• Bulletin of the Korean Chemical Society
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• v.27 no.8
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• pp.1211-1218
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• 2006

The enantiomerically pure (2R,3S)- and (2R,3R)-3-amino-2-hydroxy-4-phenylbutanoic acids (AHPBA) 1 and 3 are readily obtained from D-glucono-a-lactone. Both AHPBAs are the structural key units of KMI derivatives which are the potent inhibitors of BACE 1 ($\beta$-secretase) and HIV protease. Additionally, the obtained AHPBAs 1 and 3 are converted to dipeptides of bestatin stereoisomers 2 and 4.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2263-2270
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• 2014

Solvolysis rate constants of 2-phenylethyl-(2-$PhCH_2CH_2OCOCl$, 1) and 2,2-diphenylethyl chloroformate (2,2-$Ph_2CHCH_2OCOCl$, 2), together with the previously studied solvolyses of ${\alpha}$- and ${\beta}$-substituted chloroformate ester derivatives, are reported in pure and binary solvents at $40.0^{\circ}C$. The linear free energy relationship (LFER) and sensitivities (l and m) to changes in solvent nucleophilicity ($N_T$) and solvent ionizing power ($Y_{Cl}$) of the solvolytic reactions are analyzed using the Grunwald-Winstein equation. The kinetic solvent isotope effects (KSIEs) in methanol and activation parameter values in various solvents are investigated for 1 and 2. These results support well the bimolecular pathway with same aspects. Furthermore, the small negative values of the entropies of activation of solvolysis of 1 and 2 in the highly ionizing aqueous fluoroalcohols are consistent with the ionization character of the rate-determining step, and the KSIE values of 1.78 and 2.10 in methanol-d indicate that one molecule of solvent acts as a nucleophile and the other acts as a general-base catalyst. It is found that the ${\beta}$-substituents in alkyl chloroformate are not the important factor to decide the solvolysis reaction pathway.

• Journal of the Korean Society of Safety
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• v.1 no.1
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• pp.41-49
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• 1986

Modern technological progress demands the use of materials at high temperature and high pressure. One of the most critical factors in considering such applications-perhaps the most critical one-is creep behavior. In this study the activation energy for the creep rupture (Qf) and the stress dependence of rupture time (n') have been determined during creep of Al 7075 alloy eve, the temporature range of $200^{\circ}C to 500^{\circ}C$ and stress range of 0.64 kgf/$\textrm{mm}^2$ to 9.55 kgf/$\textrm{mm}^2$, respectively, in order to investigate the creep-rupture property. Constant load creep tests were carried out in the enperiment At around the temperature $210^{\circ}C~390^{\circ}C$ and the stress level 1.53~9.55(kgf/$\textrm{mm}^2$), the stress dependence of rupture time(n') had the value of 6.6~6.78 but at 50$0^{\circ}C$, the value of 1.3. Besides at around the temperature of $200^{\circ}C~500^{\circ}C$ and under the stress level of 0.89~8.51 (kgf/$\textrm{mm}^2$), the activation energy for the creepprupture (Qf) was nearly equal to that of the volume self diffusion of pure aluminum (34Kca1/mo1e)

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.3 no.4
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• pp.95-100
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• 2004

Plastics is used to produce precise parts with an inclusion of a reinforcement material such as glass fiber or carbon fiber to improve the dimension accuracy. The plastic goods can be produced with inaccurate dimensions, low mechanical strength, or residual stress due to the over packing of cavity inside, if the filling balance of melt resin is not accomplished. To overcome this problem, it is necessary to design the runner system with the geometrical balance at the mold design stage. However, even if the balanced runner system is achieved, a severe filling imbalance is observed practically in a multi-cavity mold. In this study, experiments were performed with Taguchi method to achieve the filling balance in multi-cavity mold with a symmetric runner system, by the use of pure PA and PA with glass fiber 33%. The experimental results were investigated to understand the effect of related molding factors on the filling imbalance for two resins.

• Proceedings of the KIPE Conference
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• 1998.10a
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• pp.774-779
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• 1998

For the speed control of motors, the position or speed sensors are necessary to obtain the position information of the rotor. Specially, SRM(Switched Reluctance Motor) needs an accurate rotor position data because both the rotor and the stator have a salient pole structure. High functional sensors like resolver or encoder are expensive and have complex connecting lines to the controller so the pure signals are apt to be mixed with noised. In the sight of SRM drives, the high temperature, heavy dust, and the EMI surroundings reduce the reliability of speed and position sensors. Therefore, the speed and position sensorless control algorithms using observer have been accepted widely. In this paper An adaptive sliding observer is described to control the SRM without speed or position sensors. The adaptive sliding observer is set on the basis of variable structure control theory. The sliding surface is constructed by current error terms and this surface guarantees the errors converge to "zero". The stability of observer is affirmed by Lyapunov stability analysis and popov's hyper stability theory.ty theory.

