• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2002.10b
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• pp.79-80
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• 2002

This paper presents an experimental study of the effect of rolling speed and surface roughness on the mixed elastohydrodynamic (EHD) lubrication characteristics for point contact formed between a real, random, rough surface, steel ball and smooth glass disc. The Thin Film Colorimetic Interferometry measurement technique has been extended to give detailed information about in-contact deformation of the microgeometry. It has enabled to derive the amplitude reduction curve that shows progressive recovering of ball roughness features with increasing speed.

• Journal of Interdisciplinary Genomics
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• v.2 no.2
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• pp.20-25
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• 2020

Mucopolysaccharidosis type III (MPS III or Sanfilippo syndrome) is a multisystem lysosomal storage disease that is inherited in an autosomal recessive manner. It consists of four subtypes (MPS IIIA, B, C, and D), each characterized by the deficiency of different enzymes that catalyze the metabolism of the glycosaminoglycan heparan sulfate at the lysosomal level. The typical clinical manifestation of MPS III includes progressive central nervous system (CNS) degeneration with accompanying systemic manifestations. Disease onset is typically before the age of ten years and death usually occurs in the second or third decade due to neurological regression or respiratory tract infections. However, there is currently no treatment for CNS symptoms in patients with MPS III. Invasive and non-invasive techniques that allow drugs to pass through the blood brain barrier and reach the CNS are being tested and have proven effective. In addition, the application of genistein treatment as a substrate reduction therapy is in progress.

• Design & Manufacturing
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• v.9 no.1
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• pp.5-8
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• 2015

The company Daewoo Precision Industries imported fine blanking press of 40 tons from Switzerland with fine blanking tool in order to produce the fuse part of bomb in 1978 at first in Korea. About 1985 the first fine blanking tool for producing the door lock parts was manufactured in the company Gold Star (now LG). And then this technology was grown up with the growth of automobile industries in Korea. Now 31 companies are closely related to the fine blanking technology and there are total 146 fine blanking presses in Korea. The developments of fine blanking technology in industries have been oriented to the production of precise fine blanking parts, the reduction of die roll height on fine blanking parts, the production of complex fine blanking parts with progressive fine blanking tool including forming and forging technology, the production of high-strength steel fine blanking parts and so on. Some R&D activities in KITECH were introduced.

• Molecules and Cells
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• v.27 no.6
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• pp.621-627
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• 2009

Spinocerebellar ataxia type 1 (SCA1) is an autosomal-dominant neurodegenerative disorder characterized by ataxia and progressive motor deterioration. SCA1 is associated with an elongated polyglutamine tract in ataxin-1, the SCA1 gene product. As summarized in this review, recent studies have clarified the molecular mechanisms of SCA1 pathogenesis and provided direction for future therapeutic approaches. The nucleus is the subcellular site where misfolded mutant ataxin-1 acts to cause SCA1 disease in the cerebellum. The role of these nuclear aggregates is the subject of intensive study. Additional proteins have been identified, whose conformational alterations occurring through interactions with the polyglutamine tract itself or non-polyglutamine regions in ataxin-1 are the cause of SCA-1 cytotoxicity. Therapeutic hope comes from the observations concerning the reduction of nuclear aggregation and alleviation of the pathogenic phenotype by the application of potent inhibitors and RNA interference.

• Asian-Australasian Journal of Animal Sciences
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• v.8 no.1
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• pp.7-11
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• 1995

Ethylene glycol was given orally in 6 crossbred male cow calves @ 12 ml/kg b wt for 2 days continuously to develop acute nephrotoxicity and monitor blood chemicals profile in affected calves. Progressive depression, hypersalivation, ataxia, incoordination, staggering gait, grinding of teeth, recumbency, coma, convulsions and death were prominent symptoms in affected calves. Respiration and pulse rates were increased whereas body temperature and rumen movements were low. Haematological investigations revealed increase in total erythrocyte count, platelets count and packed cell volume till death and total leukocyte count up to day 3 which decreased on day 4 and 5. These calves revealed azotaemia, reduction in calcium, chloride and potassium and rise in sodium and AST, ALT and alkaline phosphatase enzymes activity.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.38 no.4
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• pp.249-254
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• 2012

