• Journal of Acupuncture Research
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• 제18권4호
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• pp.201-204
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• 2001

Objective : This study was to report a clinical trial in which acupuncture treatmnt on 會陰(Huiyin, CV1) was effectively applied to a patient who had suffered from teasing pruritus ani for 38 years. pruritus ani was thought to be initiated by dystonia. Methods : The acupoint, 會陰(Huiyin, CV1) was selected, because needling on perineal muscles was mainly used to alleviate pelvic pain or pruritus ani in the light of MPS(Myofascial Pain Syndrome) theory, on which 會陰(Huiyin, CV1) was located and also had pelvic pain and pruritus ani in its indications. On the acupoint, the following maneuver was used. (1) Make a patient stand and bend forward (2) Insert a needle on 會陰(Huiyin, CV1) (3) Repeat lifting and pushing (4) Draw a needle immediately without retaining needle on the acupoint Results : The patient with Pruritus ani recovered after above treatment two times and had no recurrence up to Feb. 2001. Conclusion : In this study, Needling on 會陰(Huiyin, CV1) proved to be effective in the aspect of MPS and acupuncture treatment as well, but more clinical trials are expected to follow this study.

• 동의생리병리학회지
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• 제32권3호
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• pp.178-183
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• 2018

Pruritus is the most prominent symptom of atopic dermatitis and other skin diseases. It is not easily improved and is a major factor that threatens the quality of life of patients and their families. The purpose of this study was to evaluate the effect of HyungGae-Water, which was bath preparation made from Korean medicine herbs, for children and adolescents suffering pruritus. The participants were 50 boys and girls aged from 2 to 15 years old. The HyungGae-Water was used once a day for 6 weeks, and we were followed up three times every two weeks. Of 50 participants enrolled, 47 completed the study. The outcome variables were dermatology quality of life scales in children, pruritus VAS, and investigator global assessment (IGA). The results of the study show that the dermatology quality of life is significantly improved and the VAS of pruritus has meaningful changes. In the IGA, moderate or severe improvement was observed in 48.9% and slight improvement in 17%. There were seven suspected or less relevant adverse events using HyungGae-Water. The present results suggest that the HyungGae-Water has alleviating effect for the pruritus in children and adolescents.

• The Korean Journal of Pain
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• 제9권2호
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• pp.385-389
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• 1996

Background: Nowadays, epidural morphine is commonly used in postoperative pain control. But epidural morphine may produce some side-effects, e.g. pruritus, nausea, vomiting, urinary retention and respiratory depression. Especially, pruritus is the most common complaint in pain-controlled patients by epidural morphine. So we evaluated whether addition of epidural butorphanol affects the degree of pruritus and pain score in pain controlled patients who by epidural morphine after hysterectomy. Methods: Group 1(N=15) received postoperative epidural 0.1% bupivacaine 100ml plus morphine 10 mg, group 2(N=15) received the mixture of butorphanol 2 mg with same regime as in group 1, group 3(N=15) received the mixture of butorphanol 4 mg with same regime as in group 1. All of the three groups received these solutions by infusion pump, 1 ml/hour, for postoperative 4 days. all groups received additional morphine 1.2 mg in 0.2% bupivacaine 6ml epidurally when the peritoneum was closed under general anesthesia. The severity of pain, pruritus, nausea and vomiting was estimated by 10 cm VAS(visual analogue scale) and somnolence by positive or negative during postoperative 4 days. Results: Severity of pruritus, but not nausea and vomiting was decreased in group 2 and 3 compared with group 1(p<0.05). Pain score was increased in group 3 at postoperative day(POD) 0 and 2 compared with group 1(p<0.05). Incidence of somnolence in group 1, 2 and 3 were $2.7{\pm}0.7,\;5.3{\pm}0.7$ and $10.0{\pm}1.0$ respectively. Conclusion: These results suggest that butorphanol reduce the degree of pruritus, the most common side effect of morphine, but increase the incidence of somnolence.

