• Journal of the Korean earth science society
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• v.26 no.5
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• pp.387-394
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• 2005

We have analyzed the science-gifted educational program (year 2002) at the Seoul National University in terms of its educational objectives, scientific models, and cognitive processes in scientific inquiry in order to provide insights into developing and improving science-gifted educational program. We assumed the following items as important factors for teaching scientifically gifted students: higher-order thinking skills involving synthesis domain in the educational objectives, highly abstract nature and complexity in the scientific models, cognitive processes of planning experiments in the cognitive processes in scientific inquiry. According to the analyzed results, the program has the following characteristics: (1) the rates of both higher and lower-order thinking skill domain in the educational objectives are similarly high, but the rate of synthesis domain is relatively low; (2) in the case of the scientific models, the rate of the multiple concepts and/or processes model is relatively low, while the level of the abstractness is relatively on average (3) cognitive processes of authentic scientific inquiry is not thoroughly reflected in the scientific inquiry activities, and very few cognitive processes of planning experiments factor is reflected. Therefore, we conclude in the synthesis domain in the educational objectives, multiple concepts and/or processes model, and cognitive processes of planning experiments should be especially reflected more on the science-gifted educational program in order to serve the needs of scientifically gifted students.

• Bulletin of the Korean Chemical Society
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• v.34 no.7
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• pp.1972-1984
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• 2013

Microtubules play an important role in intracellular transport, mobility, and particularly mitosis. Paclitaxel (Taxol$^{TM}$) and paclitaxel-like compounds have been shown to be anti-tumor agents useful for various human tumors. Paclitaxel-like compounds operate by stabilizing microtubules through interface binding at the interface between two ${\beta}$-tubulin monomers in adjacent protofilaments. In this paper we present the elucidation of the structural features of paclitaxel and paclitaxel-like compounds (e.g., epothilones) with microtubule stabilizing activities, and relate their activities to spatial and chemical features of the molecules. CATALYST program was used to generate three-dimensional quantitative structure activity relationships (3D-QSARs) resulting in 3D pharmacophore models of epothilone- and paclitaxel-derivatives. Pharmacophore models were generated from diverse conformers of these compounds resulting in a high correlation between experimental and predicted biological activities (r = 0.83 and 0.91 for epothilone and paclitaxel derivatives, respectively). On the basis of biological activities of the training sets, five- and four-feature pharmacophore hypotheses were generated in the epothilone and paclitaxel series. The validation of generated hypotheses was achieved by using twelve epothilones and ten paclitaxels, respectively, which are not in the training sets. The clustering (grouping) and merging techniques were used in order to supplement spatial restrictions of each of hypothesis and to develop more comprehensive models. This approach may be of use in developing novel inhibitor candidates as well as contributing a better understanding of structural characters of many compounds useful as anticancer agents targeting microtubules.

• The Korean Journal of Pain
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• v.33 no.2
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• pp.121-130
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• 2020

Background: Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory pain models. Methods: TENS 60 Hz, 200 ㎲, 90% motor threshold (MT), SCS was applied at 60 Hz, an intensity of 90% MT, and a 0.25 ms pulse width. MA was performed by inserting a stainless-steel needle to a depth of about 4-5 mm at the Sanyinjiao (SP6) and Zusanli (ST36) acupoints on a spared nerve injury (SNI), knee joint inflammation (3% carrageenan), and non-inflammatory muscle pain (intramuscular pH 4.0 injections) in rats. Mechanical withdrawal thresholds of the paw, muscle, and/or joint were assessed before and after induction of the pain model, and daily before and after treatment. Results: The reduced withdrawal thresholds were significantly reversed by application of either TENS or SCS (P < 0.05). MA, on the other hand, increased the withdrawal threshold in animals with SNI and joint inflammation, but not chronic muscle pain. Conclusions: TENS and SCS produce similar effects in neuropathic, inflammatory and non-inflammatory muscle pain models while MA is only effective in inflammatory and neuropathic pain models.

