• 대한의용생체공학회:의공학회지
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• 제13권4호
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• pp.339-352
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• 1992

A numerical simulation of the steady and pulsatile flow across the end-to-side anastomosis was performed In order to understand the role of flow dynamics in the preferential bevel opment of distal anastomotic intimal hyperplasla. The finite element technique was employed to solve two-dimensional unsteady pulsatile flow in that region. The results of the steady flow revealed that low shear stresses occur at the proximally occluded host artery and at the recirculation region in the Inner wall just distal to the toe region of the anastomosis. The nor- mal;zed wall shear rate was increased, as was the recirculation zone size in the host artery of the by-pass graft anastomosis, with increased anastomotic junction angle. In order to min imize the size of the low wall shear region which might result in the intimal hyperplasia in the by-pass graft anastomosis, a smaller anastomotic junction angle is recommended. The pulsatile flow simulation revealed flow that regions of low and ascillating mali shear do exist near the anastomosis as In the steady simulation. The shift of stagnation point depends on the pulsation of the flow. As the flow was accelerated at systole, the stagnation point moved downstream, disappered at early diastole and reappeared during late diastole. Low shear stress was also found along both walls of the occluded proximal artery. However, the diastolic flow behavior is quite different from the steady results. The vortex near the occluded artery moved downstream and inwardly during late systole, and disappeared during diastole. Recirculations proximal to the toe and heel regions were significant during diastole. Shear stress oscillation was found along the opposite wall. The results of the present study revealed that tow shear occurs at the proximally occluded host artery aud the recirculation region in the inner wall Just dlstal to the toe region of the anastomosis. The present study suggested that the regions of fluctuated wall shear stress wit flow separation is correlated with the preferential developing regions of anastomosis neointial fibrous hyperplasia.

• Advances in biomechanics and applications
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• 제1권2호
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• pp.127-141
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• 2014

A preliminary study of a new pulsatile pump that will work to a frequency greater than 1 Hz, is presented. The fluid-structure interaction between a Newtonian blood flow and a piston drive that moves with periodic speed is simulated. The mechanism is of double effect and has four valves, two at the input flow and two at the output flow; the valves are simulated with specified velocity of closing and reopening. The simulation is made with finite elements software named COMSOL Multiphysics 3.3 to resolve the flow in a preliminary planar configuration. The geometry is 2D to determine areas of high speeds and high shear stresses that can cause hemolysis and platelet aggregation. The opening and closing valves are modelled by solid structure interacting with flow, the rhythmic opening and closing are synchronized with the piston harmonic movement. The boundary conditions at the input and output areas are only normal traction with reference pressure. On the other hand, the fluid structure interactions are manifested due to the non-slip boundary conditions over the piston moving surfaces, moving valve contours and fix pump walls. The non-physiologic frequency pulsatile pump, from the viewpoint of fluid flow analysis, is predicted feasible and with characteristic of low hemolysis and low thrombogenesis, because the stress tension and resident time are smaller than the limit and the vortices are destroyed for the periodic flow.

• 대한의용생체공학회:의공학회지
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• 제29권5호
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• pp.376-383
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• 2008

High-flux dialysis treatment removes various toxins via diffusion as well as convection, which is induced by ultrafiltration and backfiltration. In this study, in vitro (Using the distilled water and the bovine's blood) comparison test was performed to determine whether utilization of a high flux dialyzer paired with different pumps would increase the efficiency of convection. At the same blood flow rates, a pulsatile pump and a roller pump were employed to propel the distilled water and bovine whole blood to a high flux dialyzer. Pressures at the dialyzer inlet and outlet in the blood circuit and in the dialysate circuit were measured, respectively. From these data, we calculated the transmembrane pressure and predicted the ultrafiltration and backfiltration rates developed by both pumps. Using the bovine's blood experiment, ultrafiltration and backfiltration rates were 1.6 times higher with the pulsatile pump than with the roller pump. We conclude that utilization of a pulsatile pump in high flux hemodialysis treatments increases ultrafiltration volume, compared with a roller pump under conditions of the same blood flow rate.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1475-1478
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• 2008

We have investigated the blood sucking phenomena of a female mosquito. The main objective of this study is to understand the mosquito's blood sucking mechanism and eventually to develop a bio-mimic technology that can be used to resolve the problem encountered in the transport of infinitesimal biological fluids in various bio-chips and microchips. At first, the consecutive velocity fields of blood-sucking flow in a proboscis were measured using a micro-particle image velocimetry (PIV) system employed with a high-speed camera. The velocity signals of the blood-sucking flow in the proboscis represent a periodic pulsatile flow pattern and spectral analysis on the velocity waveform shows a clear peak at 6.1 Hz.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2002년도 유체기계 연구개발 발표회 논문집
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• pp.504-512
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• 2002

