CEPHALOMETRIC PREDICTORS OF OBSTRUCTIVE SLEEP APNEA

폐쇄성 수면 무호흡증에 있어 두부 규격 방사선 계측학적 기여 인자

  • Kwon, Tae-Geon (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Kyungpook National University) ;
  • Cho, Yong-Won (Dept. of Neurology, College of Medicine, Keimyung University) ;
  • Ahn, Byung-Hoon (Dept. of Otolaryngology, College of Medicine, Keimyung University) ;
  • Suh, Young-Sung (Dept. of Family Medicine, College of Medicine, Keimyung University)
  • 권대근 (경북대학교 치과대학 구강악안면외과학 교실) ;
  • 조용원 (계명대학교 의과대학 신경과학 교실) ;
  • 안병훈 (계명대학교 의과대학 이비인후과학 교실) ;
  • 서영성 (계명대학교 의과대학 가정의학 교실)
  • Published : 2003.10.30

Abstract

Purpose : This study was intended to perform cephalometric comparison between the patients with and without obstructive sleep apnea (OSA). The factors influencing the OSA in the lateral cephalogram was also investigated. Patient and Method : Twenty four patients who visited Sleep Disorder Clinic in Dongsan Medical Center, Keimyung University and evaluated with polysomnograph(PSG) and cephalogram were included in the study. The patients had apnea-hypopnea episode(AHI) over 10 times per hour was diagnosed as OSA after overnight PSG. To evaluate hard and soft tissue profile, cephalometric radiogram were taken at maximal intercuspation(P1) and mandibular protruding position(P2). The diffefence between the OSA and normal group were evaluated statistically and the stepwise regression analysis was applied to analyse the cephalometric influencing factors to OSA. Result : The OSA Group(n=14) had significantly higher Body Mass Index(BMI) than control group(n=10). Lower facial height(ANSGn) was longer in OSA group. However statistically significant difference was not detected in other anteroposterior craniofacial measurements. The soft palate lenth (PNS-P), hyoid position (MP-Hyoid) had positive correlation between AHI (r=0.496, r=0.413, respectively, p<0.05). However, the measurements of oropharyngeal airway was not different between the two groups. The hypothesis, the antero-posteriorly narrow oropharyngeal airway might aggravate the airway resistance and can give rise to higher AHI, was not accepted in the study. This can be attributed by inclusion of the patients performed uvulopalatopharyngoplasty because of the tonsilar or soft palate hypertrophy in the present study. The results of regression analysis revealed that PNS-P, upper airway width(Nph1), upper facial heght(N-ANS), and lower facial height(ANS-Gn) could influence the degree of AHI (F value < 0.0001, $R^2$ = 0.829). Conclusion : We suggest lateral cephalogram may utilized as a useful method to evaluate OSA. The patient with long soft palate, narrow upper airway width, long upper & lower facial height can be expected to have high risk of OSA. However, it should be emphasized the comphrehensive intraoral inspection including soft palate and tonsilar hypertrophy because lateral cepahlogram cannot visualize oropharyngeal status completely.

