• Journal of the Korean Applied Science and Technology
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• v.27 no.1
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• pp.1-5
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• 2010

HOMO(the highest occupied molecular orbital) and LUMO(the lowest unoccupied molecular orbital) of four recalcitrant polycyclic aromatic hydrocarbons (PAHs) were calculated by MOPAC program(CaChe Co). The previous papers which reported experimental results about radical reaction of PAHs were reviewed. The reported radical reaction positions of four PAHs corresponded with predicted positions in which ${\Delta}E$(HOMO-LUMO) was high. From these results, it appears that determining the ${\Delta}E$(HOMO-LUMO) of a PAH is a promising method for predicting the radical reaction position.

• Molecules and Cells
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• v.41 no.11
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• pp.933-942
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• 2018

Traditionally, small-molecule or antibody-based therapies against human diseases have been designed to inhibit the enzymatic activity or compete for the ligand binding sites of pathological target proteins. Despite its demonstrated effectiveness, such as in cancer treatment, this approach is often limited by recurring drug resistance. More importantly, not all molecular targets are enzymes or receptors with druggable 'hot spots' that can be directly occupied by active site-directed inhibitors. Recently, a promising new paradigm has been created, in which small-molecule chemicals harness the naturally occurring protein quality control machinery of the ubiquitin-proteasome system to specifically eradicate disease-causing proteins in cells. Such 'chemically induced protein degradation' may provide unprecedented opportunities for targeting proteins that are inherently undruggable, such as structural scaffolds and other non-enzymatic molecules, for therapeutic purposes. This review focuses on surveying recent progress in developing E3-guided proteolysis-targeting chimeras (PROTACs) and small-molecule chemical modulators of deubiquitinating enzymes upstream of or on the proteasome.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.8
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• pp.833-837
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• 2015

Li-air batteries have a promising future for because of their high energy density, which could theoretically be equal to that of gasoline. However, substantial Li-air cell performance limitations exist, which are related to the air cathode. The cell discharge products are deposited on the surfaces of the porous carbon materials in the air electrode, which blocks oxygen from diffusing to the reaction sites. Hence, the real capacity of a Li-air battery is determined by the carbon air electrode, especially by the pore volume available for the deposition of the discharged products. In this study, a simple and fast method is reported for the large-scale synthesis of carbon nanoballs (CNBs) consisting of a highly mesoporous structure for Li-air battery cathodes. The CNBs were synthesized by the solution plasma process from benzene solution, without the need for a graphite electrode for carbon growth. The CNBs so formed were then annealed to improve their electrical conductivity. Structural characterization revealed that the CNBs exhibited both an pore structure and high conductivity.

• Journal of Information Technology Services
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• v.13 no.3
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• pp.257-274
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• 2014

Social Network Services (SNSs) have grown to be new and promising tools of marketing. By referring to researches done on e-mail viral marketing, this paper operationizes SNS viral marketing effectiveness to accurately reflect marketing success in SNS environment, and tries to identify its affecting factors. As potential affecting factors, fan size, advertisement type, existence of engagement elicitation and incentive are identified. By sampling real advertisement postings on Facebook, we showed that fan size, advertisement type, and engagement elicitation are factors affecting SNS viral marketing success. This research expanded the conventional model of viral marketing into SNS settings to improve understanding on SNS viral marketing. Motivation is discussed as an important factor, and this research showed that viral campaign can be more successful when it triggers internal motivation to engage, but not the external motivation. This research could also be a guide for practitioners on how to post a successful advertisement in SNSs.

• Journal of Pharmaceutical Investigation
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• v.40 no.4
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• pp.201-212
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• 2010

Self-organized nanogels from polysaccharide derivatives offer a promising approach in treatment of cancer due to their flexibility in chemistry and their ability to improve the therapeutic index of a drug by modifying biodistribution by their preferential localization at target sites and lower distribution in normal healthy tissues. These properties have promoted studies of active cancer targeting by self-organized nanogels for even better accumulation in solid tumors. However although many researchers have reported their potential by using cell culture systems and small animal tumor models in cancer therapy, these nanogels need more decoration such as conjugation with targeting moiety and endowment of stimuli-sensitivity for precise targeting of the cancer site. In this review, we summarize the recent efforts in developing novel targeting approaches via active endocytosis and stimuli-sensitive systems responding to hyperthermic or acidic tumor pH conditions.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.2
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• pp.112-119
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• 2009