• The Research Journal of the Costume Culture
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• v.25 no.3
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• pp.270-284
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• 2017

This study aimed to create 3D-printed insoles for flat-footed senior men using 3D systems. 3D systems are product-manufacturing systems that use 3-dimensional technologies like 3D scanning, 3D modeling, and 3D printing. This study used a 3D scanner (NexScan2), 3D CAD programs including Rapidform, AutoCAD, SolidWorks, Nauta+ compiling program, and a 3D printer. In order to create insoles for flat-footed senior men, we analyzed horizontal sections of 3D foot scans We selected 20 flat-footed and 20 normal-footed subjects. To make the 3D insole models, we sliced nine lines on the surface of the subjects' 3D foot scans, and plotted 144 points on the lines. We calculated the average of these 3D coordinates, then located this average within the 3D space of the AutoCAD program and created 3D sole models using the loft surface tools of the SolidWorks program. The sole models for flat feet differed from those of normal feet in the depth of the arch at the inner sideline and the big toe line. We placed the normal-footed sole model on a flat-footed sole model, and the combination of the two models resulted in the 3D insole for flat feet. We printed the 3D modeled insole using a 3D printer. The 3D printing material was an acrylic resin similar to rubber. This made the insole model flexible and wearable. This study utilized 3D systems to create 3D insoles for flat-footed seniors and this process can be applied to manufacture other items in the fashion industry as well.

• Atmosphere
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• v.26 no.1
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• pp.1-18
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• 2016

Eleven Tropical Cyclone (TC) intensity guidance models in the western North Pacific have been validated over 2008~2014 based on various analysis methods according to the lead time of forecast, year, month, intensity, rapid intensity change, track, and geographical area with an additional focus on TCs that influenced the Korean peninsula. From the evaluation using mean absolute error and correlation coefficients for maximum wind speed forecasts up to 72 h, we found that the Hurricane Weather Research and Forecasting model (HWRF) outperforms all others overall although the Global Forecast System (GFS), the Typhoon Ensemble Prediction System of Japan Meteorological Agency (TEPS), and the Korean version of Weather and Weather Research and Forecasting model (KWRF) also shows a good performance in some lead times of forecast. In particular, HWRF shows the highest performance in predicting the intensity of strong TCs above Category 3, which may be attributed to its highest spatial resolution (~3 km). The Navy Operational Global Prediction Model (NOGAPS) and GFS were the most improved model during 2008~2014. For initial intensity error, two Japanese models, Japan Meteorological Agency Global Spectral Model (JGSM) and TEPS, had the smallest error. In track forecast, the European Centre for Medium-Range Weather Forecasts (ECMWF) and recent GFS model outperformed others. The present results has significant implications for providing basic information for operational forecasters as well as developing ensemble or consensus prediction systems.

• Proceedings of the Korean Geotechical Society Conference
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• 1991.10a
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• pp.362-375
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• 1991

Background and Necessity of the study : For more than 20 years, the soil engineering reserach group of Chonnam National University has been performing the deformation analysis of soft clayey foundation, since the University is located near the south-western coast of Korean Peninsulla, along which tide reclamation works have been under proaressing. Associsted with the fact mentioned above, the researchers have been developing a computer program in order to carry out deformation analysis of soft foundation since early 1980. Case-studies : In this research, the Biot's equation was selected as the governing equation coupled with several constitutive models including original and modified Cam-clay models, elasto-viscoplastic model, Lade's model etc. The anisotropy of soi1 can be considered in this program. To validate the accuracy of the computer program developed a couple of case-studies were performed. These include the pilot banking, sand drain considering smear effect and compound foundation reinforced with sheet pile into soft foundation.i) The pilot banking Good results could be acquired by assuming banking load as the body force composed of finite element mesh rather than equivalent concentrated load.ii) The sand drain Due to smear, the delay of consolidation was remarkable at the early stsge. so safety for the failure of foundation should be checked for the initial step of consolidation. iii) The compound foundation Accurate results were obtained by introducing the joint element method for the soft foundation reinforced with sheet pile into soiㅣ.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.50.2-50.2
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• 2013

