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ENHANCEMENT OF FREQUENCY OF RADIATION-INDUCED CHROMOSOME ABERRATIONS AND MICRONUCLEI BY ARA C AND 3AB

  • Chung, Hai-Won;Cho, Yoon-Hee;Kim, Su-Young;Kim, Tae yeon;Kim, Yang-Ji;Lee, Ra-Mi;Seo, Soo-Ra;Kim, Tae-Hwan;Ha, Sung-Hwan
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.124-124
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    • 2002
  • In order to determine the effect of the DNA repair inhibitors, cytosine arabinoside(Ara C)and 3-aminobenzamide(3AB) on the frequenceis of chromosomal aberrations and micronuclei induced by radiation. After in vitro exposure of human lymphocytes to x-ray(1-3Gy) DNA repair inhibitors, Ara C and 3AB were treated and the frequencies of micronuclei, translocation and dicentric chromosomes were analysed using FISH technique with DNA probe for chromosome 4.(omitted)

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