• 혜화의학회지
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• 제7권1호
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• pp.831-835
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• 1998

The concept of traditional oriental medicine and pharmaceutical and clinical effects were studied on holyessing obtained through carbonization of wood, before practical application. The results were obtained as follows: 1. Holyessing can be thought to be effective fluid to promote physiological metabolism as heat of water(水中之火) in the respest of oriental medicine. 2. Pharmaceutical effects of holyessing were reported to be antidiabetic effect, protective effect on liver, anticancer activity, protective effect against electronic damage, thermic effect, deodouring effect and proetcive action on atrophy dermatitis. 3. Several kinds of holyessing derived from other trees except of oak chiefly used so far had better be studied such as Morus bombycis. 4. Acute and chronic toxicity, combination of holyessing with other food, artifical correction of its taste and concentration should be absolutely studied.

• Journal of Applied Biological Chemistry
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• 제61권4호
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• pp.411-416
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• 2018

Chlorpyrifos (CPF) is one of the most heavily used organophosphate pesticides and is useful as an insecticide drug. However, CPF also causes toxic effects in nontarget organisms, including humans and animals. Jageum-Jung (JGJ) is a traditional oriental medicine, composed of five specific herbs with antioxidant and hepatoprotective properties, used for detoxification. In the present study, highly concentrated CPF was orally administrated to male Institute of Cancer Research mice to produce acute toxicity, and the protective effects of JGJ administration were investigated through statistical analysis of changes in body and organ weights and serum biochemical parameters. JGJ caused body and organ weights to recover and reduced the levels of serum biochemical parameters indicative of liver damage, such as glutamic oxalate transaminase, glutamic pyruvate transaminase, alkaline phosphatase, lactic dehydrogenase, urea, glucose, total cholesterol, and triglyceride, that had been increased by CPF treatment. Our results demonstrated that JGJ ameliorates the effects of acute chlorpyrifos-induced toxicity. Therefore, JGJ has the potential to be used as a traditional medicine to alleviate insecticide toxicity.

• 동의생리병리학회지
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• 제26권2호
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• pp.181-188
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• 2012

The object of this study was to observe the gatro protective effects of BJS-mix001, a mixed herbal formula consisted of 4 herbal drugs Pinelliae Rhizoma : Coptidis Rhizoma : Massa Medicata Fermentata : Ostreae Testa = 1 : 1 : 1 : 1 (g/g) mixtures, which were main component of oriental medicine for treating various digestive diseases, in indomethacin induced gastric damages in rats. Three different dosages of BJS-mix001 (200, 100 and 50 mg/kg) were once orally administered 30 min before indomethacin treatment. Six hrs after indomethacin treatment, changes on the gross lesion scores, fundic histopathology, MPO activity and anti oxidant activities were observed. The results were compared with omeprazole, antioxidant and proton pump inhibitor 10 mg/kg and DA-9601, a standardized extract of the herb Artemisia asiatica 100 mg/kg treated group, respectively. As results of all three different dosages of BJS-mix001 in the indomethacin induced gastric damaged rats, significant decreased gastric damages were detected as compared with the indomethacin treated control rats. BJS-mix001 also strengthened the antioxidative defense systems - decreased the level of lipid peroxidation and catalase activity but increased the level of superoxide dismutase and glutathione contents. BJS-mix001 showed similar gastro protective effects as compared with equal dosage of DA-9601, and BJS-mix001 50 mg/kg showed slighter effects as compared with omeprazole 10 mg/kg, in the present study. The results obtained in this study suggest that BJS-mix001 showed favorable effects in the indomethacin induced gastric damages mediated by strengthening of the antioxidative defense systems.

