• 기술사
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• 제45권1호
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• pp.61-62
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• 2012

Realizing that retired scientists and engineers are one of the most important human resources in contributing scientific competitiveness of the country, several policies for supporting utilizing retired scientists and engineers have been developed and performed in support of government for years. Those policies in proper priority will bring the efficient utilization mechanism of retired scientists and engineers to the society with the value and the respect of scientists and engineers at all. So, Utilization of retired scientists and engineers for advancement of Technology(Reseat programme) were summarized.

• 한국산학기술학회논문지
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• 제20권8호
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• pp.102-110
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• 2019

오늘날 프로스포츠 구단들은 한치 앞도 알 수 없는 극한의 경쟁 환경에 놓여있다. 우승 후보로 꼽히던 구단이 극심한 부진을 겪는 반면 하위권으로 예상되던 구단이 승승장구하는 등 예상하지 못한 상황들의 반복이 계속되고 있는 것이다. 이는 인적자원이 가장 중요한 요소인 스포츠 산업에서 인적자원활용과 전략에 대한 고뇌가 필요하다는 반증이기도 하다. 이에 본 연구는 우리나라 최초의 프로축구 시민구단인 대구FC 축구단을 연구대상으로 선정하여 인적자원혁신에 대한 사례분석을 실시 및 시민구단이 나아가야 할 방향성 제시를 목적으로 한다. 연구방법으로 국내 프로축구리그 성장과정 및 대구FC 성장과정을 알아보고 인적자원혁신 성공사례분석의 틀로써 Frey, et al.(2015)의 평범한 자원의 논의(the argument for ordinary resources, 이하 AOR)를 제시한다. 이후 대구FC 구단이 나아가야 할 방향에 대한 함의를 정리한다. 연구결과, 전략적인 자원(용병선수)과 평범한 자원(국내선수)의 조화와 대구FC 구단이 보여준 감독이하 코치진들에 대한 믿음을 성공요인으로 분석하였다. 본 연구의 기여로는 시작과 끝이 분명한 시간제(Time) 성격이 강한 스포츠 산업에서 구단들이 우수한 성적을 얻기 위해 구사해야 할 전략들의 방향 중 인적자원의 중요성을 언급함으로써 보다 다양한 스포츠 구단들의 전략전술 기초를 풍부히 하였다는 점이다.

• Biomolecules & Therapeutics
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• 제29권6호
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• pp.667-677
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• 2021

The elevated expression of the hyaluronan-mediated motility receptor (HMMR) is known to be highly associated with tumor progression in prostate cancer, but the molecular mechanisms underlying the regulation of HMMR expression remain unclear. Here, we report that mammalian target of rapamycin (mTOR) is a key regulator of HMMR expression, for which its kinase activity is required. Pharmacological inhibitors of mTOR, such as rapamycin and Torin2, markedly suppressed the mRNA level as well as the protein level of HMMR in LNCaP and PC-3 cells. Our data demonstrate that such regulation occurs at the transcription level. HMMR promoter reporter assays revealed that the transcription factor SRF is responsible for the mTOR-mediated transcriptional regulation of HMMR gene. Consistently, the suppression of HMMR expression by Torin2 was noticeably reversed by the overexpression of SRF. Moreover, our findings suggest that the SRF binding sites responsible for the transcriptional regulation of HMMR through the mTOR-SRF axis are located in HMMR promoter sequences carrying the first intron, downstream of the translational start site. Furthermore, the upregulation of HMMR by DHT was abolished by stimulation with rapamycin, prior to DHT treatment, suggesting that mTOR activity is required for the induction of HMMR expression by androgen. Collectively, our study provides new mechanistic insights into the role of mTOR/SRF/AR signaling in HMMR regulation in prostate cancer cells.

• 동의생리병리학회지
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• 제25권4호
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• pp.608-613
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• 2011

The aqueous Green tea comes to be used with the Oriental medicine plant, it has the numerous health benefits, including antioxidant, anti-inflammatory, and anti- carcinogenic properties. Epidermal progenitor cells give rise to multiple skin lineages: hair follicle, sebaceous gland and the overlying interfollicular epidermis. Sebocytes are the cells of the sebaceous gland, which synthesize and accumulate lipid dropolets. In order to determine the effect of Green tea on lipid production, several experiments were performed in SZ95 cells (sebocytes). We found that Green tea increased lipid droplets compared with control in a dose-dependent manner. Human sebaceous glands produce sebum, a lipid mixture of squalene, wax esters, triglycerides, cholesterol esters, and free fatty acids that is secreted onto the skin. Therefore, to investigate the effects of Green tea on intracellular lipid levels, we treated SZ95 cells with Green tea, and then examined cholesterol and triglyceride levels. After treatment of the cells with Green tea, the cholesterol and triglyceride levels of SZ95 cells were increased significantly in a dose-dependent manner.

