• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2001년도 Proceedings of 2001 International Symposium
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• pp.165-168
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• 2001

Regulation of pyrimidine nucleotide synthesis has been studied extensively in enteric bacteria and Bacillus species. Varieties of control modes have been proposed for regulation of pyrimidine nucleotide biosynthetic (pyr) genes. In Bacillus caldolyticus and B. subtilis, it has been proved that pyrimidine de novo biosynthetic operon is controlled by a regulatory protein PyrR-mediated attenuation. Another Gram-positive bacteria including Enterococcus faecalis, Lactobacillus plantarum, and wctococcus lactis have been found to constitute a pyr gene cluster containing the pyrR gene. In addition, it has been proposed that the structure of the 5' leader region of the Gram-negative extreme thermophile Thermus strain Z05 pyr operon provides a novel mechanism of PyrR-dependent coupled transcription-translation attenuation. Bacterial genome sequencing projects have identified the PyrR homologues in Haemophilus influenzae, Synechocystis sp., Mycobacterium tuberculosis, Streptococcus pneumoniae, S. pyogenes, and Clostridium acetobutylicum, which are currently investigating for their physiological functions.

• 대한화학회지
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• 제39권9호
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• pp.728-733
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• 1995

Pyrimidine의 6번위치에 chloro, methoxy, ethoxy, amino, 및 amino 기가 도입된 2-amino-4-methylcyano-5-methylsulfonylpyrimidine 유도체 6들은 2-Amino-4-methylcyano-5-methylsulfonylpyrimidine 유도체 4들과 tert-butylcyanoacetate로부터 합성되었으며 pyrimidine의 6번 위치에 methoxy, ethoxy, isopropoxy, phenoxy, amino 및 anilino기가 도입된 2-amino-4-methylcyano-5-methylsulfonylpyrimidine 유도체 4들은 2-amino-4-methylcyano-5-methylsulfonylpyrimidine 3으로부터 합성되었다.

• 대한화학회지
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• 제55권2호
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• pp.218-229
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• 2011

Imine 화합물 1을 hydrazine hydrate와 같은 nitrogenous 시약과 반응시켜서 치환된 pyrimidines 화합물을 합성하였다. 얻어진 화합물 2를 다양한 반응조건, 즉 propionic acid, formic acid, ethyl chloroformate, acdetic anhydride, carbon disulphide, cyanogene bromide, triflauroacetic acid 및 ethyl chloroacetate와 반응시켜서 대응하는 화합물을 좋은 수율로 얻었으며, 반응은 Dimroth-type 자리옮김 반응을 통하여 진행되었다.

• 약학회지
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• 제21권2호
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• pp.70-80
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• 1977

본고에서는 핵산 생합성과 Salvage patheway (Preformed Purine Utilization), De novo Pyrimidine Biosynthesis, Slavage patheway (Preformed Pyrimidine Utilization), Purine Base 및 Purine Nucleoside와 비슷한 구조를 가진 핵산 대사 길항제에 대한 내용으로 구성되어 있다.

• Archives of Pharmacal Research
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• 제13권1호
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• pp.97-100
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• 1990

A convenient route is reported for the synthesis of fused pyrrolo [2, 3-d][1, 3]-oxazine and pyrrolo [2, 3-d]-pyrimidine derivatives from 2-amino-1-benzyl-3-t-butoxy-carbonyl-4, 5-dimethylpyrrole.

• Archives of Pharmacal Research
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• 제13권1호
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• pp.103-104
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• 1990

An alkaloid was isolated from the roots of Glycyrrhiza uralensis Fisch. It was identified as 3-methyl-6, 7, 8-trihydro-pyrrolo[1, 2-alpyrimidin-2-one(I) by spectral analysis. The compounds is first found in the plant kingdom.

• 대한화학회지
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• 제54권6호
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• pp.841-843
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• 2010

• Bulletin of the Korean Chemical Society
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• 제29권11호
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• pp.2231-2236
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• 2008

• Bulletin of the Korean Chemical Society
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• 제26권7호
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• pp.1033-1034
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• 2005

• BMB Reports
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• 제33권2호
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• pp.126-132
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• 2000

The hepadnaviruses replicate their nucleic acid through a reverse transcription step. The MBP-fused HBV polymerase was expressed in E. coli and purified by using amylase affinity column chromatography. The purified protein represented DNA-dependent DNA polymerase activity. In this report, the MBP-HBV polymerase was shown to lack 3'$\rightarrow$5' exonuclease activity, like other retroviral RTs. The ratio of the insertion efficiency for the wrong versus right vase pairs indicates the misinsertion frequency (f). The nucleotide insertion fidelity (1/f), observed with the MBP-HBV polymerase and HIV-1 RT, was between 60 and 54,000, and between 50 and 73,000, respectively, showing that they are in close range. A relatively efficient nucleotide incorporation by the MBP-HBV polymerase was observed with a specificity of three groups: (1) A : T, T : A>C : G, G : C (matched pairs), (2) A : C, C : A>G: T, T : G (purine-pyrimidine and pyrimidine-purine mispairs), and (3) C : C, A : A, G : G, T : T>T : C, C : T>A : G, G : A (purine-purine or pyrimidine-pyrimidine mispairs), and their order is (1)>(2)>(3). The data from the nucleotide insertion fidelity by the MBP-HBV polymerase suggest that the HBV polymerase may be as error-prone as HIV-1 RT.