• 한국의학물리학회지:의학물리
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• 제15권2호
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• pp.100-104
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• 2004

선량 측정기의 공간적인 반응특성 때문에 나타나는 detector의 크기효과는 임상적인 선량측정을 부정확하게 만드는 중요한 원인이기에 많은 연구의 대상이 되어왔다. 관례적으로 detector response kernel은 detector 자체의 크기가 측정한 방사선의 선량분포에 대해 미친 영향에 대한 정보를 포함하고 있다. 이 kernel에 대해 다양한 수학적 모델들이 제안되었고 실험적으로 이론적으로 연구되어왔다. 이 논문은 convolution이론과 Monte Carlo simulation만을 이용하여 detector의 kernel을 결정하는 방법을 제시한다. 이 수치해석적인 방법을 사용하여 물 phantom에 잠긴 Farmer형 ion chamber의 detector response kernel을 계산하였다. 계산된 kernel은 기존의 parabolic 모델의 특성과 Gaussian 모델의 특성을 동시에 나타내고 있다. 이 kernel과 deconvolution 방법을 사용하여 측정된 6MV, 10${\times}$10 $\textrm{cm}^2$, 0.5${\times}$10 $\textrm{cm}^2$ 광자선으로부터 크기효과를 제거하였다. 크기효과가 제거된 방사선의 선량분포는 꼬리부분을 제외하고는 film이나 pin-point ion chamber에 의해 측정된 결과와 유사한 선량분포를 나타냈다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권5호
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• pp.338-345
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• 2003

Purpose : This study was intended to perform cephalometric comparison between the patients with and without obstructive sleep apnea (OSA). The factors influencing the OSA in the lateral cephalogram was also investigated. Patient and Method : Twenty four patients who visited Sleep Disorder Clinic in Dongsan Medical Center, Keimyung University and evaluated with polysomnograph(PSG) and cephalogram were included in the study. The patients had apnea-hypopnea episode(AHI) over 10 times per hour was diagnosed as OSA after overnight PSG. To evaluate hard and soft tissue profile, cephalometric radiogram were taken at maximal intercuspation(P1) and mandibular protruding position(P2). The diffefence between the OSA and normal group were evaluated statistically and the stepwise regression analysis was applied to analyse the cephalometric influencing factors to OSA. Result : The OSA Group(n=14) had significantly higher Body Mass Index(BMI) than control group(n=10). Lower facial height(ANSGn) was longer in OSA group. However statistically significant difference was not detected in other anteroposterior craniofacial measurements. The soft palate lenth (PNS-P), hyoid position (MP-Hyoid) had positive correlation between AHI (r=0.496, r=0.413, respectively, p<0.05). However, the measurements of oropharyngeal airway was not different between the two groups. The hypothesis, the antero-posteriorly narrow oropharyngeal airway might aggravate the airway resistance and can give rise to higher AHI, was not accepted in the study. This can be attributed by inclusion of the patients performed uvulopalatopharyngoplasty because of the tonsilar or soft palate hypertrophy in the present study. The results of regression analysis revealed that PNS-P, upper airway width(Nph1), upper facial heght(N-ANS), and lower facial height(ANS-Gn) could influence the degree of AHI (F value < 0.0001, $R^2$ = 0.829). Conclusion : We suggest lateral cephalogram may utilized as a useful method to evaluate OSA. The patient with long soft palate, narrow upper airway width, long upper & lower facial height can be expected to have high risk of OSA. However, it should be emphasized the comphrehensive intraoral inspection including soft palate and tonsilar hypertrophy because lateral cepahlogram cannot visualize oropharyngeal status completely.

