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Sarcopenia: Nutrition and Related Diseases

  • Du, Yang (Dept. of Food & Nutrition, Kyungsung University) ;
  • No, Jae Kyung (Dept. of Food & Nutrition, Kyungsung University)
  • Received : 2017.01.04
  • Accepted : 2017.01.23
  • Published : 2017.01.31

Abstract

"Sarcopenia", sarcopenia is an old age syndrome, and used to describe the reduction of skeletal muscle. Initially, it was thought that sarcopenia was only a senile disease characterized by degeneration of muscle tissue. However, its cause is widely regarded as multifactorial, with neurological decline, hormonal changes, inflammatory pathway activation, declines in activity, chronic illness, fatty infiltration, and poor nutrition, all shown to be contributing factors. Skeletal muscle mass can be measured by a variety of methods, currently, the commonly used methods are dual-energy X-ray scanning (DXA), computer tomography (CT), magnetic resonance imaging (MRI), etc. Muscular skeletal disorders can also be assessed by measuring appendicular skeletal muscle (ASM), particularly muscle tissue content. At the same time, sarcopenia refers to skeletal muscle cell denervation, mitochondrial dysfunction, inflammation, hormone synthesis and secretion changes and a series of consequences caused by the above process and is a progressive loss of skeletal muscle syndrome, which can lead to the decrease of muscle strength, physical and functional disorders, and increase the risk of death. Sarcopenia is mainly associated with the aging process, but also related to other causes such as severe malnutrition, neurodegenerative diseases, and disuse and endocrine diseases associated with muscular dystrophy, and it is the comprehensive results of multi-factors, so it is difficult to define that sarcopenia is caused by a specific disease. With the aging problem of the population, the incidence of this disease is increasingly common, and seriously affects the quality of the life of the elderly. This paper reviews the etiology and pathogenesis of myopathy, screening methods and diagnosis, the influence of eating habits, etc, and hopes to provide reference for the diagnosis and treatment of this disease. At present, adequate nutrition and targeted exercise remain the gold standard for the therapy of sarcopenia.

Keywords

References

  1. Abdulamee, S. A., Sulaiman, S. A., Hassali, M. A., Subramaniam, K., & Sahib, M. N. (2012) Osteoporosis and type 2 diabetes mellitus: What do we know, and what we can do? Patient Prefer Adherence, 6, 435-448.
  2. Antico, A,. Tampoia, M,. Tozzoli, R., & Bizzaro, N. (2012) Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev, 12(2), 127-136 https://doi.org/10.1016/j.autrev.2012.07.007
  3. Ascherio, A,. Munger, K., & Simon, K. C. (2010) Vitamin D and multiple sclerosis. Lancet Neurol, 9(6), 599-612. https://doi.org/10.1016/S1474-4422(10)70086-7
  4. Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., & Sayer, A. A. (2012) The age-related increase in lowgrade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell, 11(5), 912-915. https://doi.org/10.1111/j.1474-9726.2012.00849.x
  5. Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P,. Baylis, D., Syddall, H., & Sayer, A. A. (2012). The age-related increase in lowgrade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell, 11(5), 912-915. https://doi.org/10.1111/j.1474-9726.2012.00849.x
  6. Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., & Garry, P. J. (1998). Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 147(8), 755-763. https://doi.org/10.1093/oxfordjournals.aje.a009520
  7. Bijlsma, A. Y., Meskers, C. G., Westendorp, R. G., & Maier, A. B. (2012) Chronology of age-related disease definitions: Osteoporosis and sarcopenia. Ageing Res Rev, 11, 320-324. https://doi.org/10.1016/j.arr.2012.01.001
  8. Bischoff-Ferrari, H. A., Dawson-Hughes B., & Staehelin, H. B. (2009). Fall prevention with supplemental and active forms of vitamin D: A meta-analysis of randomised controlled trials. British Medical Journal, 339, Article ID b3692.
