• IE interfaces
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• v.15 no.1
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• pp.99-106
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• 2002

A recently developed alternative to traditional production planning and control systems such as material requirement planning(MRP) and just-in-time(JIT) is the drum-buffer-rope(DBR). The DBR now being implemented in growing number of manufacturing organizations enables better scheduling and decision making on the shop floor. In implementing the DBR, however, an information system is usually needed to transmit the signal that runs from the constraint to material release. In this paper we propose a different mechanism to transmit the signal in the case that the demand of product is stable, which uses the well-known Kanban system. To improve the reality, this paper shows and example of the Kanban format, its operation, and calculation of the number of Kanbans.

• KSBB Journal
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• v.29 no.6
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• pp.405-413
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• 2014

In this study, gemcitabine (Gem)-Poly(L-lactic acid) (PLLA) conjugates were synthesized through an amide linkage reaction. Then, the microparticles of Gem-PLLA/PLLA blends containing gemcitabine were prepared using a supercritical fluid process, called aerosol solvent extraction system (ASES). Gemcitabine-loaded Gem-PLLA/PLLA microparticles obtained from the ASES process showed a spherical shape. The amount of gemcitabine released after 30 day incubation in a phosphate buffer solution of pH 7.4 was about 90% of the total amount of gemcitabine present in the product.

• The Journal of Information Technology
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• v.10 no.2
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• pp.47-64
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• 2007

Finite failure NHPP models presented in the literature exhibit either constant, monotonic increasing or monotonic decreasing failure occurrence rates per fault. Accurate predictions of software release times, and estimation of the reliability and availability of a software product require quantification of a critical element of the software testing process : test coverage. This model called enhanced non-homogeneous poission process(ENHPP). In this paper, exponential coverage and S-coverage model was reviewed, proposes the exponentiated exponential coverage reliability model, which maked out efficiency substituted for gamma and Weibull model(2 parameter shape illustrated by Gupta and Kundu(2001). In this analysis of software failure data, algorithm to estimate the parameters used to maximum likelihood estimator and bisection method, model selection based on SSE statistics for the sake of efficient model, was employed.

• Natural Product Sciences
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• v.9 no.4
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• pp.273-277
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• 2003

Salicornia herbacea is an annual herb growing in salt marshes and on muddy seashores. Salicornia herbacea has been used as a fork medicine as well as a seasoned vegetable. In fork medicine, Salicornia herbacea has been used to treat a variety of diseases such as constipation, obesity, diabetes, asthma, arthritis and cancer. However, the biological mechanisms for these activities have not been characterized, nor the active components. The immunomodulatory activity of Salicornia herbacea components were studied in the present study. The components of Salicornia herbacea were prepared from the whole plant by passage through a fine screen, and then dialyzed against PBS overnight. Immunomodulatory activities of the Salicornia herbacea components were examined on a mouse macrophage cell line, RAW 264.7 cells. The Salicornia herbacea components were shown to stimulate cytokine production, nitric oxide release, and expression of surface molecules in a dose dependent manner. The Salicornia herbacea components also induced further differentiation of slightly adherent RAW 264.7 cell into strongly adherent macrophages. These results indicate that Salicornia herbacea contains immunomodulator(s) that induces activation of macrophages.

• Natural Product Sciences
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• v.10 no.1
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• pp.24-28
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• 2004

The effects of aqueous extract of Artemisia iwayomogi (Compositae) (AIAE) on the mast cell-dependent allergic and inflammatory reactions were investigated. AIAE (0.05 to 1 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80 in mice. AIAE (0.1 and 1 g/kg) also significantly inhibited local allergic reaction activated by anti-DNP IgE. AIAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. Moreover, AIAE inhibited the secretion of interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. These results provide evidence that AIAE may be beneficial in the treatment of allergic diseases.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 1998.10a
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• pp.221-226
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• 1998

