• 대한토목학회논문집
• /
• 제28권5A호
• /
• pp.665-672
• /
• 2008

본 연구에서는 교량이나 선박 등의 강구조물에서 널리 사용되고 있는 하중 전달형 십자형 필렛용접 시험편에 대해 피로시험을 실시하여, 용접 후처리 조건에 따른 피로강도를 분석하였다. 용접 후처리 방법으로는 Toe Grinding, TIG Dressing 및 Weld Profiling을 적용하였으며, 피로시험은 일정진폭 반복하중 하에서 실시하였다. 피로시험 결과 하중 전달형 십자형 필렛용접 시험편은 용접 후처리를 실시한 경우와 실시하지 않은 경우 모두에서 BS 피로설계기준의 F등급을 만족하는 결과를 나타내었다. 또한 용접 후처리 방법에 따른 피로강도의 향상 효과는 Toe Grinding, TIG Dressing, Weld Profiling 순서로 증가하는 것을 알 수 있었다.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2007년도 추계학술대회 논문집
• /
• pp.539-540
• /
• 2007

• 대한약학회:학술대회논문집
• /
• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
• /
• pp.289.1-289.1
• /
• 2001

• Applied Microscopy
• /
• 제47권3호
• /
• pp.95-100
• /
• 2017

High resolution measurements of the carrier profile in semiconductor devices is required as the semiconductor industry progresses from the 10-nm lithography node to 7-nm and beyond. We examine the factors which determine the resolution of the present method of scanning spreading resistance microscopy as well as such factors for the newer method of scanning frequency comb microscopy that is now under development. Also, for the first time, we consider the sensitivity of both methods to the location of heterogeneities in the semiconductor. In addition, mesoscopic effects on these measurements are considered for the first time. Two simple analytical models are extended to study the sensitivity to heterogeneities as well as mesoscopic effects.

• Applied Microscopy
• /
• 제42권3호
• /
• pp.158-163
• /
• 2012

Detailed comparison of low-voltage scanning electron microscopy and electron holography techniques for two-dimensional (2D) dopant profiling was carried out with using the same multilayered p-n junction specimen. The dopant profiles obtained from two methods are in good agreement with each other. It demonstrates that reliability of dopant profile measurement can be increased through precise comparison of 2D profiles obtained from various microscopic techniques.

• Journal of Korean Neurosurgical Society
• /
• 제61권3호
• /
• pp.376-385
• /
• 2018

Recent discoveries of brain tumor-related genes and fast advances in genomic testing technologies have led to the era of molecular diagnosis of brain tumor. Molecular profiling of brain tumor became the significant step in the diagnosis, the prediction of prognosis and the treatment of brain tumor. Because traditional molecular testing methods have limitations in time and cost for multiple gene tests, next-generation sequencing technologies are rapidly introduced into clinical practice. Targeted sequencing panels using these technologies have been developed for brain tumors. In this article, focused on pediatric brain tumor, key discoveries of brain tumor-related genes are reviewed and cancer panels used in the molecular profiling of brain tumor are discussed.

• BMB Reports
• /
• 제45권6호
• /
• pp.323-330
• /
• 2012

The glycome consists of all glycans (or carbohydrates) within a biological system, and modulates a wide range of important biological activities, from protein folding to cellular communications. The mining of the glycome for disease markers represents a new paradigm for biomarker discovery; however, this effort is severely complicated by the vast complexity and structural diversity of glycans. This review summarizes recent developments in analytical technology and methodology as applied to the fields of glycomics and glycoproteomics. Mass spectrometric strategies for glycan compositional profiling are described, as are potential refinements which allow structure-specific profiling. Analytical methods that can discern protein glycosylation at a specific site of modification are also discussed in detail. Biomarker discovery applications are shown at each level of analysis, highlighting the key role that glycoscience can play in helping scientists understand disease biology.

• 한국자원식물학회:학술대회논문집
• /
• 한국자원식물학회 2010년도 정기총회 및 춘계학술발표회
• /
• pp.5-5
• /
• 2010

Selection of specific medicinal sources as well as bioactive compounds is important for the preparation of medicine and related products with good quality. It is necessary to pay close attention for choosing correct medicinal sources, particularly in case of medicinal plants, because of their diversity, which can affect the quality and efficacy of medicine. Discrimination of plants based on morphological or genetic characteristics has been used as a conventional classification method of pharmaceutical sources so far; however, more need demands more general methods for accurate quality assessment of medicinal plants. In this study, ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) technique applied to this metabolic profiling is a powerful tool due to its higher sensitivity, resolution, and speed compared to conventional HPLC technique. The metabolite profiling of several medicinal plants including Panax ginseng was carried out using UPLC/Q-TOF MS and total metabolites were then subsequently applied to various statistical tools to compare the patterns. The developed metabolomics tool with UPLC/Q-TOF MS successfully identified and classified the samples tested according to their origins.

• 한국지구물리탐사학회:학술대회논문집
• /
• 한국지구물리탐사학회 1999년도 제2회 학술발표회
• /
• pp.176-201
• /
• 1999

지반조사를 위하여 흔히 시행하는 시추공 탄성파탐사, 즉 하향 탄성파탐사(downhole seismic), 수직 탄성파탐사(vertical seismic profiling; VSP), 시추공간 속도측정(crosshole seismic), 탄성파 토모그래피(seismic tomography)에 대하여 원리, 현장측정, 자료처리 등을 간략히 설명하고, 현장자료의 예를 제시하였으며 토목공학적 응용에 대해 검토하였다.

• Mass Spectrometry Letters
• /
• 제4권1호
• /
• pp.1-9
• /
• 2013

Fungal biotechnology has been well established in food and healthcare sector, and now being explored for lignocellulosic biorefinery due to their great potential to produce a wide array of extracellular enzymes for nutrient recycling. Due to global warming, environmental pollution, green house gases emission and depleting fossil fuel, fungal enzymes for lignocellulosic biomass refinery become a major focus for utilizing renewal bioresources. Proteomic technologies tender better biological understanding and exposition of cellular mechanism of cell or microbes under particular physiological condition and are very useful in characterizing fungal secretome. Hence, in addition to traditional colorimetric enzyme assay, mass-spectrometry-based quantification methods for profiling lignocellulolytic enzymes have gained increasing popularity over the past five years. Majority of these methods include two dimensional gel electrophoresis coupled to mass spectrometry, differential stable isotope labeling and label free quantitation. Therefore, in this review, we reviewed more commonly used different proteomic techniques for profiling fungal secretome with a major focus on two dimensional gel electrophoresis, liquid chromatography-based quantitative mass spectrometry for global protein identification and quantification. We also discussed weaknesses and strengths of these methodologies for comprehensive identification and quantification of extracellular proteome.