• Title/Summary/Keyword: Profiling analysis

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Enantiomeric Profiling Analysis of NSAIDs by Capillary Electrophoresis Using TM $\beta$-Cyclodextrin as the Chiral Selector

  • Kim, Ji-Young;La, Sookie;Kim, Jung-Han;Kim, Kyoung-Rae
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.400.1-400.1
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    • 2002
  • Because of the differences in pharmacological properties between enantiomers of chiral acidic non-steroidal antiinflammatory drugs (NSAIDs) in human body. accurate determinations of their optical purities have been in great need. An efficient capillary electrophoretic (CE) profiling method was developed for the enantioseparation of NSAIDs. Capillary electrophoretic conditions were optimized using TM$\beta$-cyclodextrin as the chiral selectors under MES buffer. (omitted)

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Geoacoustic Modeling for Analysis of Attenuation Characteristics using Chirp Acoustic Profiling data (광역주파수 음향반사자료의 감쇠특성 분석을 위한 지질음향모델링 기법 연구)

  • Chang Jae-Kyeong;Yang Sung-Jin
    • Geophysics and Geophysical Exploration
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    • v.2 no.4
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    • pp.202-208
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    • 1999
  • We introduce a new acoustic parameter for the classification of seafloor sediments from chirp sonar acoustic profiling data. The acoustic parameter is defined as a derivative of the unwrapped phase of the Fourier transform of acoustic profiling data. Consequently, it represents the characteristics of attenuation by dissipative dispersion in sediments. And we estimated acoustic properties by geoacoustic modeling using Chirp data obtained from the different sedimentary facies. Our classification results, when compared with the results of analysis of sampled sediments, show that the acoustic parameter discriminates sedimentary facies and bottom hardness. Thus the method in this paper is expected to be an effective means of geoacoustic modeling of the seafloor.

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Development of certified reference material (CRM)s for surface analysis II : multilayer thin films for sputter depth profiling (표면분석용 인증표준물질의 개발 II : 깊이분포도용 다층 박막 표준물질의 개발)

  • 김경중;문대원
    • Journal of the Korean Vacuum Society
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    • v.8 no.3B
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    • pp.283-289
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    • 1999
  • Multilayer thin film reference materials for the sputter depth profiling analysis are used to calibrate the sputter depth scale by measuring the sputtering rate and to optimize the sputtering conditions for the best depth resolution. Surface analysis group of Korea Research Institute of Standards and science (KRISS) have developed various types of multilayer thin films by using an ion beam sputter deposition and in-situ surface analysis system. The chemical states of the thin films reference materials were certified by in-situ XPS and the thicknesses were certified by transmission electron microscopy (TEM).

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Non-Profiling Analysis Attacks on PQC Standardization Algorithm CRYSTALS-KYBER and Countermeasures (PQC 표준화 알고리즘 CRYSTALS-KYBER에 대한 비프로파일링 분석 공격 및 대응 방안)

  • Jang, Sechang;Ha, Jaecheol
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.32 no.6
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    • pp.1045-1057
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    • 2022
  • Recently, the National Institute of Standards and Technology (NIST) announced four cryptographic algorithms as a standard candidates of Post-Quantum Cryptography (PQC). In this paper, we show that private key can be exposed by a non-profiling-based power analysis attack such as Correlation Power Analysis (CPA) and Differential Deep Learning Analysis (DDLA) on CRYSTALS-KYBER algorithm, which is decided as a standard in the PKE/KEM field. As a result of experiments, it was successful in recovering the linear polynomial coefficient of the private key. Furthermore, the private key can be sufficiently recovered with a 13.0 Normalized Maximum Margin (NMM) value when Hamming Weight of intermediate values is used as a label in DDLA. In addition, these non-profiling attacks can be prevented by applying countermeasures that randomly divides the ciphertext during the decryption process and randomizes the starting point of the coefficient-wise multiplication operation.

Development of Data Profiling Software Supporting a Microservice Architecture (마이크로 서비스 아키텍처를 지원하는 데이터 프로파일링 소프트웨어의 개발)

  • Chang, Jae-Young;Kim, Jihoon;Jee, Seowoo
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.21 no.5
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    • pp.127-134
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    • 2021
  • Recently, acquisition of high quality data has become an important issue as the expansion of the big data industry. In order to acquiring high quality data, accurate evaluation of data quality should be preceded first. The quality of data can be evaluated through meta-information such as statistics on data, and the task to extract such meta-information is called data profiling. Until now, data profiling software has typically been provided as a component or an additional service of traditional data quality or visualization tools. Hence, it was not suitable for utilizing directly in various environments. To address this problem, this paper presents the development result of data profiling software based on a microservice architecture that can be serviced in various environments. The presented data profiler provides an easy-to-use interface that requests of meta-information can be serviced through the restful API. Also, a proposed data profiler is independent of a specific environment, thus can be integrated efficiently with the various big data platforms or data analysis tools.

