• 한국동물생명공학회지
• /
• 제36권1호
• /
• pp.25-34
• /
• 2021

Kisspeptin is a key player in the central control of reproductive axis. Central administration of kisspeptin has been shown to advance puberty in rats. Stimulation of hypothalamic GnRH pulse generating mechanism by kisspeptin has been proposed to be the mechanism behind the onset of puberty. We hypothesized that chronic high doses of kisspeptin administration suppresses the reproductive axis and hence delays the pubertal onset. Hence, we investigated the effect of peripheral administration of chronic high doses of kisspeptin on pubertal onset, feed intake and body weight in female rats. Rats were treated with saline or kisspeptin (100 nmoles per day; intraperitoneal) for 26 days (day 25 to day 50 postnatal) and the day of vaginal opening was marked as day of puberty. Kisspeptin treated rats had delayed pubertal onset and reduced feed intake and body weight. Gonadal GPR54 mRNA was reduced suggesting that chronic high doses of kisspeptin may suppress the reproductive functions possibly by downregulation of GPR54 receptor. However, delay in puberty due to reduction in feed intake and body weight could not be ruled out in this study. Further, our study emphasizes the importance of dosage and duration of kisspeptin administration in the manipulation of reproductive axis. Our study, for the first time, suggests that kisspeptin and its analogues, if proven beneficial, could be used to treat precocious puberty in children. It appears that, though a promising tool for enhancing fertility, kisspeptin acts as a double-edged sword and has to be cautiously used to manipulate reproduction.

• Computers and Concrete
• /
• 제30권6호
• /
• pp.421-432
• /
• 2022

Recently, the interminable ozone depletion and the global warming concerns has led to construction industries to seek for construction materials which are eco-friendly. Regarding this, Geopolymer Concrete (GPC) is getting great interest from researchers and scientists, since it can operate by-product waste to replace cement which can lead to the reduction of greenhouse gas emission through its production. Also, compared to ordinary concrete, geopolymer concrete belongs improved mechanical and durability properties. In spite of its positive properties, the practical use of geopolymer concrete is currently limited. This is primarily owing to the scarce structural, design and application knowledge. This study investigates the Mechanical and Durability of Geopolymer Concrete Containing Fibers and Recycled Aggregate. Mixtures of elastoplastic fiber reinforced geopolymer concrete with partial replacement of recycled coarse aggregate in different proportions of 10, 20, 30, and 40% with natural aggregate were fabricated. On the other hand, geopolymer concrete of 100% natural aggregate was prepared as a control specimen. To consider both strength and durability properties and to evaluate the combined effect of recycled coarse aggregate and elastoplastic fiber, an elastoplastic fiber with the ratio of 0.4% and 0.8% were incorporated. The highest compressive strength achieved was 35 MPa when the incorporation of recycled aggregates was 10% with the inclusion of 0.4% elastoplastic fiber. From the result, it was noticed that incorporation of 10% recycled aggregate with 0.8% of the elastoplastic fiber is the perfect combination that can give a GPC having enhanced tensile strength. When specimens exposed to freezing-thawing condition, the physical appearance, compressive strength, weight loss, and ultrasonic pulse velocity of the samples was investigated. In general, all specimens tested performed resistance to freezing thawing. the obtained results indicated that combination of recycled aggregate and elastoplastic fiber up to some extent could be achieved a geopolymer concrete that can replace conventional concrete.

