• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.70-71
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• 2003

Dichlorodiphenyltrichloroethane (DDT), is a widespread environmental pollutant. In this study, we investigated the effect of DDT on testosterone production through aromatase and investigated its molecular mechanism in testicular leydig cell, R2C. We investigated that the effects of DDT on testosterone production and its effects on aromatase activity in R2C cell by radio immunoassay (RIA). (omitted)

• Journal of Ginseng Research
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• v.38 no.4
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• pp.270-277
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• 2014

Background: The effect of methyl jasmonate (MJ) on ginsenoside production in different organs of ginseng (Panax ginseng Meyer) was evaluated after the whole plant was dipped in an MJ-containing solution. MJ can induce the production of antioxidant defense genes and secondary metabolites in plants. In ginseng, MJ treatment in adventitious root resulted in the increase of dammarenediol synthase expression but a decrease of cycloartenol synthase expression, thereby enhancing ginsenoside biosynthesis. Although a previous study focused on the application of MJ to affect ginsenoside production in adventitious roots, we conducted our research on entire plants by evaluating the effect of exogenous MJ on ginsenoside production with the aim of obtaining new approaches to study ginsenoside biosynthesis response to MJ in vivo. Methods: Different parts of MJ-treated ginseng plants were analyzed for ginsenoside contents (fine root, root body, epidermis, rhizome, stem, and leaf) by high-performance liquid chromatography. Results: The total ginsenoside content of the ginseng root significantly increased after 2 d of MJ treatment compared with the control not subjected to MJ. Our results revealed that MJ treatment enhances ginsenoside production not in the epidermis but in the stele of the ginseng root, implying transportation of ginsenosides from the root vasculature to the epidermis. Application of MJ enhanced protopanaxadiol (PPD)-type ginsenosides, whereas chilling treatment induced protopanaxatriol (PPT)-type ginsenosides. Conclusion: These findings indicate that the production of PPD-type and PPT-type ginsenosides is differently affected by abiotic and biotic stresses in the ginseng plant, and they might play different defense mechanism roles.

• IMMUNE NETWORK
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• v.8 no.3
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• pp.98-105
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• 2008

Background: Allergic inflammation was induced by activated Th2 lymphocytes, leading to IgE production and eosinophil activation. A Th2 disproportion was shown in atopic children soon after birth. During specific allergen stimulation, an increase of Th2 cells was observed in most cases. In this study, we prepared new screening "whole blood" system for searching the anti-atopic materials. Cytokine production and IgE secretion from whole blood system were assessed and we confirmed the results by using animal system. Methods: Pathological features in NC/Nga mice are similar to those observed in human atopic dermatitis. Whole blood from NC/Nga mouse was stimulated by using TNCB (Th2 activator) or candidate materials of anti-atopic dermatitis, and the production of cytokines (IL-4, IL-12, and IFN-${\gamma}$) were measured by ELISA. In order to confirm the results of whole blood system, in vivo test was done by using NC/Nga mice. Results: In whole blood system, LPS and extracts of green tea, hardy orange and onion induced the production of IL-12 and IFN-${\gamma}$ while they reduced the production of IL-4. Also, LPS and extracts of onion reduced IgE production. Though atopic dermatitis was observed from a mouse stimulated with TNCB, it was not when a mouse was co-stimulated in LPS or extracts of onion. The results are same as those observed in whole blood system. Conclusion: Whole blood system was simple and speedy methods for searching a materials compared with the conventional high-cost animal system. And the results using whole blood system was proved to be reliable in our experiments for screening anti-atopic material. We expect that the system can be applied to other experiments for searching similar materials.

• Journal of Korean Institute of Industrial Engineers
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• v.12 no.1
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• pp.31-41
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• 1986

In this paper, an integrated production inventory model is developed for two products on a single facility in which the raw materials are fed to the production system as required at the facility. The aim is to determine simultaneously the optimal production schedule for two products and the optimal procurement policies for the raw materials in a way that minimizes the total variable cost of the production system. The production schedule for the more frequently set-up product is formulated by the method of equal or unequal lot sizes. For the model developed, we present a computational scheme of finding the optimal policies and carry out sensitivity analysis through example problem.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.2
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• pp.195-204
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• 2020

The purpose of this study was to investigate the effects of 14 Chung-bu medicinal materials described in the Dongui Bogam on inflammatory cytokine production in HaCaT human keratinocyte cells. In order to confirm this possibility, we screened inhibition activity of 17 cytokines using Bio-Plex Pro^TM Human Cytokine 17-plex assay in HaCaT cell lines. Of the 14 Chung-bu medicinal materials, Holotrichia (Ho) and Scorpio (Sc) exerted inhibitory effects on interleukin (IL)-5 production; Ho, Mantidis Ootheca (MO), and Hirudo (Hi) exerted inhibitory effects on IL-6 production; Ho, MO, Lumbricus (Lu), Hi, and Meretricis Concha (MC) showed significant inhibitory effects on IL-8 production; Gecko (Ge), Bombycis Faeces (BF), Cicadidae Periostracum (CP), and MC showed significant inhibitory effects on IL-13 production; and Testudinis Chinemis Plastrum et Carapax (TCPC), BF, and Lu exerted significant inhibitory effects on MIP-1β production. Results indicated that the Chung-bu medicinal materials might be a good candicate as potential anti-inflammatory agents for inhibition of skin inflammation. However, further investigations on these materials, including mechanistic studies, should be carried out to validated the effects in human skin equivalent models of dermatitis.

