• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1789-1792
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• 2006

To develop the Korean Standard Differentiation of the symptoms and signs for the Stroke(KSDS), the committee on Stroke Diagnosis Standardization of Korean Traditional Medicine was organized by nineteen experts in College of Korean Medicine, The Consensus of the second Consultation Meeting was as follows : First is the definition of the stroke on the Korean Traditional Medicine. Second is the five categories to the Differentiation of the symptoms and signs for the Stroke - fire and heat, dampness and phlegm, blood stasis, qi deficiency, yin deficiency. Third is the indices of the Differentiation of the symptoms and signs for the Stroke respectively. KSDS-1 will be applied to the clinical practice and revised. The Consensus of the third Consultation Meeting had agreed 81 symptoms indexes of KSDS.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.2
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• pp.318-321
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• 2011

In this study, when a physician make a diagnosis of the Pattern Identifications(PIs) of stroke patients, the development methods of the PIs classification function is considered by diagnostic questionnaire of the PIs for stroke patients. Clinical data collected from 1,502 stroke patients who was identically diagnosed for the PIs subtypes diagnosed by two clinical experts with more than 3 years experiences in 13 oriental medical hospitals. In order to develop the classification function into PIs using the 44 items-Fire&heat(19), Qi-deficiency(11), Yin-deficiency(7), Dampness phlegm(7)- of them was significant statistically by univariate analysis in 61 questionnaires totally, we make some comparisons of the results of discriminant analysis model and generalized logit model. The overall diagnostic accuracy rate of the PIs subtypes for discriminant model(74.37%) was higher than 3% of generalized logit model(70.09%).

• Nutrition Research and Practice
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• v.10 no.1
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• pp.26-32
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• 2016

BACKGROUND/OBJECTIVES: It has been shown that vitamin A supplementation has different effects on skeletal health and the antioxidant system. Deficiency or excess of this vitamin can lead to health problems. Vitamin A can work as either an antioxidant or prooxidant depending on its concentration. The present study was conducted to investigate the effects of different doses of vitamin A supplementation on the antioxidant system in rats. MATERIALS/METHODS: Forty Spargue-Dawley male rats were divided into four groups according to the dose of vitamin A received: 0 (A0), 4,000 (A1), 8,000 (A2), and 20,000 (A3) IU retinyl palmitate/kg diet. After a feeding period of 4 wks, lipid peroxide levels, glutathione concentration, antioxidant enzyme activities, and vitamins A and E concentrations were measured. Histopathological changes were observed in rat liver tissue using an optical microscope and transmission electron microscope. RESULTS: Lipid peroxide levels in plasma were significantly decreased in the A1 and A2 groups compared to the A0 rats. Erythrocyte catalase and hepatic superoxide dismutase activities of the A2 group were significantly higher than those of the A0 group. Hepatic glutathione peroxidase activity was significantly lower in the A3 group compared to the other groups. Total glutathione concentrations were significantly higher in the A1 and A2 groups than in the A0 group. Histological examination of liver tissue showed that excessive supplementation of vitamin A might lead to lipid droplet accumulation and nuclear membrane deformation. CONCLUSIONS: These results indicate that appropriate supplementation of vitamin A might have a beneficial effect on the antioxidant system in rats.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.4
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• pp.51-62
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• 2018

Objectives The purpose of this study is to analyze the characteristic of pediatric patients who visited oriental medical hospital for growth treatment. Methods The study was conducted with 130 pediatric patients who visited ${\bigcirc}{\bigcirc}$ Korean medicine hospital from January 2016 to August 2017. The patient's data was classified by sex, age, pattern identification and diseases. The classified data was analyzed to find the correlations and characteristics among variables. Results There were 50.8% of boys and 49.2% of girls. 6.2% of the total patients were in 'early childhood', 50.8% were in 'late childhood' and 43.1% were in 'puberty' stage. In terms of pattern identification, 44.6% of the total patients were 'Spleen-lung Qi Deficiency', 53.8% were 'Lung-kidney Yin Deficiency' and 1.5% were 'Weakness of Heart and gallbladder'. 44.3% of the patients had various diseases including rhinitis (77.6% of 120.7%). Height percentile of the children with using the Growth chart of 2017 was lower than using the Growth chart of 2007. Predicted height based on the child's bone-age were higher than the predicted height based on the parental height, although both of the precited factors were correlated to the current child's height. Conclusions This study showed the characteristic of the pediatric patients who visited oriental medical hospital for growth treatment. It helps to determine prognosis and treatment, and to explain treatment measures.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.1
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• pp.1-37
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• 2022