Keywords

References

  1. The report of an American Academy of Sleep Medicine Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999;22:667-689.
  2. Guilleminault C, Tilkian AG, Dement WC: Sleep apnea syndromes. Annu Rev Med. 1976;27:465-484. https://doi.org/10.1146/annurev.me.27.020176.002341
  3. Roth T, Roehrs T, Conway W: Behavioural morbidity of apnea. Sem Respir Med 1988;9:54-59.
  4. George CF, Smiley A: Sleep apnea and automobile crashes. Sleep 1999;22: 790-795.
  5. Galvin, JR, Rooholamini SA, Stanford W: Obstructive sleep apnea: diagnosis with ultrafast CT. Radiology 1989;171:775-778. https://doi.org/10.1148/radiology.171.3.2717750
  6. Shellock FG, Schatz CJ, Julien P, Steinburg F, Foo TK, Hopp M, Westbrook PR: Occlusion and narrowing of the pharyngeal airway in obstructive sleep apnea: evaluation by ultrafast spoiled GRASS MR imaging. Am J Roentgenol 1992;158:1019-1024. https://doi.org/10.2214/ajr.158.5.1566659
  7. Suto Y, Matsuo T, Kato T, Hori I, Inoue Y, Ogawa S, Suzuki T, Yamada M, Ohta Y: Evaluation of the pharyngeal airway in patients with sleep apnea: value of ultrafast MR imaging. Am J Roentgenol 1993;160:311-314. https://doi.org/10.2214/ajr.160.2.8424340
  8. Sher AE, Thorpy MJ, Shprintzen RJ, Spielman AJ, Burack B, McGregor PA: Predictive value of Muller’s maneuver in selection of patients for uvulopalatopharyngoplasty. Laryngoscope 1988;95:1483-1487.
  9. Shepard JWJr, Gefter WB, Guilleminault C, Hoffman EA, Hoffstein V, Hudgel DW, Suratt PM, White DP: Evaluation of the upper airway in patients with obstructive sleep apnea. Sleep 1991;14:361-371 https://doi.org/10.1093/sleep/14.4.361
  10. Katsantonis GP, Walsh JK: Somnofluroscopy: its role in the selection of candidates for uvulopalato-pharyngoplasty. Otolaryngol Head Neck Surg. 1986;94:56-60. https://doi.org/10.1177/019459988609400110
  11. Pepin JL, Ferretti G, Veale D, Romand P, Coulomb M, Brambilla C, Levy PA: Somnofluoroscopy, computed tomography, and cephalometry in the assessment of the airway in obstructive sleep apnoea. Thorax 1992;47:150-156. https://doi.org/10.1136/thx.47.3.150
  12. Woodson BT, Wooten MR: A multisensor solid-state pressure manometer to identify the level of collapse in obstructive sleep apnea. Otolaryngol Head Neck Surg. 1992;107:651-656. https://doi.org/10.1177/019459989210700507
  13. Miles PG, Vig PS, Weyant RJ, Forrest TD, Rockette HE Jr: Craniofacial structure and obstructive sleep apnea syndrome: a qualitative analysis and meta analysis of the literature. Am J Orthod Dentofac Orthop 1996;109:163-172. https://doi.org/10.1016/S0889-5406(96)70177-4
  14. Lowe AA, Gionhaku N, Takeuchi K, Fleetham JA: Three-dimensional CT reconstructions of tongue and airway in adult subjects with obstructive sleep apnea. Am J Orthod Dentofacial Orthop 1986; 90:364-374. https://doi.org/10.1016/0889-5406(86)90002-8
  15. Baik UB, Suzuki M, Ikeda M, Sugawara J, Mitani M: Relationship between cephalometric characteristics and obstructive sites in obstructive sleep apnea syndrome. Angle Orthod 2002;72:124-134
  16. deBerry-Borowiecki B, Kukwa A, Blanks RH: Cephalometric analysis for diagnosis and treatment of obstructive sleep apnea. Laryngoscope 1988;98:226-234.
  17. Partinen M, Guilleminault C, Quera-Salva MA, Jamieson A: Obstructive sleep apnea and cephalometric roentgenograms: the role of anatomic upper airway abnormalities in the definition of abnormal breathing during sleep. Chest 1988;93:1199-1205. https://doi.org/10.1378/chest.93.6.1199
  18. Fujita S, Conway W, Zorick F, Roth T: Surgical correction of anatomic abnormalities in obstructive sleep apnea syndrome: uvulopalatopharyngoplasty. Otolaryngol Head Neck Surg 1981;89:923-934. https://doi.org/10.1177/019459988108900609
  19. Liu Y, Lowe AA, Zeng X, Fu M, Fleetham JA: Cephalometric comparisons between Chinese nd Caucasian patients with obstructive sleep apnea. Am J Orthod Dentofacial Orthop 2000;117:479.485.