• Journal of Acupuncture Research
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• 제21권3호
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• pp.29-41
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• 2004

Objective : This study was produced to examine the effects of moxibustion that had been played important role to traditional oriental medical treatment on disease. Recently, it was reported that moxi-tar which is generated in the process of moxibustion as burning combustibles decreased NO and iNOS generation in C6-glioma and RAW 264.7 cells in our lab. Methods : C6-glioma cells were cultured in RPMI 1640 with FBS 10% in CO2 incubator. To study the protective effects of moxi-tar, we observed cell viability, DPPH activity, SOD activity, catalase activity and cell morphology after injury with $H_2O_2$. Results and Conclusions : Moxi-tar increased cell viability about twice as much as that of being injury by $H_2O_2$(moxi-tar $40{\mu}g/m{\ell}$, $H_2O_2$ $500{\mu}M$). And the results of free radical scavenger activity($80{\mu}g/m{\ell}$ : $78.91{\pm}4.4%$), SOD activity and catalase activity($80{\mu}g/m{\ell}$ : 21.6unit/mg protein) were increased by moxi-tar as dose-dependent manner. So we concluded that the effects of moxibustion which is played important role in Oriental medicine, might be free radical scavenger effects induced by moxi-tar. Conclusion : These results indicate that tBHP induces apoptosis through a lipid peroxidation-dependent mechanism and JS exerts the protective effect against the apoptosis by preventing peroxidation of membrane lipids.

• 동의생리병리학회지
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• 제23권6호
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• pp.1292-1298
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• 2009

Sipjeon-Daebo-Tang (SDT) is indicated for deficiency syndrome of both gi and blood, marked by pale or sallow complexion, dizziness, lassitude, shortness of breath, dislike for talking, poor appetite, pale tongue with thin whitish fur, thready and weak pulse. Gami-Sipjeon-Daebo-Tang(GSDT) is composed of 10 herbs within SDT and Cervi Pantotrichum Cornu (CPC). CPC can noursh kidney-yang, promote the production of the essence and blood, strengthen tendons and bones. Recently SDT is known as anti-cancer drug. Especially CPC is reported to have anti-oxidative action. For these reasons, we investigated the protective effects on cell death induced by chemicals such as paraquat, hydrogen peroxide and anti-oxidative effects in C6 glioma cells. In our results, GSDT accelerated proliferation rates of C6 cells in vitro. In addition, protective effects on cell death induced by hydrogen peroxide and rotenone. In addition, SOD activities were increased by treatment with both SDT and GSDT. In conclusion, these results suggest the possibility of GSDT to protect brain cell or neuronal cell from damage induced by oxidative stress. And also suggest that related mechanisms are involved in SOD activities.

• The Korean Journal of Physiology and Pharmacology
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• 제25권4호
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• pp.281-296
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• 2021

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects and mechanisms of repeated episodes of whole body hypoxic preconditioning (WBHP) in db/db mice. The protective effects of preconditioning were explored on diabetes-induced vascular dysfunction, cognitive impairment and ischemia-reperfusion (IR)-induced increase in myocardial injury. Sixteen-week old db/db (diabetic) and C57BL/6 (non-diabetic) mice were employed. There was a significant impairment in cognitive function (Morris Water Maze test), endothelial function (acetylcholine-induced relaxation in aortic rings) and a significant increase in IR-induced heart injury (Langendorff apparatus) in db/db mice. WBHP stimulus was given by exposing mice to four alternate cycles of low (8%) and normal air O₂ for 10 min each. A single episode of WBHP failed to produce protection; however, two and three episodes of WBHP significantly produced beneficial effects on the heart, brain and blood vessels. There was a significant increase in the levels of brain-derived neurotrophic factor (BDNF) and nitric oxide (NO) in response to 3 episodes of WBHP. Moreover, pretreatment with the BDNF receptor, TrkB antagonist (ANA-12) and NO synthase inhibitor (L-NAME) attenuated the protective effects imparted by three episodes of WBHP. These pharmacological agents abolished WBHP-induced restoration of p-GSK-3β/GSK-3β ratio and Nrf2 levels in IR-subjected hearts. It is concluded that repeated episodes of WHBP attenuate cognitive impairment, vascular dysfunction and enhancement in IR-induced myocardial injury in diabetic mice be due to increase in NO and BDNF levels that may eventually activate GSK-3β and Nrf2 signaling pathway to confer protection.