• 터널과지하공간
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• 제12권3호
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• pp.142-151
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• 2002

대전 식품냉동저장창고 파일럿 공동주위의 거리에 따른 비정상상태의 온도 분포를 산정하기 위해 Claesson(2001)의 해석해 및 Dirichlet과 Neuman 내부 경계조건을 갖는 수치모델들을 검토하였다. 온도 강하 단계동안 일정 표면 온도 경계조건에 기초하고 있는 Claesson의 해석해를 활용한 결과, 실제 암반에서의 온도 계측결과를 오차 평균 0.89$^{\circ}C$ 수준으로서 비교적 정확히 예측할 수 있었는데, $0^{\circ}C$근처의 실험실 암석 열물성을 입력하였고 현지 암반 조건을 표현하기 위한 특별한 물성 보정을 하지 않았다. 내부 공동 암반 벽면을 통한 열유속을 갖는 수치해석의 경우, 대류 열전달계수와 공동 내부 온도가 냉각시간에 따라 변화하기 때문에 경계조건을 가하기 어려운 단점을 극복하기 위해 새로운 경계조건 설정 기법을 제안하였다. 그 결과 오차 평균 1.58$^{\circ}C$의 수준으로서 온도 계측치와 부합하였다. 또한 공동 벽면에서 고정 온도 조건을 갖는 수치해와 비교하였다. 마지막으로 Claesson의 해석해 및 다양한 내부 경계조건을 갖는 수치모델을 활용하여, 공동 주변의 온도 분포를 정확히 예측할 수 있는 일련의 해석 단계 프로그램을 제안하였다.

• 대한치과교정학회지
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• 제28권2호
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• pp.175-187
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• 1998

본 연구는 치료후 빈번한 재발로 인해 치료에 어려움을 겪는 III급 부정교합의 치료후 예후를 예측하는 데 도움을 주고자, 교정치료후 관찰기간동안 측모와 교합이 양호한 상태로 유지된 안정군(Stable group, n=12)과 그렇지 않고 재발의 경향을 보인 재발군(Relapse group, n=13)으로 나누고, 초진시 계측항목을 이용한 t-test, 상관분석 그리고 판별분석을 시행한 결과 다음과 같은 결론을 얻었다. 1. 상하악골의 전후방적인 위치와 관계를 나타내는 항목인 SNA, SNB, ANB, Angle of convexity 그리고 APDI에서 두 군간 통계학적으로 유의성 있는 차이를 보여주지 않아(p>0.05) 두 군간 전후방적 인 골격 형태에 있어서는 차이가 나지 않음을 알 수 있었다. 2. 교합평면의 경사도와 관련된 항목인 Wits, AB to Occlusal plane angle 그리고 Occlusal plane to Mandibular Plane angle에서 두 군간 통계학적으로 유의성 있는 차이를 보여(p<0.05)재발군의 교합평면이 안정군에 비해 전하방으로 많이 경사져 있음을 알 수 있었다. 3. 상하치열관계를 나타내는 항목인 Overjet에서 안정군이 재발군에 비해 절대치로 더 커(p<0.01) 전후방 골격부조화에 의한 것이 아닐 경우 치열의 전후방부조화가 클수록 치료후 예후가 좋음을 알 수 있었다. 4. 상관분석결과 Overjet과 Occlusal plane to Mandibular plane angle만이 통계학적으로 유의성 있는 상관관계를 보여 주었다(p<0.001, p<0.01). 5. 판별에 기여도가 높은 3항목 즉 Overjet, AB to Occlusal paine angle 그리고 Articular angle을 이용한 판별식을 도출하였으며, 이를 이용할 때 본 연구에 사용한 표본의 88%를 올바르게 판별할 수 있었다.

• 한국환경과학회지
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• 제20권6호
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• pp.783-788
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• 2011