  20. Li KK, Powell NB, Kushida C, Riley RW, Adornato B, Guilleminault C: A comparison of Asian and White patients with obstructive sleep apnea syndrome. Laryngoscope 1999;109:1937-1940. https://doi.org/10.1097/00005537-199912000-00007
  21. Friedman M, Tanyeri H, La Rosa M, Landsberg R, Vaidyanathan K, Pieri S, Caldarelli D: Clinical predictors of obstructive sleep apnea. Laryngoscope. 1999;109:1901-1907. https://doi.org/10.1097/00005537-199912000-00002
  22. Jamieson A, Guilleminault C, Partinen M, Quera-Salva MA: Obstructive sleep apnea patients have craniomandibular abnormalities. Sleep 1986;9:469-477. https://doi.org/10.1093/sleep/9.4.469
  23. Lowe AA, Fleetham JA, Adachi S, Ryan CF: Cephalometric and computed tomographic predictors of obstructive sleep apnea severity. Am J Orthod Dentofacial Orthop 1995;107:589-595. https://doi.org/10.1016/S0889-5406(95)70101-X
  24. Hui DS, Ko FW, Chu SY, FOK JP, Chan MC, Li TS, et al; Cephalometric assessment of craniofacial morphology in chinease patient with obstructive sleep apnea. Resp Med 2003;97:640-646
  25. Imes NK, Orr WC, Smith RO, Rogers RM: Retrognathia and sleep. JAMA 1977; 237: 1596-1597. https://doi.org/10.1001/jama.237.15.1596
  26. Tangugsorn V, Skatvedt O, Krogstad O, Lyberg T: Obstructive sleep apnea: a cephalometric study. Part I. Cervico-craniofacial skeletal morphology. Eur J Orthod 1995;17:45-56.
  27. Lowe, AA, Ozbek MM, Miyamoto K, Pae EK, Fleetham JA: Cephalometric and demographic characteristics of obstructive sleep apnea: an evaluation with partial least square analysis. Angle Orthod 1997;67:143-154.
  28. Finkelstein Y, Wexler D, Horowitz E, Berger G, Nachmani A, Shapiro-Feinberg M, Ophir D: Frontal and lateral cephalometry in patients with sleep-disordered breathing. Laryngoscope 2001;111:634-641. https://doi.org/10.1097/00005537-200104000-00014
  29. Battagel JM, L’Estrange PR: The cephalometric morphology of patients with obstructive sleep apnoea. Eur J Orthod 1996;18:557-569. https://doi.org/10.1093/ejo/18.1.557
  30. Bacon WH, Turiot JC, Krieger J, Stierie JL: Cephalometric evaluation of pharyngeal obstructive factors in patients with sleep apnea syndrome. Angle Orthod 1989;60:115-122.
  31. Pracharktam N, Hans MG, Strohl KP, Redline S: Upright and supine cephalometric evaluation of obstructive sleep apnea syndrome and snoring subjects. Angle Orthod 1994;64:63-74.
  32. Yamada T, Tanne K, Miyamoto K, Yamauchi K: Influence of nasal respiratory obstruction on craniofacial growth in young Macaca fuscata monkeys. Am J Orthod Dentofac Orthop 1997;111:38-43. https://doi.org/10.1016/S0889-5406(97)70300-7
  33. Hiyama, S, Takashi O, Ishiwata Y, Kuroda T: Supine cephalometric study on sleep-related changes in upper airway structures in normal subjects. Sleep 2000;23:783-790. https://doi.org/10.1093/sleep/23.6.783
  34. Remmers JE, deGroot WJ, Sauerland EK, Anch AM: Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 1978;44:931-938. https://doi.org/10.1152/jappl.1978.44.6.931
  35. Haponik EF, Smith PL, Bohlman ME, Allen RP, Goldman SM, Bleeker ER: Computerized tomography in obstructive sleep apnea. Correlation of airway size with physiology during sleep and wakefulness. Am Rev Respir Dis 1983;127:221-226.
  36. Guilleminault C, Riley R, Powell N: Obstructive sleep apnea and abnormal cephalometric measurements. Chest 1984;86:793-794. https://doi.org/10.1378/chest.86.5.793
  37. Riley R, Guilleminault C, Powell N, Simmons FB: Palatopharyngoplasty failure, cephalometric roentgenograms, and obstructive sleep apnea. Otolaryngol Head Neck Surg 1985;93:240-244. https://doi.org/10.1177/019459988509300222
  38. Mallampati SR, Gatt SP, Gugino LD, Desai SP, Waraksa B, Freiberger D, Liu PL: A clinical sign to predict difficult tracheal intubation: a prospective study. Can Anaesth Soc J 1985;32:429-434. https://doi.org/10.1007/BF03011357