factor analysis, reliability analysis, correlation analysis, and multiple regression analysis, using SPSS 21.0 statistical program. Results - Among the organizational culture types, the clan and adhocracy cultures, which emphasize flexibility and autonomy, were relatively more important for the psychological empowerment of workers than the hierarchy and market cultures. Clan culture was the most important factor in terms of meaning and competence, and adhocracy culture was the most important factor in self-determination and impact. However, the hierarchy and market cultures that pursue control and stability were also cultural types that positively affected psychological empowerment of the workers. Hierarchy culture showed positive effects on meaning, competence, and impact except self-determination, and market culture had positive effect only on competency. Conclusions - The study found that organizational culture is an important predictor of psychological empowerment of the employees in casino companies and that important organizational culture types may be different for each sub-factor of psychological empowerment. It suggests that casino companies have to try to recognize and secure diverse organizational culture in order to activate psychological empowerment of their employees because they can provide quality service for customers. Therefore, it is necessary to create a harmonious and balanced culture between promoting flexible and autonomous organizational atmosphere, and stably controlling and operating the organization.

• 분석과학
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• 제30권6호
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• pp.379-389
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• 2017

In this study, we set up an analytical method that can be used for rapid and accurate determination of representative isoquinoline alkaloids in medicinal plants using UPLC-ESI-Q-TOF MS (ultra pressure liquid chromatography-electrospray ionization-quadrupole-time-of-flight mass spectrometry). The compounds were eluted on a C18 column with 0.1 % formic acid and acetonitrile, and separated with good resolution within 13 min. Each of the separated components was characterized by precursor ions (generated by ESI-Q-TOF) and fragment ions (produced by collision-induced dissociation, CID), which were used as a reliable database. We also performed method validation: analytes showed excellent linearity ($R^2$, 0.9971-0.9996), LOD (5-25 ng/mL), LOQ (17-82 ng/mL), accuracy (91.6-97.4 %) as well as intra- and inter-day precisions (RSD, 1.8-3.2 %). In the analysis of Chelidonium majus L., magnoflorine, coptisine, sanguinarine, berberine and palmatine were detected by matching retention times and characteristic fragment ion patterns of reference standards. We also confirmed that, among the quantified components, coptisine was present in the highest quantity. Furthermore, alkaloid profiling was carried out by analyzing the fragment ion patterns corresponding to peaks of unknown components. In this manner, protopine, chelidonine, stylopine, dihydroberberine, canadine, and nitidine were tentatively identified. We also proposed the molecular structure of the fragment ions that appear in the mass spectrum. Therefore, we concluded that our suggested method for the determination of major isoquinoline alkaloids by UPLC-Q-TOF can be useful not only for quality control, but also for rapid and accurate investigation of phytochemical constituents of medicinal plants.

• 생약학회지
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• 제49권1호
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• pp.76-83
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• 2018

A traditional herbal formula, Gyeji-tang has been used to treat the early colds, headache, chills, and fever in Asian countries. In this study, we were performed simultaneous determination of the 14 bioactive marker compounds, gallic acid, spinosin, paeoniflorin, albiflorin, liquiritin apioside, liquiritin, 6'''-feruloylspinosin, liquilitigenin, coumarin, cinnmamic acid, benzoylpaeoniflorin, cinnamaldehyde, glycyrrhizin, and 6-gingerol in Gyeji-tang using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS/MS). Analytical column was used a Waters Acquity UPLC BEH $C_{18}$ analytical column ($2.1{\times}100mm$, $1.7{\mu}m$) and maintained at $45^{\circ}C$ with a flow rate of 0.3 mL/min. The mobile phase consists of 0.1% (v/v) formic acid in water and acetonitrile with gradient elution. The MS analysis was conducted using multiple reaction monitoring in the positive and negative modes by a Waters ACQUITY TQD LC-MS/MS system. The calibration curves of 14 bioactive marker compounds showed linearity with correlation coefficients ${\geq}0.9798$. The limits of detection and quantification values were in the range of 0.11-6.66 ng/mL and 0.34-19.99 ng/mL, respectively. As a result of the analysis using the established LC-MS/MS method, the amounts of tested 14 compounds in the lyophilized Gyeji-tang sample were detected up to $85.7{\mu}g/g$. These results may be useful for quality assessment of a traditional herbal formulas.

