• Nonlinear Functional Analysis and Applications
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• 제28권2호
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• pp.439-448
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• 2023

In this article, we are interested in studying the fractional Sadik Transform and a combination of the method of steps that will be applied together to find accurate solutions or approximations to homogeneous and non-homogeneous delayed fractional differential equations with constant-coefficient and possible extension to time-dependent delays. The results show that the process is correct, exact, and easy to do for solving delayed fractional differential equations near the origin. Finally, we provide several examples to illustrate the applicability of this method.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제30권2호
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• pp.191-201
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• 2023

In this paper the control system described by Urysohn type integral equation is studied. It is assumed that control functions are integrally constrained. The trajectory of the system is defined as multivariable continuous function which satisfies the system's equation everywhere. It is shown that the set of trajectories is Lipschitz continuous with respect to the parameter which characterizes the bound of the control resource. An upper estimation for the diameter of the set of trajectories is obtained. The robustness of the trajectories with respect to the fast consumption of the remaining control resource is discussed. It is proved that every trajectory can be approximated by the trajectory obtained by full consumption of the control resource.

• 한국미생물·생명공학회지
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• 제51권4호
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• pp.333-352
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• 2023

Transaminase represents the most important biocatalysts used for the synthesis of chiral amines due to their stereoselectivity. They allow asymmetric synthesis with high yields and enantioselectivity from their corresponding ketones. Due to their environmentally friendly access for the preparation of chiral amines, they have attracted growing attention in recent times. Thus, the production of chiral compounds by transaminase catalysed reactions is considered as an important application in synthetic organic chemistry. Therefore, transaminase is considered to be an important enzyme in the pharmaceutical and chemical industries. ω-Transaminase holds great potential because of its wide substrate specificity thus making it a suitable enzyme to be used at an industrial scale. This review highlights the reaction mechanism, classification, substrate specificity, and biochemical properties. The review also showcases the application of ω-transaminase in organic chemistry with a focus on the production of active pharmaceutical ingredients (APIs).

• 한국재료학회지
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• 제34권2호
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• pp.72-78
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• 2024

The lightweight and high strength characteristics of aluminum alloy materials make them have promising prospects in the field of construction engineering. This paper primarily focuses on aluminum alloy materials. Aluminum alloy was combined with concrete, wood and carbon fiber reinforced plastic (CFRP) cloth to create a composite column. The axial compression test was then conducted to understand the mechanical properties of different composite structures. It was found that the pure aluminum tube exhibited poor performance in the axial compression test, with an ultimate load of only 302.56 kN. However, the performance of the various composite columns showed varying degrees of improvement. With the increase of the load, the displacement and strain of each specimen rapidly increased, and after reaching the ultimate load, both load and strain gradually decreased. In comparison, the aluminum alloy-concrete composite column performed better than the aluminum alloy-wood composite column, while the aluminum alloy-wood-CFRP cloth composite column demonstrated superior performance. These results highlight excellent performance potential for aluminum alloy-wood-CFRP composite columns in practical applications.

• Nonlinear Functional Analysis and Applications
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• 제29권2호
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• pp.527-543
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• 2024

In the realm of differential games and bioeconomic modeling, where intricate systems and multifaceted interactions abound, we explore the precision and efficiency of the Chebyshev Tau method (CTM). We begin with the Weierstrass Approximation Theorem, employing Chebyshev polynomials to pave the way for solving intricate bioeconomic differential games. Our case study revolves around a three-player bioeconomic differential game, unveiling a unique open-loop Nash equilibrium using Hamiltonians and the FilippovCesari existence theorem. We then transition to numerical implementation, employing CTM to resolve a Three-Point Boundary Value Problem (TPBVP) with varying degrees of approximation.

• Asian-Australasian Journal of Animal Sciences
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• 제27권1호
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• pp.93-100
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• 2014