• 동의생리병리학회지
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• 제29권3호
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• pp.223-229
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• 2015

In this study, we investigated the effect of ethanol extracts from Gentianae scabrae bunge (GSB) on the activities of antioxidant, whitening and anti-inflammation. Viability of cells was measured by neutral red (NR) assay, and inhibitory effects of GSB on melanin synthesis was determined the melanin production in B16F10 cells. The expression level of matrix metalloproteinase-1 (MMP-1) in media was analyzed by ELISA kit, and nitric oxide (NO) production in RAW264.7 cells was monitored by measuring the nitrite content in culture medium. GSB showed highly efficacy in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and significantly reduced melanin synthesis in B16F10 cells. MMP-1 production in UVB-stimulated human dermal fibroblast (HDF) cells was inhibited by GSB treatments. NO production was suppressed by the treatment of GSB in LPS-stimulated RAW264.7 cells. From this results, it was indicated that GSB could be utilized as anti-aging and whitening cosmetic ingredients.

• 한국기술사회:학술대회논문집
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• 한국기술사회 1983년도 한일기술사 합동 심포지움
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• pp.74-77
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• 1983

To attain the rich and comfortable human living, much development and economic growth are needed. But the radical development destroys natural environments or resources, and also the life environments are destroyed. How to maintain the balance between development and environments forms an important problem. Since 1955, a great deal of damage has been done to human being by the pollution of air, water or noise in Japan, for example, Minamata-byo (1956), arsenical poisoning by mkil (1955), Cd-I taiitai-byo (1955), asthma by air pollution, etc. Now, there are over 100,000 sick persons suffering from pollution in Japan. To prevent the pollution, the first act was made 1967, the kind of which were defined as follow:air, water, soil, noise, vibration ground subsidence, and bad smell. Laws on these were established 1970∼1981, and the environments here ave gradually being improved. The mentioned above gituation necsesitates the measuring or chemical analysis of pollution data, but the many cost is necessary to obtain such data. The special environment measuring certifier was needed and the Measurement Law was amended 1974. Some comment will be given of the present condition of environmental measuring certifier.

• 수산해양교육연구
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• 제19권1호
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• pp.150-160
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• 2007

The school system of fisheries high school was proper to specialist objective school system in order to training for expert human resource development.Training a field of human resources development from fisheries high school is fallow; fisheries production, seamen's training, ship engine and refrigerator, marine electronic telecommunication and information, fisheries foods production and fisheries foods production and distribution, fishery fisheries self-management, marine distribution, management and conservation of marine environment, safety and marine prevention of disasters, apparatus of marine development, under water area development.A new department opening and each department was revised toward to department name and department character. The unit-lesson hour of curriculum according to specialist objective school system of fisheries and marine highschool was revised. professional subject 98 unit-lesson hour(52%), normality subject 90 unit-lesson hour(48%), and educational activity of professional subject 10unit-lesson hour, total training activity 10 unit-lesson hour. And the special objective school system need to revise curriculum of 208 total unit-lesson hour.

• 동의생리병리학회지
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• 제31권3호
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• pp.167-172
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• 2017

In this study, we investigated the effect of Puerariae Radix ethanol extracts (EPR). The effect of the EPR on proliferation of human hair dermal papilla cells(HHDPCs) by MTT assay and observed Expression of mechanisms that regulate cell proliferation extracellular signal-regulated kinase(ERK) and Akt by western blot. The results showed EPR increased the proliferation of HHDPCs and up-regulation phosphorylation of ERK and Akt. ERK and Akt increased by EPR inhibited phosphorylation by PD98059 (ERK inhibitor) and LY294002 (Akt inhibitor), and cell proliferation was also inhibited. These results suggested EPR increases the proliferation of HHDPCs through phosphorylation of ERK and Akt, and therefore is a beneficial effect for the alopecia treatment.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2004년도 추계학술발표대회 논문집
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• pp.149-152
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• 2004

Currently, with the development of an advanced industrial form, attention to human life has risen gradually. On the basis of aboves, Oriental medical industry has been achieved revolutionarily, and moreover the new word 'Well-being' has been born due to the value of life and attention to health. All who live in the 21-century have worried about problem with health and well-being, and the substitute medical science centering around the Oriental medicine has come up as the major concern, not to speak of the Oriental the West. Domestically, Research and attention to the Oriental medicine has increased, and its importance has appeared. At the moment, locally self-governing groups have taken an active step to study the genetic resources centering around locally- breedy wild medicinal herbfor their economy growth. Accordingly, in the historic view, to discover our medicinal herb's essence and to supply professional, systemical infomation of herb genetic, the necessity of professional exhibition museum can come up. under the above circumstances, I propose the public information museum in local area.

• International Journal of Human Ecology
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• 제10권2호
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• pp.25-37
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• 2009

This study investigated differences in related factors affecting life satisfaction with the elderly in or above middle class experiencing successful ageing. In the study, the respondents were 206 elderly people whose occupation (professional career) placed them in the middle and upper class range residing in metropolitan Seoul. Major results are summarized as follows: (1) In order to test gender differences, results of t-test show that there are 13 variables with seven of those being statistically significant and the rest being insignificant. (2) Needs fulfillment and physical functioning are significant factors for Korean male elders to be satisfied with their later lives. Needs fulfillment, physical functioning, group activity, and learning activity are significant factors for Korean female elders to be satisfied with their later lives.