• 제목/요약/키워드: Progressive reduction

검색결과 153건 처리시간 0.027초

백서 두개골 실험적 결손부에서 Para-Dioxanone 차단막의 골조직 재생 효과 (THE BONE REGENERATIVE EFFECTS OF PARADIOXANONE ON THE CALVARIAL CRITICAL SIZE DEFECT IN SPRAGUE DAWLEY RATS)

  • 권석훈;석헌주;김종관;정한성;문익상
    • Journal of Periodontal and Implant Science
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    • 제33권1호
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    • pp.61-77
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    • 2003
  • The major goals of periodontal therapy are the functional regeneration of periodontal supporting structures already destructed by periodontal disease as well as the reduction of signs and symptoms of progressive periodontal disease. There have been many efforts to develop materials and therapeutic methods to promote periodontal wound healing. Bone graft & guided tissue are being used for the regeneration of destroyed periodontium these days. Non-resorbable membranes were used for Guided tissue regeneration in early days, however more researches are focused on resorbable membranes these days. The aim of this study is to evaluate the osteogenesis of paradioxanone membrane on the calvarial critical size defect in Sprague Dawley rats. An 8 mm diameter surgical defect was produced with a trephine bur in the area of the midsagittal suture. The rats were divided into three groups: Untreated control group, Biomesh(R) group and paradioxanone group. The animals were sacrificed at 4, 8 and 12 weeks after surgical procedure. The specimens were examined by histologic, histomorphometric analyses. The results are as follows: 1. In histological view on Biomesh(R), no visible signs of resorption was observed at 4 weeks but progressive resorption was observed at 8 weeks through 12 weeks. Paradioxanone membrane expanded at 4 weeks, and rapid resorption was observed at 8 weeks. In both the membranes, inflammatory cells were observed around them. Inflammatory cells decreased with time but were still present at 12 weeks. More inflammatory cells were observed in paradioxanone membranes than in Biomesh(R) membrane. 2. The area of newly formed bone in the defects were 0.001${\pm}$0.001, 0.006${\pm}$0.005, 0.002${\pm}$0.003 at the 4 weeks, 0.021${\pm}$0.020, 0.133${\pm}$0.073, 0.118${\pm}$0.070 at the 8 weeks and 0.163${\pm}$0.067, 0.500${\pm}$0.197, 0.487${\pm}$0.214 at the 12 weeks in the control group, Biomesh(R) group and experimental group respectively. Compared to the control group, Biomesh(R) group displayed significant differences at 4,8, and 12 weeks and the paradioxanone group at 8 and 12 weeks.(P<0.05)

휨항복 후 부착파괴하는 철근콘크리트 부재의 부착 연성 평가 (Evaluation for Deformability of RC Members Failing in Bond after Flexural Yielding)

  • 최한별;이정윤
    • 콘크리트학회논문집
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    • 제24권3호
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    • pp.259-266
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    • 2012
  • 일반적인 내진 설계에서는 구조물의 연성적인 거동을 유도하기 위해서 보-기둥 접합부에 인접한 보에 소성힌지가 발생하도록 한다. 따라서 철근콘크리트 부재의 부착강도와 전단강도가 휨강도보다 큰 값을 가져야 하고, 전단이나 부착파괴가 요구된 연성에 도달하기 이전에 발생하지 않아야 한다. 하지만 전단경간비가 짧은 부재의 경우에는 전단이나 부착 거동의 지배를 받는 경우가 많고, 핀칭 효과로 인해 에너지 소산이 비교적 적게 발생하므로 요구된 연성에 도달하지 못하고 파괴될 수 있다. 이 논문에서는 전단경간비가 짧은 철근콘크리트 부재의 거동 분석과 연성 예측, 특히 부착 연성 능력을 평가하기 위한 방법을 제안하였다. 이것은 반복하중에 의해 저감되는 잠재 전단강도와 잠재부착내력 모델, 그리고 소성힌지 형성에 따른 휨부착응력의 급격한 증대를 도식화하여 나타낼 수 있다. 제안된 해석법은 각 값의 변화 추이를 비교하여 부재의 거동을 파악하고, 부착 거동의 지배를 받는 부재의 경우, 부착내력과 휨부착응력의 값이 만나는 지점까지를 그 부재의 부착 연성으로 평가하는 방법이다. 이 방법은 기존에 수행된 8개의 보, 기둥 시험체를 통해 비교 및 검토하였으며 부재 거동에 대한 예측은 정확히 일치하였으나, 부착 연성 능력에 대해서는 과소평가 되었다. 그 이유는 부재의 부착강도를 실제 부착강도보다 비교적 낮게 예측한 부착강도식에서 찾을 수 있으며, 다른 부착 내력 모델에 대한 부착 연성 평가에 대한 연구가 추후 필요할 것으로 사료된다.