• 약학회지
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• 제52권2호
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• pp.93-100
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• 2008

A liquid chromatographic method with tandom spectrometric detection (LC/MS/MS) for the simultaneous determination of doxifluridine and its active metabolite, 5-fluorouracil (5-FU) was developed over the concentration range of $5{\sim}2000$ ng/ml, respectively. Doxifluridine, 5-FU and internal standard, 5-chlorouracil (5-CU), were extracted from liver and intestine tissue via protein precipitation. Acetonitrile was used as the extraction solvent and the supernatant was evaporated and reconstructed in mobile phase. Optimum chromatographic separation was achieved on a Agilent Zorbax $C_{18}$ ($100\;mm{\times}2.1\;mm$, $3.5\;{\mu}m$) column with mobile phase run in isocratic with methanol : water (20 : 80, v/v). The flow rate was 0.2 ml/min with total cycle time of 5 min. The lower limit of quantification was validated at 5.0 ng/ml of liver and intestine tissue, for both doxifluridine and 5-FU, respectively. The intra-day and inter-day precision and accuracy of quality control (QC) samples were <11% coefficient of variation and <7% relative error from theoretical concentration for both analytes. In addition, the special designed stability study was performed, because the metabolism of doxifluridine occurs spontaneously even in ice bath for monkey liver. The stability of doxifluridine in liver and intestine of monkey and beagle dog was compared. It was found that bioanalytical validation could not be performed for the monkey liver; however, beagle dog's liver has relatively low speed of metabolism compared to monkey liver and instead of monkey liver, beagle dog's liver could be used for the validation. Bioanalytical validation could be performed in monkey intestine. Eventually, this developed method for liver and intestine will be useful in support of the toxicokinetic and pharmacokinetic studies of doxifluridine and 5-FU.

• 생약학회지
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• 제43권1호
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• pp.10-15
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• 2012

An accurate and sensitive analysis method was established for simultaneous determination of three bioactive compounds (glycyrrhizin, 6-gingerol and ginsenoside Rg3) in the Ejung Tang with high-performance liquid chromatography (HPLC)-photodiode array detection (DAD)-electrospray ionization (ESI)-Mass spectrometry (MS). The optimizing chromatographic separations a were acquired by an $C_{18}$ column ($5{\mu}m$, $4.6I.D{\times}250mm$, SHISHEDO) using gradient elution with water comprising 0.1% TFA(trifluoroacetic acid) and acetonitrile at a performing temperature of $35^{\circ}C$. Flow rate was 1.0 ml/min. A detection UV wavelength set at 205 nm and 250 nm. The three compounds were identified by electrospray ionization mass spectrometry. All calibration curves indicated great linear regression within test ranges ($R^2>0.9997$). The established method provided acceptable precision and accuracy. The relative standard deviations (RSDs) of intra-day and inter-day were less than 2.00% and 3.00%, respectively. The recoveries were found to range from 94.49 to 101.10% for the three compounds analyzed. These results showed that this method was effective and reliable for quality control of Eiung-Tang.