Telecare, one of the e-healthcare services with lCT, is a promising technology which aims to monitor the state of patients and then provide the medical services appropriately in remote sites. Virtual telecare team based on the concept of virtual collaborative teams which consist of a patient, a doctor, and a telecare team, operates on a temporary basis in need. Reputation, which means the degree of a patient's belief to a doctor in consideration, is the most important factor to make the virtual telecare team trustable. In this paper, we propose the fuzzy reputation model of a virtual telecare team, which is a reputation-based trust model based on fuzzy set theory. An illustrative example is also given in order to show the applicability of the model to the concept of a virtual telecare team.

• Biomedical Science Letters
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• v.24 no.3
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• pp.253-262
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• 2018

Platelets are activated at sites of vascular injury via several molecules, such as adenosine diphosphate, collagen and thrombin. Full platelet aggregation is absolutely essential for normal hemostasis. Moreover, this physiological event can trigger circulatory disorders, such as thrombosis, atherosclerosis, and cardiovascular disease. Therefore, platelet function inhibition is a promising approach in preventing platelet-mediated circulatory disease. Many studies reported the involvement of mitogen-activated protein kinases (MAPKs) signaling pathways in platelet functions. However, these studies were limited. Thus, we examined MAPK signaling pathways in human platelets using specific MAPK inhibitors, such as PD98059, SB203580, and SP600125. We observed that these inhibitors were involved in calcium mobilization and influx in human platelets. They also suppressed thrombin-induced ${\alpha}$- and ${\delta}$-granule release. These results suggest that PD98059, SB203580, and SP600125 exhibit $Ca^{2+}$ antagonistic effects.

• Journal of Microbiology and Biotechnology
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• v.21 no.7
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• pp.675-678
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• 2011

DNA methylation in Streptomyces griseus IFO 13350 was analyzed by high-performance liquid chromatographic analysis and bisulfite-based analysis to reveal two methylation sites, 5'-$GC^{5m}$ CGGC-3' and 5'-$GAG^{5m}$ CTC-3'. The methylation was reconstituted in Escherichia coli by simultaneous expression of S. griseus SGR4675 and S. achromogenes M.SacI. The E. coli cells produced plasmids that mimicked the methylation profile of S. griseus DNA, which was readily introduced into S. griseus. The results of this study raise the possibility of a promising approach to establish efficient transformation in several streptomycetes.

• International Journal of Railway
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• v.7 no.3
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• pp.80-84
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• 2014

The purpose of this paper was to review Intelligent Compaction (IC) techniques, which is regarded relatively new to the railroad roadbed construction activity. Most of civil structures are built on roadbed that supposed to provide adequate load bearing support to the upper structure through the qualified compaction process. However, it is not uncommon for structure failure attributed to inadequate compaction control take place in field sites. Unlike traditional compaction control method to check field density at several locations, IC techniques continuously measure various compaction quality indices that represent compaction uniformity. In this paper, a series of literature review relevant to IC techniques was conducted to provide concise summary on the following categories: 1) background of IC technique; 2) Summary of IC vendors and basic principles; 3) modeling of IC behavior, and 4) case study along with correlation between IC with other measurements. In summary, IC technologies seem to be promising in future railroad construction to achieve better compaction quality control so that the serviceability of railroad can be ensured with minimizing rehabilitation and maintenance activities.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.2
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• pp.29.2-29.2
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• 2018

Korean Neutrino Observatory (KNO) aims to make important discoveries in particle physics and astronomy by building a gigantic neutrino telescope consisting of 260 kiloton water and 40,000 20 inch photomultiplier tubes. Using J-PARC neutrino beam, leptonic CP violation (CPV) could be discovered if the CP is maximally violated, and neutrino mass ordering is guaranteed to be determined with more than 6 sigma for any CPV value. As a neutrino telescope, solar and Supernova burst/relic neutrinos could be studied very precisely. Indirect dark matter search sensitivity is improved by 3 to 4 times than that of Super Kamiokande. There are several candidate sites in Korea and especially Mt. Bisul and Mt. Bohyun are very promising according to our site survey. In this talk, an overview of the KNO is presented.