Galaxy clusters, the largest gravitationally bound systems, are an important means to place constraints on cosmological models. Moreover, they are excellent places to test galaxy evolution models in connection to the environments. To this day, massive clusters have been found unexpectedly at high redshfit (Kang & Im 2009, Durret et al. 2011, Tashikawa et al. 2012), and evolution of galaxies in cluster has not been fully understood. Finding galaxy cluster candidates at z > 1 in wide, deep imaging survey data will enable us to solve such issues of modern extragalactic astronomy. We report new candidates of galaxy clusters in the wide and deep survey fields, European Large Area ISO Survey North1(ELAIS-N1) and North2(ELAIS-N2) fields, covering sky area of $8.75deg^2$ and $4.85deg^2$ each. We also suggest a new useful colour-colour selection technique to separate 1 < z < 2 galaxies from low-z galaxies by combining multi-wavelength data from the UKIRT Infrared Deep Sky Survey Deep Extragalactic Survey (UKIDSS DXS, JK bands), Spitzer Wise-area InfraRed Extragalactic survey (SWIRE, Optical-Infrared bands), Canada France Hawaii Telescope (CFHT, z band) and Infrared Medium-deep Survey(IMS, J band).

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.7
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• pp.2409-2420
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• 1996

This paper describes the development of a general program for the design and part load performance analysis of single-shaft-heavy-duty gas turbines. Efforts are made to fully represent the real component features by the characteristic models and special emphasis is put on the modeling of cooled turbine stages. The design analysis routine is applied to simulate the performance of current gas turbines and its appropriateness for system analysis is validated. Meanwhile, the component parameters of real engines which describe the technology level are obtained. The program is extended to predicting the part load operation of gas turbines with the aid of models for the off-design characteristics of compressor, turbine and other main components. Part load simulation can be carried out only with limited numbers of input data. It is demonstrated that the program accurately estimates the part load characteristics of real turbines.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.70.2-70.2
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• 2014

Galaxy clusters, the largest gravitationally bound systems, are an important means to place constraints on cosmological models. Moreover, they are excellent places to test galaxy evolution models in connection to the environments. To this day, massive clusters have been found unexpectedly(Kang & Im 2009, Durret et al. 2011, Tashikawa et al. 2012) and evolution of galaxies in cluster have been still controversial (Elbaz et al. 2007, Cooper et al. 2008, Tran et al. 2009). Finding galaxy cluster candidates in a wide, deep imaging survey data will enable us to solve the such issues of modern extragalactic astronomy. We have used multi-wavelength data from the UKIRT Infrared Deep Sky Survey Deep Extragalactic Survey (UKIDSS DXS/J and K bands), Spitzer Wise-area InfraRed Extragalactic survey (SWIRE/two mid-infrared bands), the Panoramic Survey Telescope and Rapid Response System (PAN-STARRS/ g, r, i, z, y bands) and Infrared Medium-deep Survey(IMS/J band). We report new candidates of galaxy clusters and properties of their member galaxies in one of the wide and deep survey fields ELAIS-N1, European Large Area ISO Survey North1, covering sky area of $8.75deg^2$.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.11
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• pp.3525-3537
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• 1996

This paper presents a CAD program develpoed on a microcomputer in order to support graphic and computational assessment of ergonomic problems associated with the design of a man-in-cab system. The program is coded to help workspace designers with ergonomic evaluations needed in the design stage. This paper proposed a biomechanical -ergonomic evaluations needed using man and workplace models. The human model is developed to have dimensions obtained from the Korean anthropometric data reported in 1992. Its graphical representation is based on a wire-frame model but, whenever necessary, body segments can be represented by a solid model with hidden line/faces removed and shaded. Workplace models are presented for cabs of the excavator, one of the most popular construction vehicles. A workplace model consists of an operator seat, a steering wheel. two control levers, two pedals, and a control panel. The workplace elements can be modified in their sizes, positions, and orientations by changing the reference point and design parameters. An algorithm for the view test is suggested and loaded to provide a visual evaluaiton of the overall layout of a workplace model.