• Yonsei Medical Journal
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• 제59권9호
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• pp.1057-1063
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• 2018

Purpose: Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association between CAS and IR in non-diabetic individuals has not been elucidated. The aim of the present study was to evaluate the impact of IR on CAS in patients without DM. Materials and Methods: A total of 330 eligible patients without DM and coronary artery disease who underwent acetylcholine (Ach) provocation test were enrolled in this study. Inclusion criteria included both hemoglobin A1c <6.0% and fasting glucose level <110 mg/dL without type 2 DM. Patients were divided into quartile groups according the level of homeostasis model assessment of insulin resistance (HOMA-IR): 1Q (n=82; HOMA-IR<1.35), 2Q (n=82; $1.35{\leq}HOMA-IR<1.93$), 3Q (n=83; $1.93{\leq}HOMA-IR<2.73$), and 4Q (n=83; $HOMA-IR{\geq}2.73$). Results: In the present study, the higher HOMA-IR group (3Q and 4Q) was older and had higher body mass index, fasting blood glucose, serum insulin, hemoglobin A1c, total cholesterol, and triglyceride levels than the lower HOMA-IR group (1Q). Also, poor IR (3Q and 4Q) was considerably associated with frequent CAS. Compared with Q1, the hazard ratios for Q3 and Q4 were 3.55 (95% CI: 1.79-7.03, p<0.001) and 2.12 (95% CI: 1.07-4.21, p=0.031), respectively, after adjustment of baseline risk confounders. Also, diffuse spasm and accompanying chest pain during Ach test were more strongly associated with IR patients with CAS. Conclusion: HOMA-IR was significantly negatively correlated with reference diameter measured after nitroglycerin and significantly positively correlated with diffuse spasm and chest pain.

• 실천공학교육논문지
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• 제14권1호
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• pp.219-224
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• 2022

강화학습의 기본적인 알고리즘으로 많이 사용되고 있는 Q-Learning은 현재 상태에서 취할 수 있는 행동의 보상 중 가장 큰 값을 선택하는 Greedy action을 통해 보상을 최대화하는 방향으로 에이전트를 학습시키는 기법이다. 본 논문에서는 Frozen Lake 8*8 그리드 환경에서 Q-Learning을 사용하여 에이전트의 학습 속도를 높일 수 있는 정책에 관하여 연구하였다. 또한, Q-learning 의 기존 알고리즘과 에이전트의 행동에 '방향성'이라는 속성을 부여한 알고리즘의 학습 결과 비교를 진행하였다. 결과적으로, 본 논문에서 제안한 Q-Learning 정책이 통상적인 알고리즘보다 정확도와 학습 속도 모두 크게 높일 수 있는 것을 분석되었다.

• Clinical and Experimental Reproductive Medicine
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• 제49권4호
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• pp.277-284
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• 2022

Objective: Oxidative stress is a key player in the development of idiopathic male infertility (IMI), and various antioxidants have been used for the treatment of IMI with inconsistent results. Coenzyme Q10 (CoQ10) is a cofactor and an antioxidant that may improve semen parameters and reduce oxidative stress in patients with idiopathic oligoasthenospermia (OA). Therefore, this study aimed to explore the effect of CoQ10 on semen parameters and antioxidant markers in patients with idiopathic OA. Methods: Fifty patients with idiopathic OA and 35 fertile controls were enrolled in this prospective controlled study. All participants underwent a comprehensive fertility assessment. All patients received CoQ10 (300 mg/day) orally once daily for 3 months. Semen parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured in patients and controls at the start of the study and after 3 months. Results: Treatment with CoQ10 resulted in increased sperm progressive motility (p<0.05), total motility (p<0.01), seminal TAC (p<0.01), SOD (p<0.05), GPx (p<0.001), and seminal CoQ10 (p<0.001) levels and reduced ROS (p<0.01) in patients as compared to baseline. Sperm concentration and motility were also significantly correlated with antioxidant measures and seminal CoQ10 levels (r=0.38-0.57). Conclusion: CoQ10 therapy (300 mg/day for 3 months) improved sperm motility and seminal antioxidant markers in patients with idiopathic OA. Therefore, CoQ10 could be a promising treatment for patients with idiopathic infertility and may improve their fertility potential.