• Advances in concrete construction
• /
• 제13권6호
• /
• pp.433-450
• /
• 2022

The conventional disposal methods of waste tires are harmful to the environment. Moreover, the recycling/reuse of waste tires in domestic and industrial applications is limited due to parent product's quality control and environmental concerns. Additionally, the recycling industry often prefers powdered rubber particles (<0.60 mm). However, the processing of waste tires yields both powdered and coarser (>0.60 mm) size fractions. Reprocessing of coarser rubber requires higher energy increasing the product cost. Therefore, the waste tire rubber (WTR) less favored by the recycling industry is encouraged for use in construction products as one of the environment-friendly disposal methods. In this study, WTR fiber >0.60 mm size fraction is collected from the industry and sorted into 0.60-1.18, 1.18-2.36-, and 2.36-4.75-mm sizes. The effects of different fiber size fractions are studied by incorporating it as fine aggregates at 10%, 20%, and 30% in the self-compacting rubberized concrete (SCRC). The experimental investigations are carried out by performing fresh and hardened state tests. As the fresh state tests, the slump-flow, T500, V-funnel, and L-box are performed. As the hardened state tests, the scanning electron microscope, compressive strength, flexural strength and split tensile strength tests are conducted. Also, the water absorption, porosity, and ultrasonic pulse velocity tests are performed to measure durability. Furthermore, SCRC's energy absorption capacity is evaluated using the falling weight impact test. The statistical significance of content and size fraction of WTR fiber on SCRC is evaluated using the analysis of variance (ANOVA). As the general conclusion, implementation of various size fraction WTR fiber as fine aggregate showed potential for producing concrete for construction applications. Thus, use of WTR fiber in concrete is suggested for safe, and feasible waste tire disposal.

• 대한통합의학회지
• /
• 제11권3호
• /
• pp.11-23
• /
• 2023

Purpose : The stress of job-seeking college students is gradually worsening due to the continuing recession in the job market. Therefore, this study aims to verify whether intervention with an 'aromatherapy education program,' which combines theory and practice, has greater effect on stress, self-efficacy, and autonomic nervous system function than simple inhalation of essential oils in female college students preparing for employment. Methods : A single-blind, randomized controlled trial was conducted once a week for a total of 4 weeks with 29 female college students preparing for employment. Interventions included essential oil inhalation combined with an aromatherapy education program (experimental group(EG), n=14) and essential oil inhalation alone (control group(CG), n=15); measurements were taken before, immediately after, and 2 weeks after completion of the intervention. Evaluations were conducted using the job-seeking stress scale, stress VAS, self-efficacy scale, and a pulse-wave measuring instrument. Results : There were significant differences between the CG and EG groups with repeated measurements of job-seeking stress (p=.003), cognitive stress (p<.001), and self-efficacy (p<.001). There was a significant interaction between group and time. There were also significant differences between the CG and EG in terms of autonomic nervous system changes stress index(p=.047), total power(p=.029), high frequency(p=.036), and low frequency/high frequency ratio(p=.049). However, there was no significant difference in low frequency between the groups. Conclusion : The aromatherapy education program was more effective in improving job-seeking stress, cognitive stress, self-efficacy, and autonomic nervous system function than simple essential oil inhalation. For the aromatherapy education program to be useful as a complementary intervention for stress management in job seekers, it will be necessary to gather additional evidence of its efficacy by conducting follow-up studies with diverse participants and expanding the numbers, and durations, of the interventions.

• 한국동물번식학회:학술대회논문집
• /
• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
• /
• pp.22-22
• /
• 2003

This study was conducted to determine effects of polyvinyl alcohol (PVA), fetal bovine serum (FBS) and bovine serum albumin (BSA) on blastocoel formation, cell number, apoptosis and apoptosis-related gene expression of porcine diploid parthenotes developing in vitro. Embryos were collected from 2-cell or late 4-cell diploid parthenotes that activated with electro pulse, and in vitro cultured in the NCSU 23 medium supplemented without or with 0.1% PVA, 10% FBS or 0.4% BSA for day 7. The morphological analysis of apoptosis in embryos was carried out using propidium iodide staining and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling. The expressions of Bcl-xL, Bak and P53 in blastocyst stage parthenotes and in vivo-derived blastocysts were determined using semiquantitative RT-PCR. The addition of 0.4% BSA to the culture medium enhanced the development of 2- or late 4-cell stage parthenotes to the blastocysts stage (P < 0.01) while FBS decreased the incidence of blastocoel formation. FBS also reduced cell numbers of blastocysts developed from both 2- (P < 0.001) and late 4-cell (P < 0.05) embryos and increased percentage of apoptosis in the blastocysts (P < 0.001). The relative abundance of Bcl-xL mRNA in diploid parthenotes cultured from 2-cell stage in the presence of BSA is similar with that in in vivo derived embryos, but is significantly higher than in parthenotes cultured with FBS, PVA or none protein supplement control. Bak mRNA showed a significant increase at the blastocyst stage in FBS supplement medium. This result suggests that apoptosis related gene expression is significantly affected by protein supplements, which may result in alteration of apoptosis and embryo viability of porcine embryos developing in vitro.