• The Korean Journal of Pain
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• v.9 no.1
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• pp.215-218
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• 1996

Frostbite involves freezing of tissues and usually affects the distal aspects of the extremities or exposed parts of the face. such as the ears, nose, chin, and cheeks. It produces tissue injury by ice crystal formation between the cells, cellular dehydration, and microvascular occulsion. There are four degrees of frostbite. First degree is accompanied by erythema and edema; second degree, by vesiculation, blistering, and eschar formation; third degree, by hemorrhagic blistering and bluish gray discoloration; and fourth degree, by injury to subcutaneous tissue, muscle, tendon, and bone leading to mottled, dry, black, and necrotic changes. We successfully treated 2 patients suffering from frostbite by performing sympathetic ganglion block with pure alcohol. We concluded sympathetic ganglion block is one of the most effective treatments for frostbite.

• Tribology and Lubricants
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• v.18 no.1
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• pp.1-8
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• 2002

Nano adhesion and friction between a $Si_{3}N_{4}$ AFM(atomic force microscope) tip and thin silver films were experimentally studied. Tests were performed to measure the nano adhesion and friction in both AFM and LFM(lateral force microscope) modes in various range of normal loads. Thin silver films deposited by IBAD (ion beam assisted deposition) on Si-wafer (100) and other Si-wafers of different surface roughness were used. Results showed that nano adhesion and friction decreased with the surface roughness. When the Si surfaces were coated by pure silver, the adhesion and friction decreased. But the adhesion and friction were not affected by the thickness of IBAD silver coating. As the normal force increased, the adhesion forces of bare Si-wafer and IBAD silver coating film remained constant, but the friction forces increased linearly. Test results suggested that the friction was mainly governed by the adhesion as long as the load was low.

• Korean Journal of Pharmacognosy
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• v.43 no.3
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• pp.250-256
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• 2012

In order to extract the curcuminoid such as curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) in turmeric (Curcuma longa), solvent extraction methods (dipping and ultrasonic extraction method) and solid-phase extraction (SPE) were used. RP-HPLC (reverse-phase high-performance liquid chromatography) and TLC (thin-layer chromatography) were used for identification and analysis the three curcuminoid. From the experimental results, it is evident that the percentage of curcuminoid extracted from turmeric by ultrasonic extraction method was higher than dipping method. The percentage of curcumin extracted from turmeric by pure methanol was higher than any aqueous methanolic composition. Moreover, the total peak area of three curcuminoid was above 92% in RP-HPLC using solid-phase extraction. These results will form a database for investigating the constituents of natural products and the resources of pharmaceutical, nutrition, and cosmetic products.

• Textile Coloration and Finishing
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• v.23 no.2
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• pp.118-130
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• 2011

In this study, hydrophilic polyurethane (PU) was synthesized by one shot process to get good non-swelling effect and to keep high breathability using reactive silicone oil of mono terminal and bi-terminal types. We also blended non reactive silicone oil with pure hydrophilic PU to compare non-swelling effect and breathability with hydrophilic PU synthesized by the two types of reactive silicone oils. The hydrophilic films were analyzed by nuclear magnetic resonance (NMR) spectroscopy, scanning electron microscope (SEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray photo electron (XPS) spectroscopy, energy dispersive spectrometry (EDS), breathability, waterproofness, tensile strength, contact angle and swelling effect. The results showed that the film made by hydrophilic PU which was synthesized with mono terminal type silicone oil provided good non-swelling effect and acceptable moisture permeability due to the modified surface properties.

• The Korean Journal of Cytopathology
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• v.5 no.2
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• pp.189-193
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• 1994

Malignant thymoma is usually manifested as a mediastinal mass. Occasiomally, these tumors may be associated with a variety of systemic syndromes, such as myasthenia gravis, pure red cell aplasia or hypogammaglobulinemia However, it is generally accepted that thymomas rarely metastasize and the frequency of extrathoracic metastasis has been reported as 1 to 15%. In general, nuclear changes of tumor cells such as enlarged size, irregular shape and altered textures are determining factors in the assessment of the grade of malignancy. We experienced a case of malignant thymoma of anterior mediastinum in a 35-year-old woman. After 3 years, she developed recurrent malignant thymoma in the right supraclavicular area, diagnosed by aspiration biopsy cytology.