한방비만프로그램을 통한 체중과 부위별 복부둘레의 경과 관찰 및 상관성 연구 (The Progress Report of Weight and Waist Circumference through the Oriental Obesity Treatment)

  • 허수정;이재은;김현진;조현주;명성민
    • 한방비만학회지
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    • 제9권2호
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    • pp.47-56
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    • 2009
  • Objectives The purpose of this study was to investigate the progress of weight and waist circumference(WC) through oriental obesity treatment and clarify the correlation between weight loss and WC change. Methods The subjects were treated from January 2007 to September 2009 in J Oriental Medical Center. Herbal medicine, electroacupuncture, oriental obesity physiotherapy were performed for a month. We checked the change of weight and WC at every treatment. We classified the WC into upper, middle, lower parts specifically and measured them individually. Measurements were analyzed by using one-way repeated measures ANOVA and we also investigated correlation between weight loss and WC change. Results (1) During the first and second treatment sessions, the weight loss was the highest, $0.96{\pm}0.86\;kg$($1.46{\pm}1.32\;%$) and during the 5th and 6th treatment sessions, the lowest $0.37{\pm}0.616\;kg$. The final weight loss was $3.71{\pm}1.476\;kg$($5.51{\pm}2.12\;%$). (2) After 8 treatment sessions, the reductions of upper, middle and lower WC were $3.59{\pm}2.26\;%$, $5.93{\pm}2.75\;%$, $5.51{\pm}3.22\;%$, respectively. As the patients received more treatment, there was a progressive decline in the variation of weight and middle WC. However, the decline rate of upper and middle WC fluctuated during the treatments, forming a W-shaped curve. (3) Analysis of the correlation between the weight loss and WC change shows that the reduction of middle WC was most closely associated with the weight loss. Conclusions This study indicated that the rate of weight loss and WC reduction showed stagnation during the 5th and 6th treatment sessions, and the reduction of middle WC was most closely associated with the weight loss. Since the progress of weight and WC change is an important field of research on obesity, further systemic studies would be needed for the foundation of a clinical guideline.

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1-methyl-4-phenylpyridinium으로 유도된 신경 손상에 대한 quercetin-3-O-glucuronide의 보호 효과 (Protective Effects of Quercetin-3-O-glucuronide against 1-methyl-4-phenylpyridinium-induced Neurotoxicity)

  • 파리야르라메스;바스또라통킹;서정원
    • 생명과학회지
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    • 제29권2호
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    • pp.191-197
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    • 2019
  • 파킨슨병은 운동완서, 근육경직, 진전 및 비정상적인 자세 등을 임상적 특징으로 하는 주로 운동 신경계에 영향을 주는 진행성 신경 퇴행성 질환이다. 파킨슨병은 산화 스트레스와 세포 내 신호 전달 경로의 조절 장애에 의한 뇌 흑색치밀부에서의 도파민성 신경세포의 사멸을 특징으로 한다. Quercetin의 주요 대사산물인 Quercetin-3-O-glucuronide (Q3GA)는 신경 보호 효과가 있는 것으로 보고 되어 왔다. 본 연구에서는 SH-SY5Y 세포에서 1-methyl-4-phenyl pyridinium ($MPP^+$)에 의해 유도된 신경 독성에 대한 Q3GA의 신경 보호 효과와 그 분자 조절 기전을 조사하였다. Q3GA는 $MPP^+$에 의해 유도된 세포 사멸을 유의적으로 감소시켰으며 PARP 절단을 감소시켰다. 또한, Bax/Bcl-2 비율의 감소와 함께 $MPP^+$에 의해 증가된 세포 내 ROS를 감소시켰다. Q3GA는 $MPP^+$에 의해 감소된 Akt와 CREB의 인산화를 유의적으로 회복시켰지만, ERK에는 영향을 미치지 않았다. 이 결과는 Q3GA가 ROS 생산 억제와 Akt/CREB 신호 전달 경로를 통해 $MPP^+$ 에 의해 유도된 신경 독성을 억제시킬 수 있음을 시사한다. 본 연구는 Q3GA가 파킨슨병에 대한 예방제 또는 치료제로 개발될 수 있는 가능성을 제시한다.