The banning of the use of antibiotics as feed additive has accelerated investigations of alternative feed additives in animal production. This experiment investigated the effect of pure citric acid or acidifier blend supplementation as substitute for antibiotic growth promoters on growth performance, fecal microbial count, and humoral immunity in weaned piglets challenged with Salmonella enterica serover Typhimurium and Escherichia coli KCTC 2571. A total of 60 newly weaned piglets (crossbred, 28-d-old; average 8 kg initial weight) were randomly assigned to four dietary treatments in a completely randomized design. Dietary treatments included NC (negative control; basal diet), PC (positive control; basal diet+0.002% apramycin), T1 (basal diet+0.5% pure citric acid), and T2 (basal diet+0.4% acidifier blend). All piglets were orally challenged with 5 mL of culture fluid containing $2.3{\times}10^8$ cfu/mL of E. coli KCTC 2571 and $5.9{\times}10^8$ cfu/mL of S. typhimurium at the beginning of the experiment. The PC group showed the highest ADG and ADFI, whereas gain:feed was improved in the PC and T1 group (p<0.05). All dietary treatments showed significant reduction in fecal counts of Salmonella and E. coli, compared to NC (p<0.05), with PC being better than T1 and T2. Significant elevation in fecal Lactobacillus spp. counts was shown by treatments with T1, T2, and PC, whereas Bacillus spp. counts were increased by treatment with T1 and T2 compared to NC and PC diet (p<0.05). Serum IgG concentration was increased by T1 diet (p<0.05), whereas IgM and IgA were not significantly affected by any of the dietary treatments (p>0.05). From these above results, it can be concluded that, as alternatives to antibiotics dietary acidification with pure citric acid or acidifiers blend did not fully ameliorate the negative effects of microbial challenges in respect of growth performance and microbial environment, however improved immunity suggested further research with different dose levels.

• 분석과학
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• 제6권2호
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• pp.167-180
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• 1993

Pack cementation법을 이용하여 한국과학기술연구원에서 개발한 세계 최강의 고운 단조용 초내열합금인 KM 1557에 내산화성이 우수한 알루미나이드 코팅층 제조시 코팅처리 변수들이 코팅층의 형성과정에 미치는 영향을 연구하였다. 알루미나이드 코팅처리는 pure 알루미늄 분말을 사용한 high-activity process와 Codep 합금분말을 사용한 low-activity process로 나누어 실시하였다. High-activity process의 경우 활성제의 종류와 첨가량 및 알루미늄의 첨가량에 따라 알루미늄의 증착속도와 알루미나이드 코팅층의 형성속도 및 단면조직은 큰 영향을 받는다. Low-activity process의 경우 알루미늄의 증착속도와 알루미나이드 코팅층의 형성속도 및 단면조직은 활성제의 종류에 전혀 영향을 받지 않으며 단조 활성제의 첨가량에 영향을 받는다. 그러나 활성제의 종류에 따라 코팅층의 표면조직의 결정립 크기가 달라진다. 알루미늄의 활동도에 관계없이 알루미늄의 증착속도는 시간의 평방근에 비례하며, 활성제의 종류에 따라 parabolic rate constants인 $K_p$값이 달라진다. High-activity process의 경우 알루미늄 증착에 필요한 활성화에너지는 활성제의 종류에 따라 달라지나, low-activity process의 경우 활성제의 종류에 관계없이 알루미늄의 증착에 필요한 활성화에너지는 약 12~14 Kcal/mole 정도의 값이 된다.

• 한국환경생태학회지
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• 제23권3호
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• pp.258-271
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• 2009

외부환경 변화와 천이의 영향으로 쇠퇴현상이 나타나고 있는 서울시 소나무림의 식생환경을 개선하고자 교목층 우점종의 경쟁관계, 하층식생내 경쟁종 출현 유무, 관리정도 등에 근거하여 유형을 구분하고 생태적 관리방안을 제안하였다. 서울시 소나무림을 생태적 특성에 따라 분류하면 소나무순림에 속하는 토지극상림(26.1%)과 소나무순림(21.5%), 소나무와 타 수종이 경쟁하는 소나무-신갈나무림(28.0%), 소나무-리기다소나무림(13.1%), 소나무-상수리나무림(4.2%)등으로 구분되었다. 이들 유형에 대한 정밀한 식생조사 결과, 토지극상, 답압피해, 식생관리로 인해 교목층과 하층에 경쟁종이 출현하지 않아 소나무림 유지가 가능한 4개 군집은 하층식생 보완 등 소극적인 관리가 필요하였다. 반면 교목층과 하층에 소나무와 경쟁수종인 낙엽성 참나무류와 외래종이 출현하는 4개 군집은 생태적 지위가 동일한 경쟁종관리, 하층식생 도입 등 적극적인 관리기법을 적용해야 소나무군집을 유지할 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8259-8263
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• 2016