• Nutrition Research and Practice
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• 제15권3호
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• pp.279-293
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• 2021

BACKGROUND/OBJECTIVES: The steamed ginger has been shown to have antioxidative effects and a protective effect against obesity. In the present study, we investigated the effects of ethanolic extract of steamed ginger (SGE) on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity (DIO) mouse model. MATERIALS/METHODS: The protective effects of SGE on adipogenesis were examined in 3T3-L1 adipocytes by measuring lipid accumulations and genes involved in adipogenesis. Male C57BL/6J mice were fed a normal diet (ND, 10% fat w/w), a high-fat diet (HFD, 60% fat w/w), and HFD supplemented with either 40 mg/kg or 80 mg/kg of SGE for 12 weeks. Serum chemistry was measured, and the expression of genes involved in lipid metabolism was determined in the adipose tissue. Histological analysis and micro-computed tomography were performed to identify lipid accumulations in epididymal fat pads. RESULTS: In 3T3-L1 cells, SGE significantly decreased lipid accumulation, with concomitant decreases in the expression of adipogenesis-related genes. SGE significantly attenuated the increase in body, liver, and epididymal adipose tissue weights by HFD. Serum total cholesterol and triglyceride levels were significantly lower in SGE fed groups compared to HFD. In adipose tissue, SGE significantly decreased adipocyte size than that of HFD and altered adipogenesis-related genes. CONCLUSIONS: In conclusion, steamed ginger exerted anti-obesity effects by regulating genes involved in adipogenesis and lipogenesis in 3T3-L1 cell and epididymal adipose tissue of DIO mice.

• 한국조명전기설비학회지:조명전기설비
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• 제11권4호
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• pp.109-116
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• 1997

I본 논문은 교류 전원용 바리스터와 LC필터를 조합한 서지 보호장치에 대해서 기술하였다. 지금까지 교류 전류용 서지 보호장치로써 바리스터만이 주로 사용되어 왔으나, 이것은 급상승하고 높은 잔류전압 때문에 보호되어야 할 장비에 해로운 결과를 초래하는 경우도 있다. 따라서 본 연구에서는 교류 전원용 서지 보호장치의 차단 성능을 향상시키기 위하여 바리스터와 LC필터로 구성된 조합형 서지 보호장치를 설계.제작하였다. 그리고 서지 보호장치의 동작특성과 차단 성능의 분석에 대한 실험을 1.2/50[$\mu\textrm{s}$] 임펄스 발생기를 적용하여 수행하였다. 결론적으로 본 연구에서 제시한 조합형 서지보호장치는 서지 전압을 더욱 낮게 제한할 수 있고, dV/dt의 값을 매우 낮은 값으로 감소시키며, LC필터에 의한 출력단의 고주파 전압을 효과적으로 감쇠시킬수 있기 때문에 전자시스템의 손상과 전도를 더욱 더 효과적으로 방지할 수 있다.

• 디지털융복합연구
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• 제15권12호
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• pp.59-70
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• 2017

본 연구는 중도입국 청소년의 학교적응에 영향을 미치는데 있어 위험요인에 대한 보호요인의 조절효과가 있는지를 알아보고자 하였다. 이를 위해 2015년 전국다문화가족실태조사 대상 중 만 9~24세 청소년 자녀 6,079명 데이터에 가중치를 적용한 69,720명을 분석하였다. 분석결과 첫째, 중도입국 청소년의 위험요인인 차별경험, 학교폭력, 우울은 학교적응에 모두 부적인 영향을 미쳤다. 보호요인인 부모관계, 자아존중감, 한국어 능력, 국적취득은 학교적응에 모두 정적인 영향을 보였다. 둘째, 중도입국 청소년의 학교적응에 있어 3개의 위험요인 가운데 우울을 조절하는 보호요인 중에는 자아존중감과 국적취득 변인, 학교폭력을 조절하는 보호요인은 부모관계, 자아존중감, 한국어 능력, 국적취득 변인으로 분석되었다. 본 연구의 분석결과를 토대로 중도입국 청소년에 대한 우울감소, 학력폭력 대처, 다양한 역량강화 프로그램 개발과 지원을 주요 사회복지적 실천방안으로 제시하였다.

• Bulletin of the Korean Chemical Society
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• 제28권10호
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• pp.1881-1884
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• 2007