• 한국산학기술학회논문지
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• 제17권1호
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• pp.45-53
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• 2016

본 연구 목적은 화상환자의 소양증 특성을 파악하기 위한 서술적 조사 연구로 화상환자 소양증 기초자료 제공을 위함이다. 심부 2도 이상 화상으로 입원 중인 급성기 화상환자 95명을 대상으로 자기보고식 설문지를 이용하여 화상관련 특성과 소양증 관련 특성을 측정하였다. 연구결과 대상자의 화상범위는 평균 $18.95{\pm}17.10%$였으며, 소양증 중증도 평균 $48.83{\pm}23.96$점, 증상고통 평균 $46.42{\pm}25.80$점으로 나타났다. 소양증 빈도에 따른 결과는 '항상' 경험할 때 그렇지 않은 경우보다 잠들기 어려움(F=4.817, p=.004), 기분 나빠짐(F=5.955, p<.001), 집중력 저하(F=6.483, p<.001)에서 유의한 차이를 보였고, 지속시간에 따른 소양증 결과는 30분 이상 지속 시 30분 이내보다, 잠들기 어려움(F=7.452, p<.001), 기분 나빠짐(F=3.655, p=.015), 집중력 저하(F=12.564, p<.001)에서 통계적으로 유의한 차이가 있었다. 화상환자의 소양증 빈도는 지속시간(r=.29, p=.004), 중증도(r=.45, p<.001), 증상고통(r=.44, p<.001) 및 소양증 결과(r=.29, p=.004)와 양의 상관관계를 보였다. 본 연구 결과는 소양증을 경험하는 화상환자의 간호중재를 위한 근거자료로 활용 될 수 있을 것이다.

• Biomolecules & Therapeutics
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• 제18권3호
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• pp.246-256
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• 2010

Atopic dermatitis is a common skin disease affecting up to 10% of children and approximately 2% of adults. Atopic dermatitis exhibits four major symptoms, including intense itching, dry skin, redness and exudation. The "itch-scratch-itch" cycle is one of the major features in atopic dermatitis. The pathophysiology and neurobiology of pruritus is unclear. Currently there are no single and universally effective pharmacological antipruritic drugs for treatment of atopic dermatitis. Thus, controlling of itch is a very important unmet need in patients suffering from atopic dermatitis. This article will update progress during the past 10 years of research in the field of pruritus of atopic dermatitis, focusing on aspects of pruritogens (including inflammatory lipids, histamine, serotonin, proteinases, proteinase-activating receptors, neurotransmitters, neuropeptides, and opioid peptides), antipruritic therapies, and emerging new targets. Based on recent progress, researchers expect to identify exciting possibilities for improved treatments and to develop new antipruritic drugs acting through novel targets, such as histamine H4 receptor, gastrin-releasing peptide receptor, MrgprA3, thromboxane A2 receptor and the putative SPC receptor.

• 한방안이비인후피부과학회지
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• 제29권2호
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• pp.112-122
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• 2016

Objectives : The purpose of this report is to know the effect of Korean medical treatments on pemphigus vulgaris with generalized pruritus. Methods : We treated a 44-years-old woman patient with pemphigus vulgaris on the whole body with Korean medicine. After Korean medical treatment for 17 weeks, we measured the extinction of blisters and decrease of pruritus. We recorded pictures of changes on symptoms. Results & Conclusions : The symptoms of pemphigus vulgaris were significantly improved. The blisters and itching were decreased and skin damages were almost recovered. Thus Korean medical treatments are effective on pemphigus vulgaris.

• 기본간호학회지
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• 제10권2호
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• pp.187-197
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• 2003

Purpose: This experimental study was to verify the effects of the mineral oil on skin under casts for relief of skin dryness and pruritus. Method: Participants in the study were inpatients at C university hospital in D city who had long leg casts. The mineral oil was applied to the skin under the casts in the experimental group of 18 patients and was not applied to the control group, also 18 patients. During the experimentation, the participants in the experimental group were informed about how to apply the mineral oil and 1 week later were responsible for applying the oil themselves. The oil was applied three times a day. Data collection was done from July 28, 2002 to September 28, 2002. The analyses were carried using frequencies, percentages, $x^2$-test, t-test, and repeated measures ANOVA with the SPSS WIN 10.0 program. Results: Hypothesis 1, 'The experimental group using the mineral oil application showed remarkably less dryness in the skin compared to the control group' was accepted (F=16.39, p=0.000). Hypothesis 2, 'The experimental group using the mineral, oil application showed remarkably less pruritus compared to the control group' was accepted (F=34.01, p=0.000). Conclusion: These results demonstrate that mineral oil application to skin under casts was effective in treating skin dryness and pruritus. Accordingly, it is concluded that mineral oil application to skin under casts can be an effective nurse intervention to treat skin dryness and pruritus.

