• 한국동물위생학회지
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• 제15권1호
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• pp.26-31
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• 1992

The oil emulsion and alhydrogel vaccines were prepared from a strain of enterotoxigenic Escherichia coli isolated from calves with diarrhea and their protective efficacy and immunogenicity were tested in Guinea-pigs. Enterotoxigenic Escherichia coli, isolated from calves with diarrhea, has K99 and F4l antigen as 46.2％ and 50.9％ with 48 and 53 strains respectively out of 104 strains. The protective efficacy of the gel and oil vaccines were 60% and 80% respectively. Agglutinin titers to sera of Guinea-pigs vaccinated with experimental gel and oil vaccines peaked at 5 and 6 weeks after vaccination.

• Journal of Radiation Protection and Research
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• 제35권4호
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• pp.157-162
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• 2010

의료기관 영상의학과의 방사선사 1,322명을 대상으로 의료기관 형태별 방사선장해 방어행위에 영향을 미치는 요인을 설문조사하였다. 의료기관 형태별 방사선장해 방어행위 수준차이를 비교한 결과 병원과 의원은 차이가 없었고 대학병원과 종합병원이 병원과 의원에 비하여 평균이 높았다(p<0.001). 대학병원인 경우의 방사선장해 방어행위에 영향을 미치는 요인은 방사선장해 방어환경, 과제특수성 자기효능감, 자기효능감, 행위기대, 환자수, 교육회수, 방사선장해 방어태도로 나타났다($R^2$=0.528). 종합병원인 경우의 방사선장해 방어 행위에 영향을 미치는 요인은 방사선장해 방어환경, 행위기대, 방어태도로 나타났다($R^2$=0.686). 병원인 경우의 방사선장해 방어행위에 영향을 미치는 요인은 방사선장해 방어환경, 행위기대, 방어태도, 자기효능감으로 나타났다($R^2$=0.679). 의원인 경우의 방사선장해 방어행위에 영향을 미치는 요인은 방사선장해 방어환경 하나만 나타났다($R^2$=0.222).

• Biomolecules & Therapeutics
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• 제6권2호
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• pp.191-198
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• 1998

Vsrio vulnificus is an estuarine gram-negative human pathogen that affects people with chronic hepatitis, alcoholic cirrhosis, diabetes mellitus or other underlying diseases. V. vulnificus infection is mediated primarily by consumption of raw fish or by exposure of pre-existing wounds to seawater, causing permanent tissue damages or fatal septic shock. We have been developing a vaccine against V. vulnificus composed of whole cell Iysate of a V. vulnificus O-antigen serotype 4 strain. Oral administration of the V. vulnificus;oral vaccine;immunogenicity;protective efficacy vaccine elicited a high serum antibody response in rabbits. The induced antibodies were reactive not only to the homologous strain but also to heterologous O-antigen serotype strains, indicating cross-reactivities among serotypes. Western blot analysis revealed that the antibodies are mainly specific for outer membrane proteins (OMPs) and reacted equally well with OMPs purified from 9 O-antigen serotypes. The rabbit antisera showed opsonophagocytic killing activity against heterologous strains as well as the homologous strain. Passively transferred rabbit antisera into mice were protective against a lethal V. vulnificus infection. These data demonstrate that oral administration of the V. vulnificus vaccine induced a systemic antibody response which had a protective efficacy against V. vulnificus infections, suggesting that this vaccine preparation could be used to develop an oral vaccine against V. vulnificus.

• Journal of Radiation Protection and Research
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• 제34권3호
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• pp.95-101
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• 2009

Protective behavior of radiological technologists against radiation exposure is important to achieve reduction of the patient doses without compromising medical achievements. This study attempts to provide a basic model for the sophisticated intervention strategy that increases the level of the protective behavior of the technologists. The model was applied to real situations in Korea to demonstrate its utility. The results of this study are summarized as follows: First, the protective environment showed the highest relationship in the factors considered, r=0.637 (p<0.01). Secondly, the important factors were protective environment in environment characteristics, expectation for the protective behavior 0.228 (p<0.001), self-efficacy 0.142 (p<0.001), and attitude for the protective behavior 0.178 (p<0.001) in personal characteristics, and daily patient -0.112 (p<0.001) and number of the participation in the education session for the protective behavior 0.074 (p<0.05). Thirdly, the final protective behavior model by a path analysis method had direct influence on the attitude 0.171 (p<0.01) and environment 0.405 (p<0.01) for the protective behavior, self efficacy 0.122 (p<0.01), expectation for the protective behavior 0.16 (p<0.01), and self-efficacy in the specialty of projects 0.154 (p<0.01). The acceptance of the model determined by the absolute fit index (GFI), 0.969, and by the incremental fit index (CFI), 0.943, showed very significant levels. Value of $x^2$/df that is a factor applied to verify the acceptance of the model was 37, which implies that the result can be accepted in the desirable range. In addition, the parsimonious fit index configured by AGFI (0.890) and TLI (0.852) was also considered as a scale that accepts the model in practical applications. In case of the establishment of some specific intervention strategies based on the protective behavior model against harmful radiation effects proposed in this study, the strategy will provide an effective way to prevent medical harmful radiation effects that could cause severe injuries to people.

