• Journal of the Korea Society of Computer and Information
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• v.19 no.2
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• pp.161-171
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• 2014

In this paper the flow dynamics of the flue gas equipment in the desulfurization system was numerically analyzed by simulating the problems for the turbulent and combustion flow from Induced Draft Fan(I.D.Fan) outlet to Booster Up Fan(B.U.Fan) inlet using the commercial CFD software of CFD-ACE+ in CFDRC company for Computational Fluid Dynamic Analysis. The guide vane of this section was examined for the minimum pressure loss and the uniform flow dynamic to B.U.Fan with the proper velocity from I.D,Fan exit to B,U,Fan inlet section at the boiler both the maximum continuous rating and the design base. The guide vanes at I,D.Fan outlet and B.U.Fan inlet were removed and modified by numerical simulation of the CFD analysis. The flue gas at the system had the less pressure loss and the uniform flow dynamics of the flow velocity and flow line by comparing with the old design equipment.

• IMMUNE NETWORK
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• v.14 no.6
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• pp.321-327
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• 2014

TGF-${\beta}$ induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-${\beta}$ signal-transducing transcription factors, mediate germline (GL) ${\alpha}$ transcription induced by TGF-${\beta}1$, resulting in IgA switching by mouse B cells. Post-translational sumoylation of Smad3 and Smad4 regulates TGF-${\beta}$-induced transcriptional activation in certain cell types. In the present study, we investigated the effect of sumoylation on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ transcription and IgA switching by mouse B cell line, CH12F3-2A. Overexpression of small ubiquitin-like modifier (SUMO)-1, SUMO-2 or SUMO-3 did not affect TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity, expression of endogenous $GL{\alpha}$ transcripts, surface IgA expression, and IgA production. Next, we tested the effect of the E3 ligase PIASy on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity. We found that PIASy overexpression suppresses the $GL{\alpha}$ promoter activity in cooperation with histone deacetylase 1. Taken together, these results suggest that SUMO itself does not affect regulation of $GL{\alpha}$ transcription and IgA switching induced by TGF-${\beta}1$/Smad3/4, while PIASy acts as a repressor.

• IMMUNE NETWORK
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• v.14 no.3
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• pp.128-137
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• 2014

Respiratory viruses can induce acute respiratory disease. Clinical symptoms and manifestations are dependent on interactions between the virus and host immune system. Dendritic cells (DCs), along with alveolar macrophages, constitute the first line of sentinel cells in the innate immune response against respiratory viral infection. DCs play an essential role in regulating the immune response by bridging innate and adaptive immunity. In the steady state, lung DCs can be subdivided into $CD103^+$ conventional DCs (cDCs), $CD11b^+$ cDCs, and plasmacytoid DCs (pDCs). In the inflammatory state, like a respiratory viral infection, monocyte-derived DCs (moDCs) are recruited to the lung. In inflammatory lung, discrimination between moDCs and $CD11b^+$ DCs in the inflamed lung has been a critical challenge in understanding their role in the antiviral response. In particular, $CD103^+$ cDCs migrate from the intraepithelial base to the draining mediastinal lymph nodes to primarily induce the $CD8^+$ T cell response against the invading virus. Lymphoid $CD8{\alpha}^+$ cDCs, which have a developmental relationship with $CD103^+$ cDCs, also play an important role in viral antigen presentation. Moreover, pDCs have been reported to promote an antiviral response by inducing type I interferon production rather than adaptive immunity. However, the role of these cells in respiratory infections remains unclear. These different DC subsets have functional specialization against respiratory viral infection. Under certain viral infection, contextually controlling the balance of these specialized DC subsets is important for an effective immune response and maintenance of homeostasis.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.123-130
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• 2020

Prior to the introduction of automated systems such as jewelry CAD and CAM, the jewelry manufacturing industry had many originals made by hand. However, after the introduction of the automated system, original craftsmen with high technology have disappeared, and computer designers and 3D printing print engineers are taking their place. The introduction of automated systems such as CAD and CAM in the existing hand-made production line has resulted in diversification of designs and cutting-edge and specialization of jewelry manufacturing. In the domestic jewelry industry, the dependence of automation systems such as CAD and CAM in the manufacturing process continues to increase, and the situation is taking up more and more parts in the jewelry design curriculum of universities. From these results, the CAD/CAM automation system field in the jewelry manufacturing industry becomes an essential and important field in the future.