Different from the main land of South Korea, Jeju Island has been in difficulties for measuring discharge. Due to high infiltration rate, most of streams in Jeju Island are usually in the dried state except six streams with the steady base flow, and the unique geological characteristics such as steep slope and short traveling distance of runoff have forced rainfall runoff usually to occur during very short period of time like one or two days. While discharge observations in Jeju Island have been conducted only for 16 sites with fixed electromagnetic surface velocimetry, effective analysis and validation of observed discharge data and operation of the monitoring sites still have been limited due to very few professions to maintain such jobs. This research is sponsored by Ministry of Land, Transport and Maritime Affairs to build water cycle monitoring and management system of Jeju Island. Specifically, the research focuses on optimizing discharge measurement techniques adjusted for Jeju Island, expanding the monitoring sites, and validating the existing discharge data. First of all, we attempted to conduct discharge measurements in streams with steady base flow, by utilizing various recent discharge monitoring techniques, such as ADCP, LSPIV, Magnetic Velocimetry, and Electromagnetic Wave Surface Velocimetry. ADCP has been known to be the most accurate in terms of discharge measurement compared with other techniques, thus that the discharge measurement taken by ADCP could be used as a benchmark data for validation of others. However, there are still concerns of using ADCP in flood seasons; thereby LSPIV would be able to be applied for replacing ADCP in such flooded situation in the stream. In addition, sort of practical approaches such as Magnetic Velocimetry, and Electromagnetic Wave Surface Velocimetry would also be validated, which usually measure velocity in the designated parts of stream and assume the measured velocity to be representative for whole cross-section or profile at any specified location. The result of the comparison and analysis will be used for correcting existing discharge measurement by Electromagnetic Wave Surface Velocimetry and finding the most optimized discharge techniques in the future.

• 대기
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• 제23권4호
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• pp.471-483
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• 2013

Nighttime sea fog detection from satellite is very hard due to limitation in using visible channels. Currently, most widely used method for the detection is the Dual Channel Difference (DCD) method based on Brightness Temperature Difference between 3.7 and 11 ${\mu}m$ channel (BTD). However, this method have difficulty in distinguishing between fog and low cloud, and sometimes misjudges middle/high cloud as well as clear scene as fog. Using CALIPSO Lidar Profile measurements, we have analyzed the intrinsic problems in detecting nighttime sea fog from various satellite remote sensing algorithms and suggested the direction for the improvement of the algorithm. From the comparison with CALIPSO measurements for May-July in 2011, the DCD method excessively overestimates foggy pixels (2542 pixels). Among them, only 524 pixel are real foggy pixels, but 331 pixels and 1687 pixels are clear and other type of clouds, respectively. The 514 of real foggy pixels accounts for 70% of 749 foggy pixels identified by CALIPSO. Our proposed new algorithm detects foggy pixels by comparing the difference between cloud top temperature and underneath sea surface temperature from assimilated data along with the DCD method. We have used two types of cloud top temperature, which obtained from 11 ${\mu}m$ brightness temperature (B_S1) and operational COMS algorithm (B_S2). The detected foggy 1794 pixels from B_S1 and 1490 pixel from B_S2 are significantly reduced the overestimation detected by the DCD method. However, 477 and 446 pixels have been found to be real foggy pixels, 329 and 264 pixels be clear, and 989 and 780 pixels be other type of clouds, detected by B_S1 and B_S2 respectively. The analysis of the operational COMS fog detection algorithm reveals that the cloud screening process was strictly enforced, which resulted in underestimation of foggy pixel. The 538 of total detected foggy pixels obtain only 187 of real foggy pixels, but 61 of clear pixels and 290 of other type clouds. Our analysis suggests that there is no winner for nighttime sea fog detection algorithms, but loser because real foggy pixels are less than 30% among the foggy pixels declared by all algorithms. This overwhelming evidence reveals that current nighttime sea fog algorithms have provided a lot of misjudged information, which are mostly originated from difficulty in distinguishing between clear and cloudy scene as well as fog and other type clouds. Therefore, in-depth researches are urgently required to reduce the enormous error in nighttime sea fog detection from satellite.

• Asian-Australasian Journal of Animal Sciences
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• 제20권9호
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• pp.1374-1388
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• 2007