• Advances in materials Research
• /
• 제11권2호
• /
• pp.121-146
• /
• 2022

In the recent years, the use of agricultural waste in green cement mortar and concrete production has attracted considerable attention because of potential saving in the large areas of landfills and potential enhancement on the performance of mortar. In this research, microparticles of palm oil fuel ash (POFA) obtained from a multistage thermal and mechanical treatment processes of raw POFA originating from palm oil mill was utilized as a pozzolanic material to produce high-performance cement mortar (HPCM). POFA was used as a partial replacement material to ordinary Portland cement (OPC) at replacement levels of 0, 5, 10, 15, 20, 25, 30, 35, 40% by volume. Sand with particle size smaller than 300 ㎛ was used to enhance the performance of the HPCM. The HPCM mixes were tested for workability, compressive strength, ultrasonic pulse velocity (UPV), porosity and absorption. The results portray that the incorporation of micro POFA in HPCMs led to a slight reduction in the compressive strength. At 40% replacement level, the compressive strength was 87.4 MPa at 28 days which is suitable for many high strength applications. Although adding POFA to the cement mixtures harmed the absorption and porosity, those properties were very low at 3.4% and 11.5% respectively at a 40% POFA replacement ratio and after 28 days of curing. The HPCM mixtures containing POFA exhibited greater increase in strength and UPV as well as greater reduction in absorption and porosity than the control OPC mortar from 7 to 28 days of curing age, as a result of the pozzolanic reaction of POFA. Micro POFA with finely graded sand resulted in a dense and high strength cement mortar due to the pozzolanic reaction and increased packing effect. Therefore, it is demonstrated that the POFA could be used with high replacement ratios as a pozzolanic material to produce HPCM.

• 농업생명과학연구
• /
• 제50권2호
• /
• pp.187-194
• /
• 2016

본 연구는 무창돈사에서 최적 환경조절이 가능한 시스템을 구축하고자 환경조절이 가능한 모형돈사를 제작하여 온도분포특성을 분석하고 ICT 융합기술을 활용한 온도센서 위치 최적화 및 컨트롤 일체형 환기팬을 개발하고자 하였다. 팬 상부에 부착된 센서에 의해 측정된 온도는 다른 측점온도보다 1℃ 내의 낮은 온도차를 나타내어 측정오차를 고려할 때 온도센서가 팬 상부에 위치하여도 문제가 없을 것으로 판단되었다. 환기팬 성능은 최대 출력일 때 회전수 1920rpm, 송풍량 125㎥/min로 나타났으며, 최대 효율은 개방면적비 약 70%를 고려할 경우 사용된 환기팬의 적정 송풍량은 75㎥/min에 60pa로 나타났다. 댐퍼의 개방면적비가 약 70%일 때 환기팬의 동력과 상관없이 최대효율을 나타내었다. 팬의 출력별 회전수는 출력 100%일 때 최대 1,920rpm으로 나타났으며, 컨트롤러의 펄스 듀티비를 변화시킴에 따라 AC 출력 위상이 지연 없이 변화하는 것으로 나타나 빠른 응답속도로 팬 속도조절이 가능한 것으로 판단되었다.

