• 제목/요약/키워드: Proximal Effect

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발아(發芽)한 서목태(鼠目太)가 난소적출 흰쥐의 Cathepsin-K에 미치는 영향 (Effect of Germinated Seed of Rhynchosia Volubilis on Cathepsin-K in Ovariectomized Rats)

  • 정호롱;이응세;차윤엽
    • 동의생리병리학회지
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    • 제19권1호
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    • pp.184-190
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    • 2005
  • The aim of this study is to find out what inhibition effects the Germinated Seed of Rhynchosia Volubilis(GSRV) has by its feeding period on the bone absorption in ovariectomized white rats. Close examination of the amounts of the Cathepsin-K in the rats by the groups of one, two and three-day germination periods led to the following conclusions. Feeding non-ovariectomized white rats with GSRV by the groups of one, two and three-day germination periods showed less amounts of Cathepsin-K in their proximal tibia in all the feeding periods of two, three and four weeks than in the case of control group, revealing a statistical significance. Feeding ovariectomized white rats with GSRV by the groups of one, two and three-day germination periods showed less amounts of Cathepsin-K in their proximal tibia in all the feeding periods of two, three and four weeks than in the case of the control group, revealing a statistical significance. Therefore, the Germinated Seed of Rhynchosia Volubilis(GSRV) is believed to have inhibition effects on bone resorption.

유한요소 분석을 이용한 하중 위치에 따른 구치부 임플란트 국소의치 지지골의 응력 분포 연구 (Finite element analysis of stress distribution on supporting bone of posterior implant partial dentures by loading location)

  • 손성식;김영직;이명곤
    • 대한치과기공학회지
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    • 제29권1호
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    • pp.93-101
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    • 2007
  • The purpose of this study is to evaluate the effect of three different oblique mechanical loading to occlusal surfaces of posterior implant partial dentures on the stress distributions in surrounding bone, using 3-dimensional finite element method. A 3-dimensional finite element model of a posterior implant partial dentures composed of three unit implants, simplified 3 gold alloy crown and supporting bone was developed according to the design of AVANA self tapping implant for this study. Three kinds of surface distributed oblique loads(300 N) are applied to following occlusal surfaces in the three crowns; 1) All occlusal surfaces in the three crown(load of 300 N was shared to three crown), 2) Occlusal surface of centered crown (load of 300 N was applied to a centered crown), 3) Occlusal surface of proximal crown(load of 300 N was applied to a distal proximal crown). In the results, 141 MPa of maximum von Mises stress was calculated at third loading condition and 98 MPa of minimum von Mises stress was calculated at first loading condition. From the results, location and type of occlusive loading conditions are important for the safety of supporting bone.

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근위경골절골술에서 해부학적 축과 역학적 축의 변화가 경골후방경사각에 미치는 영향 (The Effect of Anatomical Axis and Mechanical Axis on Change of Posterior Tibial Slope Angle in PTO(Proximal Tibial Osteotomy))

  • 신은지;김철웅;이호상;배지훈;왕준호;;오동준
    • 대한기계학회:학술대회논문집
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    • 대한기계학회 2008년도 추계학술대회A
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    • pp.1543-1546
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    • 2008
  • The purpose of this study was to investigate factors affecting the change of tibial posterior slope and introduce a mathematical model which calculate, through 3-dimensional analysis of the proximal tibia, how the angle of the opening wedge along the anteromedial tibial cortex influences the tibial posterior slope and valgus correction when performing a medial open wedge osteotomy. This mathematical model with navigation system can be guidelines which provide surgeons on preoperative and intraoperative measurements to maintain or correct the tibial slope and to obtain the desired valgus correction of the lower limb during an opening wedge osteotomy.

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식이지방의 양적 변화가 대장 상피세포 증식에 미치는 영향 (Effect of Various Levels of Dietary Fat on Cell Proliferation of Rat Colon)

  • 이중희
    • Journal of Nutrition and Health
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    • 제32권4호
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    • pp.394-400
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    • 1999
  • Since it has generally been considered that high-hat diets promote carcinogenesis, fat intake of less than 30% of total calories has been recommended to reduce the risk of cancer. Specific dietary guidelines for fat intake to reduce the risk of colon cancer have not yet been established. In order to determine the level of dietary fat needed the risk of colon cancer, rats were fed one of four experimental fat diets, very low(7% of total calories from corn oil, VLC), low(15% LC), medium (30%, MC), and high fat(45%, HC). Cell proliferation as an intermediate biomarker of color carcinogenesis was measured by the in vivo incorporation of bromodeoxyuridine into DNA. Fecal lipid excretion was measured by gravimetric method. As fat levels in the diet increased, fecal lipid concentrations also increased (VLC

