Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지

Polymorphism of Q-35 (Balofloxacin)

Q-35(발오플록사신)의 결정다형

  • 손영택 (덕성여자대학교 약학대학) ;
  • 전혜련 (덕성여자대학교 약학대학)
  • Published : 2001.06.20
Download PDF
⟨ Previous Next ⟩

Abstract

Six polymorphic modifications of Balofloxacin (Q-35) were obtained by the recrystallization from different organic solvents and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD). The dissolution patterns of these six modifications were also checked in distilled water at $37{\pm}0.5^{\circ}C$, 50 rpm for 60 minutes. The polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 1 was faster than that of other polymorphic modifications. The transformation during storage was also studied.

Keywords