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http://dx.doi.org/10.15188/kjopp.2017.06.31.3.167

Effect of Puerariae Radix Ethanol Extract on the Proliferation of Human Dermal Papilla Cells  

Park, Seol A (Department of Beauty Design Graduate School, Wonkwang University)
Ko, Kyoung Sook (Department of Beauty Design Graduate School, Wonkwang University)
In, Myoung Hee (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Mun, Yeun Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Woo, Won Hong (Department of Anatomy, College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.31, no.3, 2017 , pp. 167-172 More about this Journal
Abstract
In this study, we investigated the effect of Puerariae Radix ethanol extracts (EPR). The effect of the EPR on proliferation of human hair dermal papilla cells(HHDPCs) by MTT assay and observed Expression of mechanisms that regulate cell proliferation extracellular signal-regulated kinase(ERK) and Akt by western blot. The results showed EPR increased the proliferation of HHDPCs and up-regulation phosphorylation of ERK and Akt. ERK and Akt increased by EPR inhibited phosphorylation by PD98059 (ERK inhibitor) and LY294002 (Akt inhibitor), and cell proliferation was also inhibited. These results suggested EPR increases the proliferation of HHDPCs through phosphorylation of ERK and Akt, and therefore is a beneficial effect for the alopecia treatment.
Keywords
Puerariae Radix; HHDPCs; cell proliferation; ERK; Akt;
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Times Cited By KSCI : 11  (Citation Analysis)
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