Three experiments were conducted to investigate the hypothesis that cows grazing on pasture produce the highest proportion of c-9 t-11 CLA in milk fat and no further increase can be achieved through supplementation of diets rich in linoleic acid, such as full-fat extruded soybeans or soybean oil. In experiment 1, 18 lactating Holstein cows were used in a randomized complete block design with measurements made from wk 4 to 6 of the experiment. In experiment 2, three cannulated lactating Holstein cows were used in a $3{\times}3$ Latin square design. Each period was 4 wk with measurements made in the final wk of each period. Cows in both experiments were assigned at random to treatments: a, conventional total mixed ration (TMR); b, pasture (PS); or c, PS supplemented with 2.5 kg/cow per day of full-fat extruded soybeans (PES). In both experiments, feed intake, milk yield, milk composition, and fatty acid profile of milk and blood serum were measured, along with fatty acid composition of bacteria harvested from rumen digesta in experiment 2. In experiment 3, 10 cows which had continuously grazed a pasture for six weeks were assigned to two groups, with one group (n = 5) on pasture diet alone (PS) and the other group (n = 5) supplemented with 452 g of soy oil/cow per day for 7 d (OIL). In experiment 1, cows in PS treatment produced 350% more c-9, t-11 CLA compared with cows in TMR treatment (1.70 vs. 0.5% of fat), with no further increase for cows in PES treatment (1.50% of fat). Serum c-9, t-11 CLA increased by 233% in PS treatment compared with TMR treatment (0.21 vs. 0.09% of fat) with no further increase for cows in PES treatment (0.18% of fat). In experiment 2, cows in PS treatment produced 300% more c-9 t-11 CLA in their milk fat compared with cows in TMR treatment (1.77 vs. 0.59% of fat), but no further increase for cows in PES treatment (1.84% of fat) was observed. Serum c-9, t-11 CLA increased by 250% for cows in PS treatment compared with cows in TMR treatment (0.27 vs. 0.11% of fat), with no further increase for cows in PES treatment (0.31% of fat). The c-9, t-11 CLA content of ruminal bacteria for cows in PS treatment was 200% or more of TMR treatment, but no further increase in bacterial c-9, t-11 CLA for cows in PES treatment was observed. Supplementation of soy oil in experiment 3 also did not increase the c-9 t-11 CLA content of milk fat compared with cows fed a full pasture diet (1.60 vs. 1.54% of fat). Based on these findings, it was concluded that supplementing with feeds rich in linoleic acid, such as full-fat extruded soybeans or an equivalent amount of soy oil, to cows grazing perennial ryegrass pasture may not increase milk fat c-9 t-11 CLA contents.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7897-7907
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• 2014

Background: There is paucity of studies defining the prevalence of non-communicable disease (NCD) risk factors in Saudi Arabia despite the surging epidemic of obesity, change in dietary habits and sedentary lifestyle. Objectives: This cross-sectional study aimed to assess the prevalence of NCDs risk factors among employees at King Faisal University in Al Hassa, Saudi Arabia and to determine the possible correlates for clustering of NCDs risk factors among them. Materials and Methods: All employees were invited to participate; the World Health Organization STEPwise approach was used for data collection which consisted of a personal interview to collect socio-demographic characteristics, NCD history, tobacco use, vegetables and fruit consumption, and physical activity (PA), followed by anthropometric measurements namely weight, height and waist circumference and blood pressure measurements, subjects were finally subjected to biochemical tests with determination of fasting plasma glucose, serum triglycerides, cholesterol and high density lipoproteins. Results: Of the surveyed employees (n=691), daily current smokers accounted for 22.7%. 94.9%, 95.1% and 86% consumed < 5 servings per day of vegetables, fruits and both fruits and vegetables respectively, 73% were physically inactive, 64% were overweight or obese, 22.1% had hypertension, and 21.5% were diabetics. Elevated cholesterol levels were found in 36.6%, low high density lipoproteins in 36.8%, and elevated triglycerides in 36.1%. Only 3% had no NCD risk factors, and 57.6% had ${\geq}3$ factors. Multivariate logistic regression showed that gender (being male, adjusted odds ratio 'aOR'=1.51), aged ${\geq}50$ years (aOR=3.06), < college education (aOR=1.75), current smokers (aOR=2.37), being obese (aOR=6.96) and having a low PA level (aOR=4.59) were the significant positive predictors for clustering of NCD risk factors. Conclusions: Over fifty percent of the studied university's employees had multiple (${\geq}3$) NCD risk factors. Screening and health promotion initiatives should be launched at least targeting the modifiable factors to avert the excessive risk for cardiovascular disease, diabetes mellitus and several types of cancers.