• 한국환경교육학회지:환경교육
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• 제15권1호
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• pp.18-30
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• 2002

So far, the environmentally responsible behavior(ERB) model has been applied successfully to explain environment behaviors. But the ERB model has several limitations such as underestimation of social factors on environment behaviors. This study planned to point out that the emotional aspects should be considered seriously for explaining human's behaviors to conserve the environment in the ERB model. In this study, the effects of emotional aspects, such as perceived severity or perceived danger, on environment behaviors were investigated and the protective motivation theory(Rogers, 1983) and the ERB-based tentative model were compared Results showed that teenagers in urban areas realized clearly the severity and danger of environmental threats and do environmentally responsible behaviors more than ones in rural areas. Two model's goodness of fit to explain observed environment behaviors were analyzed through the regression analysis and the AMOS analysis. In the regression analysis, self-efficacy, confirmity toward social norm, and knowledge were involved in the regression equation as statistically meaningful variables in the ERB-based tentative model and self-efficacy and perceived severity were involved in the protective motivation theory. Especially, the AMOS analysis showed that the protective motivation theory was more valid model lot explaining environment behaviors than the ERB-based tentative model. In conclusion, it is reasonable that emotional aspects should be considered as meaningful variables for explaining environment behaviors.

• Parasites, Hosts and Diseases
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• 제43권1호
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• pp.19-25
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• 2005

Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against N. caninum infection was evaluated in vitro and in vivo. Two major immunodominant surface antigens (NcSAG1 and NcSRS2) and two dense granule proteins (NcDG1 and NcDG2) of N. caninum tachyzoites were expressed in E. coli, respectively. An in vitro neutralization assay using polyclonal antisera raised against each recombinant antigen showed inhibitory effects on the invasion of N. caninum tachyzoites into host cells. Separate groups of gerbils were immunized with the purified recombinant proteins singly or in combinations and animals were then challenged with N. caninum. Following these experimental challenges, the protective efficacy of each vaccination was determined by assessing animal survival rate. All experimental groups showed protective effects of different degrees against experimental infection. The highest protection efficacy was observed for combined vaccination with NcSRS2 and NcDG1. Our results indicate that combined vaccination with the N. caninum recombinant antigens, NcSRS2 and NcDG1, induces the highest protective effect against N. caninum infection in vitro and in vivo.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6477-6480
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• 2015

Purpose: Given the importance of sun protection in the prevention of skin cancer, this study was designed to determine predictors of sun-protective practices among a sample of Iranian female college students based on protection motivation theory (PMT) variables. Materials and Methods: In this cross-sectional study, a total of 201 female college students in Iran University of Medical Sciences were selected. Demographic and PMT variables were assessed with a 67-item questionnaire. Multiple linear regression was used to identify demographic and PMT variables that were associated with sun-protective practices and intention. Results: one percent of participants always wore a hat with a brim, 3.5% gloves and 15.9% sunglasses while outdoors. Only 10.9% regularly had their skin checked by a doctor. Perceived rewards, response efficacy, fear, self-efficacy and marital status were the five variables which could predict 39% variance of participants intention to perform sun-protective practices. Also, intention and response cost explained 31% of the variance of sun-protective practices. Conclusions: These predictive variables may be used to develop theory-based education interventions to prevent skin cancer among college students.

• Journal of Microbiology and Biotechnology
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• 제7권6호
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• pp.423-428
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• 1997

Vibrio vulnificus is a halophilic gram-negative human pathogen, which affects people with underlying liver diseases or a suppressed immune system, often leading to primary septicemia with a mortality rate of higher than 60%. In an effort to develop an oral vaccine against V. vulnificus infection, we prepared a whole cell killed vaccine of V. vulnificus on a large scale and compared the immunogenicity and protective efficacy of the vaccine administered in three formulation forms in rabbits. Since V. vulnificus O-antigen serotypes 1, 2, 3, 4, 5, and 7 account for more than 95% of clinical isolates, we prepared cell lysates from these six serotype strains and mixed in equal amounts for a vaccine. The vaccine was administered to rabbits intramuscularly (i.m.), orally as granules or as enteric-coated granules. In rabbits, all three formulation forms elicited a high level of serum IgG antibody reactive not only to the six strains but also to other O-antigen serotypes 6, 8 and 9, indicating cross-reactivities among the strains. Immunotherapeutic efficacy of the antisera was also evaluated by a passive immunization assay, which revealed that the orally immunized antisera as well as the i.m. immunized antisera was protective against a subsequent lethal challenge of V. vulnificus. These data demonstrate that oral immunization with a V. vulnificus whole cell lysate vaccine induced a systemic immune response and suggest the feasibility of development of this vaccine preparation as an oral vaccine.

• Journal of Preventive Medicine and Public Health
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• 제16권1호
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• pp.5-11
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• 1983

1982년 5월 1일부터 9월 30일까지 5개월간 대구시내 중구 동구 서구 남구 북구 수성구 6개보건소에 등록되어 치료받고 있는 20세미만 폐결핵환자중 BCG접종 유무가 명확한 400명과 동 보건소에 참아온 일반환자 가운데 거주지역, 성 및 연령에 맞추어 뽑은 대조군 659명을 대상으로 BCG접종율을 기준삼아 BCG의 폐결핵 예방효과를 조사한 결과 그 성적을 요약하면 다음과 같다. BCG접종군이 비접종군보다 비교위험도가 2분의 1로 낮게 나타났으며, BCG접종으로 인한 예방효과는 51.5%였다. 따라서 BCG의 효과에 대한 많은 논란과 방해적으로 작용할요인, BCG접종으로 인한 합병증등 여러가지 문제들이 있으나 결핵유병율이 2.5%나되는 우리나라에서는 앞으로도 계속 BCG접종을 권장하여야 것 것으로 본다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.1613-1616
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• 2008

Hiroshima University opened the advanced display laboratory (ADL) in 2006 to specifically focus on the PDP researches. The mission of ADL is to lay the bases for the innovative PDP technologies. Our research efforts have been concentrated on the fundamental study of protective materials and phosphors, and also of the effect of protective materials with high $\gamma$ emission in the high luminous efficacy. This paper briefly introduces the present status of our research activities.