• 한국광학회지
• /
• 제34권6호
• /
• pp.225-234
• /
• 2023

모드 잠금 레이저는 주기성을 가지고 짧은 시간 동안 레이저 출력이 펄스로 동작한다. 그러나 시간-주파수 영역에서 모드 잠금된 펄스 레이저의 펄스 반복률의 주기성은 푸리에 변환으로 일정한 주파수 간격을 가진 광 주파수 빗과 같이 이해된다. 이때 광 주파수 빗의 각 주파수 성분은 연속적으로 발진하는 수십만 개의 단일 주파수 성분을 가진 continuous-wave 레이저들과 같다. 광 주파수 빗은 약 20년 전에 개발되어 세계에서 가장 정밀한 원자 시계의 개발을 가능케 하고 안정된 광 주파수를 정밀하게 전송하는 데에 사용되었으며, 다양한 응용연구로도 발전했다. 본 논문에서는 광 주파수 빗의 단일 주파수 구성 요소를 선택적으로 추출하고, 광 빗의 주파수 구성 요소를 제어하는 연구를 소개한다. 또한 광 주파수 빗의 개념과 원리를 해설함으로써 시간-주파수 도메인에서 빛의 특성을 이해하고, 광 주파수 빗을 활용한 다양한 응용 연구를 개발하는 데 도움을 주고자 한다.

• 디지털정책학회지
• /
• 제2권4호
• /
• pp.25-32
• /
• 2023

논문은 PPG 기반 센서에서 측정한 심박수(HR), 심박변이도(HRV) 데이터를 기반으로 DNN(Deep Neural Network) 혈당예측 모델을 개발하는 연구이다. 혈당 예측은 다층퍼셉트론(MLP) 신경망을 이용하였다. DNN 심층학습은 11의 독립변수가 있는 입력층, 은닉층, 출력층으로 구성된다. 혈당 예측모델의 학습결과는 MAE=0.3781, MSE=0.8518, 및 RMSE=0.9229이며, 결정계수(R²)는 0.9994이다. PPG기반의 디지털기기를 이용한 비채혈적 생체신호를 이용하여 혈당관리의 가능성을 확인하였다. PPG기반의 표준화된 활력신호 획득 및 해석법, 다량의 데이터기반 심층학습(Deep Learning)의 데이터셋, 정확성를 실증하는 연구가 이어진다면 개의 혈당관리에 편이성과 대안적인 방법을 제공할 수 있을 것이다.

• 한국환경생태학회지
• /
• 제37권6호
• /
• pp.464-472
• /
• 2023

중년여성은 발달주기 상 신체적, 정신적 스트레스를 많이 받는 시기이다. 이러한 스트레스는 만성적인 고통과 질병으로 연결되기 때문에 삶의 질을 저하시키는 원인이 된다. 이에 대한 대안으로 산림치유가 주목받고 있다. 산림치유는 산림의 치유적 요소를 통해 인간의 건강을 향상시키는 것을 말한다. 이에 본 연구는 감각통찰기반 산림치유 프로그램이 중년 여성의 스트레스 저감에 효과가 있는지를 확인하기 위하여 수행되었다. 이를 위해 산림치유 프로그램에 참가하기를 원하는 중년 여성을 모집하여 실험집단과 통제집단으로 각 20명씩 무작위 배정하여 사전-사후 검사를 실시하였다. 산림치유 프로그램은 감각과 통찰 기반으로 6시간 8회기로 구성되었다. 산림치유 프로그램 장소는 제주 사려니숲에서 진행하였으며, 측정도구는 지각된 스트레스, 여가만족도, 맥파검사를 통한 스트레스 지수를 측정하여 비교하였다. 연구 결과 산림치유 프로그램은 스트레스를 낮추고, 여가만족도를 향상시키는 것으로 나타났다.