Background: Nano-therapy has the potential to revolutionize cancer therapy. Chrysin, a natural flavonoid, was recently recognized as having important biological roles in chemical defenses and nitrogen fixation, with anti-inflammatory and anti-oxidant effects but the poor water solubility of flavonoids limitstheir bioavailability and biomedical applications. Objective: Chrysin loaded PLGA-PEG-PLGA was assessed for improvement of solubility, drug tolerance and adverse effects and accumulation in a gastric cancer cell line (AGS). Materials and Methods: Chrysin loaded PLGA-PEG copolymers were prepared using the double emulsion method (W/O/W). The morphology and size distributions of the prepared PLGA-PEG nanospheres were investigated by 1H NMR, FT-IR and SEM. The in vitro cytotoxicity of pure and nano-chrysin was tested by MTT assay and miR-34a was measured by real-time PCR. Results: 1H NMR, FT-IR and SEM confirmed the PLGA-PEG structure and chrysin loaded on nanoparticles. The MTT results for different concentrations of chrysin at different times for the treatment of AGS cell line showed IC50 values of 68.2, 56.2 and $42.3{\mu}M$ and 58.2, 44.2, $36.8{\mu}M$ after 24, 48, and 72 hours of treatment, respectively for chrysin itslef and chrysin-loaded nanoparticles. The results of real time PCR showed that expression of miR-34a was upregulated to a greater extent via nano chrysin rather than free chrysin. Conclusions: Our study demonstrates chrysin loaded PLGA-PEG promises a natural and efficient system for anticancer drug delivery to fight gastric cancer.

• 한국산림과학회지
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• 제98권6호
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• pp.772-779
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• 2009

산림 생태계 내 탄소 수지에 관한 기초자료를 확보하기 위해 소나무와 참나무류의 순림 및 이들의 혼효임분에 대한 탄소 저장량을 추정하였다. 연구대상지는 강원도 횡성군 둔내면 일대로 임분별로 흉고직경 5 cm 이상 임목에 대한 흉고단면적($m^2/ha$)을 기준으로 소나무:참나무류의 비율이 95:5인 소나무 순림과 0:100인 참나무류 순림, 그리고 20:80-70:30인 혼효림을 선정하였다. 각각의 임분 내 식생, 낙엽층, 고사목의 생체량과 탄소 농도를 분석하고, 0-30 cm 깊이까지의 토양 탄소 농도를 분석하였다. 식생(상층 임목과 하층 식생)의 탄소 저장량은 참나무류 순림에서 147.6 Mg C/ha, 소나무 순림에서 141.4 Mg C/ha, 혼효림에서 115.8 Mg C/ha 등으로 통계적으로 유의한 차이는 없었다. 낙엽층 내 탄소 저장량은 소나무 순림에서 12.7 Mg C/ha, 참나무류 순림에서 9.9 Mg C/ha와 혼효림에서 8.4 Mg C/ha 등이었으며, 고사목 내 탄소 저장량은 혼효림에서 2.2 Mg/ha, 참나무류 순림에서 1.7 Mg/ha 와 소나무 순림에서 1.1 Mg/ha 등으로 낙엽층의 탄소량은 임분간 유의한 차이가 있었으나(p<0.05), 고사목의 탄소 저장량은 임분간 유의한 차이가 없었다(p>0.05). 지표로부터 30 cm 깊이까지의 토양 탄소 저장량은 소나무 순림에서 44.4 Mg C/ha이고, 혼효림에서 41.6 Mg C/ha과 참나무류 순림에서 33.3 Mg C/ha 등의 분포를 보였으나 임분간 유의한 차이는 없었다. 생태계 내 총 탄소 저장량은 소나무 순림에서 199.6 Mg C/ha, 참나무류 순림에서 192.5 Mg C/ha, 혼효림에서 169.1 Mg C/ha 등으로 임분별로 통계적으로 유의한 차이는 없었다. 탄소 저장량이 혼효림에서 순림보다 낮은 것은 탄소 저장량의 대부분을 차지하는 식생의 탄소 저장량이 혼효림에서 더 낮기 때문이었다. 혼효림의 식생은 소나무와 참나무류의 종간경쟁으로 참나무류의 직경생장이 둔화되고 임분 밀도가 높아 참나무류 임목간의 경쟁이 심하게 되어 순림보다 낮은 생체량을 보이는 것으로 추정된다. 혼효임분에서 탄소 저장량을 증가시키기 위해서는 간벌과 같은 적절한 임분관리를 통한 임분의 종내 및 종간경쟁을 완화시킬 필요가 있는 것으로 사료된다.