• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.1
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• pp.61-66
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• 2006

The simple Langmuir isotherm is frequently employed to describe the equilibrium behavior of protein adsorption on a wide variety of adsorbents. The two adjustable parameters of the Langmuir isotherm - the saturation capacity, or $q_m$, and the dissociation constant, $K_d$ - are usually estimated by fitting the isotherm equation to the equilibrium data acquired from batch equilibration experiments. In this study, we have evaluated the possibility of estimating $q_m$ and $K_d$ for the adsorption of bovine serum albumin to a cation exchanger using batch kinetic data. A rate model predicated on the kinetic form of the Langmuir isotherm, with three adjustable parameters ($q_m,\;K_d$, and a rate constant), was fitted to a single kinetic profile. The value of $q_m$ determined as the result of this approach was quantitatively consistent with the $q_m$ value derived from the traditional batch equilibrium data. However, the $K_d$ value could not be retrieved from the kinetic profile, as the model fit proved insensitive to this parameter. Sensitivity analysis provided significant insight into the identifiability of the three model parameters.

• Journal of The Korean Astronomical Society
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• v.24 no.2
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• pp.151-159
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• 1991

Using the photographic imagery of the SO galaxy NGC 5102, the equivalent luminosity profile and the fractional integrated luminosity curve have been derived. Several photometric parameters of the galaxy, such as a total magnitude ($B_T$), equivalent radius ($r^*_e$), effective surface brightness (${\mu}^*_e$), and concentration indices ($C_{21}$, $C_{32}$) were derived from the luminosity profiles. According to the decomposition method from the nonlinear least squares fitting, photometric parameters of the bulge (${\mu}_e$, $r_e$) and the exponential disk (${\mu}(0)$, ${\alpha}^{-1}$), and the bulge to total luminosity ratio (B/T) were obtained. The derived central disk surface brightness (${\mu} (0)\;=\;22.06\;{\pm}\;0.18\;mag/\Box"$) and the evaluated B/T ratio (= 0.52) of the NGC 5102 are close to the mean values (${\mu} (0)\;=\;21.65\;{\pm}\;0.3\;mag/\Box"$, B/T=0.63) of the SO galaxies. Analysis showed that a lens-like hump is embedded in the equivalent luminosity profile of the NGC 5102.

• IE interfaces
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• v.11 no.2
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• pp.65-78
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• 1998

The letters of the automobile tire are usually engraved on the side-wall. The shape of the side-wall is a sculptured surface generated by the rotational sweeping of a profile curve. The letters laid on the side-wall are usually designed by a 2-dimensional CAD. It is impossible to machine the letters on the surface accurately by 3-axis NC machining, because the axis of cutter should be tilted to align with the normal vector of the surface. In this case. the degree of freedom for the machine is at least four. This paper describes an idea for tool path generation of a 4-axis machine by using the 2-dimensional CAD data of the letters and the surface of the side-wall. This study includes the following procedures; (1) measuring the profile of the side-wall surface and curve-fitting of the measured points. (2) the 'non-parallel projection' of the letters on the side-wall, and (3) an inverse kinematics of the 4-axis lettering machine. Procedures in this paper are programmed in C-language on Windows95 environment. With a PC based CNC controller and a 4-axis lettering machine. these are tested sucessfully for the practical use.

• Wind and Structures
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• v.17 no.4
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• pp.419-433
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• 2013

This paper investigates the vertical profiles of horizontal mean wind speed and direction based on the synchronized measurements from a Doppler radar profiler and an anemometer during 16 tropical cyclones at a coastal site in Hong Kong. The speed profiles with both open sea and hilly exposures were found to follow the log-law below a height of 500 m. Above this height, there was an additional wind speed shear in the profile for hilly upwind terrain. The fitting parameters with both the power-law and the log-law varied with wind strength. The direction profiles were also sensitive to local terrain setups and surrounding topographic features. For a uniform open sea terrain, wind direction veered logarithmically with height from the surface level up to the free atmospheric altitude of about 1200 m. The accumulated veering angle within the whole boundary layer was observed to be $30^{\circ}$. Mean wind direction under other terrain conditions also increased logarithmically with height above 500 m with a trend of rougher exposures corresponding to lager veering angles. A number of empirical parameters for engineering applications were presented, including the speed adjustment factors, power exponents of speed profiles, and veering angle, etc. The objective of this study aims to provide useful information on boundary layer wind characteristics for wind-resistant design of high-rise structures in coastal areas.

• Proceedings of the Korean Vacuum Society Conference
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• 2015.08a
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• pp.61.1-61.1
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• 2015

Nanoscale semiconductor plasma processing has become one of the most challenging issues due to the limits of physicochemical fabrication routes with its inherent complexity. The mission of future and emerging plasma processing for development of next generation semiconductor processing is to achieve the ideal nanostructures without abnormal profiles and damages, such as 3D NAND cell array with ultra-high aspect ratio, cylinder capacitors, shallow trench isolation, and 3D logic devices. In spite of significant contributions of research frontiers, these processes are still unveiled due to their inherent complexity of physicochemical behaviors, and gaps in academic research prevent their predictable simulation. To overcome these issues, a Korean plasma consortium began in 2009 with the principal aim to develop a realistic and ultrafast 3D topography simulator of semiconductor plasma processing coupled with zero-D bulk plasma models. In this work, aspects of this computational tool are introduced. The simulator was composed of a multiple 3D level-set based moving algorithm, zero-D bulk plasma module including pulsed plasma processing, a 3D ballistic transport module, and a surface reaction module. The main rate coefficients in bulk and surface reaction models were extracted by molecular simulations or fitting experimental data from several diagnostic tools in an inductively coupled fluorocarbon plasma system. Furthermore, it is well known that realistic ballistic transport is a simulation bottleneck due to the brute-force computation required. In this work, effective parallel computing using graphics processing units was applied to improve the computational performance drastically, so that computer-aided design of these processes is possible due to drastically reduced computational time. Finally, it is demonstrated that 3D feature profile simulations coupled with bulk plasma models can lead to better understanding of abnormal behaviors, such as necking, bowing, etch stops and twisting during high aspect ratio contact hole etch.

