• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2006년도 Proceedings of The Convention
• /
• pp.139-145
• /
• 2006

Kaneka Corporation (Kaneka) has been manufacturing CoQ10 under GMP regulation since 1977. Kaneka has a sophisticated quality control system and has been supplying high quality CoQ10 materials to the worldwide customers (Kaneka CoQ10) for about 30 years. Kaneka CoQ10 is characterized by a lot of safety data, which are derived from clinical trials with healthy volunteers (single-dose and 4-week multi-dose safety studies), animal studies (13-week sub-chronic study in dogs and 52-week chronic study in rats), three types of mutagenicity test, six type of skin irritation test (for cosmetics), and others. The risk assessment of CoQ10 was performed by Council for Responsible Nutrition (USA). They reviewed many of available clinical data including clinical trials using Kaneka Q10, and concluded that the upper level for supplements (ULS) of CoQ10 is 1,200 mg/day (Hathcock and Shao. 2006, Regulatory Toxicology and Pharmacology, 45, 282 - 288).

• 한국약용작물학회:학술대회논문집
• /
• 한국약용작물학회 2006년도 Proceedings of The Convention of The Korean Society of Applied Pharmacology
• /
• pp.139-145
• /
• 2006

Kaneka Corporation (Kaneka) has been manufacturing CoQ10 under GMP regulation since 1977. Kaneka has a sophisticated quality control system and has been supplying high quality CoQ10 materials to the worldwide customers (Kaneka CoQ10) for about 30 years. Kaneka CoQ10 is characterized by a lot of safety data, which are derived from clinical trials with healthy volunteers (single-dose and 4-week multi-dose safety studies), animal studies (13-week sub-chronic study in dogs and 52-week chronic study in rats), three types of mutagenicity test, six type of skin irritation test (for cosmetics), and others. The risk assessment of CoQ10 was performed by Council for Responsible Nutrition (USA). They reviewed many of available clinical data including clinical trials using Kaneka Q10, and concluded that the upper level for supplements (ULS) of CoQ10 is 1,200mg/day (Hathcock and Shao. 2006, Regulatory Toxicology and Pharmacology, $\underline{45}$, 282 - 288).

• Advances in Traditional Medicine
• /
• 제10권4호
• /
• pp.239-253
• /
• 2010

Coenzyme $Q_{10}$ ($CoQ_{10}$, or ubiquinone) is an electron carrier of the mitochondrial respiratory chain (electron transport chain) with antioxidant properties. In view of the involvement of $CoQ_{10}$ in oxidative phosphorylation and cellular antioxidant protection a deficiency in this quinone would be expected to contribute to disease pathophysiology by causing a failure in energy metabolism and antioxidant status. Indeed, a deficit in $CoQ_{10}$ status has been determined in a number of neuromuscular and neurodegenerative disorders. Primary disorders of $CoQ_{10}$ biosynthesis are potentially treatable conditions and therefore a high degree of clinical awareness about this condition is essential. A secondary loss of $CoQ_{10}$ status following HMG-CoA reductase inhibitor (statins) treatment has been implicated in the pathophysiology of the myotoxicity associated with this pharmacotherapy. $CoQ_{10}$ and its analogue, idebenone, have been widely used in the treatment of neurodegenerative and neuromuscular disorders. These compounds could potentially play a role in the treatment of mitochondrial disorders, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Friedreich's ataxia, and other conditions which have been linked to mitochondrial dysfunction. This article reviews the physiological roles of $CoQ_{10}$, as well as the rationale and the role in clinical practice of $CoQ_{10}$ supplementation in different neurological diseases, from primary $CoQ_{10}$ deficiency to neurodegenerative disorders. These will help in future for treatment of patients suffering from neurodegenerative disease.

• 충청수학회지
• /
• 제26권1호
• /
• pp.147-159
• /
• 2013

Hamada ([8]) and Maruta ([17]) proved the minimum length $n_3(6,\;d)=g_3(6,\;d)+1$ for some ternary codes. In this paper we consider such minimum length problem for $q{\geq}4$, and we prove that $n_q(6,\;d)=g_q(6,\;d)+1$ for $d=q^5-q^3-q^2-2q+e$, $1{\leq}e{\leq}q$. Combining this result with Theorem A in [4], we have $n_q(6,\;d)=g-q(6,\;d)+1$ for $q^5-q^3-q^2-2q+1{\leq}d{\leq}q^5-q^3-q^2$ with $q{\geq}4$. Note that $n_q(6,\;d)=g_q(6,\;d)$ for $q^5-q^3-q^2+1{\leq}d{\leq}q^5$ by Theorem 1.2.

• 대한수학회보
• /
• 제45권3호
• /
• pp.419-425
• /
• 2008

For $q^5-q^3-q^2-q+1{\leq}d{\leq}q^5-q^3-q^2$, we prove the non-existence of a $[g_q(6,d),6,d]_q$ code and we give a $[g_q(6,d)+1,6,d]_q$ code by constructing appropriate 0-cycle in the projective space, where $g_q (k,d)={{\sum}^{k-1}_{i=0}}{\lceil}\frac{d}{q^i}{\rceil}$. Consequently, we have the minimum length $n_q(6,d)=g_q(6,d)+1\;for\;q^5-q^3-q^2-q+1{\leq}d{\leq}q^5-q^3-q^2\;and\;q{\geq}3$.

