• Journal of Pharmaceutical Investigation
• /
• 제23권3호
• /
• pp.155-163
• /
• 1993

Inclusion complexation of 1,7,21,27-tetraaza[7.1.7.1]paracyclophane (CPM 55) with 2,7-dihydroxynaphthalene (2,7-DHN) or 1,3-dihydroxynaphthalene (1,3-DHN) in pD 1.17 $DCl-D_2O$ solution was investigated by $^1H$ nuclear magnetic resonance spectroscopy (NMR) using 4,4'-dimethylaminodiphenylmethane (ACM 11) as an acyclic analog of CPM 55. In CPM 55-naphthalene derivative complex, alkyl protons located in the cavity of CPM 55 were shown to be subjected to anisotropic shielding and protons of naphthalene moiety shifted remarkably to upfield. However, in ACM 11-naphthalene derivative systems, chemical shifts for protons of both DHN compounds were not significant. The remarkable chemical shift changes suggested that the naphthalene moiety of 2,7-DHN or 1,3-DHN was included in the hydrophobic cavity of CPM 55 in aqueous solution. From the continuous variation plots of induced chemical shifts of 2,7-DHN, it was found that 2,7-DHN was included in the cavity of CPM 55 at 1:1 molar stoichiometry. Both computer simulation of a inclusion complex and strong upfield chemical shift changes of 2,7-DHN protons supported the conformation of pseudoaxial inclusion as the presumed geometry of the host-guest complex.

• Nuclear Engineering and Technology
• /
• 제52권8호
• /
• pp.1817-1825
• /
• 2020

Background: Cosmic ray-induced particles can lead to failure of semiconductors packaged for export during air transport. This work performed MCNP 6.2 simulations to optimize shielding against neutrons and protons induced by cosmic radiation Methods and materials: The energy spectra of protons and neutrons by incident angle at the flight altitude were determined using atmospheric cuboid model. Various candidates for the shielding materials and the geometry of the Unit Load Device Container were evaluated to determine the conditions that allow optimal shielding at all sides of the container. Results: It was found that neutrons and protons, at the flight altitude, generally travel with a downward trajectory especially for the particles with high energy. This indicated that the largest number of particles struck the top of the container. Furthermore, the simulation results showed that, among the materials tested, borated polyethylene and stainless steel were the most optimal shielding materials. The optimal shielding structure was also determined with the weight limit of the container in consideration. Conclusions: Under the determined optimal shielding conditions, a significantly reduced number of neutrons and protons reach the contents inside the container, which ultimately reduces the possibility of semiconductor failure during air transport.

• 한국항공우주학회지
• /
• 제32권5호
• /
• pp.116-121
• /
• 2004

사이클로트론 가속기를 이용한 양성자 우주환경의 모사시험이 수행되었다. 모사시험에 사용된 사이클로트론은 양성자를 약 $10^6-10^8\;protons/cm^2/s$의 선속에서 200 MeV까지 가속 할 수 있다. 가속된 양성자는 우주에서 사용될 MPC860 소자에 입사되었으며, 양성자 조사에 의한 소자의 누적 반응과 순간 반응이 모두 관찰되었다. 주된 순간 반응은 저장된 데이터의 변화였으나, 간헐적인 기능 정지 현상도 관찰되었다. 누적 반응은 소자 내에서 소모되는 전류의 증가로 나타났다.

• Nuclear Engineering and Technology
• /
• 제55권8호
• /
• pp.2984-2996
• /
• 2023

A 100 kW thermal power pool-type light water reactor and Pu(Be) as a fast neutron source were used to determine the appropriate carrier for irradiating boron-containing samples with neutron beams. The tested materials (carriers) were subjected to neutron beams in the reactor's tangential channel. The geometrical arrangement of experimental facilities relative to the neutron beam trajectory, as well as the effect of sample thickness on the count rate, were investigated. The majority of the detectable charged particles emitted by the neutron beam's interaction with tested materials and the detector's detecting layer are protons (recoiled hydrogen) and particles generated in nuclear reactions (protons and alpha particles), respectively. Stopping and Range of Ions in Matter (SRIM) software was used to do theoretical calculations for the range of expected released particles in various materials, including human tissue. The results of measurement and calculation are in good agreement. According to experiments and theoretical calculations, the number of protons emitted by tissue-like materials may commit a dose comparable to that of boron capture reactions. Furthermore, the range of protons is significantly larger than that of alpha particles, which most probably changes dose distribution in healthy cells surrounding the tumor, which is undesirable in the BNCT approach.

• Bulletin of the Korean Chemical Society
• /
• 제26권5호
• /
• pp.740-746
• /
• 2005

In this article, we report the tandem mass spectrometry investigations for the electron capture efficiencies of the protons belonging to the different locations (generations) in a poly(propylene imine) dendrimer with three layers of a repeat unit (named as the third generation dendrimer). The employed tandem mass spectrometry methods include SORI-CAD (sustained off-resonance irradiation collisional activation dissociation) and ECD(electron capture dissociation) mass spectrometry. We obtained SORI-CAD spectra for the dendrimer ions in the different charge states, ranging from 2+ to 4+. The analysis of fragmentation sites provides the information as to where the protons are distributed among various generations of the dendrimer. Based upon this, a new strategy to study the electron capture efficiencies of the protons is utilized to examine a new type of triplycharged ions by SORI-CAD, i.e., the 3+ ions generated from the charge reduction of the native 4+ ions by ECD: (M+4H)$^{4+}\;+\;e^-\;{\rightarrow}$ (M+4H)$^{3+\bullet}$ ${\rightarrow}\;({H^{\bullet}}_{ejected}$) + (M+3H)$^{3+}\;\rightarrow$ CAD. Interestingly, comparison of these four SORICAD spectra indicates that the proton distribution in the charge-reduced 3+ ions is very close to that in the native 4+ ions. It further suggests that in this synthetic polymer ($\sim$1.7 kDa) with an artificial architecture, the electron capture efficiencies of the protons are actually insensitive to where they are located in the molecule. This is somewhat contradictory to common expectations that the protons in the inner generations may not be well exposed to the incoming electron irradiation as much as the outer ones are, thus may be less efficient for electron capture. This finding may carry some implications for the case of medium sized peptide ions with similar masses, which are known to show no obvious site-specific fragmentations in ECD MS.