• Journal of Korean Society for Quality Management
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• v.43 no.3
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• pp.273-288
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• 2015

Purpose: In this study, we apply environmental stress screening (ESS) to battle management system (BMS) of a tank and use the ESS profile based on production process data, guided by MIL-HDBK-781/344/2164. Methods: To optimize ESS Profile of the BMS of a tank, we estimate ESS model parameters (e.g., defect density, screening strength) using primary production failure reporting and corrective action system (FRACAS) data of military supply contract firm. Results: First, we collect the Primary production FRACAS data of military supply contract firm. Second, we compute curve fitting approach to find patent defect density and latent defect density using FRACAS data. Third, we solve the equation of Defect Density(patent defect density + latent defect density)($D_{IN}$) and Screening Strength(SS) Using second step data. As a result of analysis according to the order, we calculate $D_{IN}$(Temperature stress case : 74.02, Vibration stress : 10.252) and : SS(Temperature stress case : 0.4632, Vibration stress : 0.4142) and confirm the Condition II-D based on MIL-HDBK-344. According to Condition II-D, it is necessary to modify existing ESS profile through decreasing the $D_{IN}$ and increasing the SS. Conclusion: Identification of defect causes through ESS approach reduce defect densities for production. It provides feedback to a lessons-learned data base to avoid similar problems on next generation tank BMS.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.591-592
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• 2015

X1822-371 is a low mass X-ray binary with an accretion disk corona exhibiting partial eclipses and pulsations in the X-ray band. We update its orbital ephemeris by combining new RXTE observations and historical records, with a total time span of 34 years. There were 11 RXTE observations in 2011 but the eclipsing profile can be seen in only 4 of them. The eclipsing center times were obtained by fitting the profile with the same model as previous studies. Combined with the eclipsing center times reported by Iaria et al. (2011), the O-C analysis was processed. A quadratic model was applied to fit the O-C results and produced a mean orbital period derivative of $\dot{P}_{orb}=1.339(25){\times}10^{-10}s/s$, which is slightly smaller than previous records. In addition to the orbital modulation from the orbital profile, we also present our preliminary results for measuring the orbital parameters using the orbital Doppler effect from the pulsation of the neutron star in X1822-371. The updated orbital parameters from eclipsing profiles will be further compared with the ones from pulsar timing.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.5
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• pp.1182-1191
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• 1994

This paper presents an enhanced method of slit beam projection intended for the rapid measurement of 3-dimensional surface profiles of dies and molds. Special emphasis is given to optimizing the design of optical system so that the measuring accuracy can be maximized by adopting two-plane camera calibration together with sub-pixel image processing techniques. Finally, several measurement examples are discussed to demonstrate that an actual measuring accuracy of $\pm$ 0.2 mm can be achieved over the measuring range of 500 mm{\times}300mm{\times}200mm$.

• Journal of Powder Materials
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• v.10 no.5
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• pp.318-324
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• 2003

The nano-scale crystallite sizes of uranium oxide powders in simulated spent fuel were measured by the neutron diffraction line broadening method in order to analyze the sintering behavior of the dry process fuel. The mixed $UO_2$ and fission product powders were dry-milled in an attritor for 30, 60, and 120 min. The diffraction patterns of the powders were obtained by using the high resolution powder diffractometer in the HANARO research reactor. Diffraction line broadening due to crystallite size was measured using various techniques such as the Stokes' deconvolution, profile fitting methods using Cauchy function, Gaussian function, and Voigt function, and the Warren-Averbach method. The non-uniform strain, stacking fault and twin probability were measured using the information from the diffraction pattern. The realistic crystallite size could be obtained after separation of the contribution from the non-uniform strain, stacking fault and twin.

• East Asian mathematical journal
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• v.36 no.1
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• pp.81-90
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• 2020

Many compartment models assume a kinetically homogeneous amount of materials that have well-stirred compartments. However, based on observations from such processes, they have been heuristically fitted by exponential or gamma distributions even though biological media are inhomogeneous in real environments. Fractional differential equations using a specific kernel in Pharmacokinetic/Pharmacodynamic (PKPD) model are recently introduced to account for abnormal drug disposition. We discuss a tumor growth inhibition (TGI) model using fractional-order derivative from it. This represents a tumor growth delay by cytotoxic agents and additionally show variations in the equilibrium points by the change of fractional order. The result indicates that the equilibrium depends on the tumor size as well as a change of the fractional order. We find that the smaller the fractional order, the smaller the equilibrium value. However, a difference of them is the number of concavities and this indicates that TGI over time profile for fitting or prediction should be determined properly either fractional order or tumor sizes according to the number of concavities shown in experimental data.