• 한국지진공학회논문집
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• 제28권4호
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• pp.183-191
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• 2024

Accurate seismic vulnerability assessment requires high quality and large amounts of ground motion data. Ground motion data generated from time series contains not only the seismic waves but also the background noise. Therefore, it is crucial to determine the high-pass cut-off frequency to reduce the background noise. Traditional methods for determining the high-pass filter frequency are based on human inspection, such as comparing the noise and the signal Fourier Amplitude Spectrum (FAS), f² trend line fitting, and inspection of the displacement curve after filtering. However, these methods are subject to human error and unsuitable for automating the process. This study used a deep learning approach to determine the high-pass filter frequency. We used the Mel-spectrogram for feature extraction and mixup technique to overcome the lack of data. We selected convolutional neural network (CNN) models such as ResNet, DenseNet, and EfficientNet for transfer learning. Additionally, we chose ViT and DeiT for transformer-based models. The results showed that ResNet had the highest performance with R² (the coefficient of determination) at 0.977 and the lowest mean absolute error (MAE) and RMSE (root mean square error) at 0.006 and 0.074, respectively. When applied to a seismic event and compared to the traditional methods, the determination of the high-pass filter frequency through the deep learning method showed a difference of 0.1 Hz, which demonstrates that it can be used as a replacement for traditional methods. We anticipate that this study will pave the way for automating ground motion processing, which could be applied to the system to handle large amounts of data efficiently.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1999년도 가을 학술발표회 논문집
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• pp.209-216
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• 1999

In tunneling and road cuts by blasting, it is of the utmost importance that the remaining rock is of high quality in order to avoid rockfall, rockslides and excessive maintenance work. Therefore, numerous blasting techniques which make use of decoupled charge or shock wave superposition effect have been used to control overbrake. In this paper. some approximate method for the determination of blast load according to the charge condition was introduced at first and, instrumented tests were conducted in small scale transparent material to investigate the shape and amplitude of blast load around the bore hole. Compare to the fully coupled charge, low amplitude of blast load around the bore hole was observed in the decoupled charge and explosion gas pressure was important in the shape of blast load. Therefore, quasi-static behaviour of the crack pattern was shown due to low loading rate.

• Biomolecules & Therapeutics
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• 제13권2호
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• pp.90-94
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• 2005

Prazosin hydrochloride is an antihypertensive drug with selective ${\alpha}_1$-adrenoreceptor blocking effects. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of prazosin in human plasma. A reversed-phase C18 column was used for the separation of prazosin and terazosin (internal standard) with a mobile phase composed of water, acetonitrile and triethylamine(75:25:0.1, V/V;pH5.0) at a flow rate of 1.5 ml/min. the fluorescence detector was set at excitation and emissionwavelengths of 250 and 370 nm, respectively. Intra-and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 0.5 ng/ml. Good recovery (>80%) was seen in plasma. Prazosin was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study in plasma after oral administration of a single 2-mg dose as prazosin base to 16 healthy volunteers. The maximum plasma concentration of prazosin was 23.1 ${\pm}$ 16.5 ng/ml at 2.1 h, and the mean area under the curve and elimination half-life were calculated to be 108.4 ${\pm}$ 74.2 ng ${\cdot}$hr/ml and 2.5 ${\pm}$ 0.6 h, respectively.

• Journal of Information Processing Systems
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• 제2권2호
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• pp.88-94
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• 2006

In wireless cellular networks, previous researches on admission control policies and resource allocation algorithm considered the QoS (Quality of Service) in terms of CDP (Call Dropping Probability) and CBP (Call Blocking Probability). However, since the QoS was considered only within a predetermined cell capacity, the results indicated a serious overload problem of systems not guaranteeing both CDP and CBP constraints, especially in the hotspot cell. That is why a close interrelationship between CDP, CBP and cell capacity exists. Thus, it is indispensable to consider optimal cell capacity guaranteeing multiple QoS (CDP and CBP) at the time of initial cell planning for networks deployment. In this paper, we will suggest a distributed determination scheme of optimal cell capacity guaranteeing both CDP and CBP from a long-term perspective for initial cell planning. The cell-provisioning scheme is performed by using both the two-dimensional continuous-time Markov chain and an iterative method called the Gauss-Seidel method. Finally, numerical and simulation results will demonstrate that our scheme successfully determines an optimal cell capacity guaranteeing both CDP and CBP constraints for initial cell planning.