Investigating Organ Toxicity Profile of Tenofovir and Tenofovir Nanoparticle on the Liver and Kidney: Experimental Animal Study |
Peter, Aniekan Imo
(Discipline of Clinical Anatomy, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal)
Naidu, Edwin CS (Discipline of Clinical Anatomy, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) Akang, Edidiong (Discipline of Clinical Anatomy, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) Ogedengbe, Oluwatosin O (Discipline of Clinical Anatomy, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) Offor, Ugochukwu (Discipline of Clinical Anatomy, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) Rambharose, Sanjeev (Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal) Kalhapure, Rahul (Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal) Chuturgoon, Anil (Discipline of Medical Biochemistry, University of KwaZulu-Natal) Govender, Thirumala (Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal) Azu, Onyemaechi O (Discipline of Clinical Anatomy, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) |
1 | Sonawane, S.J., Kalhapure, R.S., Jadhav, M., Rambharose, S., Mocktar, C. and Govender, T. (2015) Transforming linoleic acid into a nanoemulsion for enhanced activity against methicillin susceptible and resistant Staphylococcus aureus. RSC Adv., 5, 90482-90492. DOI |
2 | Ogedengbe, O.O., Jegede, A.I., Onanuga, I.O., Offor, U., Naidu, E.C., Peter, A.I. and Azu, O.O. (2016) Coconut oil extract mitigates testicular injury following adjuvant treatment with antiretroviral drugs. Toxicol. Res., 32, 317-325. DOI |
3 | Statistics SAoo (2016) Statistics South Africa. P0302. Midyear population estimates, 2016. |
4 | GBD 2015 HIV Collaborators (2016) Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the global burden of disease study 2015. Lancet HIV, 3, e361-e387. DOI |
5 | UNAIDS (2017) Fact sheet - Latest statistics on the status of the AIDS epidemic. |
6 | Yildirimer, L., Thanh, N.T., Loizidou, M. and Seifalian, A.M. (2011) Toxicology and clinical potential of nanoparticles. Nano Today, 6, 585-607. DOI |
7 | Parasuraman, S. (2011) Toxicological screening. J. Pharmacol. Pharmacother., 2, 74-79. DOI |
8 | Council, N.R. (2010) Guide for the Care and Use of Laboratory Animals. National Academies Press. |
9 | Valdovinos, M.G., Schroeder, S.R. and Kim, G. (2003) Prevalence and correlates of psychotropic medication use among adults with developmental disabilities: 1970-2000. Int. Rev. Res. Ment. Retard., 26, 175-220. |
10 | Bailey, S.A., Zidell, R.H. and Perry, R.W. (2004) Relationships between organ weight and body/brain weight in the rat: what is the best analytical endpoint? Toxicol. Pathol., 32, 448-466. DOI |
11 | Piao, Y., Liu, Y. and Xie, X. (2013) Change trends of organ weight background data in sprague dawley rats at different ages. J. Toxicol. Pathol., 26, 29-34. DOI |
12 | Street, J.M., Souza, A.C., Alvarez Prats, A., Horino, T., Hu, X., Yuen, P.S. and Star, R.A. (2014) Automated quantification of renal fibrosis with Sirius Red and polarization contrast microscopy. Physiol. Rep., 2, e12088. DOI |
13 | Onyije, F., Ngokere, A., Ligha, A., Mgbere, O. and Avwioro, O. (2017) Computer-assisted image analysis in the diagnosis of gynaecological lesions: a quantitative and comparative investigation of haematoxylin-eosin with special dyes on tissue. J. Cancer Res. Pract., 4, 5-13. DOI |
14 | Alomar, M.J. (2014) Factors affecting the development of adverse drug reactions. Saudi Pharm. J., 22, 83-94. DOI |
15 | Iavicoli, I., Fontana, L. and Nordberg, G. (2016) The effectsof nanoparticles on the renal system. Crit. Rev. Toxicol., 46,490-560. DOI |
16 | Anders, M. (1980) Metabolism of drugs by the kidney. Kidney Int., 18, 636-647. DOI |
17 | Kuntzman, R., Mark, L., Brand, L., Jacobson, M., Levin, W. and Conney, A. (1966) Metabolism of drugs and carcingens by human liver enzymes. J. Pharmacol. Exp. Ther., 152, 151-156. |
18 | Liu, L., Ye, Q., Lu, M., Chen, S.-T., Tseng, H.-W., Lo, Y.-C. and Ho, C. (2017) A new approach to deliver anti-cancer nanodrugs with reduced off-target toxicities and improved efficiency by temporarily blunting the reticuloendothelial system with intralipid. Sci. Rep., 7, 16106. DOI |
19 | Ghasempour, S., Shokrgozar, M.A., Ghasempour, R. and Alipour, M. (2015) Investigating the cytotoxicity of iron oxide nanoparticles in in vivo and in vitro studies. Exp. Toxicol. Pathol., 67, 509-515. DOI |
20 | Gowda, S., Desai, P.B., Kulkarni, S.S., Hull, V.V., Math, A.A. and Vernekar, S.N. (2010) Markers of renal function tests. N. Am. J. Med. Sci., 2, 170-173. |