• The Journal of Fisheries Business Administration
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• v.28 no.2
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• pp.67-85
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• 1997

The subject of this study is limited to the market of producting and the analyzed the change of the supply structures, but the wide range of the study also contains the relationship present movement of consumption and the supply stuctures. To put it concretely, the present movement of the structre and the development of the market of producting are examined with the fisheries processing firms. The factors which dominate the structure of fisheries processing are; first, fisheries products as raw materials of processing; second, man-power; third, processing facilities and techniques; forth, a market where the products will be consumed. In particular, the conditions of supply of raw materials which are major factor have been worse and worse due to exhaustion of marine resources and so the capacity of fisheries production has been reduced. Furthermore, the conditions of manpower also are in trouble. Under the conditons, raw materials are imported largely and many companies try to make overseas enpansion for cheap manpower and raw materials. Particulaly, the relationship between consumption market and the structure of processing in a place of producton is analyzed newly. I try to show new logic that demands of consumption market are reflected strongerly to production with the development of consumption market and the rights of decision on the choice of raw materials and a processing item have been handed over to consumption market. In a word, I try to examined closely the new supply structure of fisheries products and the structure of consumption market through the analysis of the structure of processing in a place of production.

• Journal of architectural history
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• v.25 no.5
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• pp.27-40
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• 2016

The purpose of this study was to comprehend the procurement system of iron materials and the production process of ironwork in royal tombs constructions in the later Joseon period. For this purpose, sixteen Sanneung-uigwes were analyzed. The following conclusions have been reached through the study. First, it was procuring five types of iron materials in constructions of royal tombs. Sincheol had been supplied up to the mid-18th century. On the other hand, the amount of jeongcheol was increased rapidly. Because of the procurement system of initial tools was changed from bokjeong(a kind of tribute) to self-production in the Noyaso. Second, the government stockpiles were utilized as much as possible than bokjeong to manage the limited construction period and sudden construction start. Third, before moving the site of tombs, the melting furnace was installed in the Gungisi(armament factory). The amount of the melting furnace was increased from 5 to 8 since producing the initial tools in the Noyaso. Fourth, six kinds of master artisans were worked in the field of producing ironwork. Metal worker was assigned to one person per melting furnace. Fifth, the quality of final iron materials was controlled by use. Since the 19th century, it had been produced enhanced ironwork.

• Journal of radiological science and technology
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• v.3 no.1
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• pp.67-72
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• 1980

To shield the radiation, we can make use of various materials, but the scattered rays can be caused by the shielding materials. The degree of the scattered rays production is influenced by the nature of the shielding materials and the energy of the radiation, therefore to choose the proper shielding material is the most important matter in radiation protection. Authors made an experimental study on the scattered rays generated from the shielding materials, and obtained the results as follows: 1. In the ranking of the scattered rays production: Cement bricks, black colored fire bricks, and red colored fire bricks were marked the first the second, and the third ranking respectly, and the last order was lead plates. 2. In the relative ranking of the scattered rays production by energy increase: Lead plates were marked the first order, the next and third order were red colored fire bricks and black colored fire bricks respectly, and cement bricks were marked the last order. 3. The scattered ray ratio of lateral-back point per lateral point were generally decreased by energy increment. The diminishing orders were that lead plates were the first order, and the next and the third order were red colored fire bricks and black colored fire bricks respectly, cement bricks were marked the last order.

• Journal of the Korean Society of Costume
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• v.65 no.2
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• pp.125-143
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• 2015

This study is to propose an 'education-training-certificate of qualification' design of fashion accessories production, which can be applied to education in universities and individuals. It is based on the National Competency Standards (NCS), which was developed through the '2013 National Competency Standards Development Project' for the fashion accessories production. FGI (Focus Group Interviews), which is a research methodology, is carried out on target groups of educational experts and specialists in the field of fashion accessories production. Through this, five courses were suggested; first, 'fashion accessories design' course was proposed for the education and training of 'design development' and 'development of raw materials'. Secondly, 'fashion product production' course was proposed for the education and training of 'production of samples'. Thirdly, 'fashion product manufacture and planning' course was proposed for the competency element units: 'calculation of cost', 'determination of mass production model and price', 'planning of the main manufacturing process' and 'ordering of raw materials'. Lastly, 'mass production of fashion products' course and the 'field practice of fashion product manufacture' course were proposed for the competency element units: 'planning for mass production', 'preparation for mass production', 'mass production' and 'inspection of completed products'. In addition, a new certificate of 'technician of fashion accessory production' was proposed in order to test qualified skills for the fashion accessories production. The test is composed of a written examination of short-answer questions, technical drawing and production.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 1998.11a
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• pp.119-122
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• 1998

Chemical analysis, measurement of pumping rates of 60 production wells and depth to water tables of 57 monitoring wells were carried to protect depletion of water resources and deterioration of water quality for the commercial portable ground-water. Borehole depth of production well averages 149m(31 boreholes), casing depth is 28m(29 boreholes), production rate is 70 $m^3$/day and depth to water table of monitoring well is 23.26m, respectively. The geology of 60 wells can be divided into Daebo granite(20), Okchun metarmorphic complex(18), Precambrian granitic gneiss(15), Bulguksa granite(4), Cheju volcanics(2), Cretaceous sedimentary rock(1). Average electrical conductivity and pH are 152$\mu$S/cm, and 7.35, respectively. The contents of major cation and anion predominantly $Ca^{2+}$>N $a^{+}$>M $g^{2+}$> $K^{+}$ and HC $O_{3}$$^{－}$ >S $O_{4}$$^{2-}$>Cl￣>F￣. Water type is predominantly $Ca^{2+}$-HC $O_{3}$$^{－}$(81.7%). It's possible that water chemistry of some wells were affected not only by the geology of boreholes penetrated but by inflows of surface water or shallow ground-water. Therefore, it is strongly necessary to steadily monitor the water quality and hydrogeologic conditins of production wells.ells.ls.ells.