The processing conditions for the mass production of platelet WS$_2$ lubricant powder were optimized. The mixture of tungsten and sulfur powders was sealed in a vacuum of 10$^{-3}$ torr and heat-treated at 850$\circ$C for 2 h. The internal pressure of reaction chamber was maintained at certain level by controlling the release valve automatically. The reaction product was the platelet WS$_2$ powder with an average size of 15 $\mu$m. The synthesized WS$_2$ powder was then coated on the wiper-blade of automobiles and the commercial deep-grooved ball bearing using wet and dry coating methods, respectively. High lubricity and wear resistance of wet coated wiper-blade were confirmed by the life test of 70,000 cycles. The life-time of the ball bearing assembled after WS$_2$ coating onto each part increased 50 times compared to the non-coated ball bearing.

• Journal of Pharmaceutical Investigation
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• v.40 no.4
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• pp.251-254
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• 2010

The formation of acylated peptide impurities in poly(lactide-co-glycolide) (PLGA) formulations is one of the major challenges to the development of successful sustained-release product. Octreotide, synthetic analogue of somatostatin, has been identified to be acylated in PLGA microsphere formulations. The purpose of this study was to investigate the pH effect on the formation of acylated octreotides by PLGA. In the incubation with PLGA in 0.1 M phosphate buffer at pH 7.4, approximately 98% of octreotide adsorbed to PLGA through 14 days and 66.3% of acylated octreotides were produced after 42 days, whereas the interaction of octreotide with PLGA was significantly inhibited in the incubation at pH 4, in which the acylated octreotides were observed to be 9.2% after 42 days. In the interaction study at pH 4.1-7.4, the production of acylated octreotides was demonstrated to be dependent on environmental pH. Below pH 5.0, the acylation of octreotide was significantly inhibited. This study indicates that the pH is the major factor for the formation of acylated octreotide in PLGA formulations.

• Natural Product Sciences
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• v.7 no.4
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• pp.95-101
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• 2001

We investigated the effect of aqueous extract of Terminalia chebula (Combretaceae)(TCAE) on the immediate hypersensitivity reaction in vivo and in vivo. TCAE (0.01 to 1 g/kg) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in mice. When TCAE was pretreated at concentrations ranging from 0.01 to 1 g/kg, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. TCAE (0.001 to 1 mg/ml) also dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) IgE. TCAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis $factor-{\alpha}$ production from RPMC. These results indicate that TCAE inhibits immediate hypersensitivity reaction in vivo and in vitro.

• Natural Product Sciences
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• v.17 no.3
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• pp.239-244
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• 2011

Immediate-type hypersensitivity is involved in many allergic diseases such as asthma, allergic rhinitis and anaphylaxis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells releases inflammatory mediators, such as histamine and pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of the aqueous extract of Schizonepeta tenuifolia (AEST) (Labiatae) on the immediate-type allergic reaction. AEST inhibited compound 48/80-induced systemic allergic reaction. AEST attenuated immunoglobulin E (IgE)-mediated skin allergic reaction and histamine release from human mast cell line (HMC-1) cells. In addition, AEST decreased the gene expression and secretion of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated HMC-1 cells. Our results indicate that AEST inhibits the mast cell-derived allergic reactions and involvement of histamine and pro-inflammatory cytokines in these effects.

• International Journal of Advanced Culture Technology
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• v.3 no.1
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• pp.78-85
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• 2015

In Thailand, the electricity consumption is very high with the intention of reduce high temperature in the building. Since 2000, a lot of people paying attention to Green-Building concept. A similar concept is natural building, which is usually on a smaller scale and tends to focus on the use of natural materials that are available locally. Therefore, the Earth-Block (EAB) product is appropriated approach to reduce energy consumption in the buildings. The EAB is produced with environmentally friendly process, which does not release harmful pollution and effective cost. The main significant character is durable materials for building construction. This study aims to develop the new thermal insulation by using soil-cement with vetiver grass fibre. Additionally, it describes the innovative systems used in production of EAB materials by mixing the soil-cement with vetiver grass fibre. This paper reveals lowest costs, space configurations changing and greater design flexibility for constructing the building.