Analysis of Seed Hair Formation Related Genes by EST Profiling in Carrot (Daucus carota var. sativa) (EST profiling을 통한 당근(Daucus carota var. sativa)의 종모 형성에 관련된 유전자 분석)

  • Hwang, Eun-Mi;Oh, Gyu-Dong;Shim, Eun-Jo;Jeon, Sang-Jin;Park, Young-Doo
    • Horticultural Science & Technology
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    • v.28 no.6
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    • pp.1039-1050
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    • 2010
  • Carrot is one of the useful crops used abundantly in cooking in Western as well as Asia regions such as China and Korea. However, seed coats have hairs which should be removed to increase germination rate. Furthermore, because of seed hairs, farmers face several additional losses, such as time consumption, manpower, capital and so on, for seed handling. To prevent these problems, study of gene related hair formation using short-hair seed lines is required. We analyzed genes related to hair formation from seed through expressed sequenced tag (EST) profiling, based on the fact that the development of carrot seed hair is related to cellulose synthesis pathway in secondary cell wall synthesis stage. To study the gene expression related to hair formation of the carrot seed, a cDNA library was constructed by using the early maturation stage of the short-hair line (659-1) and hairy seed line (677-14). In short-hair (659-1) and hairy seed (677-14) lines, results from of EST profiling through BLASTX search analysis using the NCBI database showed that 172 and 224 unigenes had significant homology with known protein sequences, whereas 233 and 192 unigenes were not, respectively. All ESTs were grouped into 16 categories according to their putative functions. Twenty nine unigenes among all ESTs were considered to be genes regulating seed hair development from cellulose synthesis pathway during secondary cell wall synthesis stage; in results, 14 unigenes related to seed hair development were found only in hairy seed line.

Analyzing the Intellectual Structure of School Library Researches with Citation-Weighted Author Profiling (인용가중 저자프로파일링을 이용한 학교도서관 연구의 지적구조 분석)

  • Lee, Jae Yun
    • Journal of the Korean Society for Library and Information Science
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    • v.54 no.2
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    • pp.197-223
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    • 2020
  • In this study, citation-weighted author profiling (CWAP) was developed as a new method that combines the advantages of both author profiling (AP) method and author co-citation analysis (ACA) method. In AP method, words reflect the author's main topics of study. On the other hand, what words reflect in CWAP is topics that the author mainly influences. This enables detailed topic identification, which is the advantage of AP method, and at the same time determines the subjects in which the author has influence, as with ACA method. The proposed CWAP method was applied experimentally to analyze the intellectual structure of school library research in Korea. The results of the trial application revealed in detail what topics each author has a high influence on, and the change of influence over time was also clearly revealed. The CWAP method proposed in this study is expected to be used as a technique to grasp detailed topics from the viewpoint of research influence on which topics the author has been cited for, not as a research productivity perspective of how many papers the author has published.

Discrimination of Korean rice varieties as revealed by DNA profiling and its relationship with genetic diversity (한국 육성 벼 품종의 DNA profiling에 의한 유전적 다양성 분석 및 품종 판별)

  • Kim, Me-Sun;Song, Jae-Young;Kang, Kwon-Kyoo;Cho, Yong-Gu
    • Journal of Plant Biotechnology
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    • v.44 no.3
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    • pp.243-263
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    • 2017
  • This study is to establish the varietal discrimination based on DNA profiling of different varieties of rice. We examined the genetic distance among Korean rice varieties using allele frequencies and a genetic diversity analysis with Simple Sequence Repeats (SSRs) markers. The analysis of the genetic diversity and genetic relationships of 243 Korean rice varieties was varied out using 20 SSRs markers. A total of 268 alleles were detected, ranging from 6 to 32, with an average of 13.45 alleles per locus, and and average of gene diversity (GD) of 0.556. Seven SSR markers were selected as key markers for discrimination among the Korean rice varieties. Concerning the results, 243 varieties (100%) were discriminated among by using acrylamide gel and fragment analyzer-based markers. In conclusion, this study provides useful basic data that can be utilized concerning Korean rice varieties breeding and development. In addition, we will have to manage and conserve as a valuable genetic resource, without losing the diversity of Korean rice varieties.

Metabolic profiling reveals an increase in stress-related metabolites in Arabidopsis thaliana exposed to honeybees

  • Baek, Seung-A;Kim, Kil Won;Kim, Ja Ock;Kim, Tae Jin;Ahn, Soon Kil;Choi, Jaehyuk;Kim, Jinho;Ahn, Jaegyoon;Kim, Jae Kwang
    • Journal of Applied Biological Chemistry
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    • v.64 no.2
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    • pp.141-151
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    • 2021
  • Insects affect crop harvest yield and quality, making plant response mechanisms to insect herbivores a heavily studied topic. However, analysis of plant responses to honeybees is rare. In this study, comprehensive metabolic profiling of Arabidopsis thaliana exposed to honeybees was performed to investigate which metabolites were changed by the insect. A total of 85 metabolites-including chlorophylls, carotenoids, glucosinolates, policosanols, tocopherols, phytosterols, β-amyrin, amino acids, organic acids, sugars, and starch-were identified using high performance liquid chromatography, gas chromatography-mass spectrometry, and gas chromatography-time-of-flight mass spectrometry. The metabolite profiling analysis of Arabidopsis exposed to honeybees showed higher levels of stress-related metabolites. The levels of glucosinolates (glucoraphanin, 4-methoxyglucobrassicin), policosanols (eicosanol, docosanol, tricosanol, tetracosanol), tocopherols (β-tocopherol, γ-tocopherol), putrescine, lysine, and sugars (arabinose, fructose, glucose, mannitol, mannose, raffinose) in Arabidopsis exposed to honeybees were higher than those in unexposed Arabidopsis. Glucosinolates act as defensive compounds against herbivores; policosanols are components of plant waxes; tocopherols act as an antioxidant; and putrescine, lysine, and sugars contribute to stress regulation. Our results suggest that Arabidopsis perceives honeybees as a stress and changes its metabolites to overcome the stress. This is the first step to determining how Arabidopsis reacts to exposure to honeybees.