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Stress Analysis of Femoral Stems on Non-Cemented Total Hip Replacement - A Three-Dimensional Finite Element Analysis -

  • Kim, Sung-Kon;Chae, Soo-Won;Jeong, Jung-Hwan
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1997년도 추계학술대회
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    • pp.263-266
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    • 1997
  • Three dimensional numerical model based on the finite element method(FEM) were developed to predict the mechanical behavior of hip implants. The purpose of this study is to investigate the stress distribution of two types of cementless total hip replacement femoral component -a straight stem and a curved stem, and to compare their effect on the stress shielding between two types by three dimensional finite element method. The authors analyzed von Mises stress in the cortex & stem and compared the stress between the straight and the curved stem. In comparison of stresses between two different design of femoral stem, there was 25% more decrease of stress in straight stem than curved stem in the medial cortex at proximal region. The straight stem had consistently much lower stresses than the curved stem throughout the whole medial cortex with maximum 70% reduction of stress. However, there was little change in stress between nature and 2 implanted femur throughout the lateral cortex. Stress of femoral stem was much higher in the straight stem than the curved stem up to 60%. The straight stem had more chance of stress shielding and a risk of fatigue fracture of the stem compared with the curved stem in noncement hip arthroplasty. In design of femoral stem still we have to consider to develop design to distribute more even stress on the proximal medial cortex.

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비심리적 처치프로그램에 의한 고등학생 수학불안집단 간의 뇌파 연구 (A Brain-based Study with Two Groups of High Math Anxiety and Low Math Anxiety through the Non-psychological Remedy Program of Functional Tasks)

  • 고상숙;이창연
    • 한국수학교육학회지시리즈A:수학교육
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    • 제55권3호
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    • pp.383-396
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    • 2016
  • This study investigated highschool students' brain waves on functional tasks such as a transition(F task) from equation to graph and the other transition(G task) vice versa. A total of 39 students participated in the study who attended a high school located in Gyunggi province. These students were divided into two groups, HMA and LMA by MASS test revised by Ko, & Yi (2012). The functional tasks for the stroop task to measure EEG were provided from a previous study, Seok(2015). The results indicated two groups on G tasks showed deeper and wider brain waves which demonstrated G tasks were more difficult than F tasks. However, HMA group had an effect of the non-psychological program which had given more chances on G tasks rather than F tasks within Students' Zone of Proximal Development. Also, HMA group's brain waves had more ranges in amplitude and width of waves. These results imply that the characteristics of students' brain waves with math anxiety are consistent to the previous studies.

Initiation and propagation of a crack in the orthopedic cement of a THR using XFEM

  • Gasmi, Bachir;Abderrahmene, Sahli;Smail, Benbarek;Benaoumeur, Aour
    • Advances in Computational Design
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    • 제4권3호
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    • pp.295-305
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    • 2019
  • The sealing cement of total hip arthroplasty is the most widely used binder in orthopedic surgery for anchoring implants to their recipient bones. Nevertheless, this latter remains a fragile material with weak mechanical properties. Inside this material cracks initiate from cavities. These cracks propagate under the effect of fatigue and lead to the failure of this binder and consequently the loosening of the prosthesis. In this context, this work consists to predict the position of cracks initiation and their propagations path using the Extended Finite Element Method (XFEM). The results show that cracks can only be initiated from a sharp edges of an ellipsoidal cavity which the ratio of the minor axis over the major axis is equal to 0.1. A maximum crack length of 19 ?m found for a cavity situated in the proximal zone position under a static loading. All cracks propagate in same(almost) way regardless of the cavity(site of initiation) position and its inclination in the proximal zone.

Stop-flow방법으로 분석한 Guanethidine의 이뇨작용 (Stop-flow Analysis of the Diuretic Action of Guanethidine in the Dog)

  • 고석태;김성원;김성오
    • 약학회지
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    • 제19권4호
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    • pp.227-233
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    • 1975
  • The diuretic action of guanethidine was investigated in the dogs by means of the stop-flow technique. Guanethidine increased the rejection of sodium in the ascending limb of Henle's loop, as well as in the proximal and distal tubules, resulting in the decrease of the concentrating ability of the kidney, in marked natriuresis and diuresis. It was also effective during an osomotic diuresis, which was induced by infusing 10% mannitol can exhibit its effect even under the diuretic action of mercurophylline, suggesting a different mechanism from that of mercuric iuretics.

