• 한국직업건강간호학회지
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• 제29권4호
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• pp.363-371
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• 2020

Purpose: This study aimed to evaluate the effect of information regarding health and safety risks on the subjective health status of workers using data from the Fifth Korean Working Conditions Survey. Methods: Among the survey respondents, 30,094 people classified as salaried workers, of which 8,513 (28.3%) used protective equipment. Results: Although the majority of workers using protective equipment reported being well-informed about safety and health risks, 15% of them were still insufficiently informed. Multivariate analyses have shown that the subjective health status of workers using protective equipment was significantly better if they received sufficient information. When the workers using protective equipment were classified by the kinds of hazards they were exposed to, the satisfaction of information was also significantly beneficial for the subjective health status of all groups. However, in workers who did not use protective equipment, information satisfaction did not appear to be a significant factor. Conclusion: These results suggest that when providing information on safety and health risks, it is necessary to focus on workers using protective equipment, for whom the effects of the policy are clearly expected.

• Archives of Pharmacal Research
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• 제27권3호
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• pp.324-333
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• 2004

To determine whether Insulin-like growth factor (IGF-I) treatment represents a potential means of enhancing the survival of cardiac muscle cells from adriamycin (ADR)-induced cell death, the present study examined the ability of IGF-I to prevent cell death. The study was performed utilising the embryonic, rat, cardiac muscle cell line, H9C2. Incubating cardiac muscle cells in the presence of adriamycin increased cell death, as determined by MTT assay and annexin V-positive cell number. The addition of 100 ng/mL IGF-I, in the presence of adriamycin, decreased apoptosis. The effect of IGF-I on phosphorylation of PI, a substrate of phosphatidylinositol 3-kinase (PI 3-kinase) or protein kinase B (AKT), was also examined in H9C2 cardiac muscle cells. IGF-I increased the phosphorylation of ERK 1 and 2 and $PKC{\;}{\zeta}{\;}kinase$. The use of inhibitors of PI 3-kinase (LY 294002), in the cell death assay, demonstrated partial abrogation of the protective effect of IGF-I. The MEK1 inhibitor-PD098059 and the PKC inhibitor-chelerythrine exhibited no effect on IGF-1-induced cell protection. In the regulatory subunit of PI3K-p85- dominant, negative plasmid-transfected cells, the IGF-1-induced protective effect was reversed. This data demonstrates that IGF-I protects cardiac muscle cells from ADR-induced cell death. Although IGF-I activates several signaling pathways that contribute to its protective effect in other cell types, only activation of PI 3-kinase contributes to this effect in H9C2 cardiac muscle cells.

• 한국사회복지학
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• 제59권2호
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• pp.251-275
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• 2007

아동학대는 그 자체로 아동의 전반적 발달에 영향을 주며, 심각한 사회문제를 야기할 수 있기 때문에 중요하게 검토되어야 할 문제이다. 이와 관련하여 아동학대 연구가 활발히 진행되고 있으나, 대부분의 연구가 학대의 부정적 결과에만 초점을 두고 있어 아동학대를 경험했음에도 불구하고 성공적으로 적응하는 적응유연 한 아동들을 설명하는데 제한적이었다. 이에 본 연구는 학대경험에도 불구하고 유능함을 보이는 아동의 특성, 즉 보호요인에 초점을 두고 보호요인이 어떻게 적응유연성에 영향을 미치는지 살펴보고자 한다. 이를 위해 한국청소년개발원에서 2004년에 전국의 초등학교 4학년 아동을 대상으로 조사한 한국청소년패널조사(KYPS) 자료를 사용하였다. 분석방법은 측정모형과 구조모형을 동시에 고려하고 측정오차를 포함하여 분석하는 구조방정식모형인 Mplus를 사용하였다. 분석결과, 위험요인인 학대는 아동의 적응유연성에 부정적 영향을 미치며, 보호요인은 적응유연성에는 긍정적 영향을 미치고, 위험요인이 적응유연성에 미치는 부정적 영향을 매개하여 완화시키는 것으로 나타났다. 이상의 결과를 토대로 피학대아동의 적응유연성을 향상시키기 위한 실천적 개입전략을 살펴보았다.