Bilateral coronoid process hyperplasia is a rare condition characterized by an enlarged mandibular coronoid process. The painless progressive reduction of a mouth opening is caused by coronoid process impingement on the posterior aspect of the zygomatic bone. Hyperplasia of the bilateral coronoid process leads to the restriction of a mandibular opening consequent to the impingement of the enlarged coronoid process on the temporal surface of the zygomatic bone or with the medial surface of the zygomatic arch. The process has been diagnosed as developmental hyperplasia. Otherwise, the development of the coronoid process may be associated with growth hormone. This paper describes a case of trismus caused by coronoid hyperplasia in an idiopathic short-stature patient who received growth hormone therapy by somatropin injections.

• Korean Journal of Construction Engineering and Management
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• v.9 no.6
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• pp.268-276
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• 2008

In highway construction projects, concrete pavement productivity has been challenged with constructors and decision-makers; at present there are few methods available to accurately evaluate the factors impacting on it. Any inefficient method to analyze it leads to the excessive schedule, higher rehabilitation costs, shorter service life, and reduction of ride quality. To implement these negative outcomes, constructors or decision-makers need a systematic tool that can be used to categorize the factors related to construction productivity. This paper applies multiple regression technique for productivity analysis of the Jointed Plane Concrete Pavement (JPCP), identifies the significant factors, and provides a predictive model assisting in monitoring and managing the productivity of the JPCP construction process. The completed and progressive projects are employed to derive and assess the proposed model. The results are analyzed to illustrate its capabilities.

• Proceedings of the KIEE Conference
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• summer
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• pp.409-411
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• 2004

The need for Fault Current Limiters (FCL) is associated with the continuous growth and interconnection of modem power systems and increase in dispersed generation facilities, which result in progressive increase in the short circuit capacity far beyond their original design capacity. Fault Current Limiters (FCL) clips the fault currents and reduces the electromechanical stresses on the network and the need to handle excessive fault currents. In addition, the reduction of the fault duration Provided by the limiter should increase the power transmission capability and improve the dynamic stability. This paper proposes the model of resistive type superconducting fault current limiter using EMTDC(Electromagnetic transients for DC analysis program). In order to verify the effectiveness of the SFCL, in this paper, the analysis of fault current in a transmission system through the EMTDC based simulation by using the modeled component of a resistive type SFCL is peformed and the detailed results are given.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.177-180
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• 2008

Parkinson's disease is the second most common neurodegenerative disorder. It is slowly progressive disease that affects a small area of cells in the mid brain known as the substantia nigra. Gradual degeneration of these cells causes a reduction in a vital chemical known as dopamine. In the diagnosis of Parkinson's disease, it has difficulty in biopsy and limits in radiologic modalities. $^{18}F-FDG$ PET shows various findings from normal to diffuse decrement of FDG uptake. $^{18}F-FDG$ PET is expected to be a evaluation tool in the treatment of Parkinson's disease.

• BMB Reports
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• v.37 no.6
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• pp.642-647
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• 2004

The lysine residues of Bacillus licheniformis $\alpha$-amylase (BLA) were chemically modified using citraconic anhydride or succinic anhydride. Modification caused fundamental changes in the enzymes specificity, as indicated by a dramatic increase in maltosidase and a reduction in amylase activity. These changes in substrate specificity were found to coincide with a change in the cleavage pattern of the substrates and with a conversion of the native endo- form of the enzyme to a modified exo- form. Progressive increases in the productions of $\rho$-nitrophenol or glucose, when para nitrophenyl-maltoheptaoside or soluble starch, respectively, was used as substrate, were observed upon modification. The described changes were affected by the size of incorporated modified reagent: citraconic anhydride was more effective than succinic anhydride. Reasons for the observed changes are discussed and reasons for the effectivenesses of chemical modifications for tailoring enzyme specificities are suggested.