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경골 근위부 종양에서 인공 삽입물 사용시 슬개골 전적출술이 관절기능 회복에 미치는 영향 (The Effect of Total Patellectomy in the Prosthetic Replacement of Proximal Tibia)

  • 박일형;김재도;인주철;전인호
    • 대한골관절종양학회지
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    • 제2권1호
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    • pp.8-17
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    • 1996
  • The purpose of this study is a comparative evaluation of range motion, especially extension deficit between the group of total patellectomy and that of intact patella, after reconstruction of the patellar tendon in the prosthetic replacement of a proximal tibia. Between 1990 and 1994, 15 patients who had a primary malignancy on proximal tibia were operated on. All patients were evaluated clinically and radiographically. Two patients were excluded because one had a deep infection treated with arthrodesis of the knee and the other was a composite allograft. The mean follow-up of the 13 patients was 27 months(15-47), including 10 osteosarcomas, 1 chondrosarcoma, 1 malignant fibrous histiocytoma and 1 malignant giant cell tumor. Eleven patients had a resection of the proximal tibia and 2 had an extracapsular total knee resection with distal femur. Reconstruction of the defect was done in 8 cases with a custom-made Link Endo-Model Total Rotation Knee Joint Prosthesis, and in 5 with How Medica Modular Resection System (HMRS). We used two methods to reconstruct the ligamentum patellae. Fixation of the patellar tendon to the prosthesis only with suturing and/or stapling(group SS) was done in 7. Transposition of gastrocnemius muscle to enhance fixation and to cover the prosthesis(group TG) was done in 6. Regardless of fixation methods, total patellectomy was done in 5 either to lengthen the patellar tendon or to make primary skin closure easier or for both. In 8 cases, patella was left intact or resurfaced with polyethylene prosthesis. Active extension was measured while the patient was in a sitting position. There is no statistically meaningful difference in terms of extension deficit (Wilcoxon rank test, p=0.8800) between patellectomy group and intact patella group, and between group of fixation only with suturing and that of gastrocnemius transposition. Two cases of extension deficit over 30 degree were seen in group SS and in the group of intact patella. Conclusively, total patellectomy could be an option without increasing the risk of extension deficit when primary skin closure is difficult or patellar tendon is a little bit short to be fixed. There is no rating in the Enneking system of functional evaluation that this finding into consideration.

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냉부하검사(CST)를 활용한 수부냉증의 침치료 효과에 대한 예비 연구 (Effects of Acupuncture on patients with cold hypersensitivity by Cold Stress Test : pilot study)

  • 황덕상;조정훈;이창훈;장준복;김용석;이경섭;이윤재
    • 대한한방체열의학회지
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    • 제5권1호
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    • pp.69-77
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    • 2006
  • Purpose : There are many patients with cold hypersensitivity who want oriental medicine treatment. But there has been no study of acupucture treatment effect on patients. So we examined effects of acupuncture treatment at different acupuncture points and compared results of 1st cold stress test and 2nd cold stress test. Method : 8 patients with hand cold hypersensitivity applied for this study. To rule out an bias, we excluded the patients with skin diseases, spinal nerve disease of cervial spine, external wounds. We measured body temperature with D.I.T.I. We performed cold stress test(CST) by 6 thermographic observation using D.I.T.I ; the 1st was taken after 15 minutes-resting, the 2nd was immediately taken after 1 minute soak in $20^{\circ}C$ water, the 3rd was taken at 10 minutes after the soak, and after a week, the 4th was taken after 15 minutes resting, the 5th was immediately taken after 1 minute soak in $20^{\circ}C$ water, the 6th was taken after 10 minutes with acupunture treatment. There were two groups of patients. First group was acupuncture that performed acupuncture therapy on distal points. Second group was acupuncture that performed acupuncture therapy on proximal points. We compared first CST and second CST recovery rate result. Results : The recovery rate at distal points acupuncture therapy was higher than before of that. but not significantly different. The recovery rate at proximal points acupuncture therapy was significantly higher than before of that. The recovery rate of both the back, the palms, all fingers of after proximal acupuncture therapy was significantly higher than before of that. Conclusions : Acupuncture could be effective therapy method on cold hypersensitivity, especially using proximal acupuncture points could be good at cold hypersensitivity patients. This was pilot study of very small samples, results had limitations. For further results more examine would be needed.

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