• The Korean Journal of Physiology and Pharmacology
• /
• v.22 no.3
• /
• pp.321-329
• /
• 2018

It was recently reported that the $C_{max}$ and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions between rosuvastatin and two perpetrators, telmisartan and cyclosporine. Published (cyclosporine) or newly developed (telmisartan) PBPK models were used to this end. The rosuvastatin model in Simcyp (version 15)'s drug library was modified to reflect racial differences in rosuvastatin exposure. In the telmisartan-rosuvastatin case, simulated rosuvastatin $C_{maxI}/C_{max}$ and $AUC_I/AUC$ (with/without telmisartan) ratios were 1.92 and 1.14, respectively, and the $T_{max}$ changed from 3.35 h to 1.40 h with coadministration of telmisartan, which were consistent with the aforementioned report ($C_{maxI}/C_{max}$: 2.01, $AUC_I/AUC$:1.18, $T_{max}:5h{\rightarrow}0.75h$). In the next case of cyclosporine-rosuvastatin, the simulated rosuvastatin $C_{maxI}/C_{max}$ and $AUC_I/AUC$ (with/without cyclosporine) ratios were 3.29 and 1.30, respectively. The decrease in the $CL_{int,BCRP,intestine}$ of rosuvastatin by telmisartan and cyclosporine in the PBPK model was pivotal to reproducing this finding in Simcyp. Our PBPK model demonstrated that the major causes of increase in rosuvastatin exposure are mediated by intestinal BCRP (rosuvastatin-telmisartan interaction) or by both of BCRP and OATP1B1/3 (rosuvastatin-cyclosporine interaction).

• Proceedings of the KIEE Conference
• /
• 2011.07a
• /
• pp.2075-2076
• /
• 2011

The stator winding faults diagnosis technique based on MCSA is as follows. Firstly, collecting the 3 phase motor currents, that signal is transformed by (d-q transform, $i_d$, $i_q$). Park's vector pattern, the circle that is down by d-q transformed currents($i_d$, $i_q$). The circle is widely used for stator winding faults detection. The current distortion ratio(DR), defined by the ratio of max-axis and min-axis of ellipse of Park's vector's pattern. In this study, distortion ratio of Park's vector pattern is suggested for Auto diagnosis of stator winding short fault and usefulness of distortion ratio is verified through simulation using LabVIEW program.

• Journal of the Chungcheong Mathematical Society
• /
• v.34 no.2
• /
• pp.181-188
• /
• 2021

Let X be a nondegenerate reduced closed subscheme in ℙⁿ. Assume that π_q : X → Y = π_q(X) ⊂ ℙ^n-1 is a generic projection from the center q ∈ Sec(X) \ X where Sec(X) = ℙⁿ. Let Z be the singular locus of the projection π_q(X) ⊂ ℙ^n-1. Suppose that I_X has the almost minimal presentation, which is of the form R(-3)^β_2,1 ⊕ R(-4) → R(-2)^β_1,1 → I_X → 0. In this paper, we prove the followings: (a) Z is either a linear space or a quadric hypersurface in a linear subspace; (b) $H^1({\mathcal{I}_X(k)})=H^1({\mathcal{I}_Y(k)})$ for all k ∈ ℤ; (c) reg(Y) ≤ max{reg(X), 4}; (d) Y is cut out by at most quartic hypersurfaces.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2022.10a
• /
• pp.27-27
• /
• 2022

(-)-Epicatechin (EC), a primary form of flavan-3ol and a building block of proanthocyanidins, has health benefits as it is a potent antioxidant. So far, no quantitative trait loci (QTLs) associated with EC have yet been identified in soybean. In this study, QTLs for EC and hilum color were identified in recombinant inbred lines (RILs) derived from the varieties Jinpung and IT109098 using high-resolution single nucleotide polymorphism linkage mapping. This revealed two major QTLs for EC content, qEC06 and qEC08. qEC06 spanned the T Locus encoding flavonoid 3'-hydroxylase. qEC08, located near the I locus on Chr08, was also a major QTL for hilum color; however, allelic stacking of qEC08 and I revealed no relationship between I and EC content. RILs with IT 109098 alleles at both qEC06 and qEC08 had higher EC content than other lines. These results will enable the production of soybean varieties with high EC content via marker-assisted selection.