Bileaflet mechanical valves have the complications such as hemolytic and thromboembolic events, leaflet damage, and leaflet break. These complications are related with the fluid velocity and shear stress characteristics of mechanical heart valves. This fact makes clear the importance of determining the fluid velocity and shear stress characteristics of mechanical heart valves, and requires a detailed understanding of these system properties and further substantial research. The first aim of current study is to introduce fluid-structure interaction method for calculation of unsteady and three-dimensional blood flow through bileaflet valve and leaflet behavior interacted with its flow, and to overcome the shortness of previous studies, where the leaflet motion has been ignored or simplified, by using FSI method. To accomplish this goal, a finite volume computational fluid dynamics code and a finite element structure dynamics code have been used concurrently to solve the flow and structure equations, respectively, to investigate the interaction between the blood flow and leaflet. Physiologic ventricular and aortic pressure waveforms were prescribed as flow boundary conditions. The interaction of aortic flow and valve motion were computed.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 12th Asian Congress of Fluid Mechanics
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• pp.77.1-77.1
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• 2008

• Journal of Mechanical Science and Technology
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• 제15권5호
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• pp.613-622
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• 2001

Interaction of blood flow and leaflet behavior in a bileaflet mechanical heart valve was investigated using computational analysis. Blood flows of a Newtonian fluid and a non-Newtonian fluid with Carreau model were modeled as pulsatile, laminar, and incompressible. A finite volume computational fluid dynamics code and a finite element structure dynamics code were used concurrently to solve the flow and structure equations, respectively, where the two equations were strongly coupled. Physiologic ventricular and aortic pressure waveforms were used as flow boundary conditions. Flow fields, leaflet behaviors, and shear stresses with time were obtained for Newtonian and non-Newtonian fluid cases. At the fully opened phase three jets through the leaflets were found and large vortices were present in the sinus area. At the very final stage of the closing phase, the angular velocity of the leaflet was enormously large. Large shear stress was found on leaflet tips and in the orifice region between two leaflets at the final stage of closing phase. This method using fluid-structure interaction turned out to be a useful tool to analyze the different designs of existing and future bileaflet valves.

• 한국유체기계학회 논문집
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• 제6권3호
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• pp.51-57
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• 2003

Characteristics of the high frequency pulsatile flow have been investigated experimentally to understand the flow phenomena in the hydraulic system. One axis fatigue test bed, which is widely used for automobile field test, is used. Four pressure transducers, an amplifier and a A/D convertor are used to obtain the high frequency pulsatile pressure waveform in hydraulic system. The characteristics of frequency are analyzed by power spectrum method. According to the variations of pump input pressure and actuator acceleration frequency, the pressure is measured with or without an accumulator. The amplitude of pressure with accumulator is very lower than those without accumulator due to absorbing function of accumulator. As the frequency of actuator acceleration is increased, the effect of accumulator become very important to decrease the amplitude of pulsatile pressure waveform with high frequencies.

• 설비공학논문집
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• 제9권4호
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• pp.561-571
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• 1997

In this paper, the fundamental equations are developed for the pulsatile laminar flow generated by changing the oscillatory flow with $0{\leq}f{\leq}48Hz$ into a steady one with $0{\leq}Re{\leq}2500$ in a rigid circular pipe. Analytical solutions for the wave propagation factor k, the axial distributions of cross-sectional mean velocity $u_m$ and pressure p are schematically derived and confirmed experimentally. The axial distributions of centerline velocity and pressure were measured by using Pitot-static tubes and strain gauge type pressure transducers, respectively. The cross-sectional mean velocity was calculated from the centerline velocity by applying the parabolic distribution of the laminar flow and it was confirmed by using the ultrasonic flowmeter. It was found that the axial distributions of cross-sectional mean velocity and pressure agree well with theoretical ones and depend only on the Reynolds number Re and angular velocity $\omega$.

• 유변학
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• 제8권1호
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• pp.1-10
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• 1996

본 논문에서는 협착이 발생된 원관내 뉴턴유체와 비뉴턴유체의 정상 및 맥동유동특 서을 유한요소법으로 해석하였다. 본연구는 맥동유동특성에서 협착관 형상의 변화, 협착이 주기적으로 발생된 협착관에서 협착부사이의 거리와 협착부의 수가유동특성에 미치는 영향 을 검토하였다. 레이놀즈수가 일정할 때 협착이 발생된 원형관내 뉴턴유체와 비뉴턴유체의 맥동유동특성은 정상유동의 경우와 크게 다르게 나타난다. 맥동유동에서는 정상유동보다 관 중앙부에서 속도분포가 훨씬 평탄하고 맥동유동의 속도분포는 감속시에 비하여 가속시에 관 중앙부의 속도분포가 더 평탄하게 나타난다. 정상유동과 맥동유동으 감속시에서는 협착부 하류의 벽면에서 재순환영역이 발생된다. 협착부의 수가 증가하면 각 협착부 주위의 속도장 은 유사하게 나타나지만 전체 압력손실은 크게 증가한다. 협착부사이의 거리가 변화될 경우 맥동유동속도의 국소최대치와 국소최소치의 차이가 가속시에는 거의 없지만 감속시에는 협 착부사이의 거리에 따라 다르게 나타난다.