• Asian Journal of Atmospheric Environment
• /
• 제12권2호
• /
• pp.153-164
• /
• 2018

We measured $^1H$ and $^{13}C$ nuclear magnetic resonance (NMR) spectra of Humic-like substances (HULIS) in urban atmospheric aerosols isolated by diethylaminoethyl (DEAE) and hydrophilic-lipophilic balance (HLB) resin to characterize their chemical structure. HULIS isolated by DEAE resin were characterized by relatively high contents of aromatic protons and relatively low contents of aliphatic protons in comparison with HULIS isolated by HLB resin, while the contents of protons bound to oxygenated aliphatic carbon atoms were similar. These results were consistent with the results of the $^{13}C$ NMR analysis and indicate that hydrophobic components were more selectively adsorbed onto HLB, while DEAE resins selectively retained aromatic carboxylic acids. Furthermore, we demonstrated that the chemical structural features of HULIS were significantly different between spring and summer samples and that these disparities were reflective of their different sources. The estimated concentrations of HULIS in spring were found to be regulated by vehicle emissions and pollen dispersion, while the behavior of HULIS in summer was similar to photochemical oxidant and nitrogen dioxide concentrations. The proportion of aliphatic protons for summer samples was higher than that for spring samples, while the proportion of aromatic protons for summer samples was lower than that for spring samples. These seasonal changes of the chemical structure may also involve in their functional expression in the atmosphere.

• Journal of Astronomy and Space Sciences
• /
• 제30권3호
• /
• pp.133-140
• /
• 2013

Most of high energy cosmic rays (CRs) are thought to be produced by diffusive shock acceleration (DSA) at supernova remnants (SNRs) within the Galaxy. Fortunately, nonthermal emissions from CR protons and electrons can provide direct observational evidence for such a model and place strong constraints on the complex nonlinear plasma processes in DSA theory. In this study we calculate the energy spectra of CR protons and electrons in Type Ia SNRs, using time-dependent DSA simulations that incorporate phenomenological models for some wave-particle interactions. We demonstrate that the time-dependent evolution of the self-amplified magnetic fields, Alfv$\acute{e}$nic drift, and escape of the highest energy particles affect the energy spectra of accelerated protons and electrons, and so resulting nonthermal radiation spectrum. Especially, the spectral cutoffs in X-ray and ${\gamma}$-ray emission spectra are regulated by the evolution of the highest energy particles, which are injected at the early phase of SNRs. Thus detailed understandings of nonlinear wave-particle interactions and time-dependent DSA simulations of SNRs are crucial in testing the SNR hypothesis for the origin of Galactic cosmic rays.

• 한국임상수의학회지
• /
• 제16권1호
• /
• pp.75-79
• /
• 1999

Magnetic resonance imaging (MRI) is an imaging technique used to produce high quality images of the inside of the animal body. MRI is based on the principles of nuclear magnetic resonance (NMR) and started out as a tomographic imaging technique, that is it produced an image of the NMR signal in a thin slice through the animal body. The animal body is primarily fat and water, Fat and water have many hydrogen atoms. Hydrogen nuclei have an NMR signal. For these reasons magnetic resonance imaging primarily images the NMR signal from the hydrogen nuclei. Hydrogen protons, within the body align with the magnetic field. By applying short radio frequency (RF) pulses to a specific anatomical slice, the protons in the slice absorb energy at this resonant frequency causing them to spin perpendicular to the magnetic field. As the protons relax back into alignment with the magnetic field, a signal is received by an RF coil that acts as an antennae. This signal is processed by a computer to produce diagnostic images of the anatomical area of interest.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
• /
• 한국우주과학회 2011년도 한국우주과학회보 제20권1호
• /
• pp.28.1-28.1
• /
• 2011

Radiation-induced displacement damage which has caused the increase of the dark current in the focal plane adopted in the Ozone Monitoring Instrument (OMI) was studied in regards of the primary protons and the secondaries generated by the protons in the orbit. By using the Monte Carlo N-Particle Transport Code System (MCNPX) version 2.4.0 along with the Stopping and Range of Ions in Matter version 2010 (SRIM2010), effects of the primary protons as well as secondary particles including neutron, electron, and photon were investigated. After their doses and fluxes that reached onto the charge-coupled device (CCD) were examined, displacement damage induced by major sources was presented.

• 한국자기공명학회논문지
• /
• 제18권1호
• /
• pp.41-46
• /
• 2014

In order to obtain information on the structural geometry of $NH_4HSeO_4$ near the phase transition temperature, the spectrum and spin-lattice relaxation time in the rotating frame $T_{1{\rho}}$ for the ammonium and hydrogen-bond protons were investigated through $^1H$ MAS NMR. $T_{1{\rho}}$ for the hydrogen-bond protons abruptly decreased at high temperature and it is associated with the change in the structural geometry in $O-H{\cdots}O$ bonds. This mobility of the hydrogen-bond protons may be the main reason for the high conductivity.