• Journal of Soil and Groundwater Environment
• /
• v.16 no.4
• /
• pp.38-52
• /
• 2011

Sorption and sequential desorption experiments were conducted for Zn using a natural soil (NS) in background status by aging (1, 30 and 100 days). The sorption isotherm showed that Zn had high sorption capacity but low sorption affinity in NS. Sequential desorption was biphasic with appreciable amount of sorbed Zn residing in the desorption-resistant fraction after several desorption steps. The biphasic desorption behavior of Zn was characterized by a biphasic desorption model that includes a linear term to represent labile or easily-desorbing fraction and a Langmuirian-type term to represent desorption-resistant fraction. The biphasic desorption model indicated that the size of the maximum capacity of desorption-resistant fraction ($q^{irr}_{max}$) increased with aging in NS. Desorption kinetics and desorption-resistance of Zn in the soils collected from mine tailings (MA, MB and MC collected from surface, subsurface soils and mine waste, respectively) were investigated and compared to the bioavailability to earthworm (Eisenia fetida). Desorption kinetic data of Zn were fitted to several desorption kinetic models. The ratio ($q_{e,d}/q_0$) of remaining Zn at desorption equilibrium ($q_{e,d}$) to initial sorbed concentration ($q_0$) was in the range of 0.53~0.90 in the mine tailings which was higher than that in NS, except MA. The sequential desorption from the mine tailings with 0.01M Na$NO_3$ and 0.01M $CaCl_2$ showed that appreciable amounts of Zn are resistant to desorption due to aging or sequestration. The SM&T (Standard Measurements and Testing Programme of European Union) analysis showed that the sum of oxidizable (Step III) and residual (Step IV) fractions of Zn was linearly related with its desorption-resistance ($q^{irr}_{max}$) determined by the sequential desorption with 0.01M Na$NO_3$ ($R^2$= 0.9998) and 0.01M $CaCl_2$ ($R^2$= 0.8580). The earthworm uptake of Zn and the desorbed amount of Zn ($q_{desorbed}$ = $q_0-q_{e,d}$) in MB soil were also linearly related ($R^2$ = 0.899). Our results implicate that the ecological risk assessment of heavy metals would be possible considering the relation between desorption behaviors and bioavailability to earthworm.

• Advances in Traditional Medicine
• /
• v.4 no.4
• /
• pp.227-234
• /
• 2004

An ${\alpha}-Amylase$ was purified to apparent homogeneity from germinating soybean seeds (Glycine max). Enzyme showed high specificity for starch. ${\alpha}-Amylase$ from soybean has optimum pH at 7.6 in the pH range 4.0-10.6. At this pH, the $K_m$ of starch was 2.63 mg/ml and the $V_{max}$ was equal to 52.6 mg/ml/min protein. Optimum temperature of the enzyme was found to be $55^{\circ}C,\;Q_{10}$ equal to 1.85 and energy of activation equal to 12 kcal/mol. Additives like, EDTA reduced the activity of ${\alpha}-amylase$ whereas PMSF enhanced the activity. ${\alpha}-Amylase$ was inhibited by several heavy metal ions.

• Journal of Communications and Networks
• /
• v.18 no.3
• /
• pp.273-287
• /
• 2016

