• Clinical and Experimental Pediatrics
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• v.59 no.sup1
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• pp.19-24
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• 2016

Constitutional interstitial deletions of the long arm of chromosome 5 (5q) are quite rare, and the corresponding phenotype is not yet clearly delineated. Severe mental retardation has been described in most patients who present 5q deletions. Specifically, the interstitial deletion of chromosome 5q33.3q35.1, an extremely rare chromosomal aberration, is characterized by mental retardation, developmental delay, and facial dysmorphism. Although the severity of mental retardation varies across cases, it is the most common feature described in patients who present the 5q33.3q35.1 deletion. Here, we report a case of a de novo deletion of 5q33.3q35.1, 46,XY,del(5)(q33.3q35.1) in an 11-year-old boy with mental retardation; to the best of our knowledge this is the first case in Korea to be reported. He was diagnosed with severe mental retardation, developmental delay, facial dysmorphisms, dental anomalies, and epilepsy. Chromosomal microarray analysis using the comparative genomic hybridization array method revealed a 16-Mb-long deletion of 5q33. 3q35.1(156,409,412-172,584,708)x1. Understanding this deletion may help draw a rough phenotypic map of 5q and correlate the phenotypes with specific chromosomal regions. The 5q33.3q35.1 deletion is a rare condition; however, accurate diagnosis of the associated mental retardation is important to ensure proper genetic counseling and to guide patients as part of long-term management.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.308-308
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• 1994

열분석 (DSC, TG/DTA)을 통해 Q-35는 A, B, C의 세가지 다형이 존재함을 알수 있었으며 이중 상대습도에 따른 흡습성의 변화가 적고, 가습에 의해 다형전환이 일어나지 않는 C형이 제제에 유리하다고 사료된다. 또한C형은 분쇄, 연합 및 타정에 의한 다형의 전환이 없었다. Q-35의 용해도는 물, 메탄올, 에탄올에 각각 0.30.3.55,6.31mg/m1 이었으며 PH5이상에서는 급격히 용해도가 감소하고 산성에서는 용해도가 크게 증가하는 양상을 나타냈다. 적층시험, 배합시험을 통해 선정한부형제의 표준 처방 혼합물로 정제를 저조한 결과Q-35의 성형성은 양호하였고 Q-35의 함량이 증가함에 따라 붕해시간이 다소 지 연됨을 알수 있었다. 그러나 Q-35원료는 유동성이 적어 직타법이 적합하지 않았으며, 습식 과립압축법에 따라 저조한 정제의 붕해시간은 5-9분, 15분 후 용출은 91.$\pm$5.0% 이었다. Q-35정제를 4$0^{\circ}C$, 4$0^{\circ}C$ ㆍ 75%RH에서 6개월, 6$0^{\circ}C$에서 3개월 보존후 함량을 측정한 결과 각각 100.0, 98.7, 98.9%이었으며 그밖의 항목에서도 안정한 결과를 얻어 Q-35정제는 온도 및 습도어 안정한 것으로 사료된다. 대량생산 연구결과 Q-35의 결정수가 이탈되지 않도록 건조, 코팅 공정 중 정제의 온도를 5$0^{\circ}C$ 이하로 유지시켰다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.189-189
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• 1994

Q-35의 일회 및 반복투여 연구결과, 자타학 증상은 단지반복투여 피험자에서 중등도의 두통(1예)과 설사(3예)가 관찰되었으나 이들 설사증례는 장내 세균총 검사상 복감염에 의한 것이 아니었다. Q-35 투여 후 Q-EEG 및 평행기능의 장애 등은 관찰되지 않았으며 임상화학 검사상 반복투여 3예에서 SGOT, SGPT의 경미한 상승을 보였으나 이러한 변화는 정상 범위내에서의 변화이었다. Q-35의 반복투여에 따라 투약 3일에서 8일에 걸처 장내세균총은 일부 호기성 및 혐기성 세균총의 감소를 보였으나 투약종료 10일 후에는 투약전 상태로 회복되었다. Q-35는 투여량의 약 70 % 가 24시간 뇨중으로 배설되었으며 일회 및 반복투여의 결과 용량의존적인 동태양상은 관찰할 수 없었다. 50 mg에서 400 mg까지 일회 투여시 5.6-7.1 시간의 혈장반감기를 보였으며, 반복투여 시험에서는 평균 5.6 $\pm$ 0.7 시간의 반감기를 보였다. Q-35는 타액내로 신속히 이행되었으며 타액내 AUC는 혈장 AUC의 약 75 %에 해당하였고, 식사에 의해 약간의 흡수속도지연(Cmax 0.4 시간지연)과 공복시에 비해 82 %의 상대적 생체이용율을 보였다.

• Journal of the Chungcheong Mathematical Society
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• v.35 no.3
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• pp.227-234
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• 2022

Let 𝔽_q be a finite field with odd q elements. In this article, we prove that if E ⊆ 𝔽^d_q, d ≥ 2, and |E| ≥ q, then there exists a set Y ⊆ 𝔽^d_q with |Y| ~ q^d such that for all y ∈ Y, the number of distances between the point y and the set E is ~ q. As a corollary, we obtain that for each set E ⊆ 𝔽^d_q with |E| ≥ q, there exists a set Y ⊆ 𝔽^d_q with |Y| ~ q^d so that any set E ∪ {y} with y ∈ Y determines a positive proportion of all possible distances. The averaging argument and the pigeonhole principle play a crucial role in proving our results.

