YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Stop-flow Analysis of the Diuretic Action of Guanethidine in the Dog

Stop-flow방법으로 분석한 Guanethidine의 이뇨작용

  • Published : 1975.12.01
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Abstract

The diuretic action of guanethidine was investigated in the dogs by means of the stop-flow technique. Guanethidine increased the rejection of sodium in the ascending limb of Henle's loop, as well as in the proximal and distal tubules, resulting in the decrease of the concentrating ability of the kidney, in marked natriuresis and diuresis. It was also effective during an osomotic diuresis, which was induced by infusing 10% mannitol can exhibit its effect even under the diuretic action of mercurophylline, suggesting a different mechanism from that of mercuric iuretics.

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