• Journal of The Korean Society of Clinical Toxicology
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• v.15 no.2
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• pp.107-115
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• 2017

Purpose: Glehnia littoralis has been used to treat ischemic stroke, phlegm, cough, systemic paralysis, antipyretics and neuralgia. The pharmacological mechanisms of Glehnia littoralis include calcium channel block, coumarin derivatives, anticoagulation, anti-convulsive effect, as well as anti-oxidant and anti-inflammatory effects. Alpha-amanitin (${\alpha}$-amanitin) is a major toxin from extremely poisonous Amanita fungi. Oxidative stress, which may contribute to severe hepatotoxicity was induced by ${\alpha}$-amanitin. The aim of this study was to investigate whether Glehnia littoralis ethyl acetate extract (GLEA) has the protective antioxidant effects on ${\alpha}$-amanitin -induced hepatotoxicity. Methods: Human hepatoma cell line HepG2 cells were pretreated in the presence or absence of GLEA (50, 100 and $200{\mu}g/ml$) for 4 hours, then exposed to $60{\mu}mol/L$ of${\alpha}$-amanitin for an additional 4 hours. Cell viability was evaluated using the MTT method. AST, ALT, and LDH production in a culture medium and intracellular MDA, GSH, and SOD levels were determined. Results: GLEA (50, 100 and $200{\mu}g/ml$) significantly increased the relative cell viability by 7.11, 9.87, and 14.39%, respectively, and reduced the level of ALT by 10.39%, 34.27%, and 52.14%, AST by 9.89%, 15.16%, and 32.84%, as well as LDH by 15.86%, 22.98%, and 24.32% in culture medium, respectively. GLEA could also remarkably decrease the level of MDA and increase the content of GSH and SOD in the HepG2 cells. Conclusion: In the in vitro model, Glehnia littoralis was effective in limiting hepatic injury after ${\alpha}$-amanitin poisoning. Its antioxidant effect is attenuated by antidotal therapy.

• Korean Journal of Agricultural Science
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• v.2 no.1
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• pp.265-279
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• 1975

This study was conducted to investigate the development of Gab river-basin which was a part of the farm land enlargement to contribute to the increased production of food. The results were as follows; 1. Gab river has the upper stream which occupy 50 percent in moumtains and the mid-stream in the Daejeon city area, and the downstream in a field which is about 22.9 percent in which farming area per household is 0.82 ha., agricultural population is 76 percent except of Daejeon city. Also, urban enlargement of mid-stream basin and development of industrial area in the lower stream diminish farm land. Consequently, this area should be developed to farm land to increase farming size. 2. There is no possibility to develop farm land in mountains of which (64.9 percent) is forests and in midstream which was constructed river-improvement. But Weonjeong area and Yongcheon area will be effective area. 3. If river banks of Weonjeong area will make straight with cost of construction 195,000,000 won, bank length 6 km will be useless, water will flow smoothly, flood will be prevented, farm land will develop 21.66 ha in which rice will produce annually 81.698 M/T which is about 10,860,000 won. 4. This area has good conditions of development. that is, investment efficiency (B/C) is 1.47 more than 1.00. 5. This area is a multiple purpose development district. The reasons are that there are beautiful mountains and a reservoir to be expected to construct, so it will be a sight seeing district in the vicinity of Daejeon city. 6. If Honam railway double line and river straight construction had executed simultaneously, cost of construction 50,000,000 won would have saved.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.605-607
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• 2015