  9. Bossola, M., Muscaritoli, M., Costelli, P., Bellantone, R., Pacelli, F., Busquets, S., & Argiles, J. (2001). Increased muscle ubiquitin mRNA leVels in gasmc cancer patients. Am J Physiol Regul Integr Comp Physiol, 280(5), 1518-1523. https://doi.org/10.1152/ajpregu.2001.280.5.R1518
  10. Bossola, M., Muscaritoli, M., Costelli, P., Grieco, G., Bonelli, G., Pacelli, F. R., & Fanelli, F. (2003). Increased muscle proteasome activity correlates wim disease severity in gasic cancer patients. Arul Sung, 237(3), 384-389.
  11. Brandt, C., Nielsen, A. R., Fischer, C. P., Hansen, J., Pedersen, B. K., & Plomgaard, P. (2012). Plasma and muscle myostatin in relation to type 2 diabetes. PLoS One, 7(5), e37236. https://doi.org/10.1371/journal.pone.0037236
  12. Calder, P. C. (2006). n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. American Journal of Clinical Nutrition, 83(suppl. 6), 1505S-1519S. https://doi.org/10.1093/ajcn/83.6.1505S
  13. Campbell, W. W., Barton, M. L. Jr., Cyr-Campbell, D., Davey, S. L., Beard, J. L., Parise, G., & Evans, W. J. (1999). Effects of an omnivorous diet comdared with a 1actoovovegetarian diet on resistance-training-induced charlges inbody composition and skeletal muscle in older men. Am J Clin Nutr, 70(6), 1032-1039. https://doi.org/10.1093/ajcn/70.6.1032
  14. Canaff, L., & Hendy, G. N. (2002). Human calcium-sensing receptor gene vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem, 277(33), 30337-30350. https://doi.org/10.1074/jbc.M201804200
  15. Castaneda, C., Charnley, J. M., Evans, W. J., & Crim, M. C., (1995). Elderly women accommodate to a low-protein diet with losses ofbody cell mass, muscle function, and immune response. Am J Clin Nutr, 62(1), 30-39. https://doi.org/10.1093/ajcn/62.1.30
  16. Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., & Martin, F. C. (2010). European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: Report of the European working group on sarcopenia in older People. Age Ageing, 39(4), 412-423. https://doi.org/10.1093/ageing/afq034
  17. Daniel, B., Gladys, B., Laura, L., Vivien, G., Maria, Pia, de, la, M., Marcelo, A., & Sandra, H. (2006). Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Experimental Gerontology, 41(8), 746-752. https://doi.org/10.1016/j.exger.2006.05.001
  18. Delmonico, M. J., Harris, T. B., Lee, J.-S., Visser, M., Nevitt, M., Kritchevsky, S. B., & Tylavsky, F. A. (2007). Altemative dennitions of sarcopenia, lower extremity perfbrmance, and functional impairment with aging in older men and women. J Am Geriatr Soc, 55(5), 769-774. https://doi.org/10.1111/j.1532-5415.2007.01140.x
  19. Di, I. A., Abate, M., Di, Renzo, D., Russolillo, A., Battaglini, C., Ripari P., & Saggini, R. (2006). Sarcopenia: Age-related skeletal musclechanges from determinants to physical disability. Int J Immunopathol Pharmacol, 19(4), 703-719. https://doi.org/10.1177/039463200601900401
  20. Dreyer, H. C., & Volpi, E. (2005). Role of protein and amino acids in the pathophysiology and treatment of sarcopenia. J Am Coll Nutr, 24(2), 140S-145S. https://doi.org/10.1080/07315724.2005.10719455
  21. Dutra, D. B., Bueno, P. G., Silva, R. N., Nakahara, N. H., Selistre-Araujo, H. S., Nonaka, K. O., & Leal, A. M. (2012). Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise. Clin Exp Pharmacol Physiol, 39(5), 417-422. https://doi.org/10.1111/j.1440-1681.2012.05690.x