• 한국전기전자재료학회논문지
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• 제28권3호
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• pp.180-184
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• 2015

Stainless steel (SS) mesh was used to fabricate photoelectrode for flexible dye-seisitzed solar cells (DSSCs) in order to evaluate them as replacements for more expensive transparent conductive oxide(TCO). We fabricated the DSSCs with new type of photoelectrode, which consisted of flexible SS mesh coated with 100 nm thickness titanium (Ti) protective layer deposited using electron-beam deposition system. SS mesh DSSCs with protective layer showed higher efficiency than those without a protective layer. The best cell property in the present study showed the open circuit voltage (Voc) of 0.608 V, short-circuit current density (Jsc) of $5.73mA\;cm^{-2}$, fill factor (FF) of 65.13%, and efficiency (${\eta}$) of 2.44%. Compared with SS mesh based on DSSCs (1.66%), solar conversion of SS mesh based on DSSCs with protective layer improved about 47%.

• 지역사회간호학회지
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• 제14권4호
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• pp.639-645
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• 2003

This study was purposed to apply Aizen's Theory of Planned Behavior to workers using personal protective equipment. For this purpose, occupational health nurses conducted a survey of 173 male workers who were working at 6 different factories during the period from August to October 2003. The score of each variable related to the Theory of Planned Behavior was calculated: attitude (3.74); subjective norm(4.10); and perceived behavioral control (3.48). Four preceding factors were also assessed: behavioral belief(3.63); outcome evaluation(4.05); normative belief (4.20); and motivation to comply(4.03). Analysing the results, we found that two factors of the Theory of Planned Behavior are important in this case, which were subjective norm and perceived behavioral control that were found to be in a strong positive linkage with the use of personal protective equipment. Thus enhancing subjective norm and perceived behavioral control must be the most important goal of health education for workers who must use personal protective equipment. In addition, though behavioral intention, an intermediate factor of the Theory of Planned Behavior, was not measured in this study, subsequent studies are expected to include the factor in their models.

• 대한간호학회지
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• 제15권2호
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• pp.49-61
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• 1985

It is assumed that the more society advances in its complexity and development, the more people pay attention to their health and accordingly the more people tend to practice health protective behavior. Most of human behavior is based on social inter-actions. The concept in Locus of Control has been developed from social learning theory to help better understanding the social phenomena affecting human behavior. Multidimensional Health Locus of Control is consisted of three dimensions: Internal, Powerful Others and Chance. This study was conducted to find out the health protective behavior patterns of the people and its relationship with Health Locus of Control as an influencing factor to their behavior. All the subjects in this study were the ones of the bank employees in Seoul, Among the total of 1,430 bank employees, 761 were chosen as a sampled subjects. Questionnair survey was conducted from March 4 to March 13, 1985. Research instruments used in this study were two kinds, one was the Health Locus of Control Scale developed by Wallston & Wallston and the other was the Measuring Scale for Health Protective Behavior developed by the investigator. Analysis of data was done by using Descriptive Statistics, X²-test, t-test, ANOVA, Pearson's correlation coefficient. The results of this study are summarized as follows: The mean score of Internal was 24.1, Powerful others was 19.7 and Chance was 15.3 out of maximum range of 6-30 respectively. The mean score of Health Protective Behavior Scale fell as 53.2 out of a maximum range of 18-90. Internals were more likely closely related with sex, educational levels and religion, Powerful others were related with age, educational levels and the number of family members. Chances were related with edu cational levels. The older the subjects were, the more concerned about their health. They tended to practice more favorable health protective behaviors. Furthermore, married people tended to fay more attention to their health than single individuals. Also, the number of family members and religion affected their attitudes in the health protective behavior patterns. Internals and Powerful Others were related with health protective behaviors. If one believes he can do something about his health and others play a significant role on his health, he is more apt protective patterns more suitable for health and actually shows that he is better off.