Objectives This study aimed to provide a basis for applying Korean medical treatment for childhood anorexia in clinical practice by examining Korean medical etiology, pattern differentiation, and treatment, and focusing on research articles on Chinese medicine. Methods Articles on Chinese medicine related to childhood anorexia published before November 4, 2021, in the China National Knowledge Infrastructure (CNKI), were analyzed. The etiology, pattern differentiation, and Chinese medical treatment were summarized. Results Of a total of 73 studies, 13 were randomized controlled trials (RCT), 32 were case studies, and 28 were review papers. The most common Chinese medical etiology of childhood anorexia was emotional instability, and the western medical etiology was problems with diet and lifestyle. The most frequently reported pattern differentiations were spleen-stomach-qi deficiency (脾胃氣虛), stomach-yin deficiency (胃陰不足), and spleen failing in transportation syndrome (脾失健運). The most frequent prescriptions were modified Yangwijeungaektang (养胃增液湯加減), Samryongbakchulsan (蔘苓白术散加减), and Ekongsan (異功散加減). As frequntly used tuina acupoints, Naepalgwae (内八卦), Joksamli (足三里), and Bigyeong (脾經) were mentioned. Conclusions This study analyzed the etiology, pattern differentiation, and Korean medical treatment of anorexia in children. Based on this study, standardization and well-designed clinical studies on Korean medical treatments for childhood anorexia can be expected in the future.

• Journal of Korean Medicine for Obesity Research
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• v.21 no.2
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• pp.80-94
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• 2021

Objectives: The purpose of this study is to re-evaluate the importance of questions of obesity syndrome differentiation (OSD) questionnaire based on real-world survey and to explore the possibility of simplifying OSD types. Methods: The OSD frequency was identified, and variance threshold feature selection was performed to filter the questions. Filtered questions were clustered by K-means clustering and hierarchical clustering. After principal component analysis (PCA), the distribution patterns of the subjects were identified and the differences in the syndrome distribution were compared. Results: The frequency of OSD in spleen deficiency, phlegm (PH), and blood stasis (BS) was lower than in food retention (FR), liver qi stagnation (LS), and yang deficiency. We excluded 13 questions with low variance, 7 of which were related to BS. Filtered questions were clustered into 3 groups by K-means clustering; Cluster 1 (17 questions) mainly related to PH, BS syndromes; Cluster 2 (11 questions) related to swelling, and indigestion; Cluster 3 (11 questions) related to overeating or emotional symptoms. After PCA, significant different patterns of subjects were observed in the FR, LS, and other obesity syndromes. The questions that mainly affect the FR distribution were digestive symptoms. And emotional symptoms mainly affect the distribution of LS subjects. And other obesity syndrome was partially affected by both digestive and emotional symptoms, and also affected by symptoms related to poor circulation. Conclusions: In-depth data mining analysis identified relatively low importance questions and the potential to simplify OSD types.

• The Journal of the Society of Stroke on Korean Medicine
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• v.10 no.1
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• pp.47-53
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• 2009

Objectives : This study was aim to investigate the relationship between NIHSS and distribution of pattern identification in stroke patients. Methods : 1471 participants from the patients hospitalized for stroke within 4 weeks from April 2007 to August 2009 were included. They were grouped according to the NIHSS score; group 1 for the participants whose NIHSS were less than six, group 2 for seven to fifteen, and group 3 for over than sixteen. And the patients were re-divided into two groups according to their post-onset interval. The difference of distribution of five pattern identification for each group were investigated. And five pattern identification were re-analyzed according to the deficiency-excess pattern identification. K-W test was used for statistical synthesis, and the result was regarded as significant one, if its p-value was below 0.05. Results : Dampness-phelegm pattern was the most frequent out of five patterns in total participants as well as all the subgroups. In group 3 with more serious neurological deficit, larger proportion of patients in early acute stage was diagnosed as excess pattern including Fire-Heat pattern. On the other side the proportion of Deficiency of Qi and Yin was larger in late convalescent stage of group 3 than in other groups. But nothing was statistically significant. Conclusions : Further study including patients with more variant classification with follow-up evaluation is needed to reflect the real characteristics of stroke population.