• The Korean Journal of Pain
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• 제20권2호
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• pp.123-129
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• 2007

Background: Postoperative pruritus following the administration of epidural narcotics is a very common and undesirable side effect. Therefore, we evaluated the use of a combination of naloxone and sufentanil via patient controlled epidural analgesia to determine if the incidence of pruritus was decreased when compared to the use of sufentanil alone. Methods: Patients scheduled for subtotal gastrectomy under general anesthesia were enrolled in a prospective, double-blinded and randomized trial. All patients received a $20{\mu}g$ epidural bolus of sufentanil in 5 ml of 0.2% ropivacaine. Following administration of the epidural, patients in the sufentanyl group (S) received a continuous epidural comprised of sufentanil ($0.75{\mu}g/ml$) in 0.2% ropivacaine, whereas patients in the naloxone group (N) received an epidural infusion comprised of naloxone ($4{\mu}g/ml$) and sufentanil ($0.75{\mu}g/ml$) in 0.2% ropivacaine. The infusion rate, demand dose and lockout interval were 5 ml/hr, 0.5 ml and 15 minutes respectively. Next, the occurrence of postoperative analgesia and side effects were evaluated by blinded observers. Results: The incidence of pruritus (47.4% versus 20.0%, P = 0.013) and nausea (42 .1 % versus 20.0%, P = 0.043) were lower in group N than in group S. In addition, there were no significant differences observed in the visual analogue scale, the incidence of vomiting or the incidence of sedation. Furthermore, epidural infusion of naloxone at $0.25-0.4{\mu}g/kg/hr$ did not affect the requirement for postoperative sufentanil. Conclusions: Epidural naloxone reduces epidural sufentanil induced pruritus and nausea without reversing its analgesic effects.

• 한국산학기술학회논문지
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• 제14권9호
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• pp.4412-4420
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• 2013

알코올은 인체에 영향을 미치지 않는 곳이 없을 정도로 여러 질환들을 야기 시킨다. 이로 인해 알코올중독과 관련된 여러 연구가 진행되고 있으나 알코올중독환자의 피부질환에 관련된 연구는 국내에서 찾아보기 어렵다. 이에 민감한 피부를 가진 여성알코올중독환자의 피부질환중 소양증에 관한 연구를 하였다. 2013년 05월 1일~2013년 5월 20일까지 전국의 알코올중독치료병원 4곳에서 여성알코올중독환자 114명의 설문지와 청주, 성남시 일반인 106명의 설문지를 토대로 비교연구를 하였고, 연구 결과 알코올중독환자가 일반인에 비해 소양증 점수가 더 높았고, AUDIT-K점수와 소양증점수는 양의 상관관계가 있는 것으로 나타났으며, 음주주기, 음주량도 소양증에 관련이 있는 것으로 나타났다. 이 연구 자료가 알코올중독 환자의 피부치료의 기초자료로 활용되며 앞으로 알코올중독환자의 피부연구의 활성화를 기대한다.

• 한방안이비인후피부과학회지
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• 제15권2호
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• pp.289-301
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• 2002

Background: It is axiomatic that average life span is prolonged in proportion to the advance of socio-economic improvements and medical science. Consequently, the number of elderly patients with skin diseases is increasing. Objective: This study was performed to examine the patterns of skin diseases in elderly patients that had visited Dongguk Oriental Medical hospital, Dept. of Dermatology. We also compared these patients to the young generational groups. Methods: We studied 67 elderly patients with complaints of skin diseases who had visited our hospital from March 2000 to February 2002. We analysed their skin diseases and compared them with the younger group's. Results: The results were as follows; 1. The common disease groups were eczema(32.8$\%$); pruritus(23.9$\%$); viral infections (13.4$\%$); psoriasis(9.0$\%$); fungal infections and urticaria(6.0$\%$). 2. The disorders prevalent in men were eczema(30.0$\%$); herpes zoster & pruritus(23.3$\%$); fungal infection(13.3$\%$); psoriasis (3.3$\%$); melasma(6.7$\%$). 3. The common diseases of women's group were observed in the following order; eczema(35.l$\%$); pruritus(24.3$\%$); psoriasis(13.5$\%$); urticaria(10.8$\%$); other dermatoses(8.1$\%$); herpes zoster(5.4$\%$). 4. The most frequent skin disease for those in their 50's was eczema(32.3$\%$); 60's, pruritus(36.8$\%$); 70's, eczema(50.0); and over eighties., eczema and pruritus(40.0$\%$). Conclusion: This study suggests that dermatologic problems in the elderly are very common, especially eczema, pruritus. It is a very different pattern from the younger group's. And we have to better consider more effective management and treatment for them; especially further dermatologic studies including substantial medical care. Usually Oriental medicine is good at treating chronic diseases and less harmful. So we expect it to be generally better for elderly patients than western medicine.