• 대한수학회지
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• 제33권4호
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• pp.763-775
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• 1996

For $Q = [0,S] \times [0,T]$ let C(Q) denote Yeh-Wiener space, i.e., the space of all real-valued continuous functions x(s,t) on Q such that x(0,t) = x(s,0) = 0 for every (s,t) in Q. Yeh [10] defined a Gaussian measure $m_y$ on C(Q) (later modified in [13]) such that as a stochastic process ${x(s,t), (s,t) \epsilon Q}$ has mean $E[x(s,t)] = \smallint_{C(Q)} x(s,t)m_y(dx) = 0$ and covariance $E[x(s,t)x(u,\upsilon)] = min{s,u} min{t,\upsilon}$. Let $C_\omega \equiv C[0,T]$ denote the standard Wiener space on [0,T] with Wiener measure $m_\omega$. Yeh [12] introduced the concept of the conditional Wiener integral of F given X, E(F$\mid$X), and for case X(x) = x(T) obtained some very useful results including a Kac-Feynman integral equation.

• Journal of the Korean Statistical Society
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• 제23권2호
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• pp.367-378
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• 1994

Let P and Q be probability measures of a measurable space $(\Omega, F)$, and ${F_n}_{n \geq 1}$ be a sequence of increasing sub $\sigma$-fields which generates F. For each $n \geq 1$, let $P_n$ and $Q_n$ be the restrictions of P and Q to $F_n$, respectively. Under the assumption that $Q_n \ll P_n$ for every $n \geq 1$, a zero-one condition is derived for P and Q to have the dichotomy, i.e., either $Q \ll P$ or $Q \perp P$. Then using this condition and the Kolmogorov's zero-one law, we give new and simple proofs of the dichotomy theorems for a pair of Gaussian measures and Poisson processes with examples.

• 동서간호학연구지
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• 제29권2호
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• pp.172-184
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• 2023

Purpose: The purpose of this study was to identify the subjective relapse experiences of patients with alcohol use disorder in one's life context. Methods: A Q methodology was used to analyze the subjectivity of relapse experiences among 55 participants with alcohol use disorder. Fifty-five Q-statement were derived from interviews and literature review. Q-statements were classified into normally distributed shapes using a 9-point scale. Data were analyzed using the QUANL program. Results: Four types of relapse experiences were identified: failure to self-regulation drinking cravings, fear of relapse and awareness of the need for treatment, drinking as a coping mechanism and defensive coping, and lack of motivation to change drinking behavior. Conclusion: The results of this study suggest that patients with alcohol use disorder need a differential approach based on four types of relapse experiences in the recovery process.

• 한국자원식물학회지
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• 제22권3호
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• pp.266-272
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• 2009

Morphological characteristics of leaves, trichomes and acorns were investigated in 6-year-old artificial hybrids of Q. aliena ${\times}$ Q. mongolica var. crispula and Q. serrata ${\times}$ Q. mongolica var. crispula. Leaf shapes of Q. aliena ${\times}$ Q. mongolica var. crispula $F_{1}$ were obovate and resembled to that of Q. aliena. But several characters including the size of leaf and petiole and the shape of leaf base resembled to those of Q. mongolica var. crispula. In F1 hybrids, small stellate hairs distributed sparsely on the abaxial surface and their lay length was intermediate between both parents. There were no big differences on characters of nuts and cupules between both parents and $F_{1}$ hybrids. Leaf shapes of Q. serrata ${\times}$ Q. mongolica var. crispula $F_{1}$ were obovate-elliptic, and the leaf shape and leaf base and the length of petiole resembled to those of Q. mongolica var. crispula, but leaf size and serration resembled to those of Q. serrata. The number of serration in a leaf was intermediate between both parents. Small stellate hairs distributed sparsely and large single hairs were mixed on the reverse side of leaves. there were no big differences on the number and size of stellate hairs between $F_{1}$ hybrid and Q. serrata. It is able to distinguish $F_{1}$ hybrids from both parents by the size leaf size and shapes, leaf base and serration, petiole length and trichome type in the leaf.