  22. Ensrud, K. E., Blackwell, T. L., Cauley, J. A., Cummings, S. R., Barrett-Connor, E., Dam, T. T., & Hoffman, A. R. (2011). Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study. J Am Geriatr Soc, 59(1), 101-106. https://doi.org/10.1111/j.1532-5415.2010.03201.x
  23. Ensrud, K. E., Ewing, S. K., Fredman, L., Hochberg, M. C., Cauley, J. A., Hillier, T. A., & Cummings, S. R. (2010). Circulating 25-hydroxyvitamin D levels and frailty status in older women. J Clin Endocrinol Metab, 95(12), 5266-5273. https://doi.org/10.1210/jc.2010-2317
  24. Fielding, R. A. I., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan, van Kan, G., & Andrieu, S. (2011). Sarcopenia: An undiagnosed condition in oIder adults. Current consensus de6nition: prevalence, etiology' and consequences. Intemational working group on sarcopenia. J Am Med Dir Assoc, 12(4), 249-256. https://doi.org/10.1016/j.jamda.2011.01.003
  25. Glerup, H., Mikkelsen, K., Poulsen, L., Hass, E., Overbeck, S., Andersen, H., & Charles, P. (2000). Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Int, 66(6), 419-424. https://doi.org/10.1007/s002230010085
  26. Grimby, G., & Saltin, B. (1983). The ageing muscle. Clin Physiol, 3(3), 209-218. https://doi.org/10.1111/j.1475-097X.1983.tb00704.x
  27. Ha, L., Hauge, T., Spenning, A. B., & Iversen, P. O. (2010). Individual, nutritional support prevents undernutrition, increases muscle strength and improves QoL among elderly at nutritional risk hospitalized for acute stroke: A randomized, controlled trial. Clinical Nutrition, 29(5), 567-573. https://doi.org/10.1016/j.clnu.2010.01.011
  28. Han, K., Park, Y. M., Kwon, H. S., Ko, S. H., Lee, S. H., Yim, H. W., & Lee, W. C. (2014). Sarcopenia as a determinant of blood pressure in older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008-2010. PLoS ONE, 9(1), e86902. https://doi.org/10.1371/journal.pone.0086902
  29. Han, T., Tajar, A., & Lean, M. (2011). Obesity and weight management in the elderly. Br Med Bull, 97(1), 169-196. https://doi.org/10.1093/bmb/ldr002
  30. Houston, D. K., Stevens, J., Cai J., & Haines, P. S. (2005). Dairy, fruit, and vegetable intakes and functional limitations and disability in a biracial cohort: the atherosclerosis risk in communities study. American Journal of Clinical Nutrition, 81(2), 515-522. https://doi.org/10.1093/ajcn.81.2.515
  31. Iritani, S., Imai, K., Takai, K., Hanai, T., Ideta, T., Miyazaki, T., & Suetsugu, A. (2014). Skeletal muscle depletion is an independent prognostic factor for hepatocellular carcinoma. Journal of Gastroenterology, 50(3), 323-332. https://doi.org/10.1007/s00535-014-0964-9
  32. Janssen, I., Baumgartner, R. N., Ross, R., Rosenberg, I. H., & Roubenoff, R. (2004). Skeletal muscle cutpoints associated with elevated physical disabili risk in older menand women. Am J Epidemiol, 159(4), 413-421. https://doi.org/10.1093/aje/kwh058
  33. John, A. B., Todd, A. M., Jonathan, D. J., Francisco, L.-J., & Stephen, J. B. (2016). Sarcopenia, sarcopenic obesity and inflammation: Results from the 1999-2004. National Health and Nutrition Examination Survey Clinical Nutrition, 35(6), 1472-1483.
  34. Kaiser, M., Bandinelli, S., & Lunenfeld, B. (2010). Frailty and the role of nutrition in older people. A review of the current literature. Acta Biomedica, 81(suppl. 1), 37-45.
