• Title/Summary/Keyword: Q

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Ergogenic Effect of Cervi Cornu and CoenzymeQ10 Complex (녹각 추출물과 CoenzymeQ10 복합제가 운동능력에 미치는 영향)

  • Lee, In-hee;Kim, Min-ji;Park, Sung-woon;Park, Yeo-eun;Kim, Hyun-mi;Le, Jae-hwan
    • The Journal of Internal Korean Medicine
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    • v.36 no.3
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    • pp.297-307
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    • 2015
  • Objectives: We aimed to evaluate the effect of Cervi Cornu and coenzymeQ10 on exercise and endurance capacity in rats and mice. Methods: The extract of Cervi Cornu was manufactured by the pharmacy department of Kyung Hee Oriental Medical Hospital, and CoQ10 soft cap (Ildong Pharmaceutical) was used. In total, 24 rats and 30 mice were divided into 3 groups: Control (rat=8, mouse=10), CoQ10 alone (rat=8, mouse=10), Cervi Cornu extract, and CoQ10 (rat=8, mouse=10). Ergogenic effect was evaluated by administering the Cervi Cornu extract and coenzymeQ10 to rats and measuring the time to exhaustion during treadmill running; endurance capacity was assessed by measuring cold water swimming time, serum lactate level, and serum corticosterone level in each group. At 1 week from the end of treatment, we recalculated time to exhaustion during treadmill running in rats to investigate the long-term effect of the Cervi Cornu extract and coenzymeQ10. Results: Cervi Cornu extract has long-term benefits in that it preserves the ergogenic effect caused by exercise. Cervi Cornu and coenzymeQ10 have no effect on increasing cold water swimming time in ICR mice. CoenzymeQ10 decreases the serum corticosterone level in ICR mice performing cold water swimming test. Conclusions: Cervi Cornu seems to preserve the ergogenic effect caused by exercise, but a larger study is needed to investigate effect of Cervi Cornu and coenzymeQ10 on improving endurance capacity. CoenzymeQ10 decreases serum corticosterone level and it is related with the anti-psychological fatigue effect.

Analysis of coenzyme Q 1O in dietary supplement by HPLC (HPLC를 이용한 건강기능식품 중 코엔자임 Q10 성분 분석)

  • No, Ki-Mi;Leem, Dong-Gil;Kim, Mi-Gyeong;Park, Kyoung-Sik;Yoon, Tae-Hyung;Hong, Jin;Park, Sun-Young;Jeong, Ja-Young
    • Journal of Food Hygiene and Safety
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    • v.26 no.1
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    • pp.12-15
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    • 2011
  • A method based on high-performance liquid chromatography (HPLC) with ultraviolet detection has been developed to quantify coenzyme Q10 (CoQ10) in raw materials and dietary supplements. Single-laboratory validation has been performed on the method to determine linearity, selectivity, accuracy, limits of quantification (LOQ) and repeatability for CoQ10. An excellent linearity (r=0.999) was observed for CoQ10 in the concentration range $15.625{\sim}500\;{\mu}g/ml$ in dietary supplement. Observed recovery of CoQ10 was found to be between 98.33 and 99.38%. LOQ was found to be $250\;{\mu}g/ml$ Repeatability precision for CoQ10 was between 0.15 and 0.21% relative standard deviation (RSD). Further, limited studies showed that some adulterants and degraded material could be satisfactorily separated from CoQ10 and identified.