• Explosives and Blasting
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• v.35 no.4
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• pp.27-35
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• 2017

A total of 22 sites around openings of limestone mine are chosen to assess rock mass classification schemes such as RMR, Q-system, and GSI. RMR and Q are modified to estimate the relationship with GSI. Q' is the modified Q with SRF=1.0 and $J_w=1.0$. Rock mass is assumed to be completely dry and very favorable discontinuity orientations are assumed to estimate ${RMR_{89}}^{\prime}$. Relationships of Q-Basic RMR, Q-Total RMR, ${GSI-RMR_{89}}^{\prime}$, and GSI-Q' are analyzed, in which a correlation of ${GSI-RMR_{89}}^{\prime}$ is found to be the highest. Failure strains are calculated using the modulus ratios and most measuring sites appear to be stable with low failure strain class.

• Journal of Pharmaceutical Investigation
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• v.31 no.2
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• pp.119-123
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• 2001

Six polymorphic modifications of Balofloxacin (Q-35) were obtained by the recrystallization from different organic solvents and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD). The dissolution patterns of these six modifications were also checked in distilled water at $37{\pm}0.5^{\circ}C$, 50 rpm for 60 minutes. The polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 1 was faster than that of other polymorphic modifications. The transformation during storage was also studied.

• Biomolecules & Therapeutics
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• v.6 no.1
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• pp.73-81
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• 1998

Pregnant Sprague-Dawley rats were administered with Q-35 at the dose levels of 0, 30, 100 and 300 mg/kg/day by oral gavage from gestation day 17 to lactation period. Effects of the test chemical on general findings, reproductive performance of dams and development of Fl generation were examined. There were no treatment related changes in physical signs, body weight, necropsy findings, organ weights, delivery and nursing behavior. In 100 and 300 mg/fg/day treated groups, the food consumption of dams was decreased significantly during gestational day 19~21. The gestation length of 300 mg/tg/day treated group was increased significantly compared to the control group (22.3 $\pm$0.48 vs 22.0$\pm$0.39). Although the gestational length of all groups were in normal range of the rat, potential effect of the drug could not be ruled out. External anomaly of Fl fetus induced by Q-35 was not detected in any groups. There were no treaoent related changes in physical development, reflex functions, sensory functions, locomotor activity and motor coordinating activity. Estrus cycle, fertility and reproductive performance of Fl were not changed in all treated groups. There was no external abnormality related to the drug administration on the examination of F2. These results suggest that Q-35 has no adverse effect on the peri- and postnatal period in rats except the reduction of food consumption at the beginning of drug administration and the potential effect on the elongation of gestation length.

• Journal of Genetic Medicine
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• v.18 no.1
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• pp.48-54
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• 2021

Genetic imbalances are a major cause of congenital and developmental abnormalities. We report the first case of a 3p26 microdeletion and 5q35.2q35.3 microduplication in a newborn with multiple congenital anomalies evaluated using chromosomal microarray analysis (CMA) and fluorescence in situ hybridization (FISH). The patient was born at 30 weeks and 2 days of gestation with a body weight of 890 g. He had symmetric intrauterine growth restriction, microcephaly, facial dysmorphism (hypertelorism, blepharophimosis, mild low-set ears, high-arched palate, and micrognathia), and right thumb polydactyly. Echocardiography revealed an atrial septal defect and patent ductus arteriosus. Furthermore, CMA revealed a concurrent microdeletion in 3p26 and a microduplication in 5q35.2q35.3. FISH analysis showed that these genetic changes resulted from a translocation mutation between chromosomes 3 and 5. The patient's mother had mild intellectual disability, short stature, and facial dysmorphism, while his father had a normal phenotype. However, parental FISH analysis revealed that the asymptomatic father carried a balanced translocation of chromosomes 3p26 and 5q35. CMA and FISH tests are useful for diagnosing neonates with multiple congenital abnormalities. Further parental genetic investigation and proper genetic counseling are necessary in cases of chromosomal abnormalities inherited from parental balanced translocations.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.192-199
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• 2018

This study was conducted to examine the nursing image types and characteristics of nurses perceived by nursing college students by applying the Q methodology and to manage effective nursing education and clinical education. The survey was conducted from May 15, 2017 to May 24, 2017, and the data collection for the Q population composition was based on in-depth interviews and literature review. First, nursing college students were searched for convenience and 158 statements were obtained based on open questionnaires and 64 statements extracted from in-depth interviews and after a literature review. To select the Q sample, Q population was categorized by taking several repeated readings. Five categories were developed from these processes: quality and role, social awareness, professionalism, uniqueness, and working conditions. The selected statements were reviewed and revised by experts and 35 Q samples were finally selected. Based on this, 46 students in one nursing college classified 35 Q statements, and analyzed data using PC QUANL program. The results of the study were as follows: 2) Type I-1: Job related anxiety, Type I-2: cold and professional, Type II-1: Complaint of treatment and Type II-2: Profession-Unacceptable. These results are expected to provide useful data for understanding the characteristics of nurses' images and provide data enabling development of image improvement strategies of nursing education and clinical education.

• Journal of applied mathematics & informatics
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• v.35 no.5_6
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• pp.587-597
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• 2017

In this paper we define the (p, q)-analogue of Bernoulli numbers and polynomials by generalizing the Bernoulli numbers and polynomials, Carlitz's type q-Bernoulli numbers and polynomials. We also give some interesting properties, explicit formulas, a connection with (p, q)-analogue of Bernoulli numbers and polynomials. Finally, we investigate the zeros of the (p, q)-analogue of Bernoulli polynomials by using computer.