  35. Kalyani, R. R., Metter, E. J., Egan, J., Golden, S. H., & Ferrucci, L. (2015). Hyperglycemia predicts persistently lower muscle strength with aging. Diabetes Care, 38(1), 82-90. https://doi.org/10.2337/dc14-1166
  36. Kim, T. N., & Choi, K. M. (2013). Sarcopenia: Definition, epidemiology, and pathophysiology. J Bone Metab, 20(1), 1-10. https://doi.org/10.11005/jbm.2013.20.1.1
  37. Kimbau, S. R., & Jefferson, L. S. (2006) Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr, 136, 227S-231S. https://doi.org/10.1093/jn/136.1.227S
  38. Kim, K. M., Lim, S., Choi, S. H., Kim, J. H., Shin, C. S., Park, K. S., & Jang, H. C. (2014). Cardiometabolic implication of sarcopenia: The Korea National Health and Nutrition Examination Study (KNHANES) 2008-2010. Metabolic & Endocrine, 4, 63-69. https://doi.org/10.1016/j.ijcme.2014.06.001
  39. Lee, J. E., Kim, K. W., Paik, N. J., Jang, H. C., Chang, C. B., Baek, G. H., & Lee, Y. H. (2012). Evaluation of factors influencing grip strength in elderly Koreans. J Bone Metab, 19(2), 103-10. https://doi.org/10.11005/jbm.2012.19.2.103
  40. Liu C. J., & Latham, N. K. (2009). Progressive resistance strength training for improving physical function in older adults. Cochrane Database of Systematic Reviews, 3, Article ID CD002759.
  41. Leenders, M., Verdijk, L. B., van der Hoeven, L., Adam, J. J., van Kranenburg, J., Nilwik, R., & van Loon, L. J., (2013). Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging. J Am Med Dir Assoc, 14(8), 585-592. https://doi.org/10.1016/j.jamda.2013.02.006
  42. Lexell, J. (1993). Ageing and human muscle: Observations from Sweden. Canadian Journal of Applied Physiology, 18(1), 2-18. https://doi.org/10.1139/h93-002
  43. Liu, C. J., & Latham, N. K., (2009). Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst, 8(3), CD002759.
  44. Lu, Y., & Chen, Q. (2014). Department of hepatobiliary surgery, clinical nutrition center, clinical nutrition and metabolism key laboratory. Chin J Clinicians, 8(24), 4454-4457.
  45. Lopes, N., Paredes, J., Costa, J. L., Ylstra, B., & Schmitt, F. (2012). Vitamin D and the mammary gland: A review on its role in normal development and breast cancer. Breast Cancer Res, 14(3), 211. https://doi.org/10.1186/bcr3178
  46. Maki, T., Yamamoto, D., Nakanishi, S., Iida, K., Iguchi, G., Takahashi, Y., Kaji, H., & Chihara, K. (2012). Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats. Nutr Res, 32(9), 676-683. https://doi.org/10.1016/j.nutres.2012.07.005
  47. Mayer, O. Jr., Filipovsky, J., Seidlerova, J., Vanek, J., Dolejsova, M., Vrzalova, J., & Cifkova, R. (2012). The association between low 25-hydroxyvitamin D and increased aortic stiffness. J Hu Hypertens, 26(11), 650-655. https://doi.org/10.1038/jhh.2011.94
  48. Mitsiopoulos, N., Baumgartner, R. N., Heymsfield, S. B., Lyons, W., Gallagher, D., & Ross, R. (1998). Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol, 85(1), 115-122. https://doi.org/10.1152/jappl.1998.85.1.115
  49. Moller, N., Copeland, K. C., & Nair, K. S. (2007). Growth hormone and protein metabolism. Endocrinol Metab Clin North Am, 36(1), 89-100. https://doi.org/10.1016/j.ecl.2006.11.001
  50. Morgan, E. C., Charlotte, S., Michael, J. C., Per, A., Abigail, M., Michael, K., & Irina, C. (2009). Molecular aging and rejuvenation of human muscle stem cells. EMBO Mol Med, 1(8/9), 381-391. https://doi.org/10.1002/emmm.200900045