Origin of limestone conglomerates in the Choson Supergroup(Cambro-Ordovician), mid-east Korea

  • Kwon Y.K.;Chough S.K.;Choi D.K.;Lee D.J.
    • 한국석유지질학회:학술대회논문집
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    • 한국석유지질학회 2001년도 제8차 학술발표회 발표논문집
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    • pp.63-65
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    • 2001
  • The Chosen Supergroup (Cambro-Ordovician), mid-east Korea consists mainly of shallow marine carbonates and contains a variety of limestone conglomerates. These conglomerates largely comprise oligomictic, rounded lime-mudstone clasts of various size and shape (equant, oval, discoidal, tabular, and irregular) and dolomitic shale matrices. Most clasts are characterized by jigsaw-fit (mosaic), disorganized, or edgewise fabric and autoclastic lithology. Each conglomerate layer is commonly interbedded with limestone-dolomitic shale couplets and occasionally underlain by fractured limestone layer, capped by calcareous shale. According to composition, characteristic sedimentary structures, and fabric, limestone conglomerates in the Hwajol, Tumugol, Makkol, and Mungok formations of Chosen Supergroup can be classified into 4 types: (1) disorganized polymictic conglomerate (Cd), (2) horizontally stratified polymictic conglomerate (Cs), (3) mosaic conglomerate (Cm), and (4) disorganized/edgewise oligomictic conglomerate (Cd/e). These conglomerates are either depositional (Cd and Cs) or diagenetic (Cm and Cd/e) in origin. Depositional conglomerates are interpreted as storm deposits, tidal channel fills, or transgressive lag deposits. On the other hand, diagenetic conglomerates are not deposited by normal sedimentary processes, but formed by post-depositional diagenetic processes. Diagenetic conglomerates in the Chosen Supergroup are characterized by autoclastic and oligomictic lithology of lime-mudstone clasts, jigsaw-fit (mosaic) fabric, edgewise fabric, and a gradual transition from the underlying bed (Table 1). Autoclastic and oligomictic lithologies may be indicative of subsurface brecciation (fragmentation). Consolidation of lime-mudstone clasts pre-requisite for brecciation may result from dissolution and reprecipitation of CaCO3 by degradation of organic matter during burial. Jigsaw-fit fabric has been considered as evidence for in situ fragmentation. The edgewise fabric is most likely formed by expulsion of pore fluid during compaction. The lower boundary of intraformational conglomerates of depositional origin is commonly sharp and erosional. In contrast, diagenetic conglomerate layers mostly show a gradual transition from the underlying unit, which is indicative of progressive fragmentation upward (Fig. 1). The underlying fractured limestone layer also shows evidence for in situ fragmentation such as jigsaw-fit fabric and the same lithology as the overlying conglomerate layer (Fig, 1). Evidence from the conglomerate beds in the Chosen Supergroup suggests that diagenetic conglomerates are formed by in situ subsurface fragmentation of limestone layers and rounding of the fragments. In situ subsurface fragmentation may be primarily due to compaction, dewatering (upward-moving pore fluids), and dissolution, accompanying volume reduction. This process commonly occurs under the conditions of (1) alternating layers of carbonate-rich and carbonate-poor sediments and (B) early differential cementation of carbonate-rich layers. Differential cementation commonly takes place between alternating beds of carbonate-rich and clay-rich layers, because high carbonate content promotes cementation, whereas clay inhibits cementation. After deposition of alternating beds and differential cementation, with progressive burial, upward-moving pore fluid may raise pore-pressure in the upper part of limestone layers, due to commonly overlying impermeable shale layers (or beds). The high pore-pressure may reinforce propagation of fragmentation and cause upward-expulsion of pore fluid which probably produces edgewise fabric of tabular clasts. The fluidized flow then extends laterally, causing reorientation and further rounding of clasts. This process is analogous to that of autobrecciation, which can be analogously termed autoconglomeration. This is a fragmentation and rounding process whereby earlier semiconsolidated portions of limestone are incorporated into still fluid portions. The rounding may be due mainly to immiscibility and surface tension of lime-mud. The progressive rounding of the fragmented clasts probably results from grain attrition by fluidized flow. A synthetic study of limestone conglomerate beds in the Chosen Supergroup suggests that very small percent of the conglomerate layers are of depositional origin, whereas the rest, more than $80\%$, are of diagenetic origin. The common occurrence of diagenetic conglomerates warrants further study on limestone conglomerates elsewhere in the world.

