[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2012.45.6.132

Glycoscience aids in biomarker discovery

Hua, Serenus (Graduate School of Analytical Science and Technology, Chungnam National University)
An, Hyun-Joo (Graduate School of Analytical Science and Technology, Chungnam National University)

Publication Information

BMB Reports / v.45, no.6, 2012 , pp. 323-330 More about this Journal

Abstract

The glycome consists of all glycans (or carbohydrates) within a biological system, and modulates a wide range of important biological activities, from protein folding to cellular communications. The mining of the glycome for disease markers represents a new paradigm for biomarker discovery; however, this effort is severely complicated by the vast complexity and structural diversity of glycans. This review summarizes recent developments in analytical technology and methodology as applied to the fields of glycomics and glycoproteomics. Mass spectrometric strategies for glycan compositional profiling are described, as are potential refinements which allow structure-specific profiling. Analytical methods that can discern protein glycosylation at a specific site of modification are also discussed in detail. Biomarker discovery applications are shown at each level of analysis, highlighting the key role that glycoscience can play in helping scientists understand disease biology.

Keywords

Biomarker; Glycomics; Glycoproteomics; Glycosylation; Mass spectrometry;

Citations & Related Records

Times Cited By Web Of Science : 2 (Related Records In Web of Science)

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