  51. Morgan, E. C., Charlotte, S., Michael, J. C., Per, A., Abigail, M., Michael, K., & Irina, C. (2009). Molecular aging and rejuvenation of human muscle stem cells. EMBO Mol Med, 1(8/9), 381-391. https://doi.org/10.1002/emmm.200900045
  52. Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E., & Doehner, W. (2010). Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc, 1l(6), 391-396. https://doi.org/10.1016/j.jamda.2010.04.014
  53. Nair, L., Joana, P., Jose, Luis, C., Bauke, Y., & Fernando, S. (2012). Vitamin D and the mammary gland: A review on its role in normal development and breast cancer. Breast Cancer Research, 14, 211. https://doi.org/10.1186/bcr3178
  54. Newton, R. L., Alfonso, A., White, M. A., York-Crowe, E., Walden, H., Ryan, D., & Bray, G. A. (2005). Precent body fat measured by BIA and DEXA in obese, African-American adolescent girls. Int J Obes, 29(6), 594-602. https://doi.org/10.1038/sj.ijo.0802968
  55. Nieuwenhuizen, W. F., Weenen, H., Rigby, P., & Hetherington, M. M. (2010). Older adults and patients in need of nutritional support: Review of current treatment options and factors influencing nutritional intake. Clinical Nutrition, 29(2), 160-169. https://doi.org/10.1016/j.clnu.2009.09.003
  56. Oliveira, A., & Vaz, C. (2015) The role of sarcopenia in the risk of osteoporotic hip fracture. Clin Rheumatol, 34(10), 1673-1680. https://doi.org/10.1007/s10067-015-2943-9
  57. Park, M. S., Suh, Y. S., & Chung, Y.-J. (2014). Comparison of chronic disease risk by dietary carbohydrate energy ratio in Korean elderly: Using the 2007-2009. Korea National Health and Nutrition Examination Survey J Nutr Health, 47(4), 247-257.
  58. Park, S. W., Goodpaster, B. H., Lee, J. S., Kuller, L. H., Boudreau R., de, Rekeneire, N., & Harris, T. B. (2009). Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care, 32(11), 1993-1997. https://doi.org/10.2337/dc09-0264
  59. Pfeifer, M., Begerow, B., Minne, H. W., Abrams, C., Nachtigall, D., & Hansen, C. (2000). Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res, 15(6), 1113-1118. https://doi.org/10.1359/jbmr.2000.15.6.1113
  60. Pfeifer, M., Begerow, B., & Minne, H. W. (2002). Vitamin D and muscle function. Osteoporos Int, 13(3), 187-194. https://doi.org/10.1007/s001980200012
  61. Rebecca, K. Y., Elsa, S. S., Helaine, E. R., Deborah, E. S., Kenneth, R. F., Jane, A. C., & Eric, V. (2013). Diabetes and risk of hospitalized fall injury among older adults. Diabetes Care, 36(12), 3985-3991. https://doi.org/10.2337/dc13-0429
  62. Richard, D. S., Stefania, B., Kai, S., Jack, M. G., & Luigi, F. (2010). Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: The In CHIANTI study. Eur J Appl Physiol, 8(1), 191-195.
  63. Roberts, H., Lowry, A., & Sayer, A. (2014) Assessment and management of older people with sarcopenia. Nurs Older People, 26(5), 18-22. https://doi.org/10.7748/nop.26.5.18.e556
  64. Robinson, S., Syddall, H., Jameson, K., Batelaan, S., Martin, H., Dennison, E. M., & Cooper, C. (2009). Current patterns of diet in community-dwelling older men and women: Results from the Hertfordshire cohort study. Age and Ageing, 38(5), 594-599. https://doi.org/10.1093/ageing/afp121
  65. Roma, K.-S., Natasza, C., Aleksandra, S., Lechoslaw, B. D., Anna, F., Beata, M.-D., & Katarzyna, W.-T. (2014). The significance of body mass index in calculating the cut-off points for low muscle mass in the elderly. Methodological Issues Volume Article, ID 4503968.