• 전기전자학회논문지
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• 제25권3호
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• pp.578-583
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• 2021

본 논문에서는 반도체의 신뢰성을 테스트하기 위한 가속 시험에 대해 설명하고 자동차 반도체의 신뢰성 테스트 국제 표준인 AEC-Q100에 대해 다룬다. 반도체는 수십년 동안 사용할 수 있기 때문에 수명 전주기에서 발생하는 잠재적인 문제점을 테스트하기 위해서는 집중적으로 스트레스를 가하여 테스트 시간을 최소화하는 가속 시험이 필수적이다. 자동차 반도체에서 사용하는 대표적인 가속 시험인 AEC-Q100은 반도체에서 발생하는 각종 불량과 그 원인을 분석할 수 있도록 설계되었기 때문에 반도체의 수명과 신뢰성을 예측할 수 있을 뿐만 아니라 설계상, 제조상의 문제도 쉽게 찾아낼 수 있다. AEC-Q100은 가속 스트레스 시험, 가속 수명 시험, 패키지 적합성 시험, 공정 신뢰성 시험, 전기적 특성 시험, 결함 검출 시험, 기계적 특성 시험의 7개 테스트 그룹으로 구성되며 동작 온도에 따라 Grade 0에서 Grade 3까지 4개의 등급이 존재한다. 반도체 소자, 광전자 반도체, 센서 반도체, 멀티 칩 모듈, 수동 소자 분야에서는 각각 AEC-Q101, Q102, Q103, Q104, Q200이 사용된다.

• 한국가금학회지
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• 제49권2호
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• pp.115-124
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• 2022

Coenzyme Q10(CQ10)은 세포의 미토콘드리아 전자전달계의 산화적 인산화 작용에 중요한 역할을 하는 물질로서 최근 항산화제로서 가능성이 주목을 받고 있다. 따라서 본 시험은 산란 스트레스로서 지방간 현상이 다발하는 산란계(40주령)를 이용하여 대조군(CON), 분말 CoQ10 급여군(PCoQ, 100 mg/kg 사료) 및 유화 CoQ10 급여군(ECoQ, 100 mg/kg 사료) 등 3 처리군으로 설정하고 항산화 관련 지표를 조사하였다. 5주간의 시험 결과 분말 및 유화 CoQ10 급여는 산란계의 체중, 증체, 간 및 비장의 무게에는 영향은 미치지 않았다. CoQ10 급여 후 혈액의 전체 항산화력(total antioxidant power)을 조사한 결과 대조군과 비교 시 ECoQ 군에서 약 2배 정도 유의적으로(P<0.05) 증가하였다. PCoQ 군에서 수치상 약 1.5배의 TAP가 증가하였으나 대조군과 비교 시 유의적 차이는 없었다. 산란계의 간 조직에서 SOD, GPX 및 CAT 등 항산화 효소의 mRNA 발현은 분말 또는 유화 CoQ10 급여에 따른 유의적 효과가 없었다. 이들 항산화 효소들의 특이적 활성도를 조사한 결과 역시 분말 또는 유화 CoQ10 급여에 따른 유의적 차이가 없었다. 그러나 간 조직의 지질과산화(lipid peroxidation) 지표는 대조군과 비교 시 ECoQ에서 유의하게(P<0.05) 낮은 것으로 나타났다. 이상의 결과 유화형 COQ10 급여는 산란계에서 혈액의 전체 항산화력(TAP)을 증가시키고 간 조직에서 발생하는 활성산소를 효율적으로 제거하여 지질과산화도를 감소시키는 것으로 나타났다. 따라서 COQ10 급여는 과도한 산란 스트레스로부터 건강한 산란계를 사육할 수 있는 항산화 사료첨가제로써 이용 가능성이 높은 것으로생각된다.

• 대한수학회지
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• 제56권1호
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• pp.197-224
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• 2019

Let A be a $JB^*$-triple with Banach dual space $A^*$ and bi-dual the $JBW^*$-triple $A^{**}$. Elements x of $A^*$ of norm one may be regarded as normalised 'Q-measures' defined on the complete ortho-lattice ${\tilde{\mathcal{U}}}(A^{**})$ of tripotents in $A^{**}$. A Q-measure x possesses a support e(x) in ${\tilde{\mathcal{U}}}(A^{**})$ and a compact support $e_c(x)$ in the complete atomic lattice ${\tilde{\mathcal{U}}}_c(A)$ of elements of ${\tilde{\mathcal{U}}}(A^{**})$ compact relative to A. Necessary and sufficient conditions for an element v of ${\tilde{\mathcal{U}}}_c(A)$ to be a compact support tripotent $e_c(x)$ are given, one of which is related to the Q-covering numbers of v by families of elements of ${\tilde{\mathcal{U}}}_c(A)$.