• 한국노년학
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• 제38권4호
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• pp.1107-1125
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• 2018

본 연구는 치매환자와 동거하는 가족의 자살생각 위험요인과 보호요인에 따라 유형화를 하고, 각 유형집단이 자살생각에 미치는 영향을 분석하여 자살예방을 위한 실증적 기초 자료를 제시하는데 목적이 있다. 본 연구는 2013년 지역사회건강조사를 활용하여 치매환자와 동거하고 있는 가족 2,715명의 자료를 분석대상으로 하였고, 잠재계층모형분석과 이항로지스틱분석을 실시하였다. 주요분석내용은 (1) 자살생각의 위험요인과 보호요인의 유형화 (2) 유형화된 집단이 자살생각에 미치는 영향을 규명하고자 한다. 총24개의 자살생각 위험요인과 보호요인의 지표를 활용하여 잠재적 집단분석을 실시하여 '고위험-저보호요인'집단, '고위험-고보호요인'집단, '저위험-고보호요인'집단, '저위험-저보호요인'집단으로 유형화하였다. 분석 결과, '고위험-저보호요인'집단인 경우 자살생각이 가장 높았고, 유의하게 자살생각을 가지는 것으로 나타났다. 결과에 기반한 실천적 함의와 과제를 제시하였다.

• Journal of Microbiology and Biotechnology
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• 제16권11호
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• pp.1784-1790
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• 2006

Bacillus anthracis is a causative agent of anthrax. Anthrax toxins are composed of a protective antigen (PA), lethal factor (LF), and edema factor (EF), in which the PA is a central mediator for the delivery of the two enzymatic moieties LF and EF. Therefore, the PA has been an attractive target in the prevention and vaccinization for anthrax toxin. Recently, it has been reported that the molecule consisting of multiple copies of PA-binding peptide, covalently linked to a flexible polymer backbone, blocked intoxification of anthrax toxin in an animal model. In the present study, we have screened novel diverse peptides that bind to PA with a high affinity (picomolar range) from an M13 peptide display library and characterized the binding regions of the peptides. Our works provide a basis to develop novel potent inhibitors or diagnostic probes with a diverse polyvalence.

• 아동학회지
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• 제19권2호
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• pp.49-64
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• 1998

The theoretical process model was used to study problem behavior of children growing up at-risk. A sample of 339 children living in at-risk families were selected from among 2, 134 children in grades 4, 5, and 6 of five elementary schools in Seoul. The instruments were five risk factor scales and four protective factor scales. The Child Behavior Checklist was also used. The results of the hypothetical model of children at-risk showed that the factor of socioeconomic status led to positive child rearing attitudes in mothers, which is turn influenced children's problem behavior indirectly. In contrast, stressful life events and mother's depression influenced children's problem behavior directly. However, negative family functioning, marital discord and father's depression did not influence mother's child rearing attitudes or children's problem behavior. Mother's child rearing attitudes directly influenced children's social competence and academic achievement and indirectly influenced their problem behavior. Academic achievement did not influence problem behavior directly, but social competence influenced it directly. Mother's child rearing attitude was the most significant factor affecting children's adaptation.

• Nutrition Research and Practice
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• 제17권4호
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• pp.641-659
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• 2023

BACKGROUND/OBJECTIVES: The skin is the outermost organ of the human body and plays a protective role against external environmental damages, such as sunlight and pollution, which affect anti-oxidant defenses and skin inflammation, resulting in erythema or skin reddening, immunosuppression, and epidermal DNA damage. MATERIALS/METHODS: The present study aimed to investigate the potential protective effects of red orange complex H extract (ROC) against ultraviolet (UV)-induced skin photoaging in Skh:HR-2 mice. ROC was orally administered at doses of 20, 40, and 80 mg/kg/day for 13 weeks, along with UV irradiation of the mice for 10 weeks. RESULTS: ROC improved UV-induced skin barrier parameters, including erythema, melanin production, transepidermal water loss, elasticity, and wrinkle formation. Notably, ROC inhibited the mRNA expression of pro-inflammatory cytokines (interleukin 6 and tumor necrosis factor α) and melanogenesis. In addition, ROC recovered the UV-induced decrease in the hyaluronic acid and collagen levels by enhancing genes expression. Furthermore, ROC significantly downregulated the protein and mRNA expression of matrix metalloproteinases responsible for collagen degradation. These protective effects of ROC against photoaging are associated with the suppression of UV-induced phosphorylation of c-Jun NH2-terminal kinase and activator protein 1 activation. CONCLUSIONS: Altogether, our findings suggest that the oral administration of ROC exerts potential protective activities against photoaging in UV-irradiated hairless mice.