  66. Semba, R. D., Bartali, B., Zhou, J., Blaum, C., Ko, C. W., & Fried, L. P. (2006). Low serum micronutrient concentrations predict frailty among older women living in the community. The Journals of Gerontology Series A, 61(6), 594-599. https://doi.org/10.1093/gerona/61.6.594
  67. Stafford, M., Hemingway, H., Stansfeld, S. A., Brunner, E., & Marmot, M. (1998). Behavioural and biological correlates of physical functioning in middle aged office workers: The UK whitehall II study. Journal of Epidemiology and Community Health, 52(6) 353-358. https://doi.org/10.1136/jech.52.6.353
  68. Shioi, T., McMullen, J. R., Tarnavski, O., Converso, K., Sherwood, M. C., Manning, W. J., & Izumo, S. (2003). Rapamycin anenuates load-induced cardiac hypenrophy in mice. Circulation, 107(12), 1664-1670. https://doi.org/10.1161/01.CIR.0000057979.36322.88
  69. Snijder, M. B., van, Schoor, N. M., Pluijm, S. M., van, Dam, R. M., Visser, M., & Lips, P. (2006). Vitamin D status in relation to one-year risk of recurrent falling in older men and women. J Clin Endocrinol Metab, 91(8), 2980-2985. https://doi.org/10.1210/jc.2006-0510
  70. Sunil, K., Sruti, J., Siva, K., Lalit, M., & Kirtikumar, M. (2012). Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women. Vojnosanit Pregl, 69(3), 243-248. https://doi.org/10.2298/VSP1203243V
  71. Santilli, V., Bernetti, A., Mangone, M., & Paoloni, M. (2014). Clinical definition of sarcopenia. Clin Cases Miner Bone Metab, 11(3), 177-180.
  72. Salo, A., & Logomarsino, J. V. (2011). Relationship of vitamin D status and cardiometabolic risk factors in children and adolescents. Pediatr Endocrinol Rev, 9(1), 456-462.
  73. Symons, T. B., Sheffield-Moore, M., Mamerow, M. M., Wolfe, R. R., & Paddon-Jones, D. (2010). The anabolic response to resistance exercise and a protein-rich meal is not diminished by age. Journal of Nutrition, Health and Aging, 15(5), 376-381. https://doi.org/10.1007/s12603-010-0319-z
  74. Tang, B. M., Eslick, G. D., Nowson, C., Smith, C., & Bensoussan, A. (2007). Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: A meta-analysis. Lancet, 370(9588), 657-666. https://doi.org/10.1016/S0140-6736(07)61342-7
  75. Tomey, K. M., Sowers, M. R., Crandall, C., Johnston, J., Jannausch, M., & Yosef, M. (2008). Dietary intake related to prevalent functional limitations in midlife women. American Journal of Epidemiology, 167(8), 935-943. https://doi.org/10.1093/aje/kwm397
  76. Visser, M., Pluijm, S. M., Stel, V. S., Bosscher, R. J., & Deeg, D. J. (2002). Physical activity as a determinant of change in mobility performance: The longitudinal aging study Amsterdam. J Am Geriatr Soc, 50(11), 1774-1781. https://doi.org/10.1046/j.1532-5415.2002.50504.x
  77. Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002). Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: The health, aging and body composition study. J Am Geriatr Soc, 50(5), 897-904. https://doi.org/10.1046/j.1532-5415.2002.50217.x
  78. Visser, M., Deeg, D. J. H., Lips, P. (2003). Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The longitudinal aging study Amsterdam. J Clin Endocrinol Metab, 88(12), 5766-5772. https://doi.org/10.1210/jc.2003-030604
  79. Wang, X., Hu, Z., Hu, J., Du, J., & Mitch, W. E. (2006). Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology, 47(9), 4160-4168.
  80. Wicherts, I. S., van, Schoor, N. M., Boeke, A. J., Visser, M., Deeg, D. J., Smit, J., & Knol, D. L. (2007). Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab, 92(6), 2058-2065. https://doi.org/10.1210/jc.2006-1525
  81. Wilson, M. M., & Morley, J. E., (2003). Invited review: Aging and energy balance. J Appl Physiol, 95(4), 1728-1736. https://doi.org/10.1152/japplphysiol.00313.2003
  82. Woong, S. H., & Choi, H. (2012). Sarcopenia's clinical and physiopathological mechanism of sarcopenia. The Korean Association of Internal Medicine, 83(4), 444-454.