21 | Ahmed, S.N. and Siddiqi, Z.A. (2006) Antiepileptic drugsand liver disease. Seizure, 15, 156-164. DOI |
22 | Desai, M., Iyer, G. and Dikshit, R. (2012) Antiretroviral drugs: critical issues and recent advances. Indian J. Pharmacol., 44, 288-298. DOI |
23 | Johnson, L.F., Mossong, J., Dorrington, R.E., Schomaker, M., Hoffmann, C.J., Keiser, O., Fox, M.P., Wood, R., Prozesky, H., Giddy, J., Garone, D.B., Cornell, M., Egger, M. and Boulle, A. (2013) Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies. PLoS Med., 10, e1001418. DOI |
24 | Otieno, M. (2015) Why novel nanoparticle-based delivery platforms hold key for HIV/AIDS treatment and prevention? HIV/AIDS Res. Treat. Open J., 2, 81-85. DOI |
25 | Richman, D.D., Margolis, D.M., Delaney, M., Greene, W.C., Hazuda, D. and Pomerantz, R.J. (2009) The challenge of finding a cure for HIV infection. Science, 323, 1304-1307. DOI |
26 | Mamo, T., Moseman, E.A., Kolishetti, N., Salvador-Morales, C., Shi, J., Kuritzkes, D.R., Langer, R., von Andrian, U. and Farokhzad, O.C. (2010) Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine (Lond.), 5, 269-285. DOI |
27 | Parboosing, R., Maguire, G.E., Govender, P. and Kruger, H.G. (2012) Nanotechnology and the treatment of HIV infection. Viruses, 4, 488-520. DOI |
28 | Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A. and Liang, X.J. (2014) pH-sensitive nano-systems for drug delivery in cancer therapy. Biotechnol. Adv., 32, 693-710. DOI |
29 | Zhang, Q., Wang, X., Li, P.Z., Nguyen, K.T., Wang, X.J., Luo, Z., Zhang, H., Tan, N.S. and Zhao, Y. (2014) Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer targeted drug delivery in vivo. Adv. Funct. Mater., 24, 2450-2461. DOI |
30 | Sohail, M.F., Sarwar, H.S., Javed, I., Nadhman, A., Hussain, S.Z., Saeed, H., Raza, A., Bukhari, N.I., Hussain, I. and Shahnaz, G. (2017) Cell to rodent: toxicological profiling of folate grafted thiomer enveloped nanoliposomes. Toxicol. Res., 6, 814-821. DOI |
31 | Shi, J., Votruba, A.R., Farokhzad, O.C. and Langer, R. (2010) Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett., 10, 3223-3230. DOI |
32 | Yoo, J.-W., Irvine, D.J., Discher, D.E. and Mitragotri, S. (2011) Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat. Rev. Drug Discov., 10, 521-535. DOI |
33 | Daglar, B., Ozgur, E., Corman, M., Uzun, L. and Demirel, G. (2014) Polymeric nanocarriers for expected nanomedicine: current challenges and future prospects. RSC Adv., 4, 48639-48659. DOI |
34 | Zoroddu, M.A., Medici, S., Ledda, A., Nurchi, V.M., Lachowicz, J.I. and Peana, M. (2014) Toxicity of nanoparticles. Curr. Med. Chem., 21, 3837-3853. DOI |
35 | Suvarna, V.M. and Sangave, P.C. (2017) Development and validation of stability indicating rp-hplc method for tenofovir solid lipid nanoparticles. IJPSR, 8, 658-666. |
36 | Matlhola, K., Katata-Seru, L., Tshweu, L., Bahadur, I., Mak- gatho, G. and Balogun, M. (2015) Formulation and optimization of Eudragit RS PO-tenofovir nanocarriers using Box-Behnken experimental design. J. Nanomater., 2015, 630690. |
37 | Alukda, D., Sturgis, T. and Youan, B.C. (2011) Formulation of tenofovir-loaded functionalized solid lipid nanoparticles intended for HIV prevention. J. Pharm. Sci., 100, 3345-3356. DOI |
38 | Rambharose, S., Kalhapure, R.S. and Govender, T. (2017) Nanoemulgel using a bicephalous heterolipid as a novel approach to enhance transdermal permeation of tenofovir. Colloids Surf. B Biointerfaces, 154, 221-227. DOI |
39 | Karim, Q.A., Karim, S.S.A., Frohlich, J.A., Grobler, A.C., Baxter, C., Mansoor, L.E., Kharsany, A.B., Sibeko, S., Mlisana, K.P., Omar, Z., Gengiah, T.N., Maarschalk, S., Arulappan, N., Mlotshwa, M., Morris, L. and Taylor, D. (2010) Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science, 329, 1168-1174. DOI |
40 | Mayer, K.H., Maslankowski, L.A., Gai, F., El-Sadr, W.M., Justman, J., Kwiecien, A., Masse, B., Eshleman, S.H., Hendrix, C., Morrow, K., Rooney, J.F. and Soto-Torres, L. (2006) Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women. AIDS, 20, 543-551. DOI |
41 | Rambharose, S., Kalhapure, R.S., Akamanchi, K.G. and Govender, T. (2015) Novel dendritic derivatives of unsaturated fatty acids as promising transdermal permeation enhancers for tenofovir. J. Mater. Chem. B, 3, 6662-6675. |
42 | National Research Council (1985) Guide for the Care and Use of Laboratory Animals. National academy of science, Washington, DC, USA. |
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