• Tuberculosis and Respiratory Diseases
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• 제67권4호
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• pp.331-337
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• 2009

Background: The whole-blood interferon-gamma release assay (QuantiFERON-TB Gold [QFT-G]: Cellestis, Carnegie, Victoria, Australia) has been studied primarily for the use of diagnosing active pulmonary tuberculosis (TB) or latent TB. In the present study, the usefulness of QFT-G was evaluated for the diagnosis of extra-pulmonary tuberculosis (EP-TB). Methods: From June 2006 to February 2009, we evaluated the usefulness of QFT-G in patients (n=65) suspected with EP-TB, retrospectively. The diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the QFT-G assay were analyzed. Results: EP-TB was diagnosed in 33 (51%) participants. The overall sensitivity, specificity, PPV, and NPV of the QFT-G assay for EP-TB were 78%, 79%, 81%, and 77%, respectively. Of the 33 with EP-TB, 14 (42%) were diagnosed with TB pleurisy, 7 (21%) with TB lymphadenitis, 7 (21%) with intestinal TB, and 5 (15%) with EP-TB in other sites. In subgroup analyses according by site of infection, the QFT-G showed 86% sensitivity, 64% specificity, and 78% NPV in TB pleurisy. On the other hand, the sensitivity, specificity, and NPV of the assay were 71%, 83% and 71%, respectively in TB lymphadenitis, and 86%, 100% and 88%, respectively in intestinal TB. Among the patients with suspected alternative site EP-TB, the sensitivity, specificity, and NPV of the assay were 50%, 80% and 67%, respectively. Conclusion: The QFT-G assay showed moderate diagnostic accuracy in EP-TB. However, negative QFT-G assay does not exclude EP-TB because of the low NPV of this assay.

• 한국정밀공학회지
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• 제18권9호
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• pp.147-155
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• 2001

A new displacement type web position control system for cold mills using QFT is presented. The control system features an inner-outer cascaded system in which the inner loop provides the position tracking control of the hydraulic system and the outer loop provides the position regulation control of the web. By the sensitivity analysis and computer simulation, it is verified that the proposed control system has better robust stability and performance than the conventional control system.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.433-437
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• 2003

Quantitative Feedback Theory (QFT) is one of effective methods of robust controller design. In QFT design we can considers the phase information of the perturbed plant so it is less conservative than $H_{\infty}$ and ${\mu}$-synthesis methods and as be shown, it is more transparent than the sensitivity reduction methods mentioned . In this paper we want to overcome the major drawback of QFT method which is lack of an automatic method for loop-shaping step of the method so we focus on the following problem: Given a nominal plant and QFT bounds, synthesize a controller that achieves closed-loop stability and satisfies the QFT boundaries. The usual approach to this problem involves loop-shaping in the frequency domain by manipulating the poles and zeros of the nominal loop transfer function. This process now aided by recently developed computer aided design tools proceeds by trial and error and its success often depends heavily on the experience of the loop-shaper. Thus for the novice and First time QFT user, there is a genuine need for an automatic loop-shaping tool to generate a first-cut solution. Clearly such an automatic process must involve some sort of optimization, and while recent results on convex optimization have found fruitful applications in other areas of control theory we have tried to use LMI theory for automating the loop-shaping step of QFT design.

• Tuberculosis and Respiratory Diseases
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• 제70권2호
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• pp.125-131
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• 2011

Background: The clinical manifestation of $M.$ $tuberculosis$ infection ranges from asymptomatic latent infection, to focal forms with minimal symptoms and low bacterial burdens, and finally to advanced tuberculosis (TB) with severe symptoms and high bacillary loads. We investigated the diagnostic sensitivity of the whole-blood interferon-${\gamma}$ release assay according to the wide spectrum of clinical phenotypes. Methods: In patients diagnosed with active TB that underwent $QuantiFERON^{(R)}$ (QFT) testing, the QFT results were compared with patients known to be infected with pulmonary tuberculosis (P-TB) and extra-pulmonary TB (EP-TB). In addition, the results of the QFT test were further analyzed according to the radiographic extent of disease in patients with P-TB and the location of disease in patients with EP-TB. Results: There were no statistical differences in the overall distribution of QFT results between 177 patients with P-TB and 84 patients with EP-TB; the positive results of QFT test in patients with P-TB and EP-TB were 70.1% and 64.3%, respectively. Among patients with P-TB, patients with mild extents of disease showed higher frequency of positive results of QFT test than that of patients with severe form (75.2% vs. 57.1%, respectively; p=0.043) mainly due to an increase of indeterminate results in severe P-TB. Patients with TB pleurisy showed lower sensitivity by the QFT test than those with tuberculous lymphadenitis (48.8% vs. 78.8%, respectively; p=0.019). Conclusion: Although QFT test showed similar results between overall patients with P-TB and EP-TB, individual sensitivity was different according to the radiographic extent of disease in P-TB and the location of disease in EP-TB.

• 대한기계학회논문집A
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• 제26권1호
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• pp.31-38
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• 2002

A new steering-type web position control system for cold mills using QFT is presented. The control system features an inner-outer cascaded system in which the inner loop provides the position tracking control of hydraulic system and the outer loop provides the position regulation control of the web. By the sensitivity analysis and computer simulation, it is verified that the proposed control system has better robust stability and performance than the conventional PH) control system.

• 한국소음진동공학회논문집
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• 제15권10호
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• pp.1148-1159
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• 2005

In this paper, the various uncertainties generated in an optical disk drive (ODD) and the robust servo designs considering the uncertainties are studied. First, the brief introduction an ODD and the servo error tolerance of it are discussed. Then, the classifications of uncertainty and the concept of relative stability are introduced. Considering the uncertainty of an ODD, two robust control approaches are applied: (i) mixed sensitivity approach in H$\infty$ control theory for unstructured uncertainty, (ii) QFT for structured uncertainty Finally, the designed controllers are realized by DSP, and these controllers are applied to a commercial DVD-ROM drive. From these experiments, we prove that the designed robust controllers have more good disturbance rejection performance and robustness when it is compared to the conventional lead-lag controller.

• 대한기계학회논문집A
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• 제22권3호
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• pp.562-568
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• 1998

During the past three decades, several techniques have been suggested for robust performance design of multivariable systems within the framework of Quantitative Feedback Theory. They are all characterized and limited by the use of loop transmission inversion. A new approach within framework is described which leads to a design tehnique without loop transmission inversion. Complete sequential design algorithms are derived for performance specifications in terms of plant input disturbance, sensitivity, complimentary sensitivity and control effort.