Korean Journal of Veterinary Service (한국동물위생학회지)
- Volume 15 Issue 1
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- Pages.26-31
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- 1992
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- 3022-7372(pISSN)
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- 2287-7630(eISSN)
Studies on Protective Efficacy of Escherichia coli Vaccines
송아지 대장균 백신개발에 관한 연구
Abstract
The oil emulsion and alhydrogel vaccines were prepared from a strain of enterotoxigenic Escherichia coli isolated from calves with diarrhea and their protective efficacy and immunogenicity were tested in Guinea-pigs. Enterotoxigenic Escherichia coli, isolated from calves with diarrhea, has K99 and F4l antigen as 46.2% and 50.9% with 48 and 53 strains respectively out of 104 strains. The protective efficacy of the gel and oil vaccines were 60% and 80% respectively. Agglutinin titers to sera of Guinea-pigs vaccinated with experimental gel and oil vaccines peaked at 5 and 6 weeks after vaccination.