Distributional Uniqueness of Deciduous Oaks(Quercus L.) in the Korean Peninsula (한반도 하록 참나무류의 분포 특이성)

  • Kim, Yun-Ha;Kim, Jong-Won
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.20 no.2
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    • pp.37-59
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    • 2017
  • The Korean peninsula belongs to the temperate forest biome dominated by many deciduous oaks. We quantitatively and qualitatively studied vertical and horizontal distributions and habitat characteristics on the major oak species such as Quercus mongolica, Q. serrata, Q. variabilis, Q. dentata, Q. aliena and Q. acutissima. A total of 5,278 samples were analyzed with a species coverage and 6 principal environmental variables extracted from public database of nationwide natural environment survey. Correlation analysis was accomplished by the CANOCO using Canonical Correspondence Analysis and the Pearson correlation coefficient using PASW Statistics. The hierarchical distribution tendency of six oaks was finalized using the Goodman-Kruskal lambda coefficient of non-metric multidimensional scaling by SYN-TAX 2000. The utmost factor on the distributional segregation of oak species was the elevation, i.e. temperature. Q. serrata and Q. mongolica show clearly a diametrical distribution patterns with zonal distribution. Q. variabilis was determined as a thermophilic and xerophilous species that is a component of not only natural pseudo-climax forest but also secondary forest. The highest frequency of the dominant forest was found Q. mongolica. Whereas, Q. serrata showed the highest frequency of individual tree but the relatively lower frequency of dominant forest, which is resulted from the original habitat loss. By the benefit of the traditional Soopjeong-E, Q. acutissima dominant forests were remained rather largely. Individuals of Q. dentata occurred horizontally nationwide, but its dominant forest was the poorest. Dominant forest of Q. aliena, which is a natural vegetation, was the most rare due to a limited potential habitat.

Generalized BER Performance Analysis for Uniform M-PSK with I/Q Phase Unbalance (I/Q 위상 불균형을 고려한 Uniform M-PSK의 일반화된 BER 성능 분석)

  • Lee Jae-Yoon;Yoon Dong-Weon;Hyun Kwang-Min;Park Sang-Kyu
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.3C
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    • pp.237-244
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    • 2006
  • I/Q phase unbalance caused by non-ideal circuit components is inevitable physical phenomenons and leads to performance degradation when we implement a practical coherent M-ary phase shift keying(M-PSK) demodulator. In this paper, we present an exact and general expression involving two-dimensional Gaussian Q-functions for the bit error rate(BER) of uniform M-PSK with I/Q phase unbalance over an additive white Gaussian noise(AWGN) channel. First we derive a BER expression for the k-th bit of 8, 16-PSK signal constellations when Gray code bit mapping is employed. Then, from the derived k-th bit BER expression, we present the exact and general average BER expression for M-PSK with I/Q phase unbalance. This result can readily be applied to numerical evaluation for various cases of practical interest in an I/Q unbalanced M-PSK system, because the one- and two-dimensional Gaussian Q-functions can be easily and directly computed using commonly available mathematical software tools.

MORE GENERAL FORMS OF (∈, ∈ VQk) FUZZY FILTERS OF ORDERED SEMIGROUPS

  • Khan, Asghar;Muhammad, Shakoor;Khalaf, Mohammed M.
    • Honam Mathematical Journal
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    • v.39 no.2
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    • pp.199-216
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    • 2017
  • In the paper [Y. B. Jun, B. Davvaz and A. Khan, Filters of ordered semigroups based on the fuzzy points, JIFS 24 (2013) 619-630]. Jun et al. discussed the notion of (${\in},{\in}{\vee}q_k$)-fuzzy left (resp., right) filters as a generalization of the notion of (${\in},{\in}{\vee}q$)-fuzzy left (resp., right) filters of ordered semigroups. In this article, we try to obtain a more general form that (${\in},{\in}{\vee}q_k$)-fuzzy left (resp., right) filters in ordered semigroups. The notion of (${\in},{\in}{\vee}q_k^{\delta}$)-fuzzy left (resp., right) filters is discussed, and several properties are investigated. Characterizations of an (${\in},{\in}{\vee}q_k^{\delta}$)-fuzzy left (resp., right) filter are established. A condition for an (${\in},{\in}{\vee}q_k^{\delta}$)-fuzzy left (resp., right) filter to be a fuzzy left (resp., right) filter is provided. The important achievement of the study with an (${\in},{\in}{\vee}q_k^{\delta}$)-fuzzy left (right) filter is that the notion of an (${\in},{\in}{\vee}q_k$)-fuzzy left ( right) filter and hence an (${\in},{\in}{\vee}q$)-fuzzy left (resp. right) filter are special cases of an (${\in},{\in}{\vee}q_k^{\delta}$)-fuzzy left (resp. right) filter, and thus several results in published papers are becoming corollaries of our results obtained in this paper.