• Toxicological Research
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• 제34권3호
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• pp.221-229
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• 2018

Tenofovir nanoparticles are novel therapeutic intervention in human immunodeficiency virus (HIV) infection reaching the virus in their sanctuary sites. However, there has been no systemic toxicity testing of this formulation despite global concerns on the safety of nano drugs. Therefore, this study was designed to investigate the toxicity of Tenofovir nanoparticle (NTDF) on the liver and kidney using an animal model. Fifteen adult male Sprague-Dawley (SD) rats maintained at the animal house of the biomedical resources unit of the University of KwaZulu-Natal were weighed and divided into three groups. Control animals (A) were administered with normal saline (NS). The therapeutic doses of Tenofovir (TDF) and nanoparticles of Tenofovir (NTDF) were administered to group B and C and observed for signs of stress for four weeks after which animals were weighed and sacrificed. Liver and kidney were removed and fixed in formal saline, processed and stained using H/E, PAS and MT stains for light microscopy. Serum was obtained for renal function test (RFT) and liver function test (LFT). Cellular measurements and capturing were done using ImageJ and Leica software 2.0. Data were analysed using graph pad 6, p values < 0.05 were significant. We observed no signs of behavioural toxicity and no mortality during this study, however, in the kidneys, we reported mild morphological perturbations widening of Bowman's space, and vacuolations in glomerulus and tubules of TDF and NTDF animals. Also, there was a significant elevation of glycogen deposition in NTDF and TDF animals when compared with control. In the liver, there were mild histological changes with widening of sinusoidal spaces, vacuolations in hepatocytes and elevation of glycogen deposition in TDF and NTDF administered animals. In addition to this, there were no significant differences in stereological measurements and cell count, LFT, RFT, weight changes and organo-somatic index between treatment groups and control. In conclusion, NTDF and TDF in therapeutic doses can lead to mild hepatic and renal histological damage. Further studies are needed to understand the precise genetic mechanism.

• 생태와환경
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• 제35권2호통권98호
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• pp.79-91
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• 2002

섬진강 상류에 위치한 옥정호의 연직 수온 분포 계절 변화에 대한 시변화 모델 연구를 수행하였다. 미공병단에서 개발한 CE-QUAL-W2모델 구조에 기초하여 호수를 3개의 지류, 50개의 상하류 구획 그리고 49개의 수층으로 구성하였으며 일년동안의 연직 수온 및 유속 분 포를 시뮬레이션하였다. 호수내 5개 지점에서 매월 측정된 연직 수온 분포 자료를 이용하여 보정하고 검증하였다. 또한, 시뮬레이션한 연중 수위 자료 변화를 관측된 자료와 비교하여 호수내 물수지를 확인하였다. 모델 예측값은 실측값과 적절한 일치를 보였으나 7월 관측 자료에서 다소 차이를 보였다. 이것은 우리나라에서 여름 장마동안 급격한 수리 현상 변화를 모델이 표현할 수없는 점과 이 기간동안 사용된 기온자료의 정확성이 부족하였기 때문인 것으로 사료된다. 모델 결과는 옥정호대부분 수역에서 연중 $4^{\circ}C$ 이상을 유지하여 계절에 따른 전도현상이 없는 것을 보여준다. 그러나 상류 얕은 수역 (수심 20미터 이내)에서는 수온이 $4^{\circ}C$ 이하로 떨어지며 겨울에 물이 얼어 흔합이 일어나는 것으로 나타났다. 본 연구로부터 옥정호는 빈혼합 호수라는 결론을 얻었다. 이러한 결론은 위도 $20^{\circ}C$ 부터 $40^{\circ}C$ 사이에 위치한 호수는 일회혼합이라는 일반적 경향과는 크게 다르다. 시뮬레이션한 유속 분포를 검토한 결과 여름 장마기간동안 상류에서 유입되는 물은 수온에 의한 밀도 차이로 인하여 호수 중층으로 유입되는 것이 확인되었다.