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한국의 배기량별 평균 CO2 배출량을 고려한 자동차세의 적정 세율 분석 (Analysis of Appropriate Automobile Tax Rate Considering the Average CO2 Emissions by Engine Displacement in Korea)

  • 최현우;정민경;장현우;김동구
    • 자원ㆍ환경경제연구
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    • 제32권4호
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    • pp.217-238
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    • 2023
  • 현재 한국의 자동차세는 자동차의 배기량에 일정 세율을 곱해 부과된다. 그러나 현행 제도는 온실가스 감축이라는 당면 과제를 반영하지 못하고 있다는 지적을 받으며 개정의 필요성이 제기되고 있다. 이에 본 연구는 배기량과 CO2 배출량 간 확인되는 양의 관계에 주목하여, 평균 CO2 배출량을 고려한 자동차세의 적정 세율을 산출하고자 한다. 이를 위해 우선, 2020년 기준으로 자동차 배기량별 평균 CO2 배출량을 이용해 배기량별 연간 평균 CO2 배출량(kg/대) 을 추정하였다. 여기에 IMF(2019)가 제안한 CO2 배출량 1톤당 75달러를 기준세율로 고려해 복수의 시나리오를 분석했다. 특히, 균일한 75달러의 탄소세를 부과했을 때와 배기량별 CO2 배출량에 기반해 누진세를 부과했을 때를 비교했다. 분석 결과에 의하면, IMF가 제안한 기준세율을 한국에 그대로 적용하는 것은 세수 감소 등의 영향으로 쉽지 않으며, 현행 자동차세에 따른 세수 규모 유지, 온실가스 감축효과, 선진국의 자동차세 개편 동향 등을 고려해 정교하게 설계해야 한다는 점을 확인했다. 예를 들어, 한국에서 판매되는 대표적인 소형차량인 기아자동차의 K3(1,598cc)를 기준으로 현행 제도와 비교해보면, 현행 제도에서는 약 22만 원, IMF에 따른 동일세율과 누진세 부과 시에는 각각 약 7.9만 원과 약 8.3만 원, 영국 자동차세를 참고한 누진세 부과 시에는 약 24만 원 정도의 세금을 납부하게 된다. 이처럼 본 연구는 한국의 자동차 등록 현황 및 자동차세 현황, 주요 선진국의 자동차세 개편 동향을 파악해 차량 배기량과 CO2 배출량을 고려한 자동차 세제 개편의 영향을 국민의 조세부담을 중심으로 분석하였다.

Sarcopenia: Nutrition and Related Diseases

  • Du, Yang;No, Jae Kyung
    • 한국조리학회지
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    • 제23권1호
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    • pp.66-78
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    • 2017
  • "Sarcopenia", sarcopenia is an old age syndrome, and used to describe the reduction of skeletal muscle. Initially, it was thought that sarcopenia was only a senile disease characterized by degeneration of muscle tissue. However, its cause is widely regarded as multifactorial, with neurological decline, hormonal changes, inflammatory pathway activation, declines in activity, chronic illness, fatty infiltration, and poor nutrition, all shown to be contributing factors. Skeletal muscle mass can be measured by a variety of methods, currently, the commonly used methods are dual-energy X-ray scanning (DXA), computer tomography (CT), magnetic resonance imaging (MRI), etc. Muscular skeletal disorders can also be assessed by measuring appendicular skeletal muscle (ASM), particularly muscle tissue content. At the same time, sarcopenia refers to skeletal muscle cell denervation, mitochondrial dysfunction, inflammation, hormone synthesis and secretion changes and a series of consequences caused by the above process and is a progressive loss of skeletal muscle syndrome, which can lead to the decrease of muscle strength, physical and functional disorders, and increase the risk of death. Sarcopenia is mainly associated with the aging process, but also related to other causes such as severe malnutrition, neurodegenerative diseases, and disuse and endocrine diseases associated with muscular dystrophy, and it is the comprehensive results of multi-factors, so it is difficult to define that sarcopenia is caused by a specific disease. With the aging problem of the population, the incidence of this disease is increasingly common, and seriously affects the quality of the life of the elderly. This paper reviews the etiology and pathogenesis of myopathy, screening methods and diagnosis, the influence of eating habits, etc, and hopes to provide reference for the diagnosis and treatment of this disease. At present, adequate nutrition and targeted exercise remain the gold standard for the therapy of sarcopenia.