• The Journal of Korean Medicine
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• v.45 no.3
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• pp.91-102
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• 2024

Objectives: Recent trends in traditional Korean medicine (TKM) lung cancer treatment involve the administration of a few ready-made herbal formulas in batches. However, utilizing a TKM pathology-based formulation of herbs can fill in the gaps in holistic treatment that are often missed in a one-size-fits-all approach. The author aimed to analyze treatment trends between a traditional Chinese medicine (TCM) cancer treatment specialty book and a series of Korean lung cancer TKM treatment case reports. Methods: The frequently used pattern identification types, herbal formulas, and herbs in the lung cancer chapter of a TCM cancer treatment specialty book and case reports of TKM treatment of lung cancer were analyzed in a comparative manner. Results: Twenty-four pattern identification types for lung cancer were derived from the TCM book, and they were Phlegm-blood stasis, lung heat, and deficiency type. Six types of pattern identification types were derived from the 20 cases reports of TKM treatment, and they were blood stasis due to qi stagnation and deficiency type. Twelve cases were treated with ready-made anti-tumor herbal preparations without performing a pattern identification, accounting for two-thirds of the cases. Conclusions: The treatment of lung cancer in TCM is characterized by the use of pattern identification to formulate herbal formulas with simultaneous administration of anti-tumor herbs within the same formula. The treatment of lung cancer in TKM is relatively infrequent in its use of pattern identification. In addition, herbal formulas derived through the process of pattern identification and derived for anti-tumor purposes were often administered separately.

• Journal of Haehwa Medicine
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• v.15 no.1
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• pp.33-40
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• 2006

Objectives : This study is aimed to investigate acupuncture treatments for blurred vision, tinnitus, difficulty in urination and bi-syndrome caused by aging process through oriental medical documents. methods : We researched 21 oriental medical classics for the acupuncture treatments of blurred vision, tinnitus, difficulty in urination and bi-syndrome caused by aging or deficiency. Results & conclusions : 1. Disharmony between yin and yang, disharmony between organs, disharmony of essence, qi, spirit, blood and body fluid are the main features of aging. 2. ST36, BL18, BL10, CV24, ST1, BL23 have been most frequently used for acupuncture to treat blurred vision caused by aging. For moxibustion, ST36 has been most frequently used. 3. GB2, TE21, TE17, SI19, TE3 are the mainly used points for acupuncture to treat tinnitus and deafness caused by aging. For moxibustion, LI1 and BL15 have been most frequently used. 4. CV3, CV7, CV4, BL67, LR8, LR4 have been most frequently used to treat difficulty in urination caused by aging. 5. LI11, GB34, GB30, LI4, ST36, TE10, TE5, Sama (extra point) have been most frequently used to treat numbness, paralysis and bi syndrome caused by aging.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1463-1470
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• 2004

Paljinickmohwan(八珍益母丸) is used in female infertility. especially due to deficiency of qi and blood or Qihyulyanghe(氣血兩虛). An attempt was made to evaluate the influences of PJIMH on the serum concentrations of FSH, LH, and estradiol(E2), the histological changes of ovary and the immunohistochemical staining for AT2 receptor in ovary of rats. The results of the study were as follows : Blood FSH level significantly increased in experimental group as compared with control group. In blood LH level, experimental group as compared with control group showed no efficacy. Blood E2 level significantly increased in experimental group as compared with control group. In histological observations of ovary, ovulation increased in experimental group as compared control group, which showed no efficacy. In observations of immunohistochemical staining for AT2 receptor in ovary, there is no difference between control group and experimental group. According to these results, it can be concluded that PJIMH influences ovary to increase the ovulation of rats.