Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effect of Various Levels of Dietary Fat on Cell Proliferation of Rat Colon

식이지방의 양적 변화가 대장 상피세포 증식에 미치는 영향

  • 이중희 (가톨릭대학교 생활과학대학 식품영양학과)
  • Published : 1999.06.01
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Abstract

Since it has generally been considered that high-hat diets promote carcinogenesis, fat intake of less than 30% of total calories has been recommended to reduce the risk of cancer. Specific dietary guidelines for fat intake to reduce the risk of colon cancer have not yet been established. In order to determine the level of dietary fat needed the risk of colon cancer, rats were fed one of four experimental fat diets, very low(7% of total calories from corn oil, VLC), low(15% LC), medium (30%, MC), and high fat(45%, HC). Cell proliferation as an intermediate biomarker of color carcinogenesis was measured by the in vivo incorporation of bromodeoxyuridine into DNA. Fecal lipid excretion was measured by gravimetric method. As fat levels in the diet increased, fecal lipid concentrations also increased (VLC

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