White-box cryptography presented by Chow et al. is an obfuscation technique for protecting secret keys in software implementations even if an adversary has full access to the implementation of the encryption algorithm and full control over its execution platforms. Despite its practical importance, progress has not been substantial. In fact, it is repeated that as a proposal for a white-box implementation is reported, an attack of lower complexity is soon announced. This is mainly because most cryptanalytic methods target specific implementations, and there is no general attack tool for white-box cryptography. In this paper, we present an analytic toolbox on white-box implementations of the Chow et al.'s style using lookup tables. According to our toolbox, for a substitution-linear transformation cipher on n bits with S-boxes on m bits, the complexity for recovering the $$O\((3n/max(m_Q,m))2^{3max(m_Q,m)}+2min\{(n/m)L^{m+3}2^{2m},\;(n/m)L^32^{3m}+n{\log}L{\cdot}2^{L/2}\}\)$$, where $m_Q$ is the input size of nonlinear encodings,$m_A$ is the minimized block size of linear encodings, and $L=lcm(m_A,m_Q)$. As a result, a white-box implementation in the Chow et al.'s framework has complexity at most $O\(min\{(2^{2m}/m)n^{m+4},\;n{\log}n{\cdot}2^{n/2}\}\)$ which is much less than $2^n$. To overcome this, we introduce an idea that obfuscates two advanced encryption standard (AES)-128 ciphers at once with input/output encoding on 256 bits. To reduce storage, we use a sparse unsplit input encoding. As a result, our white-box AES implementation has up to 110-bit security against our toolbox, close to that of the original cipher. More generally, we may consider a white-box implementation of the t parallel encryption of AES to increase security.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.6
• /
• pp.342-349
• /
• 2019

We describe and anlayzes the methodology and implementation results of H / W configuration and signal characteristics analysis algorithm for analyzing equipment for analyzing OFDMA physical layer based on 802.16e. Recently, demand for signal analysis of instruments that analyze these signals with the development of digital communication signals is rapidly increasing. Accordingly, it is necessary to develop signal analysis equipment capable of analyzing characteristics of a broadband communication signal using a wideband digital signal processing module. In this paper, we have studied the basic theory of OFDMA in order to devise a device capable of analyzing characterisitcs of broadband communication signals. Second, the structure of OFDMA transmitter/receiver was examined. Third, a wideband digitizer was implemented. we design Wimax signal analysis algorithm based on OFDMA among broadband communication methods and propose Wimax physical layer analysis S/W implementation through I, Q signals. The IF downconverter used the receiver module and the LO generation module of the spectrum analyzer. Quantitative analysis result is obtained through the algorithm of Wimax signal analysis by I, Q data.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2020.11a
• /
• pp.57-60
• /
• 2020

순위다중패턴매칭문제는 길이가 n인 텍스트 T와 패턴들의 집합 P' = {P₁,P₂…,P_k}가 주어졌을 때, P'에 속하는 패턴들과 상대적인 순위가 일치하는 T의 모든 부분문자열들의 위치를 찾는 문제이다. P'에서 가장 짧은 패턴의 길이가 m, 가장 긴 패턴의 길이를 $\bar{m}$, 모든 패턴들의 길이의 합을 M, q개의 연속된 문자들을 q-그램이라 할 때, 기존에 텍스트의 핑거프린트를 이용하여 순위다중패턴매칭문제를 $O(q!+nqlogq+Mlog\bar{m}+nM)$ 시간에 해결하는 알고리즘이 제시되었다. 본 논문에서는 텍스트의 핑거프린트를 활용하여 O(max(q!,M,n))개의 스레드를 이용하여 순위다중패턴매칭문제를 평균적으로 $O(\bar{m}+qlogq+n/q!)$ 시간에 해결하는 병렬 구현 방법을 제시한다. 실험 결과, n = 1,000,000, k = 1,000, m = 5, q = 3일 때, 본 논문에서 제시하는 병렬 구현 방법은 기존의 순차 알고리즘보다 약 19.8배 빠르게 수행되었다.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.42 no.9 s.339
• /
• pp.1-8
• /
• 2005

A $0.35\mu$m SiGe BiCMOS fabrication process has been timely developed, which is aiming at wireless RF ICs development and fast growing SiGe RF market. With non-selective SiGe epilayer, SiGe HBTs in this process used trapezoidal Ge base profile for the enhanced AC performance via Ge induced bandgap niuoin. The characteristics of hFE 100, $f_{T}\;45GHz,\;F_{max}\;50GHz,\;NF_{min}\;0.8dB$ have been obtained by optimizing not only SiGe base profile but also RTA condition after emitter polysilicon deposition, which enables the SiGe technology competition against the worldwide cutting edge SiGe BiCMOS technology. In addition, the process incorporates the CMOS logic, which is fully compatible with $0.35\mu$m pure logic technology. High Q passive elements are also provided for high precision analog circuit designs, and their quality factors of W(1pF) and inductor(2nH) are 80, 12.5, respectively.