Construction of Deletion Map of 16q by LOH Analysis from HCC Patients and Physical Map on 16q 23.3 - 24.1 Region

  • Chung, Jiyeol;Choi, Nae Yun;Shim, Myoung Sup;Choi, Dong Wook;Kang, Hyen Sam;Kim, Chang Min;Kim, Ung Jin;Park, Sun Hwa;Kim, Hyeon;Lee, Byeong Jae
    • Genomics & Informatics
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    • v.1 no.2
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    • pp.101-107
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    • 2003
  • Loss of heterozygosity (LOH) has been used to detect deleted regions of a specific chromosome in cancer cells. LOH on chromosome 16q has been reported to occur frequently in progressed hepatocellular carcinoma (HCC). Liver tissues from 37 Korean HCC patients were analyzed for LOH by using 25 polymorphic microsatellite markers distributed along 16q. Out of the 37 HCC patients studied, 21 patients (56.8%) showed LOH in various regions of 16q with at least one polymorphic marker. Puring the analysis of these 21 LOH cases, 6 patients showed interstitial LOHs in which the boundary of the LOH region was defined. With two rounds of LOH analysis, five commonly occurring interstitial LOH regions were identified; 16q21-22.1, 16q22.2 - 22.3, 16q22.3, 16q23.2 and 16q23.3 - 24.1. Among the five LOH regions the 16q23.3 - 24.1 region has been reported to be related with chromosome instability. A complete physical map, which covers the 3.2 Mb region of 16q23.3 - 24.1 (D16S402 and D16S486), was constructed to identify novel candidate tumor suppressor genes. We provide the minimally tiling path map consisting of 28 BAC clones. There was one gap between NT_10422.11 and NT_019609.9 of the human genome sequence contig (NCBI sequence build 33, April 29, 2003). This gap can be filled by sequencing the R-1425M20 clone which bridges these sequence contigs.

Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats

  • Choi, Hye-Kyung;Won, Eun-Kyung;Choung, Se-Young
    • Biomolecules & Therapeutics
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    • v.24 no.2
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    • pp.171-177
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    • 2016
  • Statins, HMG-CoA reductase inhibitors, are known to cause serious muscle injuries (e.g. myopathy, myositis and rhabdomyolysis), and these adverse effects can be rescued by co-administration of coenzyme $Q_{10}$ ($CoQ_{10}$) with statins. The goal of the current research is to assess the efficacy of combined treatment of $CoQ_{10}$ with Atorvastatin for hyperlipidemia induced by high-fat diet in SD rats. 4-week-old Sprague-Dawley male rats were fed normal diet or high-fat diet for 6 weeks. Then, rats were treated with either Statin or Statin with various dosages of $CoQ_{10}$ (30, 90 or 270 mg/kg/day, p.o.) for another 6 weeks. Compared to Statin only treatment, $CoQ_{10}$ supplementation significantly reduced creatine kinase and aspartate aminotransferase levels in serum which are markers for myopathy. Moreover, $CoQ_{10}$ supplementation with Statin further reduced total fat, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol. In contrast, the levels of high-density lipoprotein-cholesterol and $CoQ_{10}$ were increased in the $CoQ_{10}$ co-treated group. These results indicate that $CoQ_{10}$ treatment not only reduces the side effects of Statin, but also has an anti-obesity effect. Therefore an intake of supplementary $CoQ_{10}$ is helpful for solving problem of obese metabolism, so the multiple prescription of $CoQ_{10}$ makes us think a possibility that can be solved in being contiguous to the obesity problem, a sort of disease of the obese metabolism.