The development of time-frequency analysis techniques allow astronomers to successfully deal with the non-stationary time series that originate from unstable physical mechanisms. We applied a recently developed time-frequency analysis method, the Hilbert-Huang transform (HHT), to two non-stationary phenomena: the superorbital modulation in the high-mass X-ray binary SMC X-1 and the quasi-periodic oscillation (QPO) of the AGN RE J1034+396. From the analysis of SMC X-1, we obtained a Hilbert spectrum that shows more detailed information in both the time and frequency domains. Then, a phase-resolved analysis of both the spectra and the orbital profiles was presented. From the spectral analysis, we noticed that the iron line production is dominated by different regions of this binary system in different superorbital phases. Furthermore, a pre-eclipse dip lying at orbital phase ~0:6-0:85 was discovered during the superorbital transition state. We further applied the HHT to analyze the QPO of RE J1034+396. From the Hilbert spectrum and the O-C analysis results, we suggest that it is better to divide the evolution of the QPO into three epochs according to their different periodicities. The correlations between the QPO periods and corresponding fluxes were also different in these three epochs. The change in periodicity and the relationships could be interpreted as the change in oscillation mode based on the diskoseismology model.

• The Journal of Advanced Prosthodontics
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• v.1 no.1
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• pp.56-61
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• 2009

STATEMENT OF PROBLEM. The success of titanium implants is due to osseointegration or the direct contact of the implant surface and bone without a fibrous connective tissue interface. PURPOSE. The purpose of this study was to evaluate the osteoblast precursor response to titanium-10 tantalum-10 niobium(Ti-Ta-Nb) alloy and its sputtered coating. MATERIAL AND METHODS. Ti-Ta-Nb coatings were sputtered onto the Ti-Ta-Nb disks. Ti6-Al-4V alloy disks were used as controls. An osteoblast precursor cell line, were used to evaluate the cell responses to the 3 groups. Cell attachment was measured using coulter counter and the cell morphology during attachment period was observed using fluorescent microscopy. Cell culture was performed at 4, 8, 12 and 16 days. RESULTS. The sputtered Ti-Ta-Nb coatings consisted of dense nanoscale grains in the range of 30 to 100 nm with alpha-Ti crystal structure. The Ti-Ta-Nb disks and its sputtered nanoscale coatings exhibited greater hydrophilicity and rougher surfaces compared to the Ti-6Al-4V disks. The sputtered nanoscale Ti-Ta-Nb coatings exhibited significantly greater cell attachment compared to Ti-6Al-4V and Ti-Ta-Nb disks. Nanoscale Ti-Ta-Nb coatings exhibited significantly greater ALP specific activity and total protein production compared to the other 2 groups CONCLUSIONS. It was concluded that nanoscale Ti-Ta-Nb coatings enhance cell adhesion. In addition, Ti-Ta-Nb alloy and its nanoscale coatings enhanced osteoblast differentiation, but did not support osteoblast precursor proliferation compared to Ti-6Al-4V. These results indicate that the new developed Ti-Ta-Nb alloy and its nanoscale Ti-Ta-Nb coatings may be useful as an implant material.

• Journal of the Society of Naval Architects of Korea
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• v.34 no.1
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• pp.50-59
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• 1997

Shipbuilder checks the status of main engine and propeller operation before sea trial. Generally these tests are carried out at a quay during fitting out of the ship. For these tests the operator has to estimate the maximum RPM with permissible torque and thrust to ensure the safety of the mooring line and ship. In this paper, the propeller characteristics according to the draft variation for a moored ship is inveatigated. From these tests, it is shown that shaft submergence is a dominant parameter in the propeller performance at shallow shaft submergence and that the propeller performance is dependent upon the propeller RPM when the shaft submergence is kept unchanged. In this study, a simple formula of the required thrust for a given propeller shaft submergence and propeller RPM is derived. 1be propeller thrust, which is calculated by another formula in case of dtep draft, is compared with results of bollard pull test for FPSO.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.22 no.3
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• pp.277-284
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• 2004

The subject of this study is to apply experimentally In resolution stereo imagery of IKONOS to producing 1:50,000 scale maps for Munsan area in Paju, being near the Military Demarcation Line, is inaccessible for aerial photography. Ground control points were acquired from GPS surveying to perform geometric corrections on images. Digital maps were produced from IKONOS stereo imagery on the digital photographic workstation. From field investigation, RMS errors of the plane and vertical positions are estimated respectively at $\pm$1.706m and $\pm$1.231m, respectively. These plane and vertical accuracies are within the tolerance limits of those provided in the NGIS Digital Topographic Map Production Rules. Therefore this suggested method is recommended for producing the large scale digital maps of 'No flight' zone near the M.D.L.