콘크리트 재료손상에 대한 유한요소상의 의미 (Numerical Implication of Concrete Material Damage at the Finite Element Levels)

  • 이인규;노영숙;김우
    • 콘크리트학회논문집
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    • 제18권1호
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    • pp.37-46
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    • 2006
  • 재료구성관계의 범위에서의 강성 성능저하의 스펙트럼 특성을 기본 유한요소법을 이용하여 개별 유한요소와 그의 조합행렬에 대한 스펙트럼 분석을 상호 비교하여 수치적인 의미를 확인하고자 한다. 본 논문의 주 관심부분은 탄성 강성특성의 저하로 인한 콘크리트 재료의 손상정도를 다양한 스펙트럼 특성인 최소고유치의 변화, 유효계수의 변화 등의 시나리오를 가지고 해의 유일성 여부, 특이성의 표현 여부 그리고 변분유계와의 근접여부 등을 관찰하였다. 1차원 및 2차원 예제가 제시되었으며 강성이 서로 다른 혼입재를 가진 2상복합체의 형식으로 콘크리트의 골재, 매트릭스를 표현하고 상호연관성 및 기하학적 영향을 고려하였다. 더불어 2차원 탄성계면요소를 이용하여 골재와 매트릭스 사이에 존재하는 약한 고리인 계면을 묘사하고 이들 계면의 탄성계수의 성능저하로 인한 전체 구조계의 영향 등을 분석, 비교하였다.

대두분 품질에 미치는 가열처리조건에 관한 연구 (Studies on the effect of heating conditions on the quality of soybean flours)

  • 이성갑;김준평
    • 기술사
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    • 제17권4호
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    • pp.28-39
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    • 1984
  • Experiments were carried out for the development of a processing method of soybean into full-fat or defatted flour, using two varieties of soybean (kwangkyo produced in Korea and Bragg produced in India) Samples were subjected to dry dehulling, size reduction and wet heat treatment processes to make soybean flours. The quality of soybean flours were evaluated, and the results obtained were summarized as follows. 1. Crude fiber content of dehulled soybean was under 3.0% which indicated satisfactory dehulling, and there was no significant difference in crude fibre content between two varieties. 2. When dehulled soybean was cracked into soy grits by a hammer mill, 98.71∼98.86% of the soy grit was in the range of 10∼18 mesh which was the optimum size of particle for quick and uniform penetration of heat into the intra-particle air spaces. 3. Moisture content of soy flour after steam treatment at 15 psig for 5 to 30 min was only 0.29∼1.68% which did not hinder the next milling operation. 4. From the color analysis of soy flours, it was observed that the dominant wavelength for all the samples are in a very narrow range from 575 to 581 nm and the color variation was from yellow to yellowish orange. Twenty to twenty five % higher reflectance was observed in the defatted flours than full fat flours. The % chroma of the defatted flour slightly increased as the duration of steaming of soy grits increased, whereas that of the full-fat flour did not. 5. The protein extractability in the defatted flour at pH 7.6 showed progressive decrease in solubility from 48.40% (Bragg), 75.20% (kwangkyo) for untreated flours to 9.75% (Bragg), 26.27% (kwangkyo) for 30 min steaming. But Kwangkyo variety showed twice higher protein extractability than Bragg variety.

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다시점 비디오 부호화를 위한 개선된 예측 구조와 움직임 추정 기법 (Improved Prediction Structure and Motion Estimation Method for Multi-view Video Coding)

  • 윤효순;김미영
    • 정보과학회 논문지
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    • 제41권11호
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    • pp.900-910
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    • 2014
  • 다시점 비디오는 하나의 3차원 장면을 여러 시점에서 다수의 카메라로 촬영 영상으로 다시점 비디오 부호화의 계산량은 카메라 수에 비례하여 증가한다. 본 논문에서는 다시점 비디오 부호화의 계산량을 줄이면서 영상 화질을 유지하는 예측 구조와 움직임 추정 기법을 제안한다. 제안한 개선된 예측 구조는 B계층 최대 인덱스 그리고 각 Bi계층의 화면수를 고려하였다. 제안한 움직임 추정 기법은 계층적인 탐색 기법으로 수정된 다이아몬드 탐색 패턴, 점진적인 다이아몬드 탐색 패턴 그리고 수정된 래스터 탐색 패턴으로 구성된다. 제안한 예측 구조와 움직임 추정 기법의 성능을 Fraunhofer-HHI의 계층적 B화면 구조와 TZ 움직임 추정 기법을 사용한 JMVC 참조 모델의 성능과 비교한 경우, 영상 화질과 발생 비트량은 비슷하지만 다시점 비디오 부호화의 계산량을 40~70% 줄인다.