• 한국정보통신학회:학술대회논문집
• /
• 한국정보통신학회 2015년도 추계학술대회
• /
• pp.930-932
• /
• 2015

본 연구는 국제특허분류(IPC) 코드 기반의 특허 정보 분석을 통해 기술 트렌드를 파악하여 새로운 기술을 예측하는 기술예측에 관한 기초연구이다. 특허 분석 대상은 2011년 이후 국내에 특허 등록된 IPC 코드 분류 기준에서 전자상거래(G06Q)가 주분류인 특허이다. 2011년 이후 전자상거래 분야 중 가장 많이 특허 등록된 분야는 G06Q 50/10 (1,652건), G06Q 30/02 (816건), G06Q 50/30 (735건), G06Q 40/02 (713건), G06Q 50/22 (530건), G06Q 30/06 (489건) 순이다.

• Clinical and Experimental Reproductive Medicine
• /
• 제49권4호
• /
• pp.277-284
• /
• 2022

Objective: Oxidative stress is a key player in the development of idiopathic male infertility (IMI), and various antioxidants have been used for the treatment of IMI with inconsistent results. Coenzyme Q10 (CoQ10) is a cofactor and an antioxidant that may improve semen parameters and reduce oxidative stress in patients with idiopathic oligoasthenospermia (OA). Therefore, this study aimed to explore the effect of CoQ10 on semen parameters and antioxidant markers in patients with idiopathic OA. Methods: Fifty patients with idiopathic OA and 35 fertile controls were enrolled in this prospective controlled study. All participants underwent a comprehensive fertility assessment. All patients received CoQ10 (300 mg/day) orally once daily for 3 months. Semen parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured in patients and controls at the start of the study and after 3 months. Results: Treatment with CoQ10 resulted in increased sperm progressive motility (p<0.05), total motility (p<0.01), seminal TAC (p<0.01), SOD (p<0.05), GPx (p<0.001), and seminal CoQ10 (p<0.001) levels and reduced ROS (p<0.01) in patients as compared to baseline. Sperm concentration and motility were also significantly correlated with antioxidant measures and seminal CoQ10 levels (r=0.38-0.57). Conclusion: CoQ10 therapy (300 mg/day for 3 months) improved sperm motility and seminal antioxidant markers in patients with idiopathic OA. Therefore, CoQ10 could be a promising treatment for patients with idiopathic infertility and may improve their fertility potential.

• 한국지구과학회지
• /
• 제22권6호
• /
• pp.500-511
• /
• 2001

양산단층이 지나는 한국 남동지방 지각의 Q$_P^{-1}$ 및 Q$_S^{-1}$를 한국자원연구소가 설치한 9점의 지진관측소 자료를 바탕으로 확장 Coda 규격화법을 이용하여 구하였다 1994년 12월부터 2000년 2월에 일어난 근지지진에서 707개 지진기록에 대하여 1${\sim}$2, 2${\sim}$4, 4${\sim}$8, 8${\sim}$16및 16${\sim}$32Hz의 대역필터를 적용하여 분석한 결과, 각 관측점의 Q$_P^{-1}$는 (7${\pm}$2)${\times}$10$^{-3}$에서 (5${\pm}$4)${\times}$10$^{-4}$으로, Q$_S^{-1}$는 5${\pm}$4)${\times}$10$^{-4}$에서 (5${\pm}$2)${\times}$10$^{-4}$로 주파수가 1.5Hz에서 24Hz로 늘어남에 따라 줄어드는 주파수 의존성이 보인다. 이들 값의 지수 회귀선은 Q$_P^{-1}$가 0.009(${\pm}$0.003)f$^{-1.05({\pm}0.14)$, Q$_S^{-1}$가 0.004(${\pm}$0.001)f$^{-0.75({\pm}0.14)$)이다.

• 한국식품영양과학회지
• /
• 제18권1호
• /
• pp.62-70
• /
• 1989

본 실험은 식이중에 첨가된 coenzyme Q10이 adriamycin (ADR)을 투여한 흰쥐의 심근 미세 구조에 미치는 영향을 규명하기 위하여 실시되었다. 실험군은 모두 ADR 2수준(1.0mg/kg B.W./week, 2.0mg/kg B.W./week)과 coenzyme Q10 3수준(무첨가군, 0.1g / kg diet 및 0.5g / kg diet)에 의한 6개의 실험군과 basal diet만을 공급하는 대조군을 설정하였다. 체중증가량은 ADR의 투여수준이 높을수록 유의적으로 감소되었으며 식이효율에 있어서는 고수준의 ADR 투여시에만 대조군에 비하여 감소되었다. 그러나 coenzyme Q10에 의한 회복효과는 나타나지 않았다. 혈장내 CPK 활성도는 ADR투여로 약간 증가되었으나 유의적인 차이는 없었으며 coenzyme Q10 급여에 대한 영향은 나타나지 않았다. 전자현미경을 통해 심장조직의 형태적변화를 살펴본 결과 ADR투여로 인해 심근세포내 미세구조의 변성을 관찰할 수 있었고 특히 mitochondria 의 변형, myofibil을 비롯한 세포 소기관의 소실 및 파괴로 빈 공간이 형성되어 있었으나 coenzyme Q10 급여군에서는 그 정도가 약화되었다. 고수준의 ADR 투여는 mitochondria 의 volume density와 surface density를 크게 감소시켰지만 고수준의 coenzyme Q10 급여에 의해 이러한 감소가 조절되었다.

• Journal of applied mathematics & informatics
• /
• 제38권1_2호
• /
• pp.37-56
• /
• 2020

In this paper we discuss some interesting properties of (p, q)-special polynomials and derive various relations. We gain some relations between (p, q)-zeta function and (p, q)-special polynomials by considering (p, q)-analogue Euler sum types. In addition, we derive the relationship